| BVF INC/IL |
$311544999 |
16001284 |
22.99% |
股份
|
| Deep Track Capital, LP |
$136271017 |
6999025 |
10.06% |
股份
|
| D. E. Shaw & Co., Inc. |
$65526421 |
3365507 |
4.84% |
股份
|
| JANUS HENDERSON GROUP PLC |
$64303830 |
3451628 |
4.75% |
股份
|
| Cormorant Asset Management, LP |
$62409781 |
3205433 |
4.61% |
股份
|
| Logos Global Management LP |
$52082250 |
2675000 |
3.84% |
股份
|
| Weiss Asset Management LP |
$50267899 |
2581813 |
3.71% |
股份
|
| CITADEL ADVISORS LLC |
$38412227 |
1972893 |
2.83% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$33397845 |
1715349 |
2.46% |
股份
|
| MPM BIOIMPACT LLC |
$31287647 |
1606967 |
2.31% |
股份
|
| JPMORGAN CHASE & CO |
$27603662 |
1386422 |
2.04% |
股份
|
| Vivo Capital, LLC |
$27258000 |
1400000 |
2.01% |
股份
|
| Point72 Asset Management, L.P. |
$22560512 |
1158732 |
1.66% |
股份
|
| BlackRock, Inc. |
$21315581 |
1094791 |
1.57% |
股份
|
| Balyasny Asset Management L.P. |
$17770561 |
912715 |
1.31% |
股份
|
| GREAT POINT PARTNERS LLC |
$16662679 |
855813 |
1.23% |
股份
|
| JANE STREET GROUP, LLC |
$16615426 |
853386 |
1.23% |
股份
|
| Candriam S.C.A. |
$14972924 |
769766 |
1.10% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$14639435 |
751897 |
1.08% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$14617628 |
750777 |
1.08% |
股份
|
| Trails Edge Capital Partners, LP |
$14602500 |
750000 |
1.08% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$12524428 |
643268 |
0.92% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$12386561 |
636187 |
0.91% |
股份
|
| MORGAN STANLEY |
$10973331 |
563602 |
0.81% |
股份
|
| MARSHALL WACE, LLP |
$10715334 |
550351 |
0.79% |
股份
|
| Qube Research & Technologies Ltd |
$9661832 |
496242 |
0.71% |
股份
|
| ALGERT GLOBAL LLC |
$7534111 |
386960 |
0.56% |
股份
|
| Rhenman & Partners Asset Management AB |
$7492056 |
384800 |
0.55% |
股份
|
| Trexquant Investment LP |
$7358609 |
377946 |
0.54% |
股份
|
| Capricorn Fund Managers Ltd |
$7294892 |
374866 |
0.54% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$6987471 |
358884 |
0.52% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$6649725 |
341537 |
0.49% |
股份
|
| Jump Financial, LLC |
$6546652 |
336243 |
0.48% |
股份
|
| UBS Group AG |
$6396323 |
328522 |
0.47% |
股份
|
| Caption Management, LLC |
$6364743 |
326900 |
0.47% |
买入期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$6249870 |
321000 |
0.46% |
买入期权
|
| Granahan Investment Management, LLC |
$6111321 |
313884 |
0.45% |
股份
|
| Boxer Capital Management, LLC |
$5354250 |
275000 |
0.40% |
股份
|
| JANE STREET GROUP, LLC |
$5334780 |
274000 |
0.39% |
买入期权
|
| CITADEL ADVISORS LLC |
$5317257 |
273100 |
0.39% |
买入期权
|
| Susquehanna Portfolio Strategies, LLC |
$4944874 |
253974 |
0.36% |
股份
|
| Holocene Advisors, LP |
$4867500 |
250000 |
0.36% |
股份
|
| Burkehill Global Management, LP |
$4867500 |
250000 |
0.36% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4823537 |
247742 |
0.36% |
股份
|
| Walleye Capital LLC |
$4806539 |
246869 |
0.35% |
股份
|
| J. Goldman & Co LP |
$4204449 |
215945 |
0.31% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$4202580 |
215849 |
0.31% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$4198744 |
215652 |
0.31% |
股份
|
| CITADEL ADVISORS LLC |
$4123746 |
211800 |
0.30% |
卖出期权
|
| Verition Fund Management LLC |
$4032276 |
207102 |
0.30% |
股份
|
| HighVista Strategies LLC |
$3659308 |
187946 |
0.27% |
股份
|
| RICE HALL JAMES & ASSOCIATES, LLC |
$3578605 |
183801 |
0.26% |
股份
|
| CONGRESS ASSET MANAGEMENT CO |
$3513323 |
180448 |
0.26% |
股份
|
| VANGUARD GROUP INC |
$3507857 |
266150 |
0.26% |
股份
|
| Kalehua Capital Management LLC |
$3421541 |
175734 |
0.25% |
股份
|
| Voleon Capital Management LP |
$3386008 |
173909 |
0.25% |
股份
|
| Exome Asset Management LLC |
$3241619 |
166493 |
0.24% |
股份
|
| Longaeva Partners L.P. |
$3145515 |
161557 |
0.23% |
股份
|
| XTX Topco Ltd |
$2968630 |
152472 |
0.22% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2943864 |
151200 |
0.22% |
卖出期权
|
| FMR LLC |
$2795090 |
143559 |
0.21% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2537467 |
130327 |
0.19% |
股份
|
| GOLDMAN SACHS GROUP INC |
$2520080 |
129434 |
0.19% |
股份
|
| Caption Management, LLC |
$2509683 |
128900 |
0.19% |
卖出期权
|
| TD Asset Management Inc |
$2497495 |
128274 |
0.18% |
股份
|
| Engineers Gate Manager LP |
$2172657 |
111590 |
0.16% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$2142000 |
110000 |
0.16% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2133523 |
109580 |
0.16% |
股份
|
| Quadrature Capital Ltd |
$2126202 |
109204 |
0.16% |
股份
|
| Polymer Capital Management (HK) LTD |
$1956015 |
100463 |
0.14% |
股份
|
| Centiva Capital, LP |
$1947000 |
100000 |
0.14% |
买入期权
|
| HEIGHTS CAPITAL MANAGEMENT, INC |
$1947000 |
100000 |
0.14% |
股份
|
| J. Goldman & Co LP |
$1947000 |
100000 |
0.14% |
买入期权
|
| Ghisallo Capital Management LLC |
$1947000 |
100000 |
0.14% |
股份
|
| SummitTX Capital, L.P. |
$1934753 |
99371 |
0.14% |
股份
|
| Jain Global LLC |
$1929983 |
99126 |
0.14% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1735806 |
131700 |
0.13% |
股份
|
| STATE STREET CORP |
$1697122 |
87166 |
0.13% |
股份
|
| Swiss National Bank |
$1695837 |
87100 |
0.13% |
股份
|
| Squarepoint Ops LLC |
$1657812 |
85147 |
0.12% |
股份
|
| Monashee Investment Management LLC |
$1460250 |
75000 |
0.11% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$1454836 |
74760 |
0.11% |
股份
|
| Mariner, LLC |
$1418907 |
72875 |
0.10% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1382380 |
74162 |
0.10% |
股份
|
| Lion Point Capital, LP |
$1314225 |
67500 |
0.10% |
股份
|
| CAPITAL FUND MANAGEMENT S.A. |
$1273221 |
65394 |
0.09% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$1143668 |
58740 |
0.08% |
股份
|
| Headlands Technologies LLC |
$1111484 |
57087 |
0.08% |
股份
|
| HAP Trading, LLC |
$1015000 |
40000 |
0.07% |
卖出期权
|
| Stonepine Capital Management, LLC |
$973500 |
50000 |
0.07% |
股份
|
| Nuveen, LLC |
$950817 |
48835 |
0.07% |
股份
|
| ExodusPoint Capital Management, LP |
$908198 |
46646 |
0.07% |
股份
|
| NORTHERN TRUST CORP |
$889000 |
45660 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$819687 |
42100 |
0.06% |
卖出期权
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$736725 |
37839 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$704717 |
36195 |
0.05% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$627985 |
32254 |
0.05% |
股份
|
| Campbell & CO Investment Adviser LLC |
$577831 |
29678 |
0.04% |
股份
|
| Aquatic Capital Management LLC |
$547769 |
28134 |
0.04% |
股份
|
| Quantbot Technologies LP |
$541402 |
27807 |
0.04% |
股份
|
| Schonfeld Strategic Advisors LLC |
$536884 |
27575 |
0.04% |
股份
|
| ADAR1 Capital Management, LLC |
$525690 |
27000 |
0.04% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$517707 |
26590 |
0.04% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$506162 |
25997 |
0.04% |
股份
|
| IEQ CAPITAL, LLC |
$483927 |
24855 |
0.04% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$473802 |
24335 |
0.03% |
股份
|
| IMC-Chicago, LLC |
$448745 |
23048 |
0.03% |
股份
|
| AXA Investment Managers S.A. |
$435613 |
60755 |
0.03% |
股份
|
| Graham Capital Management, L.P. |
$419481 |
21545 |
0.03% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$411361 |
21128 |
0.03% |
股份
|
| Legal & General Group Plc |
$409726 |
21044 |
0.03% |
股份
|
| Entropy Technologies, LP |
$386032 |
19827 |
0.03% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$379665 |
19500 |
0.03% |
买入期权
|
| OMERS ADMINISTRATION Corp |
$379665 |
19500 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$374389 |
19229 |
0.03% |
股份
|
| Man Group plc |
$343860 |
17661 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$340861 |
17507 |
0.03% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$339654 |
17445 |
0.03% |
股份
|
| SIMPLEX TRADING, LLC |
$322540 |
16566 |
0.02% |
股份
|
| Vident Advisory, LLC |
$320729 |
16473 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$301785 |
15500 |
0.02% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$271061 |
13922 |
0.02% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$262631 |
13489 |
0.02% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$257043 |
13202 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$253110 |
13000 |
0.02% |
股份
|
| Cubist Systematic Strategies, LLC |
$242905 |
33878 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$241252 |
12391 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$233017 |
11968 |
0.02% |
股份
|
| BARCLAYS PLC |
$231849 |
11908 |
0.02% |
股份
|
| Symmetry Investments LP |
$225852 |
11600 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$225774 |
11596 |
0.02% |
股份
|
| HAP Trading, LLC |
$222793 |
31073 |
0.02% |
股份
|
| Creative Planning |
$218239 |
11209 |
0.02% |
股份
|
| Rock Springs Capital Management LP |
$208251 |
10696 |
0.02% |
股份
|
| SIG BROKERAGE, LP |
$194700 |
10000 |
0.01% |
买入期权
|
| WELLS FARGO & COMPANY/MN |
$194700 |
10000 |
0.01% |
股份
|
| Crystal Cove Asset Management, LLC |
$194700 |
10000 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$173964 |
8935 |
0.01% |
股份
|
| Walleye Capital LLC |
$128502 |
6600 |
0.01% |
买入期权
|
| T. Rowe Price Investment Management, Inc. |
$83344 |
4280624 |
0.01% |
股份
|
| Ensign Peak Advisors, Inc |
$76692 |
3939 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$61895 |
3179 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$57475 |
2952 |
0.00% |
股份
|
| DEUTSCHE BANK AG\ |
$56229 |
2888 |
0.00% |
股份
|
| Advisors Asset Management, Inc. |
$52615 |
3992 |
0.00% |
股份
|
| Walleye Capital LLC |
$52569 |
2700 |
0.00% |
卖出期权
|
| US BANCORP \DE\ |
$40478 |
2079 |
0.00% |
股份
|
| Arax Advisory Partners |
$40322 |
2071 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$38200 |
1962 |
0.00% |
股份
|
| Allworth Financial LP |
$33372 |
1714 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$30490 |
1566 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$28445 |
1461 |
0.00% |
股份
|
| CITIGROUP INC |
$26440 |
1358 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$25346 |
3535 |
0.00% |
股份
|
| DecisionPoint Financial, LLC |
$23320 |
1219 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$20279 |
1041527 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$18691 |
960 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$17316 |
883 |
0.00% |
股份
|
| Essential Partners LLC |
$13824 |
710 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$13224 |
679244 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$10767 |
553 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$10229 |
514 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$9442 |
485 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$7691 |
395 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$7165 |
368 |
0.00% |
股份
|
| CWM, LLC |
$5667 |
304 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$3972 |
204 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2804 |
144 |
0.00% |
股份
|
| Quarry LP |
$2336 |
120 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$2077 |
106695 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$2000 |
92 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1966 |
101 |
0.00% |
股份
|
| IFG Advisory, LLC |
$1947 |
100 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1441 |
74 |
0.00% |
股份
|
| CVA Family Office, LLC |
$1168 |
60 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$1110 |
57 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$1090 |
56 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1052 |
54 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$954 |
49 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$780 |
40 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$516 |
26715 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$468 |
24 |
0.00% |
股份
|
| Virtu Financial LLC |
$446 |
22919 |
0.00% |
股份
|
| GAMMA Investing LLC |
$273 |
14 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$180 |
9254 |
0.00% |
股份
|
| Wilmington Savings Fund Society, FSB |
$175 |
9 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$156 |
4 |
0.00% |
股份
|
| Larson Financial Group LLC |
$136 |
7 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$117 |
6 |
0.00% |
股份
|
| HAP Trading, LLC |
$104 |
20000 |
0.00% |
买入期权
|
| FNY Investment Advisers, LLC |
$58 |
3000 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$39 |
2 |
0.00% |
股份
|
| Smallwood Wealth Investment Management, LLC |
$38 |
2 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$19 |
1 |
0.00% |
股份
|
| Avion Wealth |
$9 |
500 |
0.00% |
股份
|