| BlackRock, Inc. |
$192307120 |
5877357 |
7.77% |
股份
|
| RTW INVESTMENTS, LP |
$184001738 |
5623525 |
7.44% |
股份
|
| FMR LLC |
$173844632 |
5313100 |
7.03% |
股份
|
| Lynx1 Capital Management LP |
$132136579 |
4038404 |
5.34% |
股份
|
| Redmile Group, LLC |
$129110502 |
3945920 |
5.22% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$115151528 |
3519301 |
4.65% |
股份
|
| MORGAN STANLEY |
$112975453 |
3452795 |
4.57% |
股份
|
| BAKER BROS. ADVISORS LP |
$109176726 |
3336697 |
4.41% |
股份
|
| TORONTO DOMINION BANK |
$103829002 |
3173258 |
4.20% |
股份
|
| VANGUARD GROUP INC |
$99956846 |
3149239 |
4.04% |
股份
|
| STATE STREET CORP |
$93325293 |
2852240 |
3.77% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$84644579 |
2586937 |
3.42% |
股份
|
| BVF INC/IL |
$83356065 |
2547557 |
3.37% |
股份
|
| Siren, L.L.C. |
$65287754 |
1995347 |
2.64% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$59664920 |
1823500 |
2.41% |
股份
|
| Skorpios Trust |
$53020254 |
2256181 |
2.14% |
股份
|
| JANUS HENDERSON GROUP PLC |
$52455703 |
1612781 |
2.12% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$49884057 |
1524309 |
2.02% |
股份
|
| Assenagon Asset Management S.A. |
$36920855 |
1128388 |
1.49% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$33173608 |
1013911 |
1.34% |
股份
|
| Polar Capital Holdings Plc |
$27279188 |
833716 |
1.10% |
股份
|
| EcoR1 Capital, LLC |
$24049200 |
735000 |
0.97% |
股份
|
| MPM BIOIMPACT LLC |
$23666834 |
723314 |
0.96% |
股份
|
| Opaleye Management Inc. |
$22904000 |
700000 |
0.93% |
股份
|
| GOLDMAN SACHS GROUP INC |
$18825256 |
575344 |
0.76% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$18552011 |
566993 |
0.75% |
股份
|
| BAILLIE GIFFORD & CO |
$16925238 |
517275 |
0.68% |
股份
|
| NORTHERN TRUST CORP |
$16364057 |
500124 |
0.66% |
股份
|
| Troluce Capital Advisors LLC |
$16242732 |
496416 |
0.66% |
股份
|
| FIRST TRUST ADVISORS LP |
$16062673 |
490913 |
0.65% |
股份
|
| CITADEL ADVISORS LLC |
$16009929 |
489301 |
0.65% |
股份
|
| Candriam S.C.A. |
$15694935 |
480136 |
0.63% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$15280633 |
467012 |
0.62% |
股份
|
| Granahan Investment Management, LLC |
$15103814 |
461608 |
0.61% |
股份
|
| Erste Asset Management GmbH |
$13875261 |
428381 |
0.56% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$13169898 |
402503 |
0.53% |
股份
|
| Parkman Healthcare Partners LLC |
$11630095 |
355443 |
0.47% |
股份
|
| Artisan Partners Limited Partnership |
$11620606 |
355153 |
0.47% |
股份
|
| JANE STREET GROUP, LLC |
$10853257 |
331701 |
0.44% |
股份
|
| TANG CAPITAL MANAGEMENT LLC |
$9816000 |
300000 |
0.40% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$8540836 |
261028 |
0.35% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$8497646 |
259708 |
0.34% |
股份
|
| JPMORGAN CHASE & CO |
$8480802 |
259352 |
0.34% |
股份
|
| UBS Group AG |
$6776705 |
207112 |
0.27% |
股份
|
| Birchview Capital, LP |
$5827759 |
178110 |
0.24% |
股份
|
| Bank of New York Mellon Corp |
$5375002 |
164273 |
0.22% |
股份
|
| NORGES BANK |
$5339904 |
163200 |
0.22% |
股份
|
| FRANKLIN RESOURCES INC |
$4790044 |
146395 |
0.19% |
股份
|
| DAFNA Capital Management LLC |
$4282230 |
130875 |
0.17% |
股份
|
| ExodusPoint Capital Management, LP |
$4242475 |
129660 |
0.17% |
股份
|
| Nuveen, LLC |
$4020535 |
122877 |
0.16% |
股份
|
| GILDER GAGNON HOWE & CO LLC |
$3699487 |
113065 |
0.15% |
股份
|
| Jump Financial, LLC |
$3414332 |
104350 |
0.14% |
股份
|
| Schonfeld Strategic Advisors LLC |
$3344932 |
102229 |
0.14% |
股份
|
| Palo Alto Investors LP |
$2769126 |
84631 |
0.11% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2649273 |
80968 |
0.11% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$2633004 |
80522 |
0.11% |
股份
|
| XTX Topco Ltd |
$2604937 |
79613 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$2484451 |
75931 |
0.10% |
股份
|
| Swiss National Bank |
$2427824 |
74200 |
0.10% |
股份
|
| Trexquant Investment LP |
$2404102 |
73475 |
0.10% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$2286474 |
69880 |
0.09% |
股份
|
| CITIGROUP INC |
$2268347 |
69326 |
0.09% |
股份
|
| Invesco Ltd. |
$2213836 |
67660 |
0.09% |
股份
|
| TD Asset Management Inc |
$2198784 |
67200 |
0.09% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2164755 |
66160 |
0.09% |
股份
|
| Rhenman & Partners Asset Management AB |
$2110440 |
64500 |
0.09% |
股份
|
| ALPS ADVISORS INC |
$2061687 |
63010 |
0.08% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2040779 |
62371 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$2031418 |
62390 |
0.08% |
股份
|
| HighVista Strategies LLC |
$2006260 |
61316 |
0.08% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1968664 |
60167 |
0.08% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$1925343 |
58843 |
0.08% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1894503 |
58185 |
0.08% |
股份
|
| D. E. Shaw & Co., Inc. |
$1892754 |
57847 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$1890692 |
57784 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1663322 |
50835 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1640515 |
50138 |
0.07% |
股份
|
| Woodline Partners LP |
$1639926 |
50120 |
0.07% |
股份
|
| Quantinno Capital Management LP |
$1633644 |
49928 |
0.07% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1623272 |
49611 |
0.07% |
股份
|
| Moran Wealth Management, LLC |
$1569807 |
47977 |
0.06% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$1469128 |
44900 |
0.06% |
股份
|
| Creative Planning |
$1451721 |
44368 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$1431238 |
43742 |
0.06% |
股份
|
| HUSSMAN STRATEGIC ADVISORS, INC. |
$1374240 |
42000 |
0.06% |
股份
|
| Quadrature Capital Ltd |
$1348882 |
41225 |
0.05% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$1335467 |
40815 |
0.05% |
股份
|
| Legal & General Group Plc |
$1168268 |
35705 |
0.05% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1164766 |
35598 |
0.05% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$1104564 |
34102 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$1051359 |
32132 |
0.04% |
股份
|
| Corient Private Wealth LP |
$1008529 |
30823 |
0.04% |
股份
|
| OMERS ADMINISTRATION Corp |
$981600 |
30000 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$959023 |
29310 |
0.04% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$883833 |
27012 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$871628 |
26639 |
0.04% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$865411 |
26449 |
0.03% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$821730 |
25114 |
0.03% |
股份
|
| Cresset Asset Management, LLC |
$798728 |
24411 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$736200 |
22500 |
0.03% |
买入期权
|
| PROFUND ADVISORS LLC |
$733452 |
22416 |
0.03% |
股份
|
| Allspring Global Investments Holdings, LLC |
$711083 |
21739 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$687120 |
21000 |
0.03% |
卖出期权
|
| LPL Financial LLC |
$675504 |
20645 |
0.03% |
股份
|
| AMERIPRISE FINANCIAL INC |
$668240 |
20423 |
0.03% |
股份
|
| Balyasny Asset Management L.P. |
$652404 |
19939 |
0.03% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$558432 |
17067 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$531536 |
16245 |
0.02% |
股份
|
| Aquatic Capital Management LLC |
$506211 |
15471 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$498587 |
15238 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$480362 |
14681 |
0.02% |
股份
|
| BARCLAYS PLC |
$477909 |
14606 |
0.02% |
股份
|
| AlphaQuest LLC |
$477243 |
15036 |
0.02% |
股份
|
| CIM, LLC |
$476272 |
14556 |
0.02% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$443356 |
13550 |
0.02% |
股份
|
| OSAIC HOLDINGS, INC. |
$406119 |
12412 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$400395 |
12237 |
0.02% |
股份
|
| Advantage Alpha Capital Partners LP |
$398114 |
16941 |
0.02% |
股份
|
| PSP Research LLC |
$392640 |
12000 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$391135 |
11954 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$359037 |
10973 |
0.01% |
股份
|
| Jain Global LLC |
$356092 |
10883 |
0.01% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$354325 |
10829 |
0.01% |
股份
|
| Dorsey & Whitney Trust CO LLC |
$353900 |
10816 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$349253 |
10674 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$333777 |
10201 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$333286 |
10186 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$330865 |
10112 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$327200 |
10000 |
0.01% |
卖出期权
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$313588 |
9584 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$309826 |
9469 |
0.01% |
股份
|
| ProShare Advisors LLC |
$302758 |
9253 |
0.01% |
股份
|
| Yorktown Management & Research Co Inc |
$299388 |
9150 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$294480 |
9000 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$288067 |
8804 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$287936 |
8800 |
0.01% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$287118 |
8775 |
0.01% |
股份
|
| Inspire Advisors, LLC |
$275601 |
8423 |
0.01% |
股份
|
| Toroso Investments, LLC |
$265188 |
8355 |
0.01% |
股份
|
| Seven Fleet Capital Management LP |
$255353 |
7745 |
0.01% |
股份
|
| Entropy Technologies, LP |
$251290 |
7680 |
0.01% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$248410 |
7592 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$248050 |
7581 |
0.01% |
股份
|
| Generali Investments, Management Co LLC |
$225055 |
6912 |
0.01% |
股份
|
| State of Wyoming |
$218897 |
6690 |
0.01% |
股份
|
| Magnetar Financial LLC |
$205154 |
6270 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$201817 |
6168 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$163567 |
4999 |
0.01% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$144393 |
4413 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$96884 |
2961 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$91125 |
2785 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$87093 |
2661739 |
0.00% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$79024 |
2415139 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$74929 |
2290 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$68000 |
2092 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$67840 |
2120 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$63837 |
1951 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$39657 |
1212 |
0.00% |
股份
|
| Quantbot Technologies LP |
$34160 |
1044 |
0.00% |
股份
|
| GAMMA Investing LLC |
$28892 |
883 |
0.00% |
股份
|
| Optiver Holding B.V. |
$21857 |
668 |
0.00% |
股份
|
| CWM, LLC |
$20155 |
619 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$18127 |
554 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$17767 |
543 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$16360 |
500 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$15739 |
481 |
0.00% |
股份
|
| Quarry LP |
$15640 |
478 |
0.00% |
股份
|
| Wilmington Savings Fund Society, FSB |
$13088 |
400 |
0.00% |
股份
|
| Arax Advisory Partners |
$12205 |
373 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$9489 |
290 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$8082 |
247 |
0.00% |
股份
|
| US BANCORP \DE\ |
$7984 |
244 |
0.00% |
股份
|
| Prestige Wealth Management Group LLC |
$6544 |
200 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6315 |
193 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$5020 |
155 |
0.00% |
股份
|
| Owl Creek Wealth Partners LLC |
$4908 |
150 |
0.00% |
股份
|
| Financial Life Planners |
$4712 |
144 |
0.00% |
股份
|
| Larson Financial Group LLC |
$4057 |
124 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$2716 |
83 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2160 |
66 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$1440 |
44 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$1145 |
35 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$824 |
25197 |
0.00% |
股份
|
| Dogwood Wealth Management LLC |
$785 |
24 |
0.00% |
股份
|
| Strengthening Families & Communities, LLC |
$654 |
20 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$589 |
18 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$556 |
17 |
0.00% |
股份
|
| HARBOR CAPITAL ADVISORS, INC. |
$526 |
16073 |
0.00% |
股份
|
| Vestcor Inc |
$333 |
10171 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$328 |
10 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$294 |
9 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$262 |
8 |
0.00% |
股份
|
| Allworth Financial LP |
$197 |
6 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$184 |
5625 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$164 |
5 |
0.00% |
股份
|
| IFP Advisors, Inc |
$164 |
5 |
0.00% |
股份
|
| True Wealth Design, LLC |
$131 |
4 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$99 |
3 |
0.00% |
股份
|
| KBC Group NV |
$36 |
1096 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$24 |
731 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
16 |
0.00% |
股份
|