| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$56367922 |
8122179 |
11.65% |
股份
|
| Redmile Group, LLC |
$47830709 |
6892033 |
9.89% |
股份
|
| ORBIMED ADVISORS LLC |
$43764521 |
6306127 |
9.05% |
股份
|
| Prosight Management, LP |
$41347666 |
5957877 |
8.55% |
股份
|
| BlackRock, Inc. |
$27314521 |
3935810 |
5.65% |
股份
|
| Frazier Life Sciences Management, L.P. |
$26025000 |
3750000 |
5.38% |
股份
|
| NEXTBio Capital Management LP |
$25867795 |
3727348 |
5.35% |
股份
|
| Deep Track Capital, LP |
$25724734 |
3706734 |
5.32% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$22262583 |
3207865 |
4.60% |
股份
|
| PINNACLE ASSOCIATES LTD |
$12987807 |
1871442 |
2.68% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$12269490 |
1767938 |
2.54% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$11000534 |
1584756 |
2.27% |
股份
|
| CLARK ESTATES INC/NY |
$9925359 |
1430167 |
2.05% |
股份
|
| Aberdeen Group plc |
$9756606 |
1405851 |
2.02% |
股份
|
| VANGUARD GROUP INC |
$8678773 |
2377746 |
1.79% |
股份
|
| Point72 Asset Management, L.P. |
$8124880 |
1170732 |
1.68% |
股份
|
| 683 Capital Management, LLC |
$8031079 |
1157216 |
1.66% |
股份
|
| STATE STREET CORP |
$7123174 |
1026394 |
1.47% |
股份
|
| Boxer Capital Management, LLC |
$6940000 |
1000000 |
1.43% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$6572076 |
946985 |
1.36% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$5161701 |
743761 |
1.07% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4117668 |
593324 |
0.85% |
股份
|
| TD Asset Management Inc |
$3878599 |
558876 |
0.80% |
股份
|
| NORTHERN TRUST CORP |
$3610993 |
520316 |
0.75% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3216100 |
463415 |
0.66% |
股份
|
| S&G Foundation |
$3024098 |
435749 |
0.63% |
股份
|
| ALGERT GLOBAL LLC |
$2923038 |
421187 |
0.60% |
股份
|
| FMR LLC |
$2724616 |
392596 |
0.56% |
股份
|
| DEUTSCHE BANK AG\ |
$2474305 |
356528 |
0.51% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2131968 |
307200 |
0.44% |
买入期权
|
| Connor, Clark & Lunn Investment Management Ltd. |
$1988234 |
286489 |
0.41% |
股份
|
| Hillsdale Investment Management Inc. |
$1828121 |
263418 |
0.38% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1575873 |
227071 |
0.33% |
股份
|
| Bank of New York Mellon Corp |
$1516424 |
218505 |
0.31% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1395634 |
201100 |
0.29% |
卖出期权
|
| Caption Management, LLC |
$1388000 |
200000 |
0.29% |
买入期权
|
| MILLENNIUM MANAGEMENT LLC |
$1346416 |
194008 |
0.28% |
股份
|
| West Tower Group, LLC |
$1329878 |
191625 |
0.27% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1317899 |
189899 |
0.27% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1290472 |
185947 |
0.27% |
股份
|
| MORGAN STANLEY |
$1261081 |
181712 |
0.26% |
股份
|
| TAKEDA PHARMACEUTICAL CO LTD |
$1232329 |
515619 |
0.25% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$1080156 |
155642 |
0.22% |
股份
|
| XTX Topco Ltd |
$650653 |
93754 |
0.13% |
股份
|
| TWO SIGMA ADVISERS, LP |
$622690 |
170600 |
0.13% |
股份
|
| Jump Financial, LLC |
$616272 |
88800 |
0.13% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$600039 |
86461 |
0.12% |
股份
|
| Nuveen, LLC |
$565069 |
81422 |
0.12% |
股份
|
| LBJ Family Wealth Advisors, Ltd. |
$560000 |
82177 |
0.12% |
股份
|
| Pathstone Holdings, LLC |
$513255 |
73956 |
0.11% |
股份
|
| Squarepoint Ops LLC |
$496536 |
71547 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$496120 |
71488 |
0.10% |
股份
|
| Coastline Trust Co |
$477400 |
70000 |
0.10% |
股份
|
| Invesco Ltd. |
$452835 |
65250 |
0.09% |
股份
|
| UBS Group AG |
$397239 |
57239 |
0.08% |
股份
|
| Verdad Advisers, LP |
$397183 |
57231 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$384247 |
55367 |
0.08% |
股份
|
| BLAIR WILLIAM & CO/IL |
$378029 |
54471 |
0.08% |
股份
|
| Cerity Partners LLC |
$366050 |
52745 |
0.08% |
股份
|
| Davis Asset Management, L.P. |
$335035 |
48276 |
0.07% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$318671 |
45918 |
0.07% |
股份
|
| HSBC HOLDINGS PLC |
$311759 |
42445 |
0.06% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$293562 |
42300 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$259695 |
37420 |
0.05% |
股份
|
| AMERIPRISE FINANCIAL INC |
$246710 |
35549 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$226244 |
32600 |
0.05% |
买入期权
|
| ALLIANCEBERNSTEIN L.P. |
$213412 |
33190 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$208894 |
30100 |
0.04% |
买入期权
|
| MIDDLETON & CO INC/MA |
$208200 |
30000 |
0.04% |
股份
|
| CITIGROUP INC |
$199671 |
28771 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$195201 |
28127 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$194750 |
28062 |
0.04% |
股份
|
| EntryPoint Capital, LLC |
$183126 |
26387 |
0.04% |
股份
|
| RITHOLTZ WEALTH MANAGEMENT |
$180440 |
26000 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$175827 |
25668 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$174721 |
25176 |
0.04% |
股份
|
| Mallini Complete Financial Planning LLC |
$157066 |
22632 |
0.03% |
股份
|
| State of Wyoming |
$151188 |
21785 |
0.03% |
股份
|
| CHOREO, LLC |
$139849 |
27251 |
0.03% |
股份
|
| MGO ONE SEVEN LLC |
$138800 |
20000 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$137655 |
19835 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$125558 |
18092 |
0.03% |
股份
|
| BARCLAYS PLC |
$120575 |
17374 |
0.02% |
股份
|
| BENJAMIN EDWARDS INC |
$119992 |
17290 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$101609 |
14641 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$100630 |
14500 |
0.02% |
卖出期权
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$98548 |
14200 |
0.02% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$93222 |
13432540 |
0.02% |
股份
|
| Creative Planning |
$85605 |
12335 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$83523 |
12035 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$81739 |
11778 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$73522 |
10594 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$63966 |
9217 |
0.01% |
股份
|
| Legal & General Group Plc |
$41335 |
5956 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$38635 |
5567 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$37593 |
5417 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$35623 |
5133 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$34545 |
14454 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$29000 |
4195 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$21183 |
8863 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$18330 |
2641076 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5864 |
845 |
0.00% |
股份
|
| Larson Financial Group LLC |
$3470 |
500 |
0.00% |
股份
|
| Truvestments Capital LLC |
$3408 |
491 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$2415 |
348 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$1683 |
242932 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$884 |
370 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$474 |
68371 |
0.00% |
股份
|
| CWM, LLC |
$251 |
39 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$208 |
30 |
0.00% |
股份
|
| Quarry LP |
$180 |
26 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$146 |
21 |
0.00% |
股份
|
| Optiver Holding B.V. |
$14 |
2 |
0.00% |
股份
|