| FMR LLC |
$241280071 |
9506701 |
15.37% |
股份
|
| SR One Capital Management, LP |
$127860735 |
5037854 |
8.15% |
股份
|
| NEA Management Company, LLC |
$102109298 |
4023219 |
6.50% |
股份
|
| ENAVATE SCIENCES GP, LLC |
$99468255 |
3919159 |
6.34% |
股份
|
| FEDERATED HERMES, INC. |
$79104511 |
3116805 |
5.04% |
股份
|
| BlackRock, Inc. |
$68176389 |
2686225 |
4.34% |
股份
|
| Capital International Investors |
$63523907 |
2502912 |
4.05% |
股份
|
| Polar Capital Holdings Plc |
$61236153 |
2412772 |
3.90% |
股份
|
| Royalty Pharma Sub-Manager, LLC |
$60611247 |
2388150 |
3.86% |
股份
|
| Fairmount Funds Management LLC |
$59872055 |
2359025 |
3.81% |
股份
|
| VANGUARD GROUP INC |
$52760791 |
1453065 |
3.36% |
股份
|
| STATE STREET CORP |
$52158438 |
2055100 |
3.32% |
股份
|
| NVP ASSOCIATES, LLC |
$46660673 |
1838482 |
2.97% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$40451126 |
1593819 |
2.58% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$34386448 |
1354864 |
2.19% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$31246815 |
1231159 |
1.99% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$22406450 |
882654 |
1.43% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$21571235 |
1103388 |
1.37% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$20688507 |
815150 |
1.32% |
股份
|
| EcoR1 Capital, LLC |
$20037510 |
789500 |
1.28% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$16762729 |
660470 |
1.07% |
股份
|
| Woodline Partners LP |
$14987880 |
590539 |
0.95% |
股份
|
| Balyasny Asset Management L.P. |
$14637077 |
576717 |
0.93% |
股份
|
| ArrowMark Colorado Holdings LLC |
$14550811 |
573318 |
0.93% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$12938445 |
509789 |
0.82% |
股份
|
| Rock Springs Capital Management LP |
$12742714 |
502077 |
0.81% |
股份
|
| Pivotal bioVenture Partners Investment Advisor LLC |
$12455641 |
490766 |
0.79% |
股份
|
| NEXTBio Capital Management LP |
$10830560 |
426736 |
0.69% |
股份
|
| Vestal Point Capital, LP |
$9263700 |
365000 |
0.59% |
股份
|
| MARSHALL WACE, LLP |
$8208957 |
323442 |
0.52% |
股份
|
| JENNISON ASSOCIATES LLC |
$7970564 |
314049 |
0.51% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7737601 |
304870 |
0.49% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$7666917 |
302085 |
0.49% |
股份
|
| NORTHERN TRUST CORP |
$7135334 |
281140 |
0.45% |
股份
|
| GOLDMAN SACHS GROUP INC |
$6882117 |
271163 |
0.44% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6462332 |
254623 |
0.41% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$5858567 |
230834 |
0.37% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5740956 |
226200 |
0.37% |
买入期权
|
| Walleye Capital LLC |
$5305689 |
209050 |
0.34% |
股份
|
| Sio Capital Management, LLC |
$5293177 |
208557 |
0.34% |
股份
|
| CITADEL ADVISORS LLC |
$4968897 |
195780 |
0.32% |
股份
|
| UBS Group AG |
$4519899 |
178089 |
0.29% |
股份
|
| Voleon Capital Management LP |
$4242140 |
167145 |
0.27% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$3834563 |
151086 |
0.24% |
股份
|
| MORGAN STANLEY |
$3425767 |
134979 |
0.22% |
股份
|
| Squarepoint Ops LLC |
$3177195 |
125185 |
0.20% |
股份
|
| BARCLAYS PLC |
$2943193 |
115965 |
0.19% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$2538000 |
100000 |
0.16% |
股份
|
| Birchview Capital, LP |
$2375593 |
93601 |
0.15% |
股份
|
| Verition Fund Management LLC |
$1852435 |
72988 |
0.12% |
股份
|
| Bank of New York Mellon Corp |
$1788706 |
70477 |
0.11% |
股份
|
| J. Goldman & Co LP |
$1731728 |
68232 |
0.11% |
股份
|
| Nuveen, LLC |
$1691273 |
66638 |
0.11% |
股份
|
| ALPS ADVISORS INC |
$1616072 |
63675 |
0.10% |
股份
|
| Swiss National Bank |
$1350216 |
53200 |
0.09% |
股份
|
| Exome Asset Management LLC |
$1331003 |
52443 |
0.08% |
股份
|
| Jump Financial, LLC |
$1294939 |
51022 |
0.08% |
股份
|
| CITIGROUP INC |
$1256843 |
49521 |
0.08% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1230042 |
48465 |
0.08% |
股份
|
| XTX Topco Ltd |
$1016063 |
40034 |
0.06% |
股份
|
| Burkehill Global Management, LP |
$1015200 |
40000 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$989820 |
39000 |
0.06% |
买入期权
|
| Rafferty Asset Management, LLC |
$951978 |
37509 |
0.06% |
股份
|
| Atom Investors LP |
$942842 |
37149 |
0.06% |
股份
|
| RHUMBLINE ADVISERS |
$869128 |
34245 |
0.06% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$844646 |
33280 |
0.05% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$789319 |
31100 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$784242 |
30900 |
0.05% |
买入期权
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$747974 |
29471 |
0.05% |
股份
|
| DEUTSCHE BANK AG\ |
$733000 |
28881 |
0.05% |
股份
|
| DCF Advisers, LLC |
$715310 |
28184 |
0.05% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$683280 |
26922 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$660518 |
24445 |
0.04% |
股份
|
| WELLS FARGO & COMPANY/MN |
$659753 |
25995 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$523412 |
20623 |
0.03% |
股份
|
| Legal & General Group Plc |
$508182 |
20023 |
0.03% |
股份
|
| Invesco Ltd. |
$481053 |
18954 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$479682 |
18900 |
0.03% |
卖出期权
|
| China Universal Asset Management Co., Ltd. |
$478362 |
18848 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$478108 |
18838 |
0.03% |
股份
|
| ALLSTATE CORP |
$462957 |
18241 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$442936 |
17423 |
0.03% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$439886 |
17332 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$432501 |
17041 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$419405 |
16525 |
0.03% |
股份
|
| Point72 Asset Management, L.P. |
$409532 |
16136 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$389126 |
15332 |
0.02% |
股份
|
| NORDEA INVESTMENT MANAGEMENT AB |
$382872 |
15050 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$372426 |
14674 |
0.02% |
股份
|
| Engineers Gate Manager LP |
$329432 |
12980 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$323341 |
12740 |
0.02% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$303475 |
15523 |
0.02% |
股份
|
| Creative Planning |
$297530 |
11723 |
0.02% |
股份
|
| VARCOV Co. |
$266617 |
10505 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$261414 |
10300 |
0.02% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$229765 |
9053 |
0.01% |
股份
|
| Scientech Research LLC |
$229131 |
9028 |
0.01% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$225222 |
8874 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$217786 |
8581 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$217532 |
8571 |
0.01% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$213649 |
8418 |
0.01% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$203852 |
8032 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$191949 |
7563 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$154818 |
6100 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$120277 |
4739 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$106571 |
4199 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$71673 |
2824 |
0.00% |
股份
|
| Ameritas Investment Partners, Inc. |
$65633 |
2586 |
0.00% |
股份
|
| TOUNJIAN ADVISORY PARTNERS, LLC |
$63450 |
2500 |
0.00% |
股份
|
| Quantbot Technologies LP |
$48933 |
1928 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$32639 |
1286 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$31141 |
1226928 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$28882 |
1138 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$28781 |
1134 |
0.00% |
股份
|
| CWM, LLC |
$28778 |
1472 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$21000 |
847 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$16522 |
651 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$13680 |
539 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$13654 |
538 |
0.00% |
股份
|
| Larson Financial Group LLC |
$11523 |
454 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$10660 |
420 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$9391 |
370 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$8756 |
345 |
0.00% |
股份
|
| US BANCORP \DE\ |
$7716 |
304 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$7487 |
295 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$5685 |
224 |
0.00% |
股份
|
| iA Global Asset Management Inc. |
$5460 |
215130 |
0.00% |
股份
|
| GAMMA Investing LLC |
$4949 |
195 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$4112 |
162 |
0.00% |
股份
|
| Arax Advisory Partners |
$2640 |
104 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$2538 |
100 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$2412 |
95 |
0.00% |
股份
|
| Torren Management, LLC |
$1857 |
95 |
0.00% |
股份
|
| CSM Advisors, LLC |
$1716 |
67622 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$1701 |
67 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$1066 |
42 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$736 |
29 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$660 |
26 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$508 |
20 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$305 |
12 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$225 |
8879 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$215 |
11 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$214 |
8442 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$51 |
2 |
0.00% |
股份
|
| Essential Partners LLC |
$51 |
2 |
0.00% |
股份
|
| Allworth Financial LP |
$26 |
1 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$25 |
1 |
0.00% |
股份
|
| Freestone Grove Partners LP |
$25 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$16 |
626 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
22 |
0.00% |
股份
|