| EcoR1 Capital, LLC |
$600445942 |
22970388 |
32.29% |
股份
|
| Rubric Capital Management LP |
$182980000 |
7000000 |
9.84% |
股份
|
| BlackRock, Inc. |
$111121925 |
4251030 |
5.98% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$109342391 |
4182953 |
5.88% |
股份
|
| BVF INC/IL |
$95388572 |
3649142 |
5.13% |
股份
|
| VANGUARD GROUP INC |
$61315382 |
2328727 |
3.30% |
股份
|
| MORGAN STANLEY |
$58325141 |
2231260 |
3.14% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$46558373 |
1781116 |
2.50% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$40752208 |
1558998 |
2.19% |
股份
|
| Assenagon Asset Management S.A. |
$32727986 |
1252027 |
1.76% |
股份
|
| Nextech Invest Ltd. |
$29118548 |
1113946 |
1.57% |
股份
|
| STATE STREET CORP |
$28445966 |
1088216 |
1.53% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$25995770 |
994955 |
1.40% |
股份
|
| CITADEL ADVISORS LLC |
$23895516 |
914136 |
1.29% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$23259000 |
889802 |
1.25% |
股份
|
| FMR LLC |
$18365133 |
702568 |
0.99% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$18099012 |
692410 |
0.97% |
股份
|
| Prosight Management, LP |
$17629705 |
674434 |
0.95% |
股份
|
| Qube Research & Technologies Ltd |
$15516443 |
593590 |
0.83% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$13332236 |
510032 |
0.72% |
股份
|
| Redmile Group, LLC |
$12851836 |
491654 |
0.69% |
股份
|
| Capricorn Fund Managers Ltd |
$12717868 |
486529 |
0.68% |
股份
|
| GOLDMAN SACHS GROUP INC |
$12307288 |
470822 |
0.66% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$10939512 |
418497 |
0.59% |
股份
|
| DEUTSCHE BANK AG\ |
$10382547 |
397190 |
0.56% |
股份
|
| Hillsdale Investment Management Inc. |
$10009581 |
382922 |
0.54% |
股份
|
| FIRST TRUST ADVISORS LP |
$8897088 |
340363 |
0.48% |
股份
|
| Granahan Investment Management, LLC |
$8787144 |
336157 |
0.47% |
股份
|
| NORTHERN TRUST CORP |
$8392849 |
321073 |
0.45% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$7997401 |
319385 |
0.43% |
股份
|
| Pictet Asset Management Holding SA |
$7446189 |
308187 |
0.40% |
股份
|
| PICTON MAHONEY ASSET MANAGEMENT |
$7092908 |
271343 |
0.38% |
股份
|
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
$5849243 |
223766 |
0.31% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$5726515 |
219071 |
0.31% |
股份
|
| WELLS FARGO & COMPANY/MN |
$5677573 |
217199 |
0.31% |
股份
|
| SummitTX Capital, L.P. |
$5510364 |
210802 |
0.30% |
股份
|
| Man Group plc |
$5509763 |
210779 |
0.30% |
股份
|
| FEDERATED HERMES, INC. |
$4914190 |
187995 |
0.26% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$4350114 |
166416 |
0.23% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$4066835 |
155579 |
0.22% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$3984154 |
152416 |
0.21% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$3800390 |
145386 |
0.20% |
股份
|
| D. E. Shaw & Co., Inc. |
$3785255 |
144807 |
0.20% |
股份
|
| DIADEMA PARTNERS LP |
$3715330 |
142132 |
0.20% |
股份
|
| CITIGROUP INC |
$3435868 |
131441 |
0.18% |
股份
|
| Bank of New York Mellon Corp |
$3427107 |
131106 |
0.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3408656 |
130400 |
0.18% |
买入期权
|
| XTX Topco Ltd |
$3290425 |
125877 |
0.18% |
股份
|
| Nuveen, LLC |
$3120829 |
119389 |
0.17% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$3100282 |
118603 |
0.17% |
股份
|
| UBS Group AG |
$3008583 |
115095 |
0.16% |
股份
|
| Invesco Ltd. |
$2933222 |
112212 |
0.16% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$2908911 |
111282 |
0.16% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2875766 |
110014 |
0.15% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$2749510 |
105184 |
0.15% |
股份
|
| AXA Investment Managers S.A. |
$2705745 |
158416 |
0.15% |
股份
|
| Manatuck Hill Partners, LLC |
$2614000 |
100000 |
0.14% |
股份
|
| JPMORGAN CHASE & CO |
$2564192 |
106398 |
0.14% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2451932 |
93800 |
0.13% |
卖出期权
|
| KORNITZER CAPITAL MANAGEMENT INC /KS |
$2321232 |
88800 |
0.12% |
股份
|
| MACKENZIE FINANCIAL CORP |
$2293654 |
87745 |
0.12% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$2221639 |
84990 |
0.12% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$2181514 |
83455 |
0.12% |
股份
|
| LMR Partners LLP |
$2156550 |
82500 |
0.12% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2150380 |
82264 |
0.12% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2094337 |
80120 |
0.11% |
股份
|
| STIFEL FINANCIAL CORP |
$2018373 |
77214 |
0.11% |
股份
|
| FRANKLIN RESOURCES INC |
$2000443 |
76528 |
0.11% |
股份
|
| TEMA ETFS LLC |
$2000422 |
75975 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$1962211 |
75066 |
0.11% |
股份
|
| Swiss National Bank |
$1939588 |
74200 |
0.10% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$1915592 |
73282 |
0.10% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1878786 |
71874 |
0.10% |
股份
|
| Dana Investment Advisors, Inc. |
$1873192 |
71660 |
0.10% |
股份
|
| CREDIT AGRICOLE S A |
$1855940 |
71000 |
0.10% |
股份
|
| Fisher Asset Management, LLC |
$1850057 |
70775 |
0.10% |
股份
|
| SEGALL BRYANT & HAMILL, LLC |
$1747093 |
66836 |
0.09% |
股份
|
| Verdad Advisers, LP |
$1743224 |
66688 |
0.09% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1705583 |
65248 |
0.09% |
股份
|
| Campbell & CO Investment Adviser LLC |
$1591246 |
60874 |
0.09% |
股份
|
| ROYAL BANK OF CANADA |
$1471000 |
56278 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1399636 |
55896 |
0.08% |
股份
|
| CITADEL ADVISORS LLC |
$1364508 |
52200 |
0.07% |
买入期权
|
| Virtus Investment Advisers, LLC |
$1328566 |
50825 |
0.07% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$1272365 |
48675 |
0.07% |
股份
|
| Russell Investments Group, Ltd. |
$1251241 |
47867 |
0.07% |
股份
|
| Quantinno Capital Management LP |
$1245362 |
47642 |
0.07% |
股份
|
| Legal & General Group Plc |
$1128017 |
43160 |
0.06% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$1111577 |
42524 |
0.06% |
股份
|
| MARSHALL WACE, LLP |
$1070380 |
40948 |
0.06% |
股份
|
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC |
$1033419 |
39534 |
0.06% |
股份
|
| Aquilo Capital Management, LLC |
$1006181 |
84482 |
0.05% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$986628 |
37744 |
0.05% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$965141 |
36922 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$953352 |
36471 |
0.05% |
股份
|
| HighTower Advisors, LLC |
$943654 |
36100 |
0.05% |
股份
|
| Persistent Asset Partners Ltd |
$939341 |
35935 |
0.05% |
股份
|
| HighVista Strategies LLC |
$889100 |
34013 |
0.05% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$837838 |
32052 |
0.05% |
股份
|
| TWO SIGMA ADVISERS, LP |
$827157 |
31415 |
0.04% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$807360 |
30886 |
0.04% |
股份
|
| Creative Planning |
$777168 |
29731 |
0.04% |
股份
|
| SBI Okasan Asset Management Co.Ltd. |
$771200 |
32000 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$728888 |
27884 |
0.04% |
股份
|
| JOURNEY STRATEGIC WEALTH LLC |
$727412 |
29050 |
0.04% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$723294 |
27670 |
0.04% |
股份
|
| STRS OHIO |
$692710 |
26500 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$686933 |
26279 |
0.04% |
股份
|
| Brevan Howard Capital Management LP |
$678490 |
25956 |
0.04% |
股份
|
| Jump Financial, LLC |
$669393 |
25608 |
0.04% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$657735 |
25162 |
0.04% |
股份
|
| RITHOLTZ WEALTH MANAGEMENT |
$633712 |
24243 |
0.03% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$607206 |
23229 |
0.03% |
股份
|
| Duncan Williams Asset Management, LLC |
$577563 |
22095 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$564049 |
21578 |
0.03% |
股份
|
| BARCLAYS PLC |
$538562 |
20603 |
0.03% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$508031 |
19435 |
0.03% |
股份
|
| SIMPLEX TRADING, LLC |
$507926 |
19431 |
0.03% |
股份
|
| BetterWealth, LLC |
$486779 |
18622 |
0.03% |
股份
|
| BANK OF MONTREAL /CAN/ |
$481394 |
18416 |
0.03% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$477499 |
18267 |
0.03% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$475356 |
18185 |
0.03% |
股份
|
| JANUS HENDERSON GROUP PLC |
$455819 |
18200 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$455803 |
17437 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$454078 |
17371 |
0.02% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$452483 |
17310 |
0.02% |
股份
|
| Squarepoint Ops LLC |
$423468 |
16200 |
0.02% |
股份
|
| HSBC HOLDINGS PLC |
$421205 |
15588 |
0.02% |
股份
|
| Vinva Investment Management Ltd |
$419717 |
11983 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$400988 |
15340 |
0.02% |
股份
|
| AGF MANAGEMENT LTD |
$392100 |
15000 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$358170 |
13702 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$311981 |
11935 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$311667 |
11923 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$303799 |
11622 |
0.02% |
股份
|
| JAMES INVESTMENT RESEARCH, INC. |
$285580 |
10925 |
0.02% |
股份
|
| Ewing Morris & Co. Investment Partners Ltd. |
$283619 |
10850 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$265975 |
10175 |
0.01% |
股份
|
| Jain Global LLC |
$261661 |
10010 |
0.01% |
股份
|
| PSP Research LLC |
$261400 |
10000 |
0.01% |
股份
|
| Mitsubishi UFJ Trust & Banking Corp |
$250134 |
9569 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$243991 |
9334 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$230110 |
8803 |
0.01% |
股份
|
| Allspring Global Investments Holdings, LLC |
$225359 |
8762 |
0.01% |
股份
|
| ProShare Advisors LLC |
$223681 |
8557 |
0.01% |
股份
|
| AlphaQuest LLC |
$218881 |
8313 |
0.01% |
股份
|
| INCEPTIONR LLC |
$217302 |
8313 |
0.01% |
股份
|
| Magnetar Financial LLC |
$216753 |
8292 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$209120 |
8000 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$207552 |
7940 |
0.01% |
股份
|
| CWM, LLC |
$174153 |
6955 |
0.01% |
股份
|
| Vanguard Global Advisers, LLC |
$142698 |
5459 |
0.01% |
股份
|
| Northwest & Ethical Investments L.P. |
$111583 |
4630 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$108847 |
4164 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$85373 |
3266 |
0.00% |
股份
|
| Arax Advisory Partners |
$78368 |
2998 |
0.00% |
股份
|
| State of Wyoming |
$72983 |
2792 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$62030 |
2373 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$41432 |
1585 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$37014 |
1439 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$34217 |
1309 |
0.00% |
股份
|
| Eurizon Capital SGR S.p.A. |
$31865 |
1321 |
0.00% |
股份
|
| GAMMA Investing LLC |
$29120 |
1114 |
0.00% |
股份
|
| Optiver Holding B.V. |
$27159 |
1039 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$25382 |
971 |
0.00% |
股份
|
| LANARK FINANCIAL, INC. |
$25146 |
962 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$23474 |
898 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$23055 |
882 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$20214 |
837 |
0.00% |
股份
|
| Freestone Grove Partners LP |
$16939 |
648 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$15182 |
581 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$14894 |
570 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$12573 |
481 |
0.00% |
股份
|
| UMB Bank, n.a. |
$12129 |
464 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$12024 |
460 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$8600 |
329 |
0.00% |
股份
|
| US BANCORP \DE\ |
$8234 |
315 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$8156 |
312 |
0.00% |
股份
|
| COMERICA BANK |
$5556 |
211 |
0.00% |
股份
|
| Quarry LP |
$5489 |
210 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$4888 |
187 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$4419 |
371 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4313 |
165 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$3032 |
116 |
0.00% |
股份
|
| Allworth Financial LP |
$2824 |
108 |
0.00% |
股份
|
| IFP Advisors, Inc |
$2509 |
96 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$2490 |
94 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2091 |
80 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$2091 |
80 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$2013 |
77 |
0.00% |
股份
|
| Kilter Group LLC |
$1726 |
66 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1673 |
64 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$1595 |
61 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1517 |
58 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$1334 |
51 |
0.00% |
股份
|
| North Growth Management Ltd. |
$1201 |
46000 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1007 |
38486 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$784 |
30 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$676 |
27 |
0.00% |
股份
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$643 |
25 |
0.00% |
股份
|
| Jackson Creek Investment Advisors LLC |
$409 |
18648 |
0.00% |
股份
|
| Essential Partners LLC |
$314 |
12 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$310 |
11865 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$289 |
12 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$165 |
6321 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$157 |
6 |
0.00% |
股份
|
| Larson Financial Group LLC |
$157 |
6 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$105 |
4 |
0.00% |
股份
|
| DekaBank Deutsche Girozentrale |
$94 |
3843 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$78 |
3 |
0.00% |
股份
|
| SHELL ASSET MANAGEMENT CO |
$72 |
4212 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
40 |
0.00% |
股份
|