| RA CAPITAL MANAGEMENT, L.P. |
$120240899 |
12036126 |
10.43% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$118947393 |
11906646 |
10.31% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$97990102 |
9808819 |
8.50% |
股份
|
| Siren, L.L.C. |
$76827146 |
7690405 |
6.66% |
股份
|
| BlackRock, Inc. |
$69273136 |
6934248 |
6.01% |
股份
|
| FMR LLC |
$68690808 |
6875957 |
5.96% |
股份
|
| ARMISTICE CAPITAL, LLC |
$42737220 |
4278000 |
3.71% |
股份
|
| STATE STREET CORP |
$41711896 |
4175365 |
3.62% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$40059121 |
4009922 |
3.47% |
股份
|
| RTW INVESTMENTS, LP |
$38890331 |
3892926 |
3.37% |
股份
|
| Deep Track Capital, LP |
$35614969 |
3565062 |
3.09% |
股份
|
| FRANKLIN RESOURCES INC |
$34372673 |
3440708 |
2.98% |
股份
|
| JANUS HENDERSON GROUP PLC |
$28877004 |
4010695 |
2.50% |
股份
|
| CITADEL ADVISORS LLC |
$28123069 |
2815122 |
2.44% |
股份
|
| Alyeska Investment Group, L.P. |
$22782035 |
2280484 |
1.98% |
股份
|
| AMERIPRISE FINANCIAL INC |
$22235593 |
2225783 |
1.93% |
股份
|
| Vestal Point Capital, LP |
$21578400 |
2160000 |
1.87% |
股份
|
| VANGUARD GROUP INC |
$19485969 |
3454959 |
1.69% |
股份
|
| Redmile Group, LLC |
$19467463 |
1948695 |
1.69% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$19391710 |
1940824 |
1.68% |
股份
|
| GOLDMAN SACHS GROUP INC |
$16013141 |
1602917 |
1.39% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$15049995 |
1506506 |
1.30% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$12645298 |
1266290 |
1.10% |
股份
|
| BLAIR WILLIAM & CO/IL |
$7555207 |
756277 |
0.66% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7478404 |
748589 |
0.65% |
股份
|
| Woodline Partners LP |
$6734019 |
674076 |
0.58% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$6677816 |
668450 |
0.58% |
股份
|
| Birchview Capital, LP |
$6655298 |
666196 |
0.58% |
股份
|
| NORTHERN TRUST CORP |
$6030434 |
603647 |
0.52% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$6028685 |
603472 |
0.52% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$5235779 |
524102 |
0.45% |
股份
|
| Monashee Investment Management LLC |
$4995000 |
500000 |
0.43% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$4942353 |
494730 |
0.43% |
股份
|
| Point72 Asset Management, L.P. |
$4475600 |
448008 |
0.39% |
股份
|
| STEMPOINT CAPITAL LP |
$3584212 |
358780 |
0.31% |
股份
|
| Boxer Capital Management, LLC |
$2997000 |
300000 |
0.26% |
股份
|
| JPMORGAN CHASE & CO |
$2667443 |
281673 |
0.23% |
股份
|
| Ally Bridge Group (NY) LLC |
$2557030 |
255959 |
0.22% |
股份
|
| MORGAN STANLEY |
$2549403 |
255195 |
0.22% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2441566 |
244401 |
0.21% |
股份
|
| Bank of New York Mellon Corp |
$2429105 |
243154 |
0.21% |
股份
|
| J. Goldman & Co LP |
$2419218 |
242164 |
0.21% |
股份
|
| Nuveen, LLC |
$2414004 |
241642 |
0.21% |
股份
|
| D. E. Shaw & Co., Inc. |
$2225662 |
222789 |
0.19% |
股份
|
| UBS Group AG |
$1881587 |
188347 |
0.16% |
股份
|
| ALGERT GLOBAL LLC |
$1872316 |
187419 |
0.16% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1851797 |
185365 |
0.16% |
股份
|
| Balyasny Asset Management L.P. |
$1780747 |
178253 |
0.15% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1628740 |
163037 |
0.14% |
股份
|
| Apis Capital Advisors, LLC |
$1598400 |
160000 |
0.14% |
股份
|
| Soleus Capital Management, L.P. |
$1498500 |
150000 |
0.13% |
股份
|
| CITIGROUP INC |
$1482836 |
148432 |
0.13% |
股份
|
| Invesco Ltd. |
$1432936 |
143437 |
0.12% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1369479 |
137085 |
0.12% |
股份
|
| Qube Research & Technologies Ltd |
$1367661 |
136903 |
0.12% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1097761 |
109886 |
0.10% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1081038 |
108212 |
0.09% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1071717 |
107279 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$1049627 |
105068 |
0.09% |
股份
|
| Fisher Asset Management, LLC |
$1033775 |
103481 |
0.09% |
股份
|
| GOLDMAN SACHS GROUP INC |
$999000 |
100000 |
0.09% |
买入期权
|
| ALPS ADVISORS INC |
$998161 |
99916 |
0.09% |
股份
|
| XTX Topco Ltd |
$889450 |
89034 |
0.08% |
股份
|
| Jump Financial, LLC |
$880628 |
88151 |
0.08% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$820179 |
82100 |
0.07% |
股份
|
| Verition Fund Management LLC |
$811937 |
81275 |
0.07% |
股份
|
| Quadrature Capital Ltd |
$782117 |
78290 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$774644 |
77542 |
0.07% |
股份
|
| Quantum Private Wealth, LLC |
$738241 |
73898 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$717072 |
71779 |
0.06% |
股份
|
| Trexquant Investment LP |
$690589 |
69128 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$686942 |
68763 |
0.06% |
股份
|
| BARCLAYS PLC |
$649380 |
65003 |
0.06% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$621488 |
62211 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$617242 |
61786 |
0.05% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$606443 |
60705 |
0.05% |
股份
|
| DeepCurrents Investment Group LLC |
$591139 |
59173 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$585324 |
58591 |
0.05% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$575604 |
57618 |
0.05% |
股份
|
| Knott David M Jr |
$561518 |
56208 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$498672 |
69260 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$482516 |
48300 |
0.04% |
股份
|
| BANK OF NOVA SCOTIA |
$471538 |
47201 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$461108 |
46157 |
0.04% |
股份
|
| Virtus Investment Advisers, LLC |
$457802 |
45826 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$440959 |
44574 |
0.04% |
股份
|
| Ikarian Capital, LLC |
$429130 |
42956 |
0.04% |
股份
|
| Quantinno Capital Management LP |
$400999 |
40140 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$373626 |
37400 |
0.03% |
买入期权
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$368831 |
36920 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$365065 |
36543 |
0.03% |
股份
|
| Creative Planning |
$358241 |
35860 |
0.03% |
股份
|
| CIBC Bancorp USA Inc. |
$349411 |
34976 |
0.03% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$332577 |
33291 |
0.03% |
股份
|
| ArchPoint Investors |
$312947 |
31326 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$308691 |
30900 |
0.03% |
买入期权
|
| Engineers Gate Manager LP |
$288861 |
28915 |
0.03% |
股份
|
| HSBC HOLDINGS PLC |
$285269 |
27804 |
0.02% |
股份
|
| Atom Investors LP |
$271548 |
27182 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$231868 |
23210 |
0.02% |
股份
|
| SFMG, LLC |
$221308 |
22153 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$212218 |
21243 |
0.02% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$199291 |
19949 |
0.02% |
股份
|
| AXQ CAPITAL, LP |
$197193 |
19739 |
0.02% |
股份
|
| CIBC Private Wealth Group LLC |
$188802 |
30600 |
0.02% |
股份
|
| Skopos Labs, Inc. |
$185840 |
25811 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$169830 |
17000 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$162857 |
16302 |
0.01% |
股份
|
| Lido Advisors, LLC |
$159700 |
15986 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$156523 |
15668 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$156084 |
15624 |
0.01% |
股份
|
| INCEPTIONR LLC |
$150819 |
15097 |
0.01% |
股份
|
| ProShare Advisors LLC |
$135166 |
13530 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$132867 |
13300 |
0.01% |
卖出期权
|
| SEI INVESTMENTS CO |
$130649 |
13078 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$129520 |
12965 |
0.01% |
股份
|
| LPL Financial LLC |
$127882 |
12801 |
0.01% |
股份
|
| US BANCORP \DE\ |
$122637 |
12276 |
0.01% |
股份
|
| LMR Partners LLP |
$112857 |
11297 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$101109 |
10121 |
0.01% |
股份
|
| Quantbot Technologies LP |
$96254 |
9635 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$92757 |
9285 |
0.01% |
股份
|
| Legal & General Group Plc |
$76314 |
7639 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$71349 |
7142 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$61000 |
6057 |
0.01% |
股份
|
| Farther Finance Advisors, LLC |
$54980 |
5531 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$54306 |
5436 |
0.00% |
股份
|
| Arax Advisory Partners |
$51019 |
5107 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$49500 |
4955 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$43986 |
4403 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$42258 |
4230 |
0.00% |
股份
|
| CWM, LLC |
$38124 |
5295 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$26923 |
2695 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$19451 |
1947 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$19441 |
1946 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$15358 |
2133 |
0.00% |
股份
|
| GAMMA Investing LLC |
$14156 |
1417 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$13206 |
1322 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$10829 |
1084 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$9481 |
949 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$8561 |
857 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$6813 |
682 |
0.00% |
股份
|
| Larson Financial Group LLC |
$6434 |
644 |
0.00% |
股份
|
| True Wealth Design, LLC |
$5635 |
564 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$5624 |
563 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$3117 |
312 |
0.00% |
股份
|
| IFP Advisors, Inc |
$2977 |
298 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2827 |
283 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2637 |
264 |
0.00% |
股份
|
| Essential Partners LLC |
$2627 |
263 |
0.00% |
股份
|
| EASTERN BANK |
$1508 |
151 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1499 |
150 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1349 |
135 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1249 |
125 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$774 |
107 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$769 |
77 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$646 |
64637 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$410 |
41 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$330 |
33 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$309 |
31 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$161 |
16136 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$60 |
6 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$12 |
1199 |
0.00% |
股份
|
| HANTZ FINANCIAL SERVICES, INC. |
$10 |
1000 |
0.00% |
股份
|