| RTW INVESTMENTS, LP |
$604961620 |
8514590 |
9.33% |
股份
|
| Decheng Capital LLC |
$452707083 |
6371669 |
6.98% |
股份
|
| BlackRock, Inc. |
$444509264 |
6256288 |
6.85% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$378323559 |
5324751 |
5.83% |
股份
|
| FMR LLC |
$295674077 |
4161493 |
4.56% |
股份
|
| VANGUARD GROUP INC |
$271519293 |
6539482 |
4.19% |
股份
|
| TCG Crossover Management, LLC |
$260768136 |
3670206 |
4.02% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$246202247 |
3465197 |
3.80% |
股份
|
| STATE STREET CORP |
$244240770 |
3437590 |
3.77% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$235658143 |
3316793 |
3.63% |
股份
|
| Foresite Capital Management VI LLC |
$168358233 |
2369574 |
2.60% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$153018831 |
2153277 |
2.36% |
股份
|
| Seven Fleet Capital Management LP |
$134017068 |
1886236 |
2.07% |
股份
|
| Caption Management, LLC |
$126412160 |
1779200 |
1.95% |
买入期权
|
| EcoR1 Capital, LLC |
$106170015 |
1494300 |
1.64% |
股份
|
| DV Trading LLC |
$102268873 |
1439393 |
1.58% |
股份
|
| Avidity Partners Management LP |
$99395255 |
1398948 |
1.53% |
股份
|
| FRANKLIN RESOURCES INC |
$93280138 |
1312880 |
1.44% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$93002404 |
1374149 |
1.43% |
股份
|
| Caption Management, LLC |
$84918960 |
1195200 |
1.31% |
卖出期权
|
| MORGAN STANLEY |
$83633662 |
1177109 |
1.29% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$80393115 |
1131500 |
1.24% |
股份
|
| Foresite Capital Management V, LLC |
$76666503 |
1079050 |
1.18% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$72076900 |
1064966 |
1.11% |
股份
|
| Logos Global Management LP |
$71050000 |
1000000 |
1.10% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$69978424 |
984918 |
1.08% |
股份
|
| UBS Group AG |
$69465230 |
977695 |
1.07% |
股份
|
| ORBIMED ADVISORS LLC |
$69117440 |
972800 |
1.07% |
股份
|
| GOLDMAN SACHS GROUP INC |
$60940508 |
857713 |
0.94% |
股份
|
| Jefferies Financial Group Inc. |
$54704734 |
769947 |
0.84% |
股份
|
| Clearbridge Investments, LLC |
$52274048 |
735736 |
0.81% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$51593416 |
726154 |
0.80% |
股份
|
| NORTHERN TRUST CORP |
$48165648 |
677912 |
0.74% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$46196710 |
650200 |
0.71% |
买入期权
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$44561494 |
627185 |
0.69% |
股份
|
| EcoR1 Capital, LLC |
$39894575 |
561500 |
0.61% |
买入期权
|
| VANGUARD FIDUCIARY TRUST CO |
$38245433 |
538289 |
0.59% |
股份
|
| Bellevue Group AG |
$35069996 |
493596 |
0.54% |
股份
|
| Woodline Partners LP |
$35019906 |
492891 |
0.54% |
股份
|
| Caption Management, LLC |
$34420954 |
484461 |
0.53% |
股份
|
| Candriam S.C.A. |
$33302456 |
469170 |
0.51% |
股份
|
| Fisher Asset Management, LLC |
$32468286 |
456978 |
0.50% |
股份
|
| JPMORGAN CHASE & CO |
$30993438 |
417726 |
0.48% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$30827315 |
433882 |
0.48% |
股份
|
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
$28420000 |
400000 |
0.44% |
买入期权
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$27742041 |
390458 |
0.43% |
股份
|
| Ensign Peak Advisors, Inc |
$27037793 |
380546 |
0.42% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$26286286 |
369839 |
0.41% |
股份
|
| JENNISON ASSOCIATES LLC |
$22539546 |
317235 |
0.35% |
股份
|
| FEDERATED HERMES, INC. |
$22113318 |
311236 |
0.34% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$21611065 |
304167 |
0.33% |
股份
|
| TORONTO DOMINION BANK |
$20436254 |
287632 |
0.32% |
股份
|
| Pictet Asset Management Holding SA |
$18121942 |
255059 |
0.28% |
股份
|
| TimesSquare Capital Management, LLC |
$17170957 |
253708 |
0.26% |
股份
|
| FIRST TRUST ADVISORS LP |
$16591382 |
233517 |
0.26% |
股份
|
| Bank of New York Mellon Corp |
$16584418 |
233419 |
0.26% |
股份
|
| AMERIPRISE FINANCIAL INC |
$14883339 |
209477 |
0.23% |
股份
|
| DEUTSCHE BANK AG\ |
$14033369 |
197514 |
0.22% |
股份
|
| Nuveen, LLC |
$13387242 |
188420 |
0.21% |
股份
|
| TD Asset Management Inc |
$13055864 |
183756 |
0.20% |
股份
|
| HSBC HOLDINGS PLC |
$12488104 |
175765 |
0.19% |
股份
|
| Russell Investments Group, Ltd. |
$11895902 |
167429 |
0.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$11559835 |
162700 |
0.18% |
卖出期权
|
| STEMPOINT CAPITAL LP |
$11321746 |
159349 |
0.17% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$11040460 |
155390 |
0.17% |
股份
|
| ArrowMark Colorado Holdings LLC |
$11037902 |
155354 |
0.17% |
股份
|
| CITADEL ADVISORS LLC |
$10600660 |
149200 |
0.16% |
买入期权
|
| CITIGROUP INC |
$9607736 |
135225 |
0.15% |
股份
|
| PFM Health Sciences, LP |
$9114720 |
128286 |
0.14% |
股份
|
| LMR Partners LLP |
$8803095 |
123900 |
0.14% |
买入期权
|
| ADAR1 Capital Management, LLC |
$8431077 |
118664 |
0.13% |
股份
|
| BARCLAYS PLC |
$8427454 |
118613 |
0.13% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$7275308 |
102397 |
0.11% |
股份
|
| Swiss National Bank |
$7225785 |
101700 |
0.11% |
股份
|
| JANE STREET GROUP, LLC |
$6557915 |
92300 |
0.10% |
买入期权
|
| RHUMBLINE ADVISERS |
$6454809 |
90849 |
0.10% |
股份
|
| D. E. Shaw & Co., Inc. |
$6353078 |
89417 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$6338939 |
89218 |
0.10% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$5766205 |
81157 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$5415431 |
76220 |
0.08% |
股份
|
| PICTON MAHONEY ASSET MANAGEMENT |
$4537752 |
63867 |
0.07% |
股份
|
| Alyeska Investment Group, L.P. |
$4385845 |
61729 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4114434 |
57909 |
0.06% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$3937734 |
55422 |
0.06% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$3797978 |
53455 |
0.06% |
股份
|
| Invesco Ltd. |
$3723446 |
52406 |
0.06% |
股份
|
| Man Group plc |
$3683871 |
51849 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$3571186 |
50263 |
0.06% |
股份
|
| ALGERT GLOBAL LLC |
$3317324 |
46690 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$3194425 |
44740 |
0.05% |
股份
|
| Polar Capital Holdings Plc |
$3089467 |
43483 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$3057068 |
43027 |
0.05% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$2971809 |
41827 |
0.05% |
股份
|
| Balyasny Asset Management L.P. |
$2935147 |
41311 |
0.05% |
股份
|
| Legal & General Group Plc |
$2846405 |
40062 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$2522914 |
35509 |
0.04% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$2386286 |
33586 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$2347066 |
33034 |
0.04% |
股份
|
| Lynx1 Capital Management LP |
$2230331 |
31391 |
0.03% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$2126152 |
28837 |
0.03% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1933697 |
27216 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1847016 |
25996 |
0.03% |
股份
|
| DLD Asset Management, LP |
$1846780 |
26000 |
0.03% |
卖出期权
|
| PROFUND ADVISORS LLC |
$1845311 |
25972 |
0.03% |
股份
|
| Sicart Associates LLC |
$1776250 |
25000 |
0.03% |
股份
|
| Cubist Systematic Strategies, LLC |
$1734739 |
43067 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$1659302 |
23354 |
0.03% |
股份
|
| AlphaQuest LLC |
$1614879 |
38894 |
0.02% |
股份
|
| WESBANCO BANK INC |
$1584415 |
22300 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$1546545 |
21767 |
0.02% |
股份
|
| TEMA ETFS LLC |
$1497087 |
36057 |
0.02% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$1489492 |
20964 |
0.02% |
股份
|
| Knights of Columbus Asset Advisors LLC |
$1482813 |
20870 |
0.02% |
股份
|
| STRS OHIO |
$1477840 |
20800 |
0.02% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1421000 |
20000 |
0.02% |
买入期权
|
| LMR Partners LLP |
$1421000 |
20000 |
0.02% |
股份
|
| AMI ASSET MANAGEMENT CORP |
$1378228 |
19398 |
0.02% |
股份
|
| Voleon Capital Management LP |
$1340571 |
18868 |
0.02% |
股份
|
| HighVista Strategies LLC |
$1340500 |
18867 |
0.02% |
股份
|
| Allianz Asset Management GmbH |
$1318262 |
18554 |
0.02% |
股份
|
| Opaleye Management Inc. |
$1263908 |
17789 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$1252913 |
18500 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$1167138 |
16427 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$1163870 |
16381 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$1151863 |
16212 |
0.02% |
股份
|
| SBI Okasan Asset Management Co.Ltd. |
$1150188 |
15600 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$1132357 |
15940 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1112146 |
15653 |
0.02% |
股份
|
| Squarepoint Ops LLC |
$1028591 |
14477 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$997329 |
14037 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$993208 |
13979 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$939920 |
13229 |
0.01% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$924716 |
13015 |
0.01% |
股份
|
| Creative Planning |
$910861 |
12820 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$899000 |
12641 |
0.01% |
股份
|
| ProShare Advisors LLC |
$891892 |
12553 |
0.01% |
股份
|
| Aquatic Capital Management LLC |
$821906 |
11568 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$817075 |
11500 |
0.01% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$768122 |
10811 |
0.01% |
股份
|
| WINTON GROUP Ltd |
$717605 |
10100 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$703395 |
9900 |
0.01% |
卖出期权
|
| Point72 Asset Management, L.P. |
$653660 |
9200 |
0.01% |
买入期权
|
| Eleva Capital SAS |
$561000 |
8289 |
0.01% |
股份
|
| LPL Financial LLC |
$551419 |
7761 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$525770 |
7400 |
0.01% |
股份
|
| DIADEMA PARTNERS LP |
$518665 |
7300 |
0.01% |
买入期权
|
| XPONANCE LLC |
$514828 |
7246 |
0.01% |
股份
|
| XTX Topco Ltd |
$504100 |
7095 |
0.01% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$502302 |
6676 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$475893 |
6698 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$472127 |
6645 |
0.01% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$470131 |
6616899 |
0.01% |
股份
|
| Point72 (DIFC) Ltd |
$441952 |
10972 |
0.01% |
股份
|
| CWM, LLC |
$429091 |
6340 |
0.01% |
股份
|
| Sanctuary Advisors, LLC |
$426797 |
6007 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$423316 |
5958 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$418768 |
5894 |
0.01% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$412090 |
5800 |
0.01% |
股份
|
| Total Clarity Wealth Management, Inc. |
$406335 |
5719 |
0.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$400864 |
5642 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$390278 |
5493 |
0.01% |
股份
|
| Soleus Capital Management, L.P. |
$355250 |
5000 |
0.01% |
股份
|
| Ground Swell Capital, LLC |
$338553 |
4765 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$333082 |
4688 |
0.01% |
股份
|
| CIBC Bancorp USA Inc. |
$330667 |
4654 |
0.01% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$313757 |
4416 |
0.00% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$313117 |
4407 |
0.00% |
股份
|
| Blackstone Inc. |
$308002 |
4335 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$301963 |
4250 |
0.00% |
股份
|
| MARSHALL WACE, LLP |
$297344 |
4185 |
0.00% |
股份
|
| DeepCurrents Investment Group LLC |
$293650 |
4133 |
0.00% |
股份
|
| Cinctive Capital Management LP |
$285763 |
4022 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$280292 |
3945 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$274168 |
3810 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$270347 |
3805010 |
0.00% |
股份
|
| M&T Bank Corp |
$266728 |
3750 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$253435 |
3567 |
0.00% |
股份
|
| Allspring Global Investments Holdings, LLC |
$251872 |
3553 |
0.00% |
股份
|
| State of Wyoming |
$247112 |
3478 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$231764 |
3262 |
0.00% |
股份
|
| ELLERSON GROUP INC /ADV |
$216774 |
3051 |
0.00% |
股份
|
| VARCOV Co. |
$212724 |
2994 |
0.00% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$211019 |
2970 |
0.00% |
股份
|
| DNB Asset Management AS |
$209740 |
2952 |
0.00% |
股份
|
| Swiss Life Asset Management Ltd |
$207537 |
2921 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$166181 |
2339 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$132224 |
1861 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$127108 |
1789 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$113325 |
1595 |
0.00% |
股份
|
| Northwest & Ethical Investments L.P. |
$87370 |
1185 |
0.00% |
股份
|
| Strengthening Families & Communities, LLC |
$71618 |
1008 |
0.00% |
股份
|
| SUMMIT SECURITIES GROUP LLC |
$69345 |
976 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$68493 |
964 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$68173 |
959 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$61633 |
867465 |
0.00% |
股份
|
| GAMMA Investing LLC |
$51938 |
731 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$51085 |
719 |
0.00% |
股份
|
| WHITTIER TRUST CO OF NEVADA INC |
$46087 |
666 |
0.00% |
股份
|
| US BANCORP \DE\ |
$45827 |
645 |
0.00% |
股份
|
| COMERICA BANK |
$42661 |
1028 |
0.00% |
股份
|
| NFSG Corp |
$35525 |
500 |
0.00% |
股份
|
| FIDUCIARY FINANCIAL ADVISORS |
$28420 |
400 |
0.00% |
股份
|
| LORD, ABBETT & CO. LLC |
$25900 |
364539 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$25215 |
626 |
0.00% |
股份
|
| Arax Advisory Partners |
$23447 |
330 |
0.00% |
股份
|
| E Fund Management (Hong Kong) Co., Ltd. |
$22239 |
313 |
0.00% |
股份
|
| Optiver Holding B.V. |
$22097 |
311 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$21274 |
19 |
0.00% |
买入期权
|
| Sterling Capital Management LLC |
$18402 |
259 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$16910 |
238 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$13430 |
189 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$13345 |
181 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$11297 |
159 |
0.00% |
股份
|
| FIL Ltd |
$8952 |
126 |
0.00% |
股份
|
| Quantbot Technologies LP |
$8029 |
113 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$7816 |
110 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$7105 |
100 |
0.00% |
股份
|
| Essential Partners LLC |
$6252 |
88 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$5684 |
80 |
0.00% |
股份
|
| PRIVATE TRUST CO NA |
$5045 |
71 |
0.00% |
股份
|
| Allworth Financial LP |
$4548 |
64 |
0.00% |
股份
|
| Larson Financial Group LLC |
$3979 |
56 |
0.00% |
股份
|
| Private Wealth Management Group, LLC |
$3269 |
46 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$2842 |
40 |
0.00% |
股份
|
| Rossby Financial, LCC |
$2842 |
40 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$2765 |
39 |
0.00% |
股份
|
| Quarry LP |
$2132 |
30 |
0.00% |
股份
|
| True Wealth Design, LLC |
$2132 |
30 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2063 |
29 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$1571 |
22107 |
0.00% |
股份
|
| Manchester Capital Management LLC |
$1564 |
22 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1421 |
20 |
0.00% |
股份
|
| Handelsbanken Fonder AB |
$1401 |
20700 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$1176 |
48 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$853 |
12 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$665 |
9365 |
0.00% |
股份
|
| Rialto Wealth Management, LLC |
$640 |
9 |
0.00% |
股份
|
| IFP Advisors, Inc |
$497 |
7 |
0.00% |
股份
|
| PRAXIS INVESTMENT MANAGEMENT INC |
$266 |
3744 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$213 |
3 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$143 |
2 |
0.00% |
股份
|
| Dunhill Financial, LLC |
$101 |
1 |
0.00% |
股份
|
| Winthrop Capital Management, LLC |
$99 |
1467 |
0.00% |
股份
|
| KBC Group NV |
$82 |
1153 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$71 |
1 |
0.00% |
股份
|
| WPG Advisers, LLC |
$71 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$60 |
839 |
0.00% |
股份
|
| Covestor Ltd |
$32 |
446 |
0.00% |
股份
|