| RA CAPITAL MANAGEMENT, L.P. |
$43498354 |
17754430 |
11.14% |
股份
|
| TCG Crossover Management, LLC |
$43401690 |
17754430 |
11.12% |
股份
|
| Versant Venture Management, LLC |
$29806967 |
12166109 |
7.63% |
股份
|
| Deep Track Capital, LP |
$23183480 |
9462645 |
5.94% |
股份
|
| RTW INVESTMENTS, LP |
$21304347 |
8695652 |
5.46% |
股份
|
| Venrock Adviser, LLC |
$21304347 |
8695652 |
5.46% |
股份
|
| Commodore Capital LP |
$21304347 |
8695652 |
5.46% |
股份
|
| BlackRock, Inc. |
$19824831 |
8091768 |
5.08% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$13974016 |
5703680 |
3.58% |
股份
|
| Balyasny Asset Management L.P. |
$13531213 |
5522944 |
3.47% |
股份
|
| Point72 Asset Management, L.P. |
$12202289 |
4980526 |
3.13% |
股份
|
| Seven Fleet Capital Management LP |
$10652174 |
4347826 |
2.73% |
股份
|
| Woodline Partners LP |
$10430948 |
4257530 |
2.67% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$10277703 |
4194981 |
2.63% |
股份
|
| Trails Edge Capital Partners, LP |
$10130674 |
4134969 |
2.59% |
股份
|
| Spruce Street Capital LP |
$9944682 |
4059054 |
2.55% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$9284368 |
3789538 |
2.38% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$7301590 |
2979529 |
1.87% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$6612582 |
2699013 |
1.69% |
股份
|
| DAFNA Capital Management LLC |
$5881122 |
2400458 |
1.51% |
股份
|
| STEMPOINT CAPITAL LP |
$5258146 |
2146182 |
1.35% |
股份
|
| STATE STREET CORP |
$4515727 |
1843154 |
1.16% |
股份
|
| NORTHERN TRUST CORP |
$3905163 |
1593944 |
1.00% |
股份
|
| DV Trading LLC |
$3430000 |
1400000 |
0.88% |
股份
|
| Rock Springs Capital Management LP |
$3195650 |
1304347 |
0.82% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$3081365 |
1257700 |
0.79% |
股份
|
| Casdin Capital, LLC |
$3009066 |
1228190 |
0.77% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2487688 |
1015383 |
0.64% |
股份
|
| VANGUARD GROUP INC |
$2093350 |
2103869 |
0.54% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1806929 |
737522 |
0.46% |
股份
|
| MARSHALL WACE, LLP |
$1318085 |
537994 |
0.34% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1261108 |
1267700 |
0.32% |
股份
|
| Invesco Ltd. |
$934477 |
381419 |
0.24% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$928224 |
378867 |
0.24% |
股份
|
| Bank of New York Mellon Corp |
$732584 |
299014 |
0.19% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$664720 |
271492 |
0.17% |
股份
|
| UBS Group AG |
$569402 |
232409 |
0.15% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$426452 |
174062 |
0.11% |
股份
|
| Nuveen, LLC |
$400800 |
163592 |
0.10% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$389288 |
158893 |
0.10% |
股份
|
| GOLDMAN SACHS GROUP INC |
$368561 |
150433 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$364842 |
148915 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$314584 |
128404 |
0.08% |
股份
|
| CITADEL ADVISORS LLC |
$309852 |
126470 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$294573 |
120234 |
0.08% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$283690 |
115792 |
0.07% |
股份
|
| CITADEL ADVISORS LLC |
$276850 |
113000 |
0.07% |
买入期权
|
| CITADEL ADVISORS LLC |
$275135 |
112300 |
0.07% |
卖出期权
|
| RAYMOND JAMES FINANCIAL INC |
$223741 |
91323 |
0.06% |
股份
|
| Squarepoint Ops LLC |
$220865 |
90149 |
0.06% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$200655 |
81900 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$186935 |
76300 |
0.05% |
买入期权
|
| MetLife Investment Management, LLC |
$186864 |
76271 |
0.05% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$175118 |
77830 |
0.04% |
股份
|
| AXQ CAPITAL, LP |
$144687 |
59056 |
0.04% |
股份
|
| Spark Investment Management LLC |
$144550 |
59000 |
0.04% |
股份
|
| CITIGROUP INC |
$139652 |
57001 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$138450 |
56510 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$123411 |
51208 |
0.03% |
股份
|
| Verdad Advisers, LP |
$113190 |
46200 |
0.03% |
股份
|
| Quadrature Capital Ltd |
$112431 |
45890 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$109309 |
44616 |
0.03% |
股份
|
| Legal & General Group Plc |
$107702 |
43960 |
0.03% |
股份
|
| MORGAN STANLEY |
$94212 |
38454 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$89055 |
36349 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$84775 |
34602 |
0.02% |
股份
|
| State of Wyoming |
$81891 |
33425 |
0.02% |
股份
|
| HarbourVest Partners LLC |
$71094 |
29018 |
0.02% |
股份
|
| Parametrica Management Ltd |
$68208 |
27840 |
0.02% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$67325 |
29790 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$62629 |
25563 |
0.02% |
股份
|
| Magnus Financial Group LLC |
$61961 |
25290 |
0.02% |
股份
|
| BARCLAYS PLC |
$60514 |
24700 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$59782 |
24401 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$58964 |
24067 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$55615 |
22700 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$53900 |
22000 |
0.01% |
卖出期权
|
| Schonfeld Strategic Advisors LLC |
$52752 |
21532 |
0.01% |
股份
|
| Quadrant Private Wealth Management, LLC |
$49053 |
20022 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$45558 |
18595 |
0.01% |
股份
|
| ProShare Advisors LLC |
$39536 |
16137 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$34547 |
14101 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$30583 |
12483 |
0.01% |
股份
|
| XPONANCE LLC |
$28834 |
11769 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$27403 |
11185 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$24144 |
9855 |
0.01% |
股份
|
| FMR LLC |
$22035 |
8994 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$15000 |
6383 |
0.00% |
股份
|
| SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/ |
$12250 |
5000 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$8895 |
17861 |
0.00% |
股份
|
| Advisors Asset Management, Inc. |
$8270 |
8313 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6086 |
2484 |
0.00% |
股份
|
| Truvestments Capital LLC |
$5709 |
2330 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4158 |
1697 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$2984 |
1218 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2163 |
883 |
0.00% |
股份
|
| MARK SHEPTOFF FINANCIAL PLANNING, LLC |
$1225 |
500 |
0.00% |
股份
|
| Optiver Holding B.V. |
$902 |
368 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$720 |
294 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$530 |
1064 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$295 |
120598 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$248 |
101164 |
0.00% |
股份
|
| Arax Advisory Partners |
$243 |
99 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$86 |
35 |
0.00% |
股份
|
| Virtu Financial LLC |
$76 |
31063 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$27 |
11267 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$24 |
10000 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$2 |
1 |
0.00% |
股份
|