SION — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $435 722 930 | 9 905 045 | 20,30% | Actions |
| TPG GP A, LLC | $285 713 378 | 6 494 962 | 13,31% | Actions |
| VIKING GLOBAL INVESTORS LP | $140 556 012 | 3 195 181 | 6,55% | Actions |
| Atlas Venture Life Science Advisors, LLC | $131 776 532 | 2 995 602 | 6,14% | Actions |
| ORBIMED ADVISORS LLC | $112 433 029 | 2 555 877 | 5,24% | Actions |
| ENAVATE SCIENCES GP, LLC | $109 008 540 | 2 478 030 | 5,08% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $70 384 000 | 1 600 000 | 3,28% | Actions |
| BlackRock, Inc. | $64 875 089 | 1 474 769 | 3,02% | Actions |
| JPMORGAN CHASE & CO | $64 085 673 | 1 490 508 | 2,99% | Actions |
| JENNISON ASSOCIATES LLC | $51 562 131 | 1 172 133 | 2,40% | Actions |
| CITADEL ADVISORS LLC | $50 484 507 | 1 147 636 | 2,35% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $49 796 724 | 1 132 001 | 2,32% | Actions |
| VANGUARD GROUP INC | $48 748 883 | 1 184 951 | 2,27% | Actions |
| STATE STREET CORP | $44 937 281 | 1 021 534 | 2,09% | Actions |
| PERCEPTIVE ADVISORS LLC | $39 810 950 | 905 000 | 1,85% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $29 953 495 | 680 916 | 1,40% | Actions |
| Siren, L.L.C. | $26 856 555 | 610 515 | 1,25% | Actions |
| EVENTIDE ASSET MANAGEMENT, LLC | $20 894 402 | 474 981 | 0,97% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $20 113 984 | 457 145 | 0,94% | Actions |
| Casdin Capital, LLC | $17 596 000 | 400 000 | 0,82% | Actions |
| BAKER BROS. ADVISORS LP | $17 596 000 | 400 000 | 0,82% | Actions |
| GOLDMAN SACHS GROUP INC | $17 103 752 | 388 810 | 0,80% | Actions |
| Driehaus Capital Management LLC | $16 955 814 | 385 447 | 0,79% | Actions |
| FRANKLIN RESOURCES INC | $12 762 071 | 290 113 | 0,59% | Actions |
| Aberdeen Group plc | $12 499 231 | 284 138 | 0,58% | Actions |
| FMR LLC | $12 242 065 | 278 292 | 0,57% | Actions |
| MILLENNIUM MANAGEMENT LLC | $12 173 485 | 276 733 | 0,57% | Actions |
| Candriam S.C.A. | $10 248 950 | 233 208 | 0,48% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $9 807 527 | 222 949 | 0,46% | Actions |
| Kalehua Capital Management LLC | $8 669 197 | 197 072 | 0,40% | Actions |
| Longaeva Partners L.P. | $8 637 524 | 196 352 | 0,40% | Actions |
| Artisan Partners Limited Partnership | $8 336 017 | 189 498 | 0,39% | Actions |
| Ensign Peak Advisors, Inc | $8 117 563 | 184 532 | 0,38% | Actions |
| Soleus Capital Management, L.P. | $7 816 451 | 177 687 | 0,36% | Actions |
| NORTHERN TRUST CORP | $6 795 399 | 154 476 | 0,32% | Actions |
| MORGAN STANLEY | $6 644 558 | 151 047 | 0,31% | Actions |
| Sofinnova Investments, Inc. | $6 353 564 | 144 432 | 0,30% | Actions |
| Qube Research & Technologies Ltd | $6 172 193 | 140 309 | 0,29% | Actions |
| Alyeska Investment Group, L.P. | $5 992 406 | 136 222 | 0,28% | Actions |
| GordonMD Global Investments LP | $5 982 640 | 136 000 | 0,28% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $5 707 834 | 129 753 | 0,27% | Actions |
| Sio Capital Management, LLC | $5 622 274 | 127 808 | 0,26% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $5 342 234 | 121 442 | 0,25% | Actions |
| Artia Global Partners LP | $5 267 407 | 119 741 | 0,25% | Actions |
| UBS Group AG | $5 111 902 | 116 206 | 0,24% | Actions |
| First Turn Management, LLC | $4 860 587 | 110 493 | 0,23% | Actions |
| CITIGROUP INC | $4 846 070 | 110 163 | 0,23% | Actions |
| Ikarian Capital, LLC | $4 728 925 | 107 500 | 0,22% | Option de vente |
| D. E. Shaw & Co., Inc. | $4 471 320 | 101 644 | 0,21% | Actions |
| Rock Springs Capital Management LP | $4 373 882 | 99 429 | 0,20% | Actions |
| Walleye Capital LLC | $4 282 295 | 97 347 | 0,20% | Actions |
| Rhenman & Partners Asset Management AB | $4 271 429 | 97 100 | 0,20% | Actions |
| BANK OF AMERICA CORP /DE/ | $3 911 063 | 88 908 | 0,18% | Actions |
| AMERIPRISE FINANCIAL INC | $3 617 386 | 82 232 | 0,17% | Actions |
| Integral Health Asset Management, LLC | $3 299 250 | 75 000 | 0,15% | Actions |
| SUPERSTRING CAPITAL MANAGEMENT LP | $2 778 232 | 63 156 | 0,13% | Actions |
| STEMPOINT CAPITAL LP | $2 614 150 | 59 426 | 0,12% | Actions |
| DEUTSCHE BANK AG\ | $2 346 998 | 53 353 | 0,11% | Actions |
| SEVEN GRAND MANAGERS, LLC | $2 199 500 | 50 000 | 0,10% | Actions |
| Point72 Asset Management, L.P. | $2 169 939 | 49 328 | 0,10% | Actions |
| TD Asset Management Inc | $2 084 950 | 47 396 | 0,10% | Actions |
| ALPS ADVISORS INC | $2 002 645 | 45 525 | 0,09% | Actions |
| SILVERARC CAPITAL MANAGEMENT, LLC | $1 868 607 | 42 478 | 0,09% | Actions |
| Russell Investments Group, Ltd. | $1 858 960 | 42 258 | 0,09% | Actions |
| Bank of New York Mellon Corp | $1 829 361 | 41 586 | 0,09% | Actions |
| Nuveen, LLC | $1 814 984 | 41 259 | 0,08% | Actions |
| XTX Topco Ltd | $1 675 843 | 38 096 | 0,08% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $1 643 686 | 37 365 | 0,08% | Actions |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $1 582 232 | 35 968 | 0,07% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1 558 126 | 35 420 | 0,07% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $1 429 675 | 32 500 | 0,07% | Option de vente |
| BNP PARIBAS FINANCIAL MARKETS | $1 399 014 | 31 803 | 0,07% | Actions |
| Ishara Investments LP | $1 350 540 | 123 000 | 0,06% | Actions |
| MILLENNIUM MANAGEMENT LLC | $1 258 114 | 28 600 | 0,06% | Option de vente |
| Swiss National Bank | $1 187 730 | 27 000 | 0,06% | Actions |
| Quadrature Capital Ltd | $1 144 752 | 26 023 | 0,05% | Actions |
| Trexquant Investment LP | $1 047 402 | 23 810 | 0,05% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $1 037 548 | 23 586 | 0,05% | Actions |
| ALLIANCEBERNSTEIN L.P. | $1 020 291 | 25 450 | 0,05% | Actions |
| TUDOR INVESTMENT CORP ET AL | $993 074 | 22 575 | 0,05% | Actions |
| RHUMBLINE ADVISERS | $981 362 | 22 309 | 0,05% | Actions |
| MILLENNIUM MANAGEMENT LLC | $879 800 | 20 000 | 0,04% | Option d'achat |
| Maven Securities LTD | $879 800 | 20 000 | 0,04% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $820 193 | 18 645 | 0,04% | Actions |
| Susquehanna Portfolio Strategies, LLC | $793 316 | 18 034 | 0,04% | Actions |
| Rafferty Asset Management, LLC | $791 996 | 18 004 | 0,04% | Actions |
| Shay Capital LLC | $791 820 | 18 000 | 0,04% | Actions |
| WELLS FARGO & COMPANY/MN | $739 955 | 16 821 | 0,03% | Actions |
| Engineers Gate Manager LP | $686 376 | 15 603 | 0,03% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $653 339 | 14 852 | 0,03% | Actions |
| KENNEDY CAPITAL MANAGEMENT LLC | $555 198 | 12 621 | 0,03% | Actions |
| MARSHALL WACE, LLP | $554 230 | 12 599 | 0,03% | Actions |
| Invesco Ltd. | $546 267 | 12 418 | 0,03% | Actions |
| MetLife Investment Management, LLC | $482 658 | 10 972 | 0,02% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $463 369 | 10 582 | 0,02% | Actions |
| Jump Financial, LLC | $460 708 | 10 473 | 0,02% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $419 445 | 9 535 | 0,02% | Actions |
| PROFUND ADVISORS LLC | $402 069 | 9 140 | 0,02% | Actions |
| Virtus Investment Advisers, LLC | $400 705 | 9 109 | 0,02% | Actions |
| Legal & General Group Plc | $397 846 | 9 044 | 0,02% | Actions |
| CITADEL ADVISORS LLC | $369 516 | 8 400 | 0,02% | Option de vente |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $356 319 | 8 100 | 0,02% | Option d'achat |
| Vanguard Global Advisers, LLC | $345 409 | 7 852 | 0,02% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $338 723 | 7 700 | 0,02% | Option de vente |
| China Universal Asset Management Co., Ltd. | $316 112 | 7 186 | 0,01% | Actions |
| Quarry LP | $296 933 | 6 750 | 0,01% | Actions |
| BARCLAYS PLC | $285 715 | 6 495 | 0,01% | Actions |
| VARCOV Co. | $282 328 | 6 418 | 0,01% | Actions |
| Police & Firemen's Retirement System of New Jersey | $239 218 | 5 438 | 0,01% | Actions |
| Squarepoint Ops LLC | $238 206 | 5 415 | 0,01% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $229 540 | 5 218 | 0,01% | Actions |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $229 408 | 5 215 | 0,01% | Actions |
| SEI INVESTMENTS CO | $226 900 | 5 158 | 0,01% | Actions |
| Verition Fund Management LLC | $219 950 | 5 000 | 0,01% | Option d'achat |
| AlphaCentric Advisors LLC | $213 923 | 4 863 | 0,01% | Actions |
| Jain Global LLC | $210 272 | 4 780 | 0,01% | Actions |
| AXQ CAPITAL, LP | $202 222 | 4 597 | 0,01% | Actions |
| STRS OHIO | $153 965 | 3 500 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $153 525 | 3 490 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $136 369 | 3 100 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $88 816 | 2 019 | 0,00% | Actions |
| Quantbot Technologies LP | $80 062 | 1 820 | 0,00% | Actions |
| Ameritas Investment Partners, Inc. | $73 595 | 1 673 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $56 263 | 1 279 | 0,00% | Actions |
| Mitsubishi UFJ Asset Management Co., Ltd. | $43 990 | 1 000 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $41 615 | 946 | 0,00% | Actions |
| State of Wyoming | $35 368 | 804 | 0,00% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $31 189 | 709 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $25 000 | 568 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $21 029 | 478 016 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $16 936 | 385 | 0,00% | Actions |
| GAMMA Investing LLC | $10 734 | 244 | 0,00% | Actions |
| Federation des caisses Desjardins du Quebec | $9 238 | 210 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $8 622 | 196 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $5 015 | 114 | 0,00% | Actions |
| Hurley Capital, LLC | $4 971 | 113 | 0,00% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $4 650 | 116 | 0,00% | Actions |
| US BANCORP \DE\ | $4 575 | 104 | 0,00% | Actions |
| Sterling Capital Management LLC | $2 859 | 65 | 0,00% | Actions |
| CWM, LLC | $2 686 | 67 | 0,00% | Actions |
| Arax Advisory Partners | $1 804 | 41 | 0,00% | Actions |
| Bare Financial Services, Inc | $1 628 | 37 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $1 364 | 31 | 0,00% | Actions |
| Hughes Financial Services, LLC | $1 100 | 25 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $880 | 20 | 0,00% | Actions |
| Fortitude Family Office, LLC | $660 | 15 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $396 | 9 | 0,00% | Actions |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | $264 | 6 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $220 | 5 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $176 | 4 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $88 | 2 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $44 | 1 | 0,00% | Actions |
| Allworth Financial LP | $44 | 1 | 0,00% | Actions |
| Pacer Advisors, Inc. | $13 | 301 | 0,00% | Actions |
| Covestor Ltd | $1 | 12 | 0,00% | Actions |