ANVS Annovis Bio, Inc. Common Stock

NYSE · Biotechnology · View on SEC EDGAR ↗
$1.81
Price · Aug 25, 2026
Fundamentals as of Aug 14, 2026

ANVS Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$1.80
Market Cap
$49M
P/E (TTM)
-1.3
EPS (TTM)
$-1.40
Revenue (TTM)
$0
Div Yield
ROE
-164.0%
Debt/Equity
52W Range
$2 – $6

ANVS Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $0
Flat — no change across 7 periods
2019-12-31 2025-12-31
EPS $-1.40
6-point trend, -60.9%
2020-12-31 2025-12-31
Free Cash Flow
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ANVS
Peer Median
P/E (TTM)
5-point trend, +73.3%
-1.3
4.7
P/B
5-point trend, +74.5%
2.9
1.8

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ANVS
Peer Median
ROA
5-point trend, -207.9%
-164.8%
-68.1%
ROE
5-point trend, -415.3%
-164.0%
-111.7%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ANVS
Peer Median
Quick Ratio
5-point trend, -82.3%
5.4

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ANVS
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ANVS
Peer Median
EPS (Diluted)
5-point trend, +26.3%
$-1.40

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ANVS
Peer Median

ANVS Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 9 analysts
  • Strong Buy 2 22.2%
  • Buy 6 66.7%
  • Hold 1 11.1%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

3 analysts · 2026-08-24
Median target $8.00 +343.2%
Mean target $11.00 +509.4%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.04%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.63 $-0.40 -0.23%
Dec. 31, 2025 $-0.39 $-0.35 -0.04%
Sept. 30, 2025 $-0.37 $-0.31 -0.06%
June 30, 2025 $-0.32 $-0.41 0.09%
March 31, 2025 $-0.32 $-0.36 0.04%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ANVS $94M -2.5 -164.0%
DWTX $124M -0.6 123.6% -83.8%
ELTX -3.1
GOSS $724M -4.1 -57.7% -351.5% 201.8%
FRMM -6881.3% -368.1%
SPRO $131M 15.5 39.2% 12.8% 18.7%
IBIO $15M -0.4 77.8% -4594.2% -101.5%
CRDF $192M -4.1 -13.2% -7732.0% -88.2%
RNTX -0.6
NMAD

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for ANVS
Metric Trend 2025202420232022202120202019
Revenue Flat — no change across 7 periods $0 $0 $0 $0 $0 $0 $0
R&D Expense 7-point trend, +3148.4% $25M $20M $39M $17M $8M $3M $776.3K
SG&A Expense 7-point trend, +440.1% $4M $7M $6M $9M $6M $4M $829.4K
Operating Expenses 7-point trend, +1749.5% $30M $27M $45M $26M $15M $7M $2M
Operating Income 7-point trend, -1749.5% $-30M $-27M $-45M $-26M $-15M $-7M $-2M
Interest Income 3-point trend, +4.7% $699.1K $331.8K $667.9K · · · ·
Other Non-op 7-point trend, +36.8% $841.1K $2M $-11M $182.7K $50.1K $1M $614.6K
Pretax Income 5-point trend, -5571.6% · · $-56M $-25M $-14M $-5M $-991.0K
Income Tax Flat — no change across 2 periods $0 · · · · · $0
Net Income 7-point trend, -2811.7% $-29M $-25M $-56M $-25M $-14M $-5M $-991.0K
EPS (Basic) 6-point trend, -60.9% $-1.40 $-2.02 $-6.23 $-3.10 $-1.90 $-0.87 ·
EPS (Diluted) 6-point trend, -60.9% $-1.40 $-2.31 $-6.23 $-3.10 $-1.90 $-0.87 ·
Shares (Basic) 6-point trend, +225.8% 20,551,997 12,182,475 9,023,138 8,162,326 7,626,278 6,308,961 ·
Shares (Diluted) 6-point trend, +225.8% 20,551,997 12,235,444 9,023,138 8,162,326 7,626,278 6,308,961 ·
EBITDA 6-point trend, -347.2% $-30M $-27M $-45M $-26M $-15M $-7M ·
Balance Sheet 12
Annual Balance Sheet data for ANVS
Metric Trend 2025202420232022202120202019
Cash & Equivalents 7-point trend, +1051156.1% $20M $11M $6M $28M $46M $8M $1.9K
Current Assets 5-point trend, +1265.6% · · $10M $36M $46M $8M $747.5K
Total Assets 7-point trend, +1787.2% $21M $14M $10M $36M $46M $8M $1M
Accounts Payable 7-point trend, +109.9% $3M $2M $1M $4M $688.1K $341.9K $1M
Current Liabilities 7-point trend, +80.8% $4M $4M $4M $8M $2M $578.4K $2M
Total Liabilities 7-point trend, +61.7% $4M $5M $18M $8M $2M $578.4K $3M
Common Stock 7-point trend, +9610.7% $2.7K $1.4K $1.1K $816 $810 $689 $28
Paid-in Capital 7-point trend, +89906.1% $181M $144M $103M $82M $73M $22M $200.6K
Retained Earnings 7-point trend, -1765.1% $-164M $-135M $-110M $-54M $-29M $-14M $-9M
Stockholders' Equity 7-point trend, +296.5% $17M $9M $-8M $28M $44M $8M $-9M
Liabilities + Equity 7-point trend, +1787.2% $21M $14M $10M $36M $46M $8M $1M
Shares Outstanding 7-point trend, +9524.1% 27,199,139 14,141,521 10,519,933 8,163,923 8,100,570 6,891,608 282,614
Cash Flow 6
Annual Cash Flow data for ANVS
Metric Trend 2025202420232022202120202019
Stock-based Comp 7-point trend, +21091.5% $2M $4M $5M $9M $5M $2M $8.5K
Operating Cash Flow 7-point trend, -5276.2% $-26M $-22M $-40M $-17M $-9M $-4M $-476.5K
Stock Issued 4-point trend, +55.1% · $19M $17M · $47M $12M ·
Net Stock Activity 4-point trend, +55.1% · $19M $17M · $47M $12M ·
Financing Cash Flow 7-point trend, +7708.9% $35M $27M $17M $4.6K $47M $12M $443.1K
Net Change in Cash 7-point trend, +26944.1% $9M $5M $-23M $-17M $38M $8M $-33.5K
Profitability 2
Annual Profitability data for ANVS
Metric Trend 2025202420232022202120202019
ROA 6-point trend, -39.4% -164.8% -203.8% -243.2% -69.3% -53.5% -118.3% ·
ROE 6-point trend, -150.2% -164.0% -300.4% 10287.8% -80.5% -31.8% -65.6% ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for ANVS
Metric Trend 2025202420232022202120202019
Current Ratio 4-point trend, -83.0% · · 2.4 4.7 30.5 14.0 ·
Quick Ratio 6-point trend, -61.5% 5.4 2.7 1.3 3.7 30.3 14.0 ·
Efficiency 1
Annual Efficiency data for ANVS
Metric Trend 2025202420232022202120202019
Asset Turnover Flat — no change across 6 periods 0.0 0.0 0.0 0.0 0.0 0.0 ·
Per Share 5
Annual Per Share data for ANVS
Metric Trend 2025202420232022202120202019
Book Value / Share 6-point trend, -43.4% $0.62 $0.66 $-0.74 $3.47 $5.49 $1.09 ·
Revenue / Share Flat — no change across 5 periods $0.00 $0.00 $0.00 $0.00 $0.00 · ·
Cash Flow / Share 5-point trend, -4.1% $-1.25 $-1.79 $-4.43 $-2.12 $-1.20 · ·
Cash / Share 6-point trend, -38.7% $0.72 $0.75 $0.55 $3.48 $5.64 $1.17 ·
EPS (TTM) 6-point trend, -60.9% $-1.40 $-2.31 $-6.23 $-3.10 $-1.90 $-0.87 ·
Valuation (TTM) 8
Annual Valuation (TTM) data for ANVS
Metric Trend 2025202420232022202120202019
Revenue TTM Flat — no change across 7 periods $0 $0 $0 $0 $0 $0 $0
Net Income TTM 7-point trend, -2811.7% $-29M $-25M $-56M $-25M $-14M $-5M $-991.0K
Market Cap 6-point trend, +81.1% $94M $71M $197M $110M $142M $52M ·
P/E 6-point trend, +71.5% -2.5 -2.2 -3.0 -4.3 -9.3 -8.7 ·
P/B 6-point trend, -19.0% 5.6 7.6 -25.4 3.9 3.2 6.9 ·
P / Tangible Book 5-point trend, -19.0% 5.6 7.6 · 3.9 3.2 6.9 ·
P / Cash Flow 6-point trend, +71.9% -3.7 -3.2 -4.9 -6.3 -15.6 -13.1 ·
Earnings Yield 6-point trend, -250.6% -40.5% -45.9% -33.3% -23.1% -10.8% -11.5% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312022-09-30
Revenue $0$0$0$0
Net Income $-29M$-25M$-56M$-25M
Diluted EPS $-1.40$-2.31$-6.23$-3.10
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312022-09-30
Current Ratio 2.44.7
Quick Ratio 5.42.71.33.7

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Institutional owners (13F) 73 filers · $18.8M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
16 (+2 vs prior Q) 11 (+4 vs prior Q) 21 (+6 vs prior Q) 7 (-3 vs prior Q) +5.8M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Empery Asset Management, LP $4,466,745 2,401,476 23.80% Shares
VANGUARD CAPITAL MANAGEMENT LLC $3,064,019 1,647,322 16.32% Shares
TUDOR INVESTMENT CORP ET AL $2,524,269 1,357,134 13.45% Shares
RENAISSANCE TECHNOLOGIES LLC $1,864,092 1,002,200 9.93% Shares
TWO SIGMA INVESTMENTS, LP $1,078,002 579,571 5.74% Shares
Caption Management, LLC $883,314 474,900 4.71% Call option
MARSHALL WACE, LLP $538,326 289,423 2.87% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $531,774 285,900 2.83% Call option
VANGUARD GROUP INC $456,865 132,042 2.43% Shares
GEODE CAPITAL MANAGEMENT, LLC $435,274 233,892 2.32% Shares
VANGUARD FIDUCIARY TRUST CO $330,206 177,530 1.76% Shares
CITADEL ADVISORS LLC $275,280 148,000 1.47% Put option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $241,242 129,700 1.29% Put option
CITADEL ADVISORS LLC $213,528 114,800 1.14% Call option
Quadrature Capital Ltd $169,044 90,884 0.90% Shares
TWO SIGMA ADVISERS, LP $156,465 45,221 0.83% Shares
STATE STREET CORP $144,587 77,735 0.77% Shares
NORTHERN TRUST CORP $126,610 68,070 0.67% Shares
First National Trust Co $111,600 60,000 0.59% Shares
Sherry Group, Inc. $106,523 57,270 0.57% Shares
Headlands Technologies LLC $89,412 48,071 0.48% Shares
JANE STREET GROUP, LLC $79,050 42,500 0.42% Call option
Wescott Financial Advisory Group, LLC $77,389 41,607 0.41% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $70,079 37,677 0.37% Shares
Lokken Investment Group LLC $60,543 29,248 0.32% Shares
Dakota Wealth Management $53,940 29,000 0.29% Shares
CWA Asset Management Group, LLC $52,081 28,001 0.28% Shares
WELLS FARGO & COMPANY/MN $48,816 26,245 0.26% Shares
MILLENNIUM MANAGEMENT LLC $43,641 23,463 0.23% Shares
Sterling Investment Advisors, Ltd. $43,554 23,416 0.23% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $38,588 20,746 0.21% Shares
Wealthspire Advisors, LLC $37,200 20,000 0.20% Shares
GILL CAPITAL PARTNERS, LLC $34,557 18,579 0.18% Shares
Robertson Stephens Wealth Management, LLC $34,557 18,579 0.18% Shares
JANE STREET GROUP, LLC $30,504 16,400 0.16% Put option
Quadcap Wealth Management, LLC $29,965 16,110 0.16% Shares
StoneX Group Inc. $28,496 14,465 0.15% Shares
Bank of New York Mellon Corp $27,394 14,728 0.15% Shares
Vanguard Global Advisers, LLC $20,813 11,190 0.11% Shares
Kestra Advisory Services, LLC $19,716 10,600 0.11% Shares
Gallacher Capital Management LLC $18,600 10,000 0.10% Call option
RKL Wealth Management LLC $18,600 10,000 0.10% Shares
Wilmington Savings Fund Society, FSB $17,471 9,393 0.09% Shares
BlackRock, Inc. $13,003 6,991 0.07% Shares
Arax Advisory Partners $12,090 6,500 0.06% Shares
Gallacher Capital Management LLC $10,611 5,705 0.06% Shares
ROYAL BANK OF CANADA $10,000 5,600 0.05% Shares
CITADEL ADVISORS LLC $4,230 2,274 0.02% Shares
CoreCap Advisors, LLC $3,908 2,101 0.02% Shares
BARCLAYS PLC $3,471 1,866 0.02% Shares
Steward Partners Investment Advisory, LLC $3,432 1,845 0.02% Shares
SBI Securities Co., Ltd. $2,877 1,547 0.02% Shares
DiNuzzo Private Wealth, Inc. $2,230 1,000 0.01% Shares
Keating Financial Advisory Services, Inc. $2,013 1,082 0.01% Shares
Rockefeller Capital Management L.P. $1,860 1,000 0.01% Shares
UBS Group AG $1,177 633 0.01% Shares
FMR LLC $1,135 610 0.01% Shares
BOKF, NA $1,032 555 0.01% Shares
WR Wealth Planners, LLC $755 150 0.00% Shares
PNC Financial Services Group, Inc. $670 360 0.00% Shares
JPMORGAN CHASE & CO $593 319 0.00% Shares
Larson Financial Group LLC $558 300 0.00% Shares
Rialto Wealth Management, LLC $501 269 0.00% Shares
OSAIC HOLDINGS, INC. $372 200 0.00% Shares
MORGAN STANLEY $372 200 0.00% Shares
IFP Advisors, Inc $205 110 0.00% Shares
Global Retirement Partners, LLC $186 100 0.00% Shares
GSA CAPITAL PARTNERS LLP $93 49,904 0.00% Shares
Greenwich Wealth Management LLC $90 48,400 0.00% Shares
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO $37 20 0.00% Shares
Caitong International Asset Management Co., Ltd $11 6 0.00% Shares
Covestor Ltd $9 4,634 0.00% Shares
CITIGROUP INC $6 3 0.00% Shares

Company insiders 9 insiders · 4 officers · 6 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Maria-Luisa Maccecchini President & CEO Oct. 28, 2025 P 1,212,020 1 0 $200,000
Henry Hagopian III Chief Financial Officer Nov. 20, 2023 A 1,820 0 0 $0
Jeffrey Brian Mcgroarty Chief Financial Officer Jan. 3, 2022 A 52,833 0 0 $0
Andrew Walsh Vice President, Finance June 16, 2025 A 500 0 0 $0
Michael B Hoffman Director May 20, 2026 P 3,364,883 18 0 $4,256,887
Claudine Bruck Director Sept. 10, 2025 M 13,709 0 0 $0
Reid Mccarthy Director June 10, 2025 A 9,305 0 0 $0
Mark K. White Director July 1, 2024 A 61,167 0 0 $0
Jr. Robert M. Whelan, Director July 1, 2020 A 95,700 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 1 position

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Maria L. Maccecchini April 20, 2020 Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 4 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IWC · iShares Trust 0.01% 104,692 SH Aug. 21, 2026 Daily
DFAS · Dimensional ETF Trust 0.00% 12,209 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 393,887 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 1,219,718 SH Aug. 19, 2026 Daily