| EVENTIDE ASSET MANAGEMENT, LLC |
$31774928 |
11812241 |
8.39% |
股份
|
| BlackRock, Inc. |
$29115162 |
10823480 |
7.68% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$28247604 |
10500968 |
7.45% |
股份
|
| Affinity Asset Advisors, LLC |
$27288872 |
10144562 |
7.20% |
股份
|
| JANUS HENDERSON GROUP PLC |
$23731510 |
10714000 |
6.26% |
股份
|
| STATE STREET CORP |
$21253058 |
7900765 |
5.61% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$20874707 |
7760114 |
5.51% |
股份
|
| ADAR1 Capital Management, LLC |
$19953019 |
7417479 |
5.27% |
股份
|
| Balyasny Asset Management L.P. |
$18074314 |
6719076 |
4.77% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$16580571 |
6163781 |
4.38% |
股份
|
| FEDERATED HERMES, INC. |
$16009982 |
5951666 |
4.23% |
股份
|
| BRAIDWELL LP |
$15923358 |
5919464 |
4.20% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$10957549 |
4072653 |
2.89% |
股份
|
| TAKEDA PHARMACEUTICAL CO LTD |
$9791595 |
7531996 |
2.58% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$8342037 |
3101129 |
2.20% |
股份
|
| STEMPOINT CAPITAL LP |
$6502491 |
2417283 |
1.72% |
股份
|
| Ikarian Capital, LLC |
$6105503 |
2269704 |
1.61% |
股份
|
| Point72 Asset Management, L.P. |
$5234006 |
1945727 |
1.38% |
股份
|
| VANGUARD GROUP INC |
$5007730 |
3072227 |
1.32% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$3639570 |
1353000 |
0.96% |
股份
|
| NORTHERN TRUST CORP |
$3352114 |
1246139 |
0.88% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3068626 |
1140753 |
0.81% |
股份
|
| Propel Bio Management, LLC |
$3000797 |
1115538 |
0.79% |
股份
|
| Rosalind Advisors, Inc. |
$2980504 |
1107994 |
0.79% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2773237 |
1030943 |
0.73% |
股份
|
| Sio Capital Management, LLC |
$2704348 |
1005334 |
0.71% |
股份
|
| Ensign Peak Advisors, Inc |
$2657946 |
988084 |
0.70% |
股份
|
| Nuveen, LLC |
$2402853 |
893254 |
0.63% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2239097 |
832378 |
0.59% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2222494 |
826206 |
0.59% |
股份
|
| ORBIMED ADVISORS LLC |
$2009430 |
747000 |
0.53% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1984569 |
737758 |
0.52% |
股份
|
| Saturn V Capital Management LP |
$1783631 |
663060 |
0.47% |
股份
|
| Ally Bridge Group (NY) LLC |
$1680069 |
624561 |
0.44% |
股份
|
| UBS Group AG |
$1234487 |
458917 |
0.33% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1194473 |
444042 |
0.32% |
股份
|
| Bank of New York Mellon Corp |
$1119897 |
416318 |
0.30% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1101528 |
409490 |
0.29% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$1043445 |
387767 |
0.28% |
股份
|
| GOLDMAN SACHS GROUP INC |
$894942 |
332692 |
0.24% |
股份
|
| Informed Momentum Co LLC |
$698407 |
259631 |
0.18% |
股份
|
| Atom Investors LP |
$677439 |
251836 |
0.18% |
股份
|
| CIBC WORLD MARKET INC. |
$588709 |
218851 |
0.16% |
股份
|
| Parkman Healthcare Partners LLC |
$532477 |
197947 |
0.14% |
股份
|
| SEI INVESTMENTS CO |
$529083 |
196685 |
0.14% |
股份
|
| CITIGROUP INC |
$513946 |
191058 |
0.14% |
股份
|
| Invesco Ltd. |
$470481 |
174900 |
0.12% |
股份
|
| RHUMBLINE ADVISERS |
$457666 |
170139 |
0.12% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$455638 |
169382 |
0.12% |
股份
|
| DEUTSCHE BANK AG\ |
$401862 |
149391 |
0.11% |
股份
|
| TWO SIGMA ADVISERS, LP |
$389896 |
239200 |
0.10% |
股份
|
| Rafferty Asset Management, LLC |
$367922 |
136774 |
0.10% |
股份
|
| Velan Capital Investment Management LP |
$349700 |
130000 |
0.09% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$303701 |
112900 |
0.08% |
买入期权
|
| RENAISSANCE TECHNOLOGIES LLC |
$283795 |
105500 |
0.07% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$278146 |
103400 |
0.07% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$256717 |
95434 |
0.07% |
股份
|
| Empowered Funds, LLC |
$245419 |
91234 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$243679 |
90587 |
0.06% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$232080 |
86098 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$198791 |
73900 |
0.05% |
卖出期权
|
| TWO SIGMA SECURITIES, LLC |
$192300 |
71487 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$189914 |
70600 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$189718 |
70527 |
0.05% |
股份
|
| PROFUND ADVISORS LLC |
$187490 |
69699 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$173737 |
78260 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$172671 |
63482 |
0.05% |
股份
|
| MORGAN STANLEY |
$153111 |
56919 |
0.04% |
股份
|
| State of Wyoming |
$143748 |
53438 |
0.04% |
股份
|
| LPL Financial LLC |
$134769 |
50100 |
0.04% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$121483 |
45161 |
0.03% |
股份
|
| Cubist Systematic Strategies, LLC |
$112648 |
86652 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$110048 |
40910 |
0.03% |
股份
|
| FMR LLC |
$104937 |
39010 |
0.03% |
股份
|
| D. E. Shaw & Co., Inc. |
$99199 |
36877 |
0.03% |
股份
|
| Verdad Advisers, LP |
$95627 |
35549 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$95226 |
35400 |
0.03% |
股份
|
| Schonfeld Strategic Advisors LLC |
$94281 |
35049 |
0.02% |
股份
|
| XTX Topco Ltd |
$92375 |
34340 |
0.02% |
股份
|
| BARCLAYS PLC |
$91783 |
34120 |
0.02% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$86874 |
32295 |
0.02% |
股份
|
| Spark Investment Management LLC |
$85542 |
31800 |
0.02% |
股份
|
| Sovereign Financial Group, Inc. |
$80700 |
30000 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$78758 |
29278 |
0.02% |
股份
|
| BLAIR WILLIAM & CO/IL |
$77577 |
28839 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$77542 |
28826 |
0.02% |
股份
|
| Abel Hall, LLC |
$76192 |
28324 |
0.02% |
股份
|
| Total Clarity Wealth Management, Inc. |
$73736 |
27411 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$71016 |
26400 |
0.02% |
买入期权
|
| FIRST MANHATTAN CO. LLC. |
$69940 |
26000 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$64226 |
23876 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$62126 |
23095 |
0.02% |
股份
|
| Stonepine Capital Management, LLC |
$57297 |
21300 |
0.02% |
股份
|
| Creative Planning |
$56485 |
20998 |
0.01% |
股份
|
| ProShare Advisors LLC |
$53933 |
20049 |
0.01% |
股份
|
| Focus Partners Advisor Solutions, LLC |
$53800 |
20000 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$52046 |
19348 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$51917 |
19300 |
0.01% |
卖出期权
|
| E Fund Management Co., Ltd. |
$51879 |
19286 |
0.01% |
股份
|
| Benin Management CORP |
$51110 |
19000 |
0.01% |
股份
|
| Squarepoint Ops LLC |
$50941 |
18937 |
0.01% |
股份
|
| TLS Advisors LLC |
$50728 |
18858 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$50203 |
18663 |
0.01% |
股份
|
| Assenagon Asset Management S.A. |
$47193 |
17544 |
0.01% |
股份
|
| Cetera Investment Advisers |
$45730 |
17000 |
0.01% |
股份
|
| Legal & General Group Plc |
$39968 |
14858 |
0.01% |
股份
|
| XPONANCE LLC |
$39166 |
14560 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$37380 |
13896 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$36014 |
13388 |
0.01% |
股份
|
| Private Advisor Group, LLC |
$35441 |
13175 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$32871 |
12220 |
0.01% |
股份
|
| Allspring Global Investments Holdings, LLC |
$30576 |
11262 |
0.01% |
股份
|
| Aaron Wealth Advisors LLC |
$30219 |
11234 |
0.01% |
股份
|
| Quadcap Wealth Management, LLC |
$29889 |
11111 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$24925 |
19173 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$16581 |
6164 |
0.00% |
股份
|
| Optiver Holding B.V. |
$13711 |
5097 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$13000 |
4792 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$10760 |
4000 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7494 |
2786 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$7459 |
2925 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$7355 |
2734 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$6324 |
2351 |
0.00% |
股份
|
| Atlantic Union Bankshares Corp |
$6187 |
2300 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5673 |
2109 |
0.00% |
股份
|
| H D Vest Advisory Services |
$5608 |
17000 |
0.00% |
股份
|
| Truvestments Capital LLC |
$3564 |
1325 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$2690 |
1000 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2429 |
903 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$839 |
312 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$823 |
306 |
0.00% |
股份
|
| Sandy Spring Bank |
$718 |
2300 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$371 |
213 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$339 |
125725 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$256 |
197 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$239 |
89 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$207 |
77 |
0.00% |
股份
|
| Arax Advisory Partners |
$153 |
57 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$80 |
30 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$37 |
13613 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$6 |
2284 |
0.00% |
股份
|
| Avion Wealth |
$0 |
300 |
0.00% |
股份
|