| FMR LLC |
$97294233 |
2830378 |
19.94% |
股份
|
| TCG Crossover Management, LLC |
$41418128 |
1204891 |
8.49% |
股份
|
| Aberdeen Group plc |
$39250200 |
1141824 |
8.04% |
股份
|
| BlackRock, Inc. |
$29651600 |
862592 |
6.08% |
股份
|
| First Light Asset Management, LLC |
$27524958 |
800726 |
5.64% |
股份
|
| BAKER BROS. ADVISORS LP |
$20892713 |
607788 |
4.28% |
股份
|
| 5AM Venture Management, LLC |
$20853938 |
606660 |
4.27% |
股份
|
| BRAIDWELL LP |
$20518438 |
596900 |
4.21% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$16802672 |
488805 |
3.44% |
股份
|
| Vestal Point Capital, LP |
$14609375 |
425000 |
2.99% |
股份
|
| VANGUARD GROUP INC |
$12513872 |
599898 |
2.56% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$9700694 |
282202 |
1.99% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$9299108 |
270461 |
1.91% |
股份
|
| ORBIMED ADVISORS LLC |
$7789375 |
226600 |
1.60% |
股份
|
| STATE STREET CORP |
$7559338 |
219908 |
1.55% |
股份
|
| Ikarian Capital, LLC |
$7075647 |
205837 |
1.45% |
股份
|
| D. E. Shaw & Co., Inc. |
$6412656 |
186550 |
1.31% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$6054318 |
176100 |
1.24% |
买入期权
|
| MARSHALL WACE, LLP |
$5916833 |
172101 |
1.21% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5689922 |
165525 |
1.17% |
股份
|
| Squarepoint Ops LLC |
$4985338 |
145028 |
1.02% |
股份
|
| AMERIPRISE FINANCIAL INC |
$4896673 |
142448 |
1.00% |
股份
|
| WELLS FARGO & COMPANY/MN |
$4036588 |
117428 |
0.83% |
股份
|
| NORTHERN TRUST CORP |
$3915450 |
113904 |
0.80% |
股份
|
| Soleus Capital Management, L.P. |
$3495388 |
101684 |
0.72% |
股份
|
| Woodline Partners LP |
$3437500 |
100000 |
0.70% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3245481 |
94414 |
0.67% |
股份
|
| CITADEL ADVISORS LLC |
$3107260 |
90393 |
0.64% |
股份
|
| GOLDMAN SACHS GROUP INC |
$2541138 |
73924 |
0.52% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$2498169 |
72674 |
0.51% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$2440934 |
71009 |
0.50% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2351044 |
68394 |
0.48% |
股份
|
| JANE STREET GROUP, LLC |
$2262596 |
65821 |
0.46% |
股份
|
| MORGAN STANLEY |
$2247205 |
65373 |
0.46% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$2232313 |
64940 |
0.46% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2089003 |
60771 |
0.43% |
股份
|
| JPMORGAN CHASE & CO |
$1831995 |
55364 |
0.38% |
股份
|
| KOTLER KEVIN |
$1668800 |
80000 |
0.34% |
股份
|
| Tetragon Partners GP Ltd |
$1598988 |
46516 |
0.33% |
股份
|
| PFM Health Sciences, LP |
$1568566 |
45631 |
0.32% |
股份
|
| Jump Financial, LLC |
$1491875 |
43400 |
0.31% |
股份
|
| Prosight Management, LP |
$1365753 |
39731 |
0.28% |
股份
|
| Trexquant Investment LP |
$1271566 |
36991 |
0.26% |
股份
|
| Aldebaran Capital, LLC |
$1264897 |
36797 |
0.26% |
股份
|
| ExodusPoint Capital Management, LP |
$1211341 |
35239 |
0.25% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1080475 |
31432 |
0.22% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1046306 |
30438 |
0.21% |
股份
|
| MONIMUS CAPITAL MANAGEMENT, LP |
$967416 |
28143 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$867872 |
25247 |
0.18% |
股份
|
| ALPS ADVISORS INC |
$658178 |
19147 |
0.13% |
股份
|
| Fisher Asset Management, LLC |
$657318 |
19122 |
0.13% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$653159 |
19001 |
0.13% |
股份
|
| Quadrature Capital Ltd |
$621053 |
18067 |
0.13% |
股份
|
| SEI INVESTMENTS CO |
$585372 |
17029 |
0.12% |
股份
|
| CITADEL ADVISORS LLC |
$584375 |
17000 |
0.12% |
买入期权
|
| Clearstead Advisors, LLC |
$571657 |
16630 |
0.12% |
股份
|
| UBS Group AG |
$517516 |
15055 |
0.11% |
股份
|
| ADAR1 Capital Management, LLC |
$498472 |
14501 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$473439 |
13773 |
0.10% |
股份
|
| Nuveen, LLC |
$464544 |
13514 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$398808 |
11600 |
0.08% |
卖出期权
|
| BANK OF AMERICA CORP /DE/ |
$379604 |
11043 |
0.08% |
股份
|
| AlphaQuest LLC |
$379381 |
18187 |
0.08% |
股份
|
| Virtus Investment Advisers, LLC |
$371456 |
10806 |
0.08% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$358978 |
10443 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$345141 |
10039 |
0.07% |
股份
|
| Brevan Howard Capital Management LP |
$329072 |
9573 |
0.07% |
股份
|
| BARCLAYS PLC |
$313775 |
9128 |
0.06% |
股份
|
| Creative Planning |
$308036 |
8961 |
0.06% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$304734 |
8865 |
0.06% |
股份
|
| Vanguard Global Advisers, LLC |
$301297 |
8765 |
0.06% |
股份
|
| AlphaCentric Advisors LLC |
$238838 |
6948 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$231138 |
6724 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$230589 |
7460 |
0.05% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$227460 |
6617 |
0.05% |
股份
|
| Invesco Ltd. |
$219588 |
6388 |
0.05% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$208313 |
6060 |
0.04% |
股份
|
| Velan Capital Investment Management LP |
$206250 |
6000 |
0.04% |
股份
|
| Rangeley Capital, LLC |
$206250 |
6000 |
0.04% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$206113 |
5996 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$191365 |
5567 |
0.04% |
股份
|
| CITIGROUP INC |
$190712 |
5548 |
0.04% |
股份
|
| China Universal Asset Management Co., Ltd. |
$189166 |
5503 |
0.04% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$185625 |
5400 |
0.04% |
股份
|
| Clarius Group, LLC |
$179402 |
10130 |
0.04% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$176894 |
5146 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$161356 |
4694 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$158125 |
4600 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$90681 |
2638 |
0.02% |
股份
|
| Quantbot Technologies LP |
$62528 |
1819 |
0.01% |
股份
|
| CWM, LLC |
$56534 |
1829 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$38569 |
1122 |
0.01% |
股份
|
| US BANCORP \DE\ |
$37125 |
1080 |
0.01% |
股份
|
| Legal & General Group Plc |
$34375 |
1000 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$29013 |
844 |
0.01% |
股份
|
| Chung Wu Investment Group, LLC |
$27500 |
800 |
0.01% |
股份
|
| Arax Advisory Partners |
$24922 |
725 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$22722 |
661 |
0.00% |
股份
|
| State of Wyoming |
$20659 |
601 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$20161 |
587 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$17301 |
1103 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$15090 |
439 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$13750 |
400 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$12719 |
370 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$11808 |
382 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$11000 |
311 |
0.00% |
股份
|
| Bollard Group LLC |
$10414 |
302953 |
0.00% |
股份
|
| GAMMA Investing LLC |
$9969 |
290 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$8594 |
250 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6050 |
176 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4847 |
141 |
0.00% |
股份
|
| Axiom Investment Management LLC |
$4297 |
125 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2613 |
76 |
0.00% |
股份
|
| Allworth Financial LP |
$1788 |
52 |
0.00% |
股份
|
| Marshall & Sterling Wealth Advisors Inc. |
$1719 |
50 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1651 |
48001 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1531 |
44540 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$1375 |
40 |
0.00% |
股份
|
| Caldwell Trust Co |
$688 |
20 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$447 |
13 |
0.00% |
股份
|
| EASTERN BANK |
$447 |
13 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$378 |
11 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$284 |
8275 |
0.00% |
股份
|
| First Bancorp, Inc /ME/ |
$275 |
8 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$247 |
8 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$240 |
7 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$205 |
6 |
0.00% |
股份
|
| Essential Partners LLC |
$172 |
5 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$103 |
3 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$69 |
2 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$69 |
2 |
0.00% |
股份
|
| IFP Advisors, Inc |
$69 |
2 |
0.00% |
股份
|