| Frazier Life Sciences Management, L.P. |
$367191118 |
6652013 |
11.84% |
股份
|
| FMR LLC |
$293823234 |
5322885 |
9.47% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$274759269 |
4977523 |
8.86% |
股份
|
| NEA Management Company, LLC |
$199519627 |
3614486 |
6.43% |
股份
|
| ORBIMED ADVISORS LLC |
$189266227 |
3428736 |
6.10% |
股份
|
| BlackRock, Inc. |
$183466695 |
3323672 |
5.91% |
股份
|
| Paradigm Biocapital Advisors LP |
$138442428 |
2508015 |
4.46% |
股份
|
| NVP ASSOCIATES, LLC |
$117925692 |
2136335 |
3.80% |
股份
|
| Deep Track Capital, LP |
$95637809 |
1732569 |
3.08% |
股份
|
| Polar Capital Holdings Plc |
$88789973 |
1608514 |
2.86% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$81551818 |
1477388 |
2.63% |
股份
|
| Aaron Wealth Advisors LLC |
$64462505 |
1167799 |
2.08% |
股份
|
| Driehaus Capital Management LLC |
$58323161 |
1056579 |
1.88% |
股份
|
| VANGUARD GROUP INC |
$57333759 |
1817811 |
1.85% |
股份
|
| Kynam Capital Management, LP |
$51600905 |
934799 |
1.66% |
股份
|
| Woodline Partners LP |
$49685078 |
900092 |
1.60% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$48216758 |
873492 |
1.55% |
股份
|
| STATE STREET CORP |
$47718523 |
864466 |
1.54% |
股份
|
| Parkman Healthcare Partners LLC |
$44169550 |
800173 |
1.42% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$42683039 |
773072 |
1.38% |
股份
|
| BRAIDWELL LP |
$39240576 |
710880 |
1.26% |
股份
|
| TCG Crossover Management, LLC |
$35880000 |
650000 |
1.16% |
股份
|
| Cormorant Asset Management, LP |
$30360000 |
550000 |
0.98% |
股份
|
| Soleus Capital Management, L.P. |
$28443401 |
515279 |
0.92% |
股份
|
| GOLDMAN SACHS GROUP INC |
$25337076 |
459005 |
0.82% |
股份
|
| MARSHALL WACE, LLP |
$22184052 |
401885 |
0.72% |
股份
|
| EcoR1 Capital, LLC |
$21445200 |
388500 |
0.69% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$19138778 |
346717 |
0.62% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$16500771 |
298927 |
0.53% |
股份
|
| Rock Springs Capital Management LP |
$16461634 |
298218 |
0.53% |
股份
|
| Candriam S.C.A. |
$15986698 |
289893 |
0.52% |
股份
|
| UBS Group AG |
$15055635 |
272747 |
0.49% |
股份
|
| Opaleye Management Inc. |
$14352000 |
260000 |
0.46% |
股份
|
| FRANKLIN RESOURCES INC |
$13947108 |
252665 |
0.45% |
股份
|
| Schonfeld Strategic Advisors LLC |
$13726583 |
248670 |
0.44% |
股份
|
| MORGAN STANLEY |
$13720403 |
248558 |
0.44% |
股份
|
| NORTHERN TRUST CORP |
$13616626 |
246678 |
0.44% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$12900240 |
233700 |
0.42% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$12866844 |
233095 |
0.41% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$12483535 |
226151 |
0.40% |
股份
|
| Tetragon Partners GP Ltd |
$11235574 |
203543 |
0.36% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$11118881 |
201429 |
0.36% |
股份
|
| Caption Management, LLC |
$11040000 |
200000 |
0.36% |
买入期权
|
| Caption Management, LLC |
$11040000 |
200000 |
0.36% |
卖出期权
|
| Caligan Partners LP |
$11040000 |
200000 |
0.36% |
股份
|
| D. E. Shaw & Co., Inc. |
$10088738 |
182767 |
0.33% |
股份
|
| JPMORGAN CHASE & CO |
$7518053 |
139611 |
0.24% |
股份
|
| KVP Capital Advisors, LP |
$6708125 |
121524 |
0.22% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$6263820 |
113475 |
0.20% |
股份
|
| Burkehill Global Management, LP |
$5520000 |
100000 |
0.18% |
股份
|
| Nuveen, LLC |
$5450062 |
98733 |
0.18% |
股份
|
| TD Asset Management Inc |
$5277010 |
95598 |
0.17% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5210880 |
94400 |
0.17% |
买入期权
|
| Elmind Capital, LP |
$5023200 |
91000 |
0.16% |
股份
|
| Bank of New York Mellon Corp |
$4908760 |
88927 |
0.16% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$4860084 |
88045 |
0.16% |
股份
|
| BARCLAYS PLC |
$4849540 |
87854 |
0.16% |
股份
|
| Affinity Asset Advisors, LLC |
$4140000 |
75000 |
0.13% |
股份
|
| PFM Health Sciences, LP |
$3917599 |
70971 |
0.13% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$3883486 |
70353 |
0.13% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$3649382 |
66112 |
0.12% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$3582094 |
64893 |
0.12% |
股份
|
| Rhenman & Partners Asset Management AB |
$3422400 |
62000 |
0.11% |
股份
|
| Invesco Ltd. |
$2797425 |
50678 |
0.09% |
股份
|
| ALPS ADVISORS INC |
$2650262 |
48012 |
0.09% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$2406554 |
43597 |
0.08% |
股份
|
| Swiss National Bank |
$2368080 |
42900 |
0.08% |
股份
|
| Ensign Peak Advisors, Inc |
$2327011 |
42156 |
0.08% |
股份
|
| ALGERT GLOBAL LLC |
$2322264 |
42070 |
0.07% |
股份
|
| Creative Planning |
$2181724 |
39524 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$2075520 |
37600 |
0.07% |
买入期权
|
| RHUMBLINE ADVISERS |
$2053213 |
37196 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$1749454 |
31693 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1711200 |
31000 |
0.06% |
卖出期权
|
| WELLS FARGO & COMPANY/MN |
$1562878 |
28313 |
0.05% |
股份
|
| EXCHANGE TRADED CONCEPTS, LLC |
$1513639 |
27421 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1472957 |
26684 |
0.05% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1442486 |
26132 |
0.05% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$1424160 |
25800 |
0.05% |
股份
|
| CITIGROUP INC |
$1386734 |
25122 |
0.04% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1290355 |
23376 |
0.04% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$1251936 |
22680 |
0.04% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1247023 |
22591 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$1236480 |
22400 |
0.04% |
买入期权
|
| Legal & General Group Plc |
$1191382 |
21583 |
0.04% |
股份
|
| Cerity Partners LLC |
$1159034 |
20997 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$1047089 |
18969 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$1007400 |
18250 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$1002541 |
18162 |
0.03% |
股份
|
| Koa Wealth Management, LLC |
$944638 |
17113 |
0.03% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$925350 |
31000 |
0.03% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$881599 |
15971 |
0.03% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$814310 |
14752 |
0.03% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$798082 |
14458 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$788918 |
14292 |
0.03% |
股份
|
| DAFNA Capital Management LLC |
$651857 |
11809 |
0.02% |
股份
|
| HighVista Strategies LLC |
$642197 |
11634 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$607200 |
11000 |
0.02% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$545210 |
9877 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$544272 |
9860 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$539690 |
9777 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$508668 |
9215 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$506460 |
9175 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$505301 |
9154 |
0.02% |
股份
|
| PROFUND ADVISORS LLC |
$486422 |
8812 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$474830 |
8602 |
0.02% |
股份
|
| ACT CAPITAL MANAGEMENT, LLC |
$441600 |
8000 |
0.01% |
股份
|
| DNB Asset Management AS |
$430174 |
7793 |
0.01% |
股份
|
| AXQ CAPITAL, LP |
$428186 |
7757 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$381598 |
6913 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$358634 |
6497 |
0.01% |
股份
|
| Rafferty Asset Management, LLC |
$353832 |
6410 |
0.01% |
股份
|
| XTX Topco Ltd |
$352838 |
6392 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$336886 |
6103 |
0.01% |
股份
|
| Seven Fleet Capital Management LP |
$331200 |
6000 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$328495 |
5951 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$325625 |
5899 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$323914 |
5868 |
0.01% |
股份
|
| ProShare Advisors LLC |
$310335 |
5622 |
0.01% |
股份
|
| JANUS HENDERSON GROUP PLC |
$308176 |
10300 |
0.01% |
股份
|
| Blackstone Inc. |
$305422 |
5533 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$288751 |
5231 |
0.01% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$287040 |
5200 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$270480 |
4900 |
0.01% |
股份
|
| Verdad Advisers, LP |
$252485 |
4574 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$226210 |
4098 |
0.01% |
股份
|
| Goelzer Investment Management, Inc. |
$220800 |
4000 |
0.01% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$216054 |
7238 |
0.01% |
股份
|
| Quantbot Technologies LP |
$212796 |
3855 |
0.01% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$209760 |
3800 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$209760 |
3800 |
0.01% |
卖出期权
|
| Tower Research Capital LLC (TRC) |
$201535 |
3651 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$155498 |
2817 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$117521 |
2129 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$115147 |
2086 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$111118 |
2013 |
0.00% |
股份
|
| STRS OHIO |
$110400 |
2000 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$81000 |
1464 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$73250 |
1327 |
0.00% |
股份
|
| State of Wyoming |
$58236 |
1055 |
0.00% |
股份
|
| CWM, LLC |
$52894 |
1772 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$52550 |
952 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$44978 |
814807 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$17719 |
321 |
0.00% |
股份
|
| GAMMA Investing LLC |
$16781 |
304 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$15566 |
282 |
0.00% |
股份
|
| Arax Advisory Partners |
$15401 |
279 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$12365 |
224 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$11426 |
207 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$10552 |
180 |
0.00% |
股份
|
| FIL Ltd |
$9826 |
178 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$9494 |
172 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$6680 |
121 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6017 |
109 |
0.00% |
股份
|
| US BANCORP \DE\ |
$5962 |
108 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$4692 |
85 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$4361 |
79 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$4306 |
78 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$4185 |
80 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$2981 |
54 |
0.00% |
股份
|
| Larson Financial Group LLC |
$2705 |
49 |
0.00% |
股份
|
| Allworth Financial LP |
$2650 |
48 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2649 |
48 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2153 |
39 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$1877 |
34 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1877 |
34 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$1401 |
25377 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1049 |
19 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$1049 |
19 |
0.00% |
股份
|
| Quarry LP |
$994 |
18 |
0.00% |
股份
|
| Essential Partners LLC |
$828 |
15 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$718 |
13 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$607 |
11 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$497 |
9 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$345 |
6245 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$111 |
2 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$55 |
1 |
0.00% |
股份
|
| KBC Group NV |
$45 |
810 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
10 |
0.00% |
股份
|