| SR One Capital Management, LP |
$94438108 |
6526476 |
14.39% |
股份
|
| Logos Global Management LP |
$43410000 |
3000000 |
6.62% |
股份
|
| BAKER BROS. ADVISORS LP |
$38756882 |
2678430 |
5.91% |
股份
|
| Driehaus Capital Management LLC |
$38506334 |
2661115 |
5.87% |
股份
|
| BlackRock, Inc. |
$38490551 |
2660024 |
5.87% |
股份
|
| Point72 Asset Management, L.P. |
$34242575 |
2366453 |
5.22% |
股份
|
| Trails Edge Capital Partners, LP |
$28958550 |
2001282 |
4.41% |
股份
|
| Frazier Life Sciences Management, L.P. |
$26188587 |
1809854 |
3.99% |
股份
|
| Vivo Capital, LLC |
$23338706 |
1612903 |
3.56% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$22732688 |
1571022 |
3.46% |
股份
|
| Caption Management, LLC |
$21705000 |
1500000 |
3.31% |
买入期权
|
| Caption Management, LLC |
$16178878 |
1118098 |
2.47% |
股份
|
| VANGUARD GROUP INC |
$15297936 |
1630910 |
2.33% |
股份
|
| Almitas Capital LLC |
$14859142 |
1026893 |
2.26% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$13871597 |
958417 |
2.11% |
股份
|
| Sofinnova Investments, Inc. |
$12518503 |
865135 |
1.91% |
股份
|
| FMR LLC |
$11235405 |
776462 |
1.71% |
股份
|
| MORGAN STANLEY |
$11075699 |
765425 |
1.69% |
股份
|
| STATE STREET CORP |
$10653118 |
736221 |
1.62% |
股份
|
| Woodline Partners LP |
$10134122 |
700354 |
1.54% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$10051800 |
694743 |
1.53% |
股份
|
| GOLDMAN SACHS GROUP INC |
$9500771 |
656584 |
1.45% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$8184189 |
565597 |
1.25% |
股份
|
| Siren, L.L.C. |
$7570878 |
523212 |
1.15% |
股份
|
| Qube Research & Technologies Ltd |
$6324533 |
437079 |
0.96% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$5613101 |
387913 |
0.86% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$5557001 |
384036 |
0.85% |
股份
|
| NORTHERN TRUST CORP |
$5110762 |
353197 |
0.78% |
股份
|
| ALGERT GLOBAL LLC |
$4284350 |
296085 |
0.65% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$4088701 |
282564 |
0.62% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3925190 |
271264 |
0.60% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3638366 |
251442 |
0.55% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3331023 |
230202 |
0.51% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$3243740 |
224170 |
0.49% |
股份
|
| D. E. Shaw & Co., Inc. |
$2830983 |
195645 |
0.43% |
股份
|
| Eversept Partners, LP |
$2749300 |
190000 |
0.42% |
股份
|
| KVP Capital Advisors, LP |
$2676950 |
185000 |
0.41% |
股份
|
| J. Goldman & Co LP |
$2557862 |
176770 |
0.39% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$2137422 |
147714 |
0.33% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$2004399 |
138521 |
0.31% |
股份
|
| Balyasny Asset Management L.P. |
$1607660 |
111103 |
0.25% |
股份
|
| Elmind Capital, LP |
$1561313 |
107900 |
0.24% |
股份
|
| Nuveen, LLC |
$1515501 |
104734 |
0.23% |
股份
|
| DAFNA Capital Management LLC |
$1484622 |
102600 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$1332238 |
92069 |
0.20% |
股份
|
| China Universal Asset Management Co., Ltd. |
$1301432 |
89940 |
0.20% |
股份
|
| CITADEL ADVISORS LLC |
$1186120 |
81971 |
0.18% |
股份
|
| SummitTX Capital, L.P. |
$1167194 |
80663 |
0.18% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$1111658 |
76825 |
0.17% |
股份
|
| Palumbo Wealth Management LLC |
$1038136 |
71744 |
0.16% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1029019 |
71114 |
0.16% |
股份
|
| AMERIPRISE FINANCIAL INC |
$978143 |
67598 |
0.15% |
股份
|
| Russell Investments Group, Ltd. |
$967448 |
66859 |
0.15% |
股份
|
| ALPS ADVISORS INC |
$917268 |
63391 |
0.14% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$857333 |
59249 |
0.13% |
股份
|
| STRS OHIO |
$730735 |
50500 |
0.11% |
股份
|
| Verdad Advisers, LP |
$688150 |
47557 |
0.10% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$632745 |
43728 |
0.10% |
股份
|
| ExodusPoint Capital Management, LP |
$597408 |
41286 |
0.09% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$578800 |
40000 |
0.09% |
买入期权
|
| RHUMBLINE ADVISERS |
$551760 |
38132 |
0.08% |
股份
|
| Vanguard Global Advisers, LLC |
$514177 |
35534 |
0.08% |
股份
|
| UBS Group AG |
$502992 |
34761 |
0.08% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$482936 |
33375 |
0.07% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$476425 |
32925 |
0.07% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$471722 |
32600 |
0.07% |
股份
|
| OPPENHEIMER & CO INC |
$464299 |
32087 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$459967 |
43230 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$442970 |
30613 |
0.07% |
股份
|
| Virtus Investment Advisers, LLC |
$431597 |
29827 |
0.07% |
股份
|
| Squarepoint Ops LLC |
$428746 |
29630 |
0.07% |
股份
|
| Trexquant Investment LP |
$407331 |
28150 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$406202 |
28072 |
0.06% |
股份
|
| Corient Private Wealth LP |
$393136 |
27169 |
0.06% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$390690 |
27000 |
0.06% |
股份
|
| Quantinno Capital Management LP |
$389257 |
26901 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$329053 |
22740 |
0.05% |
股份
|
| XTX Topco Ltd |
$323882 |
22383 |
0.05% |
股份
|
| AlphaCentric Advisors LLC |
$311640 |
21537 |
0.05% |
股份
|
| Invesco Ltd. |
$310078 |
21429 |
0.05% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$299529 |
20700 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$298212 |
20609 |
0.05% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$280718 |
19400 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$240713 |
16904 |
0.04% |
股份
|
| TWO SIGMA ADVISERS, LP |
$237314 |
25300 |
0.04% |
股份
|
| CITIGROUP INC |
$229784 |
15880 |
0.04% |
股份
|
| Creative Planning |
$229263 |
15844 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$226456 |
15650 |
0.03% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$214503 |
14824 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$205054 |
14171 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$201133 |
13900 |
0.03% |
买入期权
|
| Y-Intercept (Hong Kong) Ltd |
$186808 |
12910 |
0.03% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$181642 |
12553 |
0.03% |
股份
|
| ROYAL BANK OF CANADA |
$178000 |
12254 |
0.03% |
股份
|
| BARCLAYS PLC |
$169401 |
11707 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$156652 |
10826 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$142515 |
9849 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$83217 |
5751 |
0.01% |
股份
|
| Clearstead Advisors, LLC |
$81177 |
5610 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$71019 |
4908 |
0.01% |
股份
|
| Rockefeller Capital Management L.P. |
$53308 |
3684 |
0.01% |
股份
|
| CAZ INVESTMENTS LP |
$50645 |
3500 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$43772 |
3025 |
0.01% |
股份
|
| Legal & General Group Plc |
$43222 |
2987 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$42940 |
5702 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$40415 |
2793 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$40415 |
2793 |
0.01% |
股份
|
| State of Wyoming |
$37130 |
2566 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$26277 |
1816 |
0.00% |
股份
|
| GAMMA Investing LLC |
$20982 |
1450 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$18218 |
1259 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$17494 |
1209 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$12162 |
1143 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$7774 |
537479 |
0.00% |
股份
|
| Private Wealth Management Group, LLC |
$7713 |
533 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4847 |
335 |
0.00% |
股份
|
| CWM, LLC |
$4501 |
423 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$3878 |
268 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$3458 |
239 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$3458 |
239 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$3255 |
225 |
0.00% |
股份
|
| Larson Financial Group LLC |
$2619 |
181 |
0.00% |
股份
|
| Arax Advisory Partners |
$2606 |
180 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$2488 |
172 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2315 |
160 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1563 |
108 |
0.00% |
股份
|
| Allworth Financial LP |
$1390 |
96 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$1199 |
83 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$1081 |
86 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$839 |
58 |
0.00% |
股份
|
| Quarry LP |
$449 |
31 |
0.00% |
股份
|
| US BANCORP \DE\ |
$376 |
26 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$371 |
25606 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$362 |
25 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$318 |
22 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$289 |
20 |
0.00% |
股份
|
| True Wealth Design, LLC |
$261 |
18 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$149 |
10328 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$145 |
10 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$58 |
4 |
0.00% |
股份
|
| Essential Partners LLC |
$14 |
1 |
0.00% |
股份
|
| Capital Advisors, Ltd. LLC |
$0 |
12 |
0.00% |
股份
|