| RA CAPITAL MANAGEMENT, L.P. |
$215430432 |
7255993 |
11.71% |
股份
|
| Siren, L.L.C. |
$166352179 |
5602970 |
9.04% |
股份
|
| Vestal Point Capital, LP |
$155872500 |
5250000 |
8.47% |
股份
|
| Deep Track Capital, LP |
$121729000 |
4100000 |
6.62% |
股份
|
| BlackRock, Inc. |
$114249784 |
3848090 |
6.21% |
股份
|
| RED TREE MANAGEMENT, LLC |
$93924820 |
3163517 |
5.11% |
股份
|
| TPG GP A, LLC |
$89379518 |
3010425 |
4.86% |
股份
|
| JANUS HENDERSON GROUP PLC |
$66350262 |
3339218 |
3.61% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$65812012 |
2216639 |
3.58% |
股份
|
| STATE STREET CORP |
$60832435 |
2048920 |
3.31% |
股份
|
| FRANKLIN RESOURCES INC |
$57951672 |
1951892 |
3.15% |
股份
|
| FMR LLC |
$56205248 |
1893070 |
3.05% |
股份
|
| Omega Fund Management, LLC |
$54099634 |
1822150 |
2.94% |
股份
|
| VANGUARD GROUP INC |
$36792904 |
2186150 |
2.00% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$34525388 |
1162635 |
1.88% |
股份
|
| JPMORGAN CHASE & CO |
$29808414 |
1015965 |
1.62% |
股份
|
| Jones Hill Capital LP |
$26501917 |
892621 |
1.44% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$19102000 |
643381 |
1.04% |
股份
|
| Aisling Capital Management LP |
$16891205 |
568919 |
0.92% |
股份
|
| Palo Alto Investors LP |
$16341614 |
550408 |
0.89% |
股份
|
| Rock Springs Capital Management LP |
$15892641 |
535286 |
0.86% |
股份
|
| GOLDMAN SACHS GROUP INC |
$15455635 |
520567 |
0.84% |
股份
|
| D. E. Shaw & Co., Inc. |
$14791350 |
498193 |
0.80% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$13707173 |
461724 |
0.75% |
股份
|
| NAN FUNG TRINITY (HK) LTD |
$12703906 |
427885 |
0.69% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$12437497 |
418912 |
0.68% |
股份
|
| NORTHERN TRUST CORP |
$11767424 |
396343 |
0.64% |
股份
|
| Candriam S.C.A. |
$11074986 |
373380 |
0.60% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$10851131 |
365481 |
0.59% |
股份
|
| Walleye Capital LLC |
$10487280 |
353226 |
0.57% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$10477720 |
352904 |
0.57% |
股份
|
| Ensign Peak Advisors, Inc |
$10160245 |
342211 |
0.55% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$9314911 |
313739 |
0.51% |
股份
|
| Clearbridge Investments, LLC |
$8603707 |
289785 |
0.47% |
股份
|
| AMERIPRISE FINANCIAL INC |
$8573036 |
288749 |
0.47% |
股份
|
| DAFNA Capital Management LLC |
$8460314 |
284955 |
0.46% |
股份
|
| MORGAN STANLEY |
$8428517 |
283884 |
0.46% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7786321 |
262254 |
0.42% |
股份
|
| TD Asset Management Inc |
$7752593 |
261118 |
0.42% |
股份
|
| ALGERT GLOBAL LLC |
$6924658 |
233232 |
0.38% |
股份
|
| Woodline Partners LP |
$6908566 |
232690 |
0.38% |
股份
|
| SEB Asset Management AB |
$6892698 |
232156 |
0.37% |
股份
|
| CITADEL ADVISORS LLC |
$6268806 |
211142 |
0.34% |
股份
|
| ORBIMED ADVISORS LLC |
$5673759 |
191100 |
0.31% |
股份
|
| Atle Fund Management AB |
$4324556 |
145657 |
0.24% |
股份
|
| DEUTSCHE BANK AG\ |
$4275657 |
144010 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$3582573 |
120666 |
0.19% |
股份
|
| Napean Trading & Investment Co (Singapore) PTE Ltd |
$3378128 |
113780 |
0.18% |
股份
|
| Hudson Bay Capital Management LP |
$3117450 |
105000 |
0.17% |
股份
|
| Jump Financial, LLC |
$2977907 |
100300 |
0.16% |
股份
|
| Nuveen, LLC |
$2886551 |
97223 |
0.16% |
股份
|
| CITADEL ADVISORS LLC |
$2725542 |
91800 |
0.15% |
卖出期权
|
| VOYA INVESTMENT MANAGEMENT LLC |
$2712568 |
91363 |
0.15% |
股份
|
| Rhenman & Partners Asset Management AB |
$2617173 |
88150 |
0.14% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$2455838 |
82716 |
0.13% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2142846 |
72174 |
0.12% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$2100390 |
70744 |
0.11% |
股份
|
| Shay Capital LLC |
$2018920 |
68000 |
0.11% |
股份
|
| ALPS ADVISORS INC |
$1964944 |
66182 |
0.11% |
股份
|
| UBS Group AG |
$1959124 |
65986 |
0.11% |
股份
|
| Quantinno Capital Management LP |
$1899507 |
63978 |
0.10% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$1855625 |
62500 |
0.10% |
股份
|
| FIL Ltd |
$1845946 |
62174 |
0.10% |
股份
|
| Trexquant Investment LP |
$1758242 |
59220 |
0.10% |
股份
|
| Swiss National Bank |
$1757648 |
59200 |
0.10% |
股份
|
| XTX Topco Ltd |
$1751205 |
58983 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$1632523 |
54986 |
0.09% |
股份
|
| SCS Capital Management LLC |
$1586337 |
53430 |
0.09% |
股份
|
| Mariner, LLC |
$1576823 |
53112 |
0.09% |
股份
|
| CITIGROUP INC |
$1491626 |
50240 |
0.08% |
股份
|
| Burkehill Global Management, LP |
$1484500 |
50000 |
0.08% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1383732 |
46606 |
0.08% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1301728 |
43844 |
0.07% |
股份
|
| Invesco Ltd. |
$1288219 |
43389 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1184423 |
39893 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1157910 |
39000 |
0.06% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1147400 |
38646 |
0.06% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1113641 |
55990 |
0.06% |
股份
|
| Corient Private Wealth LP |
$1089120 |
36683 |
0.06% |
股份
|
| BARCLAYS PLC |
$1030184 |
34698 |
0.06% |
股份
|
| Russell Investments Group, Ltd. |
$989834 |
33339 |
0.05% |
股份
|
| Rafferty Asset Management, LLC |
$904951 |
30480 |
0.05% |
股份
|
| Caption Management, LLC |
$890700 |
30000 |
0.05% |
买入期权
|
| Caption Management, LLC |
$890700 |
30000 |
0.05% |
卖出期权
|
| AQR CAPITAL MANAGEMENT LLC |
$888236 |
29917 |
0.05% |
股份
|
| Bleakley Financial Group, LLC |
$866384 |
29181 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$845245 |
28469 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$843196 |
28400 |
0.05% |
卖出期权
|
| MetLife Investment Management, LLC |
$774553 |
26088 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$710868 |
23943 |
0.04% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$709977 |
23913 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$708114 |
23892 |
0.04% |
股份
|
| Legal & General Group Plc |
$703742 |
23703 |
0.04% |
股份
|
| Creative Planning |
$662889 |
22327 |
0.04% |
股份
|
| NOMURA HOLDINGS INC |
$623490 |
21000 |
0.03% |
买入期权
|
| NOMURA HOLDINGS INC |
$623490 |
21000 |
0.03% |
卖出期权
|
| Aquatic Capital Management LLC |
$537805 |
18114 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$528482 |
17800 |
0.03% |
卖出期权
|
| Allianz Asset Management GmbH |
$510668 |
17200 |
0.03% |
股份
|
| Engineers Gate Manager LP |
$499030 |
16808 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$467321 |
15740 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$460195 |
15500 |
0.03% |
股份
|
| FEDERATED HERMES, INC. |
$452862 |
15253 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$447903 |
15086 |
0.02% |
股份
|
| LPL Financial LLC |
$435998 |
14685 |
0.02% |
股份
|
| Ascent Group, LLC |
$420900 |
14176 |
0.02% |
股份
|
| ADAR1 Capital Management, LLC |
$406901 |
13705 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$388939 |
13100 |
0.02% |
买入期权
|
| Police & Firemen's Retirement System of New Jersey |
$386979 |
13034 |
0.02% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$354974 |
11956 |
0.02% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$351292 |
11832 |
0.02% |
股份
|
| Voleon Capital Management LP |
$349184 |
11761 |
0.02% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$331786 |
11175 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$310468 |
10457 |
0.02% |
股份
|
| VARCOV Co. |
$299839 |
10099 |
0.02% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$298978 |
10070 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$282827 |
9526 |
0.02% |
股份
|
| Orion Porfolio Solutions, LLC |
$274781 |
9255 |
0.01% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$272346 |
9173 |
0.01% |
股份
|
| NORDEN GROUP LLC |
$264567 |
8911 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$260292 |
8767 |
0.01% |
股份
|
| Savant Capital, LLC |
$243488 |
8201 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$241350 |
8129 |
0.01% |
股份
|
| ProShare Advisors LLC |
$235828 |
7943 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$227336 |
7658 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$220508 |
7427 |
0.01% |
股份
|
| SmartHarvest Portfolios, LLC |
$218103 |
7346 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$212877 |
7170 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$190016 |
6400 |
0.01% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$188190 |
6338487 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$181109 |
6100 |
0.01% |
股份
|
| STRS OHIO |
$145481 |
4900 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$143759 |
4842 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$128854 |
4340 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$119087 |
4011 |
0.01% |
股份
|
| Larson Financial Group LLC |
$104063 |
3505 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$87259 |
2939 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$79000 |
2661 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$56538 |
1904248 |
0.00% |
股份
|
| US BANCORP \DE\ |
$49167 |
1656 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$44179 |
1488 |
0.00% |
股份
|
| GAMMA Investing LLC |
$43496 |
1465 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$39874 |
1343 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$38864 |
1309 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$26187 |
882 |
0.00% |
股份
|
| CWM, LLC |
$22635 |
1138 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$14251 |
480 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$12133 |
610 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$10807 |
364 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$8706 |
324 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$8461 |
285 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$8077 |
434 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7393 |
249 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$7276 |
248 |
0.00% |
股份
|
| PRIVATE TRUST CO NA |
$6680 |
225 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$5997 |
202 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$5790 |
195 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$5107 |
172 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$5018 |
169 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$4661 |
157 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$4605 |
292 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$4246 |
143 |
0.00% |
股份
|
| Rossby Financial, LCC |
$3563 |
120 |
0.00% |
股份
|
| Allworth Financial LP |
$2227 |
75 |
0.00% |
股份
|
| Arax Advisory Partners |
$1870 |
63 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1380 |
46492 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1188 |
40 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1069 |
36 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$950 |
32 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$925 |
71 |
0.00% |
股份
|
| Penserra Capital Management LLC |
$922 |
31066 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$891 |
30 |
0.00% |
股份
|
| WPG Advisers, LLC |
$891 |
30 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$683 |
23 |
0.00% |
股份
|
| True Wealth Design, LLC |
$683 |
23 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$327 |
11 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$326 |
11 |
0.00% |
股份
|
| Essential Partners LLC |
$267 |
9 |
0.00% |
股份
|
| COMERICA BANK |
$202 |
12 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$149 |
5 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$30 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$15 |
509 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
20 |
0.00% |
股份
|