APRE Aprea Therapeutics, Inc. - Common Stock
NASDAQ · Biotechnology · View on SEC EDGAR ↗ close Oct 2, 2026 10-K/10-Q Aug 12, 2026
$0.70
· of 52w range
· above low
· to high
$0.5552w low
$1.6952w high
Market Cap (MRQ)
$9M
P/E
-0.4
EPS
$-1.93
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52W Range
$1–$2
Analyst Rating
BUY
Price Target
$4
P/E
-0.4
ROE
-97.5%
Net Profit Margin
·
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APRE Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$0.69
Market Cap (MRQ)
$9M
P/E
-0.4
EPS
$-1.93
ROE
-97.5%
52W Range
$1–$2
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Stock splits
| Ex-date | Split | Type |
|---|---|---|
| Feb. 13, 2023 | 1-for-20 | Reverse |
10-Year Performance Revenue, net income, margins and EPS trends
EPS$-1.932019-12-31 → 2025-12-31
Free Cash Flow·2019-12-31 → 2024-12-31
Valuation & Ratios
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
| Metric | 5Y trend | APRE | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| P/E | -0.45Y avg ≈-1.0 | ≈-1.0 | · | · | |
| P/B (MRQ) | 0.25Y avg ≈0.8 | ≈0.8 | 1.2 | Undervalued | |
| Price / Cash Flow | -0.45Y avg ≈-1.1 | ≈-1.1 | · | · | |
| Price / Tangible Book | 0.55Y avg ≈5.7 | ≈5.7 | · | · |
Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.
Profitability Gross, operating and net margins; ROE, ROA, ROIC
| Metric | 5Y trend | APRE | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| ROA | -63.1%5Y avg ≈-57.6% | ≈-57.6% | -94.8% | Top tier | |
| ROE | -97.5%5Y avg ≈-79.0% | ≈-79.0% | -247.7% | Top tier |
Financial Health Debt, liquidity, solvency — balance sheet strength
| Metric | 5Y trend | APRE | 5Y avg | Peer Median | Verdict |
|---|---|---|---|---|---|
| Current Ratio (MRQ) | 13.65Y avg ≈5.9 | ≈5.9 | 2.1 | Strong liquidity | |
| Quick Ratio | 5.35Y avg ≈5.7 | ≈5.7 | 1.6 | Strong liquidity |
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
No data for this ratio group yet
Not enough fundamentals data to compute this ratio group yet.
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
No data for this ratio group yet
Not enough fundamentals data to compute this ratio group yet.
value · ≈ 5Y avg · industry median · verdict relative to median
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
19.5%
Next Report
Nov 10, 2026
| Period | Report | EPS Actual | EPS Est | Surprise |
|---|---|---|---|---|
| June 30, 2026 | Aug 10, 2026 | $-0.07 | $-0.24 | 70.8% |
| March 31, 2026 | May 13, 2026 | $-0.22 | $-0.23 | 6.2% |
| Dec. 31, 2025 | $-0.32 | $-0.40 | 19.6% | |
| Sept. 30, 2025 | $-0.47 | $-0.35 | -36.1% | |
| June 30, 2025 | $-0.53 | $-0.76 | 30.3% | |
| Dec. 31, 2024 | $-0.49 | $-0.70 | 30.0% | |
| Sept. 30, 2024 | $-0.64 | $-0.76 | 15.8% |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | · | · | · | · | $24M | $38M | $21M | $14M | |
| SG&A Expense | $6M | $6M | $8M | $21M | $14M | $15M | $9M | $2M | |
| Operating Expenses | $14M | $16M | $16M | $113M | $37M | $53M | $30M | $16M | |
| Operating Income | $-13M | $-14M | $-15M | $-113M | $-37M | · | · | · | |
| Other Non-op | $634.3K | $1M | $1M | $730.2K | $319.1K | $-667.6K | $1M | $961.1K | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-13M | $-13M | $-14M | $-113M | $-37M | $-53M | $-28M | $-16M | |
| EPS (Basic) | $-1.93 | $-2.35 | $-3.95 | $-67.99 | $-34.88 | $-50.61 | $-4.67 | · | |
| EPS (Diluted) | $-1.93 | $-2.35 | $-3.95 | $-67.99 | $-34.88 | $-50.61 | $-4.67 | · | |
| Shares (Basic) | 6,538,722 | 5,509,921 | 3,617,607 | 1,657,055 | 1,064,325 | 1,056,681 | 6,002,486 | · | |
| Shares (Diluted) | 6,538,722 | 5,509,921 | 3,617,607 | 1,657,055 | 1,064,325 | 1,056,681 | 6,002,486 | · | |
| EBITDA | $-13M | $-14M | $-15M | · | · | $28.8K | $11.1K | · |
Balance Sheet
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $15M | $23M | $22M | $29M | $53M | $89M | $130M | $66M | |
| Prepaid Expense | $961.9K | $726.3K | $914.3K | $1M | $4M | $3M | $3M | $322.1K | |
| Current Assets | $16M | $24M | $23M | $30M | $57M | $92M | $133M | $66M | |
| PP&E (Net) | $59.8K | $81.5K | $88.4K | $2.3K | $23.9K | $38.5K | $41.6K | $24.4K | |
| PP&E (Gross) | $154.0K | $154.0K | $138.5K | $45.4K | $140.9K | $152.8K | $127.1K | $98.8K | |
| Accum. Depreciation | $94.2K | $72.4K | $50.1K | $43.1K | $117.0K | $114.3K | $85.4K | $74.3K | |
| Other Non-current Assets | $271.2K | $281.7K | · | · | $29.4K | $29.4K | $107 | $111 | |
| Total Assets | $16M | $24M | $23M | $30M | $57M | $93M | $134M | $66M | |
| Accounts Payable | $713.7K | $1M | $2M | $842.8K | $2M | $5M | $2M | $2M | |
| Current Liabilities | $3M | $3M | $4M | $3M | $7M | $15M | $9M | $5M | |
| Capital Leases | · | · | · | · | · | $78.8K | $302.6K | · | |
| Total Liabilities | · | · | · | $3M | $7M | $15M | $9M | $5M | |
| Common Stock | $8.2K | $5.5K | $3.7K | $2.7K | $1.1K | $21.2K | $21.0K | $127.1K | |
| Paid-in Capital | $357M | $351M | $336M | $330M | $241M | $231M | $226M | $20M | |
| Retained Earnings | $-334M | $-321M | $-308M | $-294M | $-181M | $-144M | $-91M | $-62M | |
| AOCI | $-11M | $-11M | $-11M | $-11M | $-10M | $-10M | $-12M | $-9M | |
| Stockholders' Equity | $12M | $19M | $17M | $26M | $50M | $77M | $124M | $-51M | |
| Liabilities + Equity | $16M | $24M | $23M | $30M | $57M | $93M | $134M | $66M | |
| Shares Outstanding | 8,192,538 | 5,481,055 | 3,736,673 | 2,655,269 | 1,092,967 | 21,186,827 | 21,022,752 | 1,155,366 |
Cash Flow
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| D&A | $21.7K | $22.3K | $7.1K | $4.4K | $12.8K | $28.8K | $11.1K | $8.3K | |
| Other Non-cash | $-316.6K | $-620.3K | $2M | · | · | $12M | $1M | · | |
| Operating Cash Flow | $-13M | $-14M | $-12M | $-25M | $-38M | $-42M | $-27M | $-15M | |
| CapEx | · | $15.5K | $93.1K | · | · | $25.7K | $30.9K | $3.7K | |
| Investing Cash Flow | · | $-15.5K | $-93.1K | · | · | $-25.7K | $-30.9K | $-3.7K | |
| Stock Issued | $5M | $16M | $6M | $683.0K | $2M | · | · | · | |
| Net Stock Activity | $5M | $16M | $6M | · | · | · | · | · | |
| Financing Cash Flow | $5M | $15M | $5M | $683.0K | $2M | $150.9K | $93M | $56M | |
| Free Cash Flow | · | $-14M | $-12M | · | · | $-42M | $-27M | · |
Profitability
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| ROA | -63.1% | -55.6% | -54.1% | · | · | -47.2% | -28.1% | · | |
| ROE | -97.5% | -62.8% | -76.7% | · | · | -64.3% | -105.0% | · |
Liquidity & Solvency
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.6 | 7.0 | 5.1 | · | · | 6.0 | 14.7 | · | |
| Quick Ratio | 5.3 | 6.8 | 4.9 | · | · | 5.8 | 14.4 | · |
Per Share
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Book Value / Share | $1.52 | $3.52 | $4.54 | · | · | $3.65 | $5.91 | · | |
| Cash Flow / Share | $-1.97 | $-2.46 | $-3.37 | · | · | · | · | · | |
| Cash / Share | $1.78 | $4.17 | $5.78 | · | · | $4.20 | $6.19 | · | |
| EPS (TTM) | $-1.93 | $-2.35 | $-3.95 | $-67.99 | $-34.88 | $-50.61 | $-4.67 | · |
Valuation (TTM)
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-13M | $-13M | $-14M | $-113M | $-37M | $-53M | $-28M | · | |
| Market Cap | $7M | $18M | $18M | · | · | $2.08B | $19.29B | · | |
| P/E | -0.4 | -1.4 | -1.2 | -0.1 | -1.6 | -1.9 | -196.5 | · | |
| P/B | 0.6 | 0.9 | 1.0 | · | · | 26.9 | 155.3 | · | |
| P / Tangible Book | 0.6 | 0.9 | 1.0 | 0.7 | 25.3 | 26.9 | · | · | |
| P / Cash Flow | -0.5 | -1.3 | -1.4 | · | · | -49.9 | -722.4 | · | |
| P / FCF | · | -1.3 | -1.4 | · | · | -49.8 | -721.6 | · | |
| Earnings Yield | -226.3% | -71.4% | -84.0% | -1027.0% | -60.8% | -51.4% | -0.51% | · |
Income Statement
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SG&A Expense | $2M | $2M | $2M | $1M | $2M | $2M | $1M | $2M | $2M | $2M | $2M | $2M | $2M | $3M | $-2M | $3M | |
| Operating Expenses | $4M | $3M | $3M | $3M | $4M | $4M | $3M | $4M | $4M | $4M | $4M | $4M | $4M | $5M | $3M | $4M | |
| Operating Income | $-4M | $-3M | $-3M | $-3M | $-3M | $-4M | $-3M | $-4M | $-4M | $-3M | $-4M | $-4M | $-4M | $-5M | $-3M | $-4M | |
| Other Non-op | $440.9K | $142.5K | $187.5K | $145.0K | $148.9K | $152.9K | $331.2K | $313.2K | $376.9K | $339.6K | $231.7K | $318.3K | $392.6K | $242.6K | $209.5K | $175.5K | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-4M | $-3M | $-2M | $-3M | $-3M | $-4M | $-3M | $-4M | $-3M | $-3M | $-3M | $-3M | $-3M | $-4M | $-2M | $-4M | |
| EPS (Basic) | $-0.07 | $-0.22 | $-0.27 | $-0.47 | $-0.53 | $-0.66 | $-0.46 | $-0.64 | $-0.58 | $-0.67 | $-0.88 | $-0.86 | $-0.87 | $-1.34 | $28.30 | $-2.32 | |
| EPS (Diluted) | $-0.07 | $-0.22 | $-0.27 | $-0.47 | $-0.53 | $-0.66 | $-0.46 | $-0.64 | $-0.58 | $-0.67 | $-0.88 | $-0.86 | $-0.87 | $-1.34 | $28.30 | $-2.32 | |
| Shares (Basic) | 53,483,504 | 14,685,448 | · | 6,372,938 | 6,083,329 | 5,993,866 | · | 5,939,755 | 5,937,291 | 4,198,326 | · | 3,735,176 | 3,731,571 | 3,260,484 | · | 1,732,783 | |
| Shares (Diluted) | 53,483,504 | 14,685,448 | · | 6,372,938 | 6,083,329 | 5,993,866 | · | 5,939,755 | 5,937,291 | 4,198,326 | · | 3,735,176 | 3,731,571 | 3,260,484 | · | 1,732,783 | |
| EBITDA | $-4M | $-3M | · | $-3M | $-3M | $-4M | · | $-4M | $-4M | $-3M | · | $-4M | $-4M | $410 | · | · |
Balance Sheet
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $41M | $46M | $15M | $14M | $17M | $19M | $23M | $26M | $29M | $32M | $22M | $25M | $28M | $31M | $29M | $33M | |
| Prepaid Expense | $679.7K | $779.2K | $961.9K | $225.9K | $395.0K | $558.7K | $726.3K | $234.2K | $865.1K | $698.9K | $914.3K | $286.3K | $953.7K | $1M | $1M | $361.2K | |
| Current Assets | $42M | $47M | $16M | $14M | $17M | $20M | $24M | $26M | $30M | $33M | $23M | $26M | $29M | $32M | $30M | $33M | |
| PP&E (Net) | $64.0K | $54.4K | $59.8K | $65.2K | $70.7K | $76.1K | $81.5K | $87.0K | $92.4K | $90.2K | $88.4K | $86.2K | $1.7K | $1.9K | $2.3K | $12.2K | |
| PP&E (Gross) | · | · | $154.0K | · | · | · | $154.0K | · | · | · | $138.5K | · | · | · | $45.4K | · | |
| Accum. Depreciation | · | · | $94.2K | · | · | · | $72.4K | · | · | · | $50.1K | · | · | · | $43.1K | · | |
| Other Non-current Assets | $271.2K | $271.2K | $271.2K | $271.2K | $271.2K | $271.2K | $281.7K | $281.7K | $271.2K | · | · | · | · | · | · | $29.4K | |
| Total Assets | $42M | $48M | $16M | $14M | $17M | $20M | $24M | $27M | $30M | $33M | $23M | $26M | $29M | $32M | $30M | $34M | |
| Accounts Payable | $935.1K | $3M | $713.7K | $641.3K | $1M | $1M | $1M | $1M | $964.3K | $1M | $2M | $862.6K | $1M | $826.0K | $842.8K | $1M | |
| Current Liabilities | $3M | $5M | $3M | $3M | $3M | $3M | $3M | $4M | $3M | $3M | $4M | $4M | $4M | $4M | $3M | $4M | |
| Total Liabilities | · | · | · | · | · | · | · | · | · | · | · | · | $4M | $4M | · | $4M | |
| Common Stock | $12.4K | $12.0K | $8.2K | $6.0K | $5.8K | $5.5K | $5.5K | $5.4K | $5.4K | $5.4K | $3.7K | $3.7K | $3.7K | $3.7K | $2.7K | $52.2K | |
| Paid-in Capital | $390M | $390M | $357M | $353M | $352M | $351M | $351M | $351M | $351M | $350M | $336M | $336M | $335M | $335M | $330M | $328M | |
| Retained Earnings | $-341M | $-337M | $-334M | $-331M | $-328M | $-325M | $-321M | $-318M | $-314M | $-311M | $-308M | $-305M | $-301M | $-298M | $-294M | $-291M | |
| AOCI | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-10M | |
| Stockholders' Equity | $38M | $42M | $12M | $11M | $13M | $16M | $19M | $22M | $26M | $29M | $17M | $20M | $23M | $26M | $26M | $27M | |
| Liabilities + Equity | $42M | $48M | $16M | $14M | $17M | $20M | $24M | $27M | $30M | $33M | $23M | $26M | $29M | $32M | $30M | $34M | |
| Shares Outstanding | 12,391,136 | 11,982,776 | 8,192,538 | 5,979,292 | 5,752,175 | 5,512,656 | 5,481,055 | 5,434,903 | 5,430,215 | 5,430,215 | 3,736,673 | 3,736,673 | 3,731,571 | 3,731,571 | 2,655,269 | 52,237,885 |
Cash Flow
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $5.7K | $5.4K | $5.4K | $5.4K | $5.4K | $5.4K | $5.4K | $5.4K | $5.3K | $6.2K | $5.0K | $1.4K | $224 | $410 | $-2.4K | $122 | |
| Other Non-cash | · | $525.8K | · | · | · | $296.1K | · | · | · | $-1M | · | · | · | $1M | · | · | |
| Operating Cash Flow | $-3M | $-3M | $-3M | $-3M | $-3M | $-4M | $-4M | $-2M | $-4M | $-4M | $-4M | $-2M | $-3M | $-3M | $-4M | $-7M | |
| CapEx | · | · | · | · | · | · | $0 | $0 | $7.5K | $8.0K | $7.2K | · | · | · | · | · | |
| Investing Cash Flow | · | · | · | · | · | · | $0 | $0 | $-7.5K | $-8.0K | $-7.2K | · | · | · | · | · | |
| Stock Issued | $500.1K | $35M | $4M | $375.4K | $399.8K | $59.2K | $140.8K | $0 | $0 | $16M | $0 | $0 | $0 | $6M | $98.5K | · | |
| Net Stock Activity | · | $35M | · | · | · | $59.2K | · | · | · | $16M | · | · | · | $6M | · | · | |
| Financing Cash Flow | $-2M | $35M | $4M | $357.9K | $384.9K | $55.8K | $134.4K | $-1.2K | $-21.1K | $15M | $0 | $0 | $0 | $5M | $98.5K | · | |
| Free Cash Flow | · | · | · | · | · | · | · | · | · | $-4M | · | · | · | · | · | · |
Profitability
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -12.0% | -9.7% | · | -14.4% | -13.7% | -14.7% | · | -14.4% | -11.8% | -8.6% | · | -10.8% | -9.4% | -10.6% | · | -8.4% | |
| ROE | -13.8% | -11.5% | · | -18.1% | -16.6% | -17.7% | · | -17.9% | -14.2% | -10.1% | · | -13.7% | 52.7% | -12.5% | · | -10.1% |
Liquidity & Solvency
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 13.6 | 8.9 | · | 5.2 | 5.3 | 5.9 | · | 7.3 | 9.6 | 11.2 | · | 6.2 | 7.2 | 7.6 | · | 8.4 | |
| Quick Ratio | 13.3 | 8.8 | · | 5.1 | 5.2 | 5.7 | · | 7.2 | 9.3 | 10.9 | · | 6.1 | 7.0 | 7.3 | · | 8.3 |
Per Share
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Book Value / Share | $3.10 | $3.47 | · | $1.83 | $2.33 | $2.82 | · | $4.04 | $4.71 | $5.33 | · | $5.43 | $6.28 | $7.10 | · | $0.51 | |
| Cash Flow / Share | · | $-0.19 | · | · | · | $-0.61 | · | · | · | $-0.94 | · | · | · | $-0.91 | · | · | |
| Cash / Share | $3.33 | $3.88 | · | $2.29 | $2.87 | $3.50 | · | $4.83 | $5.28 | $5.96 | · | $6.79 | $7.42 | $8.31 | · | $0.63 | |
| EPS (TTM) | $-1.03 | $-1.49 | · | $-2.12 | $-2.29 | $-2.34 | · | $-2.77 | $-2.99 | $-3.28 | · | $25.23 | $23.77 | $-62.08 | · | $-129.78 |
Valuation (TTM)
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-12M | $-12M | · | $-13M | $-14M | $-14M | · | $-14M | $-13M | $-13M | · | $-13M | $-14M | $-109M | · | $-118M | |
| Market Cap | $10M | $9M | · | $9M | $10M | $11M | · | $15M | $22M | $36M | · | $16M | $12M | $17M | · | $679M | |
| P/E | -0.8 | -0.5 | · | -0.7 | -0.7 | -0.9 | · | -1.0 | -1.4 | -2.0 | · | 0.2 | 0.1 | -0.1 | · | -0.1 | |
| P/B | 0.3 | 0.2 | · | 0.8 | 0.7 | 0.7 | · | 0.7 | 0.9 | 1.3 | · | 0.8 | 0.5 | 0.6 | · | 25.5 | |
| P / Tangible Book | 0.3 | 0.2 | · | 0.8 | 0.7 | 0.7 | · | 0.7 | 0.9 | 1.3 | · | 0.8 | 0.5 | 0.6 | · | 25.5 | |
| P / Cash Flow | · | -3.3 | · | · | · | -3.1 | · | · | · | -9.2 | · | · | · | -5.6 | · | · | |
| Earnings Yield | -128.4% | -195.3% | · | -143.7% | -135.5% | -114.7% | · | -100.7% | -73.5% | -49.0% | · | 605.5% | 754.6% | -1398.2% | · | -998.3% |
Most recent period on the left · null values shown as ·
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Net Income | $-13M | $-13M | $-14M | $-113M | $-37M |
| Diluted EPS | $-1.93 | $-2.35 | $-3.95 | $-67.99 | $-34.88 |
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Current Ratio | 5.6 | 7.0 | 5.1 | · | · |
| Quick Ratio | 5.3 | 6.8 | 4.9 | · | · |
| Metric | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Free Cash Flow | · | $-14M | $-12M | · | · |
Institutional owners (13F) 28 filers · $2.0M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Holders
28
Value held
$2.0M
New positions
7
Exited positions
2
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 7 (0 vs prior Q) | 2 (-3 vs prior Q) | 5 (+1 vs prior Q) | 5 (0 vs prior Q) | +126K |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| AIGH Capital Management LLC | $814,768 | 1,015,541 | 41.75% | Shares |
| Vestal Point Capital, LP | $280,805 | 350,000 | 14.39% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $216,621 | 270,000 | 11.10% | Shares |
| Nantahala Capital Management, LLC | $165,081 | 205,760 | 8.46% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $84,883 | 105,800 | 4.35% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $60,072 | 74,869 | 3.08% | Shares |
| VANGUARD GROUP INC | $49,548 | 58,086 | 2.54% | Shares |
| CITADEL ADVISORS LLC | $47,015 | 58,600 | 2.41% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $36,273 | 45,211 | 1.86% | Shares |
| DIADEMA PARTNERS LP | $36,029 | 44,907 | 1.85% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $30,848 | 38,464 | 1.58% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $28,032 | 34,939 | 1.44% | Shares |
| MORGAN STANLEY | $20,723 | 25,830 | 1.06% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $18,351 | 22,882 | 0.94% | Shares |
| LPL Financial LLC | $12,879 | 16,052 | 0.66% | Shares |
| HighTower Advisors, LLC | $11,123 | 13,864 | 0.57% | Shares |
| NORTHERN TRUST CORP | $10,996 | 13,705 | 0.56% | Shares |
| Persistent Asset Partners Ltd | $9,218 | 11,490 | 0.47% | Shares |
| XTX Topco Ltd | $8,476 | 10,565 | 0.43% | Shares |
| BlackRock, Inc. | $5,755 | 7,173 | 0.29% | Shares |
| Tower Research Capital LLC (TRC) | $2,880 | 3,590 | 0.15% | Shares |
| GROUP ONE TRADING LLC | $463 | 577 | 0.02% | Shares |
| BARCLAYS PLC | $379 | 473 | 0.02% | Shares |
| OSAIC HOLDINGS, INC. | $236 | 295 | 0.01% | Shares |
| WealthCollab, LLC | $127 | 158 | 0.01% | Shares |
| FMR LLC | $36 | 45 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $13 | 16 | 0.00% | Shares |
| UBS Group AG | $2 | 3 | 0.00% | Shares |
Activists & 5%+ owners 2 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| HealthCap VII, L.P., HealthCap VII GP S.A. ×4 filings | Nov. 15, 2022 | · | Initial filing | · | SEC |
| 5AM Ventures IV, L.P., 5AM Co-Investors IV, L.P., 5AM Partners IV, LLC, 5AM Opportunities I, L.P., 5AM Opportunities I (GP), LLC, Dr. John D. Diekman, Andrew J. Schwab, Dr. Scott M. Rocklage ×6 filings | Feb. 16, 2021 | · | Initial filing | · | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Company insiders 23 insiders · 8 officers · 17 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Oren Gilad | President/CEO | March 12, 2026 A | 393,895 | 2 | 0 | $49,901 |
| John P. Hamill | SrVP/CFO/Prin Fin & Acct Ofcr | March 31, 2026 P | 43,528 | 3 | 0 | $35,965 |
| Scott M Coiante | SVP, Chief Financial Officer | July 28, 2022 A | 145,065 | 0 | 0 | $0 |
| Gregory Alan Korbel | SVP, Chief Operating Officer | July 28, 2022 A | 45,762 | 0 | 0 | $0 |
| Nadeem Q. Mirza | Chief Medical Officer | May 1, 2024 A | 6,730 | 0 | 0 | $0 |
| Eyal C. Attar | SVP, Chief Medical Officer | June 3, 2022 F | 57,233 | 0 | 0 | $0 |
| Lars B. Abrahmsen | SVP, Chief Scientific Officer | March 10, 2022 A | 43,700 | 0 | 0 | $0 |
| Gregory S. Wessels | SVP, Chief Commercial Officer | Feb. 25, 2021 A | 16,000 | 0 | 0 | $0 |
| Rifat Pamukcu | Director | June 16, 2026 A | 8,581 | 0 | 0 | $0 |
| Marc Duey | Director | June 16, 2026 A | 259,290 | 1 | 0 | $24,892 |
| Gabriela Gruia | Director | June 16, 2026 A | 4,180 | 0 | 0 | $0 |
| Bernd R. Seizinger | Director | June 16, 2026 A | 48,910 | 0 | 0 | $0 |
| Michael Grissinger | Director | June 16, 2026 A | 6,024 | 0 | 0 | $0 |
| Richard Peters | Director | June 16, 2026 A | 6,254 | 1 | 0 | $100,371 |
| Jean-Pierre Bizzari | Director | June 16, 2026 A | 4,180 | 0 | 0 | $0 |
| John B Henneman III | Director | June 16, 2026 A | 13,364 | 0 | 0 | $0 |
| Christian S Schade | Director | July 28, 2022 A | 259,246 | 0 | 0 | $0 |
| Fouad Namouni | Director | June 30, 2021 A | 4,610 | 0 | 0 | $0 |
| Michael Aaron Kelly | Director | June 30, 2021 A | 4,610 | 0 | 0 | $0 |
| Jonathan Hepple | Director | June 30, 2020 A | · | 0 | 0 | $0 |
| Johan Christenson | Director | June 30, 2020 A | 2,366,104 | 0 | 0 | $0 |
| Scott M. Rocklage | Director | June 30, 2020 A | 75,965 | 0 | 0 | $0 |
| Guido Magni | Director | Oct. 7, 2019 P | 6,500 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
ETF ownership Held by 1 ETF
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| VXF · VANGUARD INDEX FUNDS | 0.00% | 22,882 SH | Aug. 19, 2026 | Daily |
APRE Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
rating · 10 analysts
BUY
Median target
$5.00
+619.4%
4 40.0%
Strong Buy
5 50.0%
Buy
1 10.0%
Hold
0 0.0%
Sell
0 0.0%
Strong Sell
12-Month Price Target
3 analysts · 2026-09-29Mean target $3.73 +437.2%
← Below all targets
Current price $0.69
Low$1.20
Mean$3.73
High$5.00
Peer comparison (GICS sub-industry) Key metrics vs sector peers
FY basis, prices as of each company's last fiscal year-end close.
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Source: SEC 10-Q filed Aug 12, 2026