| FEDERATED HERMES, INC. |
$67551427 |
12990659 |
14.22% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$49114203 |
9445039 |
10.34% |
股份
|
| BlackRock, Inc. |
$40135113 |
7718291 |
8.45% |
股份
|
| Opaleye Management Inc. |
$32760000 |
6300000 |
6.89% |
股份
|
| Balyasny Asset Management L.P. |
$24242603 |
4662039 |
5.10% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$19946300 |
3835827 |
4.20% |
股份
|
| Siren, L.L.C. |
$17307092 |
3328287 |
3.64% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$13320601 |
2561654 |
2.80% |
股份
|
| JENNISON ASSOCIATES LLC |
$12788402 |
2459308 |
2.69% |
股份
|
| VANGUARD GROUP INC |
$11300886 |
4788511 |
2.38% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$11288227 |
2170154 |
2.38% |
股份
|
| STATE STREET CORP |
$9620666 |
1850128 |
2.02% |
股份
|
| D. E. Shaw & Co., Inc. |
$9564656 |
1839357 |
2.01% |
股份
|
| MORGAN STANLEY |
$8417671 |
1618783 |
1.77% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$7772960 |
1494800 |
1.64% |
买入期权
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7179879 |
1380746 |
1.51% |
股份
|
| GOLDMAN SACHS GROUP INC |
$6847267 |
1316782 |
1.44% |
股份
|
| Nuveen, LLC |
$6735087 |
1295209 |
1.42% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$6352726 |
1221678 |
1.34% |
股份
|
| Blackstone Inc. |
$5631220 |
1082927 |
1.19% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$5241400 |
1007962 |
1.10% |
股份
|
| Affinity Asset Advisors, LLC |
$5200000 |
1000000 |
1.09% |
股份
|
| GREAT POINT PARTNERS LLC |
$4949407 |
951809 |
1.04% |
股份
|
| Ikarian Capital, LLC |
$4862062 |
935012 |
1.02% |
股份
|
| Squadron Capital Management LLC |
$4680000 |
900000 |
0.98% |
买入期权
|
| DIMENSIONAL FUND ADVISORS LP |
$4631598 |
890733 |
0.97% |
股份
|
| 22NW, LP |
$4267396 |
820653 |
0.90% |
股份
|
| Velan Capital Investment Management LP |
$3900000 |
750000 |
0.82% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3797726 |
730332 |
0.80% |
股份
|
| NORTHERN TRUST CORP |
$3771409 |
725271 |
0.79% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3762658 |
723588 |
0.79% |
股份
|
| Woodline Partners LP |
$3181344 |
611797 |
0.67% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2969392 |
571037 |
0.62% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$2689617 |
517234 |
0.57% |
股份
|
| J. Goldman & Co LP |
$2602106 |
500405 |
0.55% |
股份
|
| Integral Health Asset Management, LLC |
$2600000 |
500000 |
0.55% |
股份
|
| UBS Group AG |
$2579371 |
496033 |
0.54% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2241580 |
431073 |
0.47% |
股份
|
| Squadron Capital Management LLC |
$2097732 |
403410 |
0.44% |
股份
|
| Vestal Point Capital, LP |
$1991595 |
382999 |
0.42% |
股份
|
| Knott David M Jr |
$1924000 |
370000 |
0.40% |
股份
|
| XTX Topco Ltd |
$1839084 |
353670 |
0.39% |
股份
|
| Driehaus Capital Management LLC |
$1505499 |
289519 |
0.32% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1492166 |
286955 |
0.31% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1454133 |
279641 |
0.31% |
股份
|
| JANE STREET GROUP, LLC |
$1372171 |
263879 |
0.29% |
股份
|
| Schonfeld Strategic Advisors LLC |
$1371478 |
263746 |
0.29% |
股份
|
| Point72 Europe (London) LLP |
$1200759 |
127740 |
0.25% |
股份
|
| FMR LLC |
$1123808 |
216117 |
0.24% |
股份
|
| Bank of New York Mellon Corp |
$1103804 |
212270 |
0.23% |
股份
|
| Russell Investments Group, Ltd. |
$1092228 |
210044 |
0.23% |
股份
|
| CITADEL ADVISORS LLC |
$957320 |
184100 |
0.20% |
买入期权
|
| Centiva Capital, LP |
$822640 |
158200 |
0.17% |
买入期权
|
| BARCLAYS PLC |
$813223 |
156389 |
0.17% |
股份
|
| GROUP ONE TRADING LLC |
$790306 |
151982 |
0.17% |
股份
|
| PFM Health Sciences, LP |
$661903 |
127289 |
0.14% |
股份
|
| Creative Planning |
$610282 |
117362 |
0.13% |
股份
|
| Walleye Capital LLC |
$564481 |
108554 |
0.12% |
股份
|
| FRANKLIN RESOURCES INC |
$544466 |
104705 |
0.11% |
股份
|
| Allostery Investments LP |
$532051 |
119294 |
0.11% |
股份
|
| SIMPLEX TRADING, LLC |
$526463 |
101243 |
0.11% |
股份
|
| Caption Management, LLC |
$520000 |
100000 |
0.11% |
买入期权
|
| CITADEL ADVISORS LLC |
$512148 |
98490 |
0.11% |
股份
|
| ALPS ADVISORS INC |
$508165 |
97724 |
0.11% |
股份
|
| AMERIPRISE FINANCIAL INC |
$507791 |
97652 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$490342 |
94298 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$488280 |
93900 |
0.10% |
卖出期权
|
| SEI INVESTMENTS CO |
$486070 |
93475 |
0.10% |
股份
|
| Virtus Investment Advisers, LLC |
$425360 |
81800 |
0.09% |
股份
|
| Jain Global LLC |
$420883 |
80939 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$420056 |
80780 |
0.09% |
股份
|
| NATIXIS |
$405600 |
78000 |
0.09% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$404679 |
77823 |
0.09% |
股份
|
| MARSHALL WACE, LLP |
$394363 |
75839 |
0.08% |
股份
|
| AlphaCentric Advisors LLC |
$375726 |
72255 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$353226 |
67928 |
0.07% |
股份
|
| Mariner, LLC |
$321162 |
61765 |
0.07% |
股份
|
| HSBC HOLDINGS PLC |
$277632 |
53597 |
0.06% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$275740 |
53027 |
0.06% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$266760 |
51300 |
0.06% |
股份
|
| ADAR1 Capital Management, LLC |
$253131 |
48679 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$245476 |
47207 |
0.05% |
股份
|
| Invesco Ltd. |
$211510 |
40675 |
0.04% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$208254 |
68280 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$208000 |
40000 |
0.04% |
卖出期权
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$205400 |
39500 |
0.04% |
股份
|
| CITIGROUP INC |
$188136 |
36180 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$187413 |
36041 |
0.04% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$185110 |
35598 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$182952 |
35183 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$182350 |
35755 |
0.04% |
股份
|
| CWM, LLC |
$170190 |
55800 |
0.04% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$164863 |
34708 |
0.03% |
股份
|
| IEQ CAPITAL, LLC |
$160087 |
30786 |
0.03% |
股份
|
| Cerity Partners LLC |
$149984 |
28843 |
0.03% |
股份
|
| Integrated Wealth Concepts LLC |
$142709 |
27444 |
0.03% |
股份
|
| Quadrature Capital Ltd |
$131950 |
25375 |
0.03% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$129984 |
24997 |
0.03% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$120692 |
23210 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$113963 |
21916 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$113360 |
21800 |
0.02% |
股份
|
| Rangeley Capital, LLC |
$102180 |
19650 |
0.02% |
股份
|
| EntryPoint Capital, LLC |
$101202 |
19462 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$97635 |
18776 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$88400 |
17000 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$79456 |
15280 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$79030 |
15198 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$78000 |
15000 |
0.02% |
股份
|
| Sequoia Financial Advisors, LLC |
$75130 |
14448 |
0.02% |
股份
|
| Polymer Capital Management (US) LLC |
$67127 |
12909 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$67080 |
12900 |
0.01% |
股份
|
| BRIGHTON JONES LLC |
$66144 |
12720 |
0.01% |
股份
|
| Arax Advisory Partners |
$64240 |
12354 |
0.01% |
股份
|
| LPL Financial LLC |
$62265 |
11974 |
0.01% |
股份
|
| ProShare Advisors LLC |
$53342 |
10258 |
0.01% |
股份
|
| Auxano Advisors, LLC |
$52000 |
10000 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$49707 |
9559 |
0.01% |
股份
|
| Legal & General Group Plc |
$41246 |
7932 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$35537 |
6834 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$26463 |
5089 |
0.01% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$26000 |
5000 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$22880 |
4400 |
0.00% |
股份
|
| IFP Advisors, Inc |
$19193 |
3691 |
0.00% |
股份
|
| Quantbot Technologies LP |
$16942 |
3258 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$16770 |
3225 |
0.00% |
股份
|
| AlphaQuest LLC |
$14141 |
5992 |
0.00% |
股份
|
| Allworth Financial LP |
$12486 |
2401 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$12000 |
2378 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$10930 |
2102 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7405 |
1424 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7301 |
1404 |
0.00% |
股份
|
| GAMMA Investing LLC |
$6001 |
1154 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5273 |
1014 |
0.00% |
股份
|
| Strategic Wealth Partners, Ltd. |
$5200 |
1000 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4658 |
903 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$4332 |
833 |
0.00% |
股份
|
| True Wealth Design, LLC |
$3921 |
754 |
0.00% |
股份
|
| Essential Partners LLC |
$3494 |
672 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$3052 |
587 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2891 |
556 |
0.00% |
股份
|
| TOTH FINANCIAL ADVISORY CORP |
$1820 |
350 |
0.00% |
股份
|
| US BANCORP \DE\ |
$1768 |
340 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$1092 |
210 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$650 |
125 |
0.00% |
股份
|
| State of Alaska, Department of Revenue |
$452 |
87000 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$448 |
86 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$395 |
76 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$385 |
74 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$362 |
70129 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$331 |
63608 |
0.00% |
股份
|
| SHP Wealth Management |
$239 |
46 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$122 |
23549 |
0.00% |
股份
|
| Virtu Financial LLC |
$119 |
22804 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$37 |
7 |
0.00% |
股份
|