| TCG Crossover Management, LLC |
$67686664 |
9533333 |
9.39% |
股份
|
| MONTANOVA CAPITAL, LLC |
$51164141 |
7206217 |
7.10% |
股份
|
| Frazier Life Sciences Management, L.P. |
$50410000 |
7100000 |
6.99% |
股份
|
| Matrix Capital Management Company, LP |
$46314000 |
6922870 |
6.42% |
股份
|
| Long Focus Capital Management, LLC |
$36349032 |
5119582 |
5.04% |
股份
|
| BlackRock, Inc. |
$33424486 |
4707674 |
4.64% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$32944000 |
4640000 |
4.57% |
股份
|
| Caligan Partners LP |
$30517561 |
4298248 |
4.23% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$29112428 |
4100342 |
4.04% |
股份
|
| FCPM III SERVICES B.V. |
$28781803 |
4053775 |
3.99% |
股份
|
| ORBIMED ADVISORS LLC |
$23666664 |
3333333 |
3.28% |
股份
|
| Medicxi Ventures Management (Jersey) Ltd |
$21583233 |
3039892 |
2.99% |
股份
|
| Nantahala Capital Management, LLC |
$20952313 |
2951030 |
2.91% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$17750000 |
2500000 |
2.46% |
股份
|
| Balyasny Asset Management L.P. |
$16717795 |
2354619 |
2.32% |
股份
|
| VANGUARD GROUP INC |
$16004132 |
2936538 |
2.22% |
股份
|
| FRANKLIN RESOURCES INC |
$14716355 |
2072726 |
2.04% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$12462919 |
1754721 |
1.73% |
股份
|
| Redmile Group, LLC |
$11833336 |
1666667 |
1.64% |
股份
|
| EcoR1 Capital, LLC |
$11833336 |
1666667 |
1.64% |
股份
|
| Trails Edge Capital Partners, LP |
$10247665 |
1443333 |
1.42% |
股份
|
| Foresite Capital Management VI LLC |
$9466671 |
1333334 |
1.31% |
股份
|
| STATE STREET CORP |
$8683186 |
1222984 |
1.20% |
股份
|
| Woodline Partners LP |
$8592299 |
1210183 |
1.19% |
股份
|
| Bellevue Group AG |
$8283336 |
1166667 |
1.15% |
股份
|
| Vivo Capital, LLC |
$8283336 |
1166667 |
1.15% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$6596447 |
929077 |
0.91% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$6435128 |
906356 |
0.89% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$6186528 |
871342 |
0.86% |
股份
|
| LEVIN CAPITAL STRATEGIES, L.P. |
$5950276 |
838067 |
0.83% |
股份
|
| B Group, Inc. |
$5426125 |
764243 |
0.75% |
股份
|
| STEMPOINT CAPITAL LP |
$5071388 |
714280 |
0.70% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$4524148 |
637204 |
0.63% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$4392726 |
618891 |
0.61% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$4384016 |
617467 |
0.61% |
股份
|
| AWM Investment Company, Inc. |
$4198123 |
591285 |
0.58% |
股份
|
| NORTHERN TRUST CORP |
$3901181 |
549462 |
0.54% |
股份
|
| Regency Capital Management Inc.\DE |
$3836804 |
540395 |
0.53% |
股份
|
| GOLDMAN SACHS GROUP INC |
$3299143 |
464668 |
0.46% |
股份
|
| FMR LLC |
$1812851 |
255331 |
0.25% |
股份
|
| MORGAN STANLEY |
$1240313 |
174692 |
0.17% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1236820 |
174200 |
0.17% |
股份
|
| Integral Health Asset Management, LLC |
$1207000 |
170000 |
0.17% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1158408 |
163156 |
0.16% |
股份
|
| XTX Topco Ltd |
$1064510 |
149931 |
0.15% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$938066 |
132122 |
0.13% |
股份
|
| Quantinno Capital Management LP |
$927658 |
130656 |
0.13% |
股份
|
| ADAR1 Capital Management, LLC |
$924079 |
130152 |
0.13% |
股份
|
| Bank of New York Mellon Corp |
$842009 |
118593 |
0.12% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$794242 |
111865 |
0.11% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$780213 |
109889 |
0.11% |
股份
|
| Qube Research & Technologies Ltd |
$777904 |
109564 |
0.11% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$755092 |
106351 |
0.10% |
股份
|
| JANE STREET GROUP, LLC |
$742660 |
104600 |
0.10% |
卖出期权
|
| BANK OF AMERICA CORP /DE/ |
$618850 |
87162 |
0.09% |
股份
|
| Nuveen, LLC |
$595009 |
83804 |
0.08% |
股份
|
| Fisher Asset Management, LLC |
$592906 |
83508 |
0.08% |
股份
|
| Jump Financial, LLC |
$518300 |
73000 |
0.07% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$505932 |
71258 |
0.07% |
股份
|
| UBS Group AG |
$491533 |
69230 |
0.07% |
股份
|
| D. E. Shaw & Co., Inc. |
$478576 |
67405 |
0.07% |
股份
|
| RHUMBLINE ADVISERS |
$451956 |
63657 |
0.06% |
股份
|
| Permanent Capital Management, LP |
$442820 |
62369 |
0.06% |
股份
|
| TBH Global Asset Management, LLC |
$428289 |
60322 |
0.06% |
股份
|
| WATER ISLAND CAPITAL LLC |
$426000 |
60000 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$368504 |
51902 |
0.05% |
股份
|
| Virtus Investment Advisers, LLC |
$362420 |
51045 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$352964 |
52760 |
0.05% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$348255 |
49050 |
0.05% |
股份
|
| Invesco Ltd. |
$318435 |
44850 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$315950 |
44500 |
0.04% |
卖出期权
|
| AMERIPRISE FINANCIAL INC |
$303042 |
42682 |
0.04% |
股份
|
| DEUTSCHE BANK AG\ |
$297093 |
41844 |
0.04% |
股份
|
| WELLS FARGO & COMPANY/MN |
$290518 |
40918 |
0.04% |
股份
|
| BANK OF NOVA SCOTIA |
$289453 |
40768 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$267542 |
37682 |
0.04% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$255870 |
36038 |
0.04% |
股份
|
| Jain Global LLC |
$217260 |
30600 |
0.03% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$215240 |
30316 |
0.03% |
股份
|
| Quadrature Capital Ltd |
$212091 |
29872 |
0.03% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$200930 |
28300 |
0.03% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$191700 |
27000 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$188389 |
27382 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$179062 |
25220 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$174333 |
24554 |
0.02% |
股份
|
| CITIGROUP INC |
$166367 |
23432 |
0.02% |
股份
|
| Engineers Gate Manager LP |
$157854 |
22233 |
0.02% |
股份
|
| nVerses Capital, LLC |
$147665 |
20798 |
0.02% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$146707 |
20663 |
0.02% |
股份
|
| TD Asset Management Inc |
$141972 |
19996 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$127729 |
17990 |
0.02% |
股份
|
| Point72 Asset Management, L.P. |
$126834 |
17864 |
0.02% |
股份
|
| Inscription Capital, LLC |
$126423 |
17806 |
0.02% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$122710 |
17940 |
0.02% |
股份
|
| Creative Planning |
$109851 |
15472 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$104370 |
14700 |
0.01% |
买入期权
|
| BARCLAYS PLC |
$102681 |
14462 |
0.01% |
股份
|
| BROWN ADVISORY INC |
$95140 |
13400 |
0.01% |
股份
|
| ExodusPoint Capital Management, LP |
$94274 |
13278 |
0.01% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$93038 |
13104 |
0.01% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$92300 |
13000 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$81799 |
11521 |
0.01% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$81224 |
11440 |
0.01% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$80919 |
11397 |
0.01% |
股份
|
| Vontobel Holding Ltd. |
$78100 |
11000 |
0.01% |
股份
|
| Polymer Capital Management (US) LLC |
$73016 |
10284 |
0.01% |
股份
|
| Focus Partners Wealth |
$71348 |
10049 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$71043 |
10006 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$49359 |
6952 |
0.01% |
股份
|
| Parallel Advisors, LLC |
$40222 |
5665 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$32830 |
4624 |
0.00% |
股份
|
| Ameritas Investment Partners, Inc. |
$32262 |
4544 |
0.00% |
股份
|
| Arax Advisory Partners |
$31397 |
4422 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$30219 |
4517 |
0.00% |
股份
|
| Legal & General Group Plc |
$29143 |
4096 |
0.00% |
股份
|
| CWM, LLC |
$26880 |
4018 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$23000 |
3121 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$18055 |
2543 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$17317 |
2439 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$14505 |
2043 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$12315 |
1790 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$9590 |
1527 |
0.00% |
股份
|
| COMERICA BANK |
$8856 |
1625 |
0.00% |
股份
|
| GAMMA Investing LLC |
$7434 |
1047 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$5822 |
820 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4388 |
618 |
0.00% |
股份
|
| Allworth Financial LP |
$3565 |
502 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$3465 |
488 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$3081 |
434 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$2592 |
365 |
0.00% |
股份
|
| US BANCORP \DE\ |
$2073 |
292 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2045 |
288 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1978 |
278471 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$1491 |
210 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1484 |
209 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1456 |
205 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1200 |
169 |
0.00% |
股份
|
| Quarry LP |
$1044 |
147 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$980 |
138 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$923 |
130 |
0.00% |
股份
|
| Essential Partners LLC |
$824 |
116 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$820 |
140 |
0.00% |
股份
|
| True Wealth Design, LLC |
$618 |
87 |
0.00% |
股份
|
| Blue Trust, Inc. |
$611 |
86 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$589 |
83 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$554 |
78 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$504 |
71 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$483 |
68 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$291 |
41 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$241 |
34 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$165 |
23 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$50 |
7 |
0.00% |
股份
|
| Inspire Investing, LLC |
$36 |
5 |
0.00% |
股份
|