| Nextech Invest Ltd. |
$77571359 |
7162637 |
5.94% |
股份
|
| BlackRock, Inc. |
$73903628 |
6823973 |
5.66% |
股份
|
| EcoR1 Capital, LLC |
$72865496 |
6728116 |
5.58% |
股份
|
| VIKING GLOBAL INVESTORS LP |
$55522832 |
5126762 |
4.25% |
股份
|
| STATE STREET CORP |
$53002020 |
4894000 |
4.06% |
股份
|
| SR One Capital Management, LP |
$49984609 |
4615384 |
3.83% |
股份
|
| Venrock Adviser, LLC |
$46783055 |
4319765 |
3.58% |
股份
|
| NEA Management Company, LLC |
$44604665 |
4118621 |
3.42% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$42791160 |
3951169 |
3.28% |
股份
|
| AIHC Capital Management Ltd |
$41462222 |
3828460 |
3.18% |
股份
|
| ALKEON CAPITAL MANAGEMENT LLC |
$40494410 |
3739096 |
3.10% |
股份
|
| Column Group LLC |
$38346615 |
3540777 |
2.94% |
股份
|
| VANGUARD GROUP INC |
$37153347 |
4541974 |
2.85% |
股份
|
| Siren, L.L.C. |
$32470419 |
2998192 |
2.49% |
股份
|
| FMR LLC |
$28542194 |
2635475 |
2.19% |
股份
|
| CITADEL ADVISORS LLC |
$28107088 |
2595299 |
2.15% |
股份
|
| GOLDMAN SACHS GROUP INC |
$26552951 |
2451796 |
2.03% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$22639952 |
2090089 |
1.73% |
股份
|
| First Turn Management, LLC |
$21847186 |
2017284 |
1.67% |
股份
|
| ORBIMED ADVISORS LLC |
$21822450 |
2015000 |
1.67% |
股份
|
| Integral Health Asset Management, LLC |
$20577000 |
1900000 |
1.58% |
股份
|
| MPM BIOIMPACT LLC |
$20383814 |
1882162 |
1.56% |
股份
|
| Vivo Capital, LLC |
$20022352 |
1848786 |
1.53% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$19503242 |
1801399 |
1.49% |
股份
|
| FRANKLIN RESOURCES INC |
$19465593 |
1797377 |
1.49% |
股份
|
| MORGAN STANLEY |
$19429237 |
1794020 |
1.49% |
股份
|
| D. E. Shaw & Co., Inc. |
$17113739 |
1580216 |
1.31% |
股份
|
| Woodline Partners LP |
$13510587 |
1247515 |
1.03% |
股份
|
| ALGERT GLOBAL LLC |
$13161623 |
1215293 |
1.01% |
股份
|
| BRAIDWELL LP |
$13153468 |
1214540 |
1.01% |
股份
|
| Candriam S.C.A. |
$12764594 |
1179768 |
0.98% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$11675336 |
1078055 |
0.89% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$11392109 |
1051903 |
0.87% |
股份
|
| Defilade Capital Management, L.P. |
$11346483 |
1047690 |
0.87% |
股份
|
| Euclidean Capital LLC |
$10715310 |
989410 |
0.82% |
股份
|
| ROYCE & ASSOCIATES LP |
$10609761 |
979664 |
0.81% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$10337886 |
954768 |
0.79% |
股份
|
| NORTHERN TRUST CORP |
$8732272 |
806304 |
0.67% |
股份
|
| Qube Research & Technologies Ltd |
$8604890 |
794542 |
0.66% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$8154806 |
752983 |
0.62% |
股份
|
| Jones Hill Capital LP |
$8093400 |
747313 |
0.62% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$8001995 |
738873 |
0.61% |
股份
|
| NEXTBio Capital Management LP |
$7647323 |
706124 |
0.59% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7556026 |
697694 |
0.58% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$7340823 |
677823 |
0.56% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$6808626 |
628682 |
0.52% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$6537681 |
603664 |
0.50% |
股份
|
| ArrowMark Colorado Holdings LLC |
$6312536 |
582875 |
0.48% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6130192 |
566038 |
0.47% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$5614922 |
518460 |
0.43% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$4397814 |
406077 |
0.34% |
股份
|
| Blue Owl Capital Holdings LP |
$4332000 |
400000 |
0.33% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$4256948 |
393070 |
0.33% |
股份
|
| Redmile Group, LLC |
$3920568 |
362010 |
0.30% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$3885273 |
358751 |
0.30% |
股份
|
| Boxer Capital Management, LLC |
$3790500 |
350000 |
0.29% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$3736762 |
345038 |
0.29% |
股份
|
| Squarepoint Ops LLC |
$3729235 |
344343 |
0.29% |
股份
|
| Pfizer Inc |
$3553775 |
372904 |
0.27% |
股份
|
| JPMORGAN CHASE & CO |
$3130462 |
308268 |
0.24% |
股份
|
| CITIGROUP INC |
$2694038 |
248757 |
0.21% |
股份
|
| TD Asset Management Inc |
$2664202 |
246002 |
0.20% |
股份
|
| UBS Group AG |
$2414256 |
222923 |
0.18% |
股份
|
| Trexquant Investment LP |
$2402300 |
221819 |
0.18% |
股份
|
| Bank of New York Mellon Corp |
$2383466 |
220080 |
0.18% |
股份
|
| XTX Topco Ltd |
$2359066 |
217827 |
0.18% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2310830 |
213373 |
0.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1935321 |
178700 |
0.15% |
买入期权
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1886824 |
174222 |
0.14% |
股份
|
| Nuveen, LLC |
$1864569 |
172167 |
0.14% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$1826241 |
168628 |
0.14% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1508251 |
139266 |
0.12% |
股份
|
| Jump Financial, LLC |
$1423062 |
131400 |
0.11% |
股份
|
| Atom Investors LP |
$1408756 |
130079 |
0.11% |
股份
|
| Ishara Investments LP |
$1332090 |
123000 |
0.10% |
股份
|
| Caption Management, LLC |
$1191300 |
110000 |
0.09% |
买入期权
|
| Invesco Ltd. |
$1167182 |
107773 |
0.09% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$1083000 |
100000 |
0.08% |
买入期权
|
| Caption Management, LLC |
$1083000 |
100000 |
0.08% |
卖出期权
|
| Russell Investments Group, Ltd. |
$1080205 |
99742 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$1017131 |
93919 |
0.08% |
股份
|
| Rafferty Asset Management, LLC |
$982963 |
90763 |
0.08% |
股份
|
| Abu Dhabi Investment Council Co P.J.S.C |
$968646 |
89441 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$942307 |
87009 |
0.07% |
股份
|
| Swiss National Bank |
$933546 |
86200 |
0.07% |
股份
|
| WINTON GROUP Ltd |
$898890 |
83000 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$808473 |
63810 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$800098 |
73878 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$780410 |
72060 |
0.06% |
股份
|
| Engineers Gate Manager LP |
$693683 |
64052 |
0.05% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$687208 |
54239 |
0.05% |
股份
|
| Caption Management, LLC |
$521248 |
48130 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$494931 |
45700 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$479703 |
44951 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$474787 |
43840 |
0.04% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$459289 |
42409 |
0.04% |
股份
|
| Virtus Investment Advisers, LLC |
$428489 |
39565 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$395501 |
36519 |
0.03% |
股份
|
| Quadrature Capital Ltd |
$393086 |
36296 |
0.03% |
股份
|
| LMR Partners LLP |
$381942 |
35267 |
0.03% |
股份
|
| AlphaQuest LLC |
$363086 |
44387 |
0.03% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$348899 |
32216 |
0.03% |
股份
|
| Legal & General Group Plc |
$332276 |
30667 |
0.03% |
股份
|
| Brevan Howard Capital Management LP |
$331983 |
30654 |
0.03% |
股份
|
| Creative Planning |
$323850 |
29903 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$310626 |
28682 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$306457 |
28297 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$281580 |
26000 |
0.02% |
买入期权
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$272797 |
25189 |
0.02% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$270750 |
25000 |
0.02% |
股份
|
| Balyasny Asset Management L.P. |
$262097 |
24201 |
0.02% |
股份
|
| GROUP ONE TRADING LLC |
$261674 |
24162 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$260819 |
24083 |
0.02% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$254505 |
23500 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$239917 |
22153 |
0.02% |
股份
|
| Quantinno Capital Management LP |
$234892 |
21689 |
0.02% |
股份
|
| TEMA ETFS LLC |
$227846 |
27854 |
0.02% |
股份
|
| Jasper Ridge Partners, L.P. |
$226022 |
20870 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$218149 |
20143 |
0.02% |
股份
|
| BARCLAYS PLC |
$214509 |
19807 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$204958 |
18925 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$199586 |
18429 |
0.02% |
股份
|
| Jain Global LLC |
$191009 |
17637 |
0.01% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$183902 |
16949 |
0.01% |
股份
|
| Quarry LP |
$182269 |
16830 |
0.01% |
股份
|
| JANUS HENDERSON GROUP PLC |
$182232 |
14400 |
0.01% |
股份
|
| ALLSTATE CORP |
$175197 |
16177 |
0.01% |
股份
|
| Blueshift Asset Management, LLC |
$166468 |
15371 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$160566 |
14826 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$154869 |
14300 |
0.01% |
卖出期权
|
| CWM, LLC |
$153244 |
12095 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$149357 |
13791 |
0.01% |
股份
|
| IEQ CAPITAL, LLC |
$145599 |
13444 |
0.01% |
股份
|
| ProShare Advisors LLC |
$142717 |
13178 |
0.01% |
股份
|
| PSP Research LLC |
$140790 |
13000 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$138602 |
12798 |
0.01% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$127794 |
11800 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$127458 |
11769 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$122487 |
11310 |
0.01% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$122379 |
11300 |
0.01% |
股份
|
| STIFEL FINANCIAL CORP |
$121665 |
11234 |
0.01% |
股份
|
| Cerity Partners LLC |
$120278 |
11106 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$115664 |
10680 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$100719 |
9300 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$89000 |
8237 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$76957 |
7106 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$73438 |
6781 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$71670 |
6617554 |
0.01% |
股份
|
| Federation des caisses Desjardins du Quebec |
$64980 |
6000 |
0.00% |
股份
|
| Arax Advisory Partners |
$56847 |
5249 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$50143 |
4630 |
0.00% |
股份
|
| Quantbot Technologies LP |
$46352 |
4280 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$34039 |
3143 |
0.00% |
股份
|
| ASSETMARK, INC |
$31894 |
2945 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$31624 |
2920 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$27465 |
2536 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$23025 |
2126 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$14925 |
1108 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$13559 |
1252 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$12195 |
1126 |
0.00% |
股份
|
| IFP Advisors, Inc |
$11133 |
1028 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$9996 |
923 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$6606 |
610 |
0.00% |
股份
|
| Essential Partners LLC |
$5567 |
514 |
0.00% |
股份
|
| GAMMA Investing LLC |
$3617 |
334 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$3401 |
314 |
0.00% |
股份
|
| Allworth Financial LP |
$3022 |
279 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2686 |
248 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$1780 |
319 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1659 |
153245 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1517 |
140 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$1375 |
127 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1365 |
126 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$1356 |
113 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1268 |
122 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$1051 |
97 |
0.00% |
股份
|
| State of Wyoming |
$964 |
89 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$899 |
83 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$899 |
83 |
0.00% |
股份
|
| Larson Financial Group LLC |
$877 |
81 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$564 |
52089 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$498 |
46 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$195 |
18 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$98 |
9 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$60 |
5593 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$22 |
2 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$16 |
1516 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
48 |
0.00% |
股份
|