APRE Aprea Therapeutics, Inc. - Common Stock
$0.68
Price · Aug 18, 2026
Fundamentals as of Aug 12, 2026
52W Range
$1–$2
11% of range
Analyst Rating
BUY
10 analysts
Price Target
$4
+424% upside
P/E (TTM)
-0.4
ROE
-97.5%
Net Profit Margin
—
APRE Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$0.68
Market Cap
$6M
P/E (TTM)
-0.4
EPS (TTM)
$-1.93
Revenue (TTM)
—
Div Yield
—
ROE
-97.5%
Debt/Equity
—
52W Range
$1 – $2
APRE Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-1.93
2019-12-31
→
2025-12-31
Free Cash Flow
—
2019-12-31
→
2024-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
APRE
Peer Median
P/E (TTM)
-0.4
—
P/B
0.4
1.3
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
APRE
Peer Median
ROA
-63.1%
-82.1%
ROE
-97.5%
-92.1%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
APRE
Peer Median
Current Ratio
5.6
2.6
Quick Ratio
5.3
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
APRE
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
APRE
Peer Median
APRE Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
10 analysts
- Strong Buy 4 40.0%
- Buy 5 50.0%
- Hold 1 10.0%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
4 analysts · 2026-08-18
Median
$4.00
Mean
$3.55
← Below all targets
$0.68
Low
$1.20
High
$5.00
Median target
$4.00
+490.0%
Mean target
$3.55
+423.6%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.09%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| March 31, 2026 | $-0.22 | $-0.23 | 0.01% |
| Dec. 31, 2025 | $-0.32 | $-0.40 | 0.08% |
| Sept. 30, 2025 | $-0.47 | $-0.35 | -0.12% |
| June 30, 2025 | $-0.53 | $-0.76 | 0.23% |
| Dec. 31, 2024 | $-0.49 | $-0.70 | 0.21% |
| Sept. 30, 2024 | $-0.64 | $-0.76 | 0.12% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| APRE | $7M | -0.4 | — | — | -97.5% | — |
| VTGN | — | -0.3 | 161.1% | -5491.3% | -136.8% | — |
| IMNN | $13M | -0.6 | — | — | -298.2% | — |
| LIMN | — | — | — | — | — | — |
| SNGX | $14M | -0.6 | -85.8% | — | -311.2% | — |
| CELZ | — | -0.8 | -45.5% | — | — | — |
| AKTX | $26.17B | — | — | — | -64.1% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 12
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | · | · | · | · | $24M | $38M | $21M | $14M | |
| SG&A Expense | $6M | $6M | $8M | $21M | $14M | $15M | $9M | $2M | |
| Operating Expenses | $14M | $16M | $16M | $113M | $37M | $53M | $30M | $16M | |
| Operating Income | $-13M | $-14M | $-15M | $-113M | $-37M | · | · | · | |
| Other Non-op | $634.3K | $1M | $1M | $730.2K | $319.1K | $-667.6K | $1M | $961.1K | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-13M | $-13M | $-14M | $-113M | $-37M | $-53M | $-28M | $-16M | |
| EPS (Basic) | $-1.93 | $-2.35 | $-3.95 | $-67.99 | $-34.88 | $-50.61 | $-4.67 | · | |
| EPS (Diluted) | $-1.93 | $-2.35 | $-3.95 | $-67.99 | $-34.88 | $-50.61 | $-4.67 | · | |
| Shares (Basic) | 6,538,722 | 5,509,921 | 3,617,607 | 1,657,055 | 1,064,325 | 1,056,681 | 6,002,486 | · | |
| Shares (Diluted) | 6,538,722 | 5,509,921 | 3,617,607 | 1,657,055 | 1,064,325 | 1,056,681 | 6,002,486 | · | |
| EBITDA | $-13M | $-14M | $-15M | · | · | $28.8K | $11.1K | · |
Balance Sheet 19
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $15M | $23M | $22M | $29M | $53M | $89M | $130M | $66M | |
| Prepaid Expense | $961.9K | $726.3K | $914.3K | $1M | $4M | $3M | $3M | $322.1K | |
| Current Assets | $16M | $24M | $23M | $30M | $57M | $92M | $133M | $66M | |
| PP&E (Net) | $59.8K | $81.5K | $88.4K | $2.3K | $23.9K | $38.5K | $41.6K | $24.4K | |
| PP&E (Gross) | $154.0K | $154.0K | $138.5K | $45.4K | $140.9K | $152.8K | $127.1K | $98.8K | |
| Accum. Depreciation | $94.2K | $72.4K | $50.1K | $43.1K | $117.0K | $114.3K | $85.4K | $74.3K | |
| Other Non-current Assets | $271.2K | $281.7K | · | · | $29.4K | $29.4K | $107 | $111 | |
| Total Assets | $16M | $24M | $23M | $30M | $57M | $93M | $134M | $66M | |
| Accounts Payable | $713.7K | $1M | $2M | $842.8K | $2M | $5M | $2M | $2M | |
| Current Liabilities | $3M | $3M | $4M | $3M | $7M | $15M | $9M | $5M | |
| Capital Leases | · | · | · | · | · | $78.8K | $302.6K | · | |
| Total Liabilities | · | · | · | $3M | $7M | $15M | $9M | $5M | |
| Common Stock | $8.2K | $5.5K | $3.7K | $2.7K | $1.1K | $21.2K | $21.0K | $127.1K | |
| Paid-in Capital | $357M | $351M | $336M | $330M | $241M | $231M | $226M | $20M | |
| Retained Earnings | $-334M | $-321M | $-308M | $-294M | $-181M | $-144M | $-91M | $-62M | |
| AOCI | $-11M | $-11M | $-11M | $-11M | $-10M | $-10M | $-12M | $-9M | |
| Stockholders' Equity | $12M | $19M | $17M | $26M | $50M | $77M | $124M | $-51M | |
| Liabilities + Equity | $16M | $24M | $23M | $30M | $57M | $93M | $134M | $66M | |
| Shares Outstanding | 8,192,538 | 5,481,055 | 3,736,673 | 2,655,269 | 1,092,967 | 21,186,827 | 21,022,752 | 1,155,366 |
Cash Flow 9
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| D&A | $21.7K | $22.3K | $7.1K | $4.4K | $12.8K | $28.8K | $11.1K | $8.3K | |
| Other Non-cash | $-316.6K | $-620.3K | $2M | · | · | $12M | $1M | · | |
| Operating Cash Flow | $-13M | $-14M | $-12M | $-25M | $-38M | $-42M | $-27M | $-15M | |
| CapEx | · | $15.5K | $93.1K | · | · | $25.7K | $30.9K | $3.7K | |
| Investing Cash Flow | · | $-15.5K | $-93.1K | · | · | $-25.7K | $-30.9K | $-3.7K | |
| Stock Issued | $5M | $16M | $6M | $683.0K | $2M | · | · | · | |
| Net Stock Activity | $5M | $16M | $6M | · | · | · | · | · | |
| Financing Cash Flow | $5M | $15M | $5M | $683.0K | $2M | $150.9K | $93M | $56M | |
| Free Cash Flow | · | $-14M | $-12M | · | · | $-42M | $-27M | · |
Profitability 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| ROA | -63.1% | -55.6% | -54.1% | · | · | -47.2% | -28.1% | · | |
| ROE | -97.5% | -62.8% | -76.7% | · | · | -64.3% | -105.0% | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.6 | 7.0 | 5.1 | · | · | 6.0 | 14.7 | · | |
| Quick Ratio | 5.3 | 6.8 | 4.9 | · | · | 5.8 | 14.4 | · |
Valuation (TTM) 8
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 |
|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-13M | $-13M | $-14M | $-113M | $-37M | $-53M | $-28M | · | |
| Market Cap | $7M | $18M | $18M | · | · | $2.08B | $19.29B | · | |
| P/E | -0.4 | -1.4 | -1.2 | -0.1 | -1.6 | -1.9 | -196.5 | · | |
| P/B | 0.6 | 0.9 | 1.0 | · | · | 26.9 | 155.3 | · | |
| P / Tangible Book | 0.6 | 0.9 | 1.0 | 0.7 | 25.3 | 26.9 | · | · | |
| P / Cash Flow | -0.5 | -1.3 | -1.4 | · | · | -49.9 | -722.4 | · | |
| P / FCF | · | -1.3 | -1.4 | · | · | -49.8 | -721.6 | · | |
| Earnings Yield | -226.3% | -71.4% | -84.0% | -1027.0% | -60.8% | -51.4% | -0.51% | · |
Income Statement 11
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SG&A Expense | $2M | $2M | $2M | $1M | $2M | $2M | $1M | $2M | $2M | $2M | $2M | $2M | $2M | $3M | $-2M | $3M | |
| Operating Expenses | $4M | $3M | $3M | $3M | $4M | $4M | $3M | $4M | $4M | $4M | $4M | $4M | $4M | $5M | $3M | $4M | |
| Operating Income | $-4M | $-3M | $-3M | $-3M | $-3M | $-4M | $-3M | $-4M | $-4M | $-3M | $-4M | $-4M | $-4M | $-5M | $-3M | $-4M | |
| Other Non-op | $440.9K | $142.5K | $187.5K | $145.0K | $148.9K | $152.9K | $331.2K | $313.2K | $376.9K | $339.6K | $231.7K | $318.3K | $392.6K | $242.6K | $209.5K | $175.5K | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-4M | $-3M | $-2M | $-3M | $-3M | $-4M | $-3M | $-4M | $-3M | $-3M | $-3M | $-3M | $-3M | $-4M | $-2M | $-4M | |
| EPS (Basic) | $-0.07 | $-0.22 | $-0.27 | $-0.47 | $-0.53 | $-0.66 | $-0.46 | $-0.64 | $-0.58 | $-0.67 | $-0.88 | $-0.86 | $-0.87 | $-1.34 | $28.30 | $-2.32 | |
| EPS (Diluted) | $-0.07 | $-0.22 | $-0.27 | $-0.47 | $-0.53 | $-0.66 | $-0.46 | $-0.64 | $-0.58 | $-0.67 | $-0.88 | $-0.86 | $-0.87 | $-1.34 | $28.30 | $-2.32 | |
| Shares (Basic) | 53,483,504 | 14,685,448 | -11,911,411 | 6,372,938 | 6,083,329 | 5,993,866 | -10,565,451 | 5,939,755 | 5,937,291 | 4,198,326 | -7,109,624 | 3,735,176 | 3,731,571 | 3,260,484 | -2,303,896 | 1,732,783 | |
| Shares (Diluted) | 53,483,504 | 14,685,448 | -11,911,411 | 6,372,938 | 6,083,329 | 5,993,866 | -10,565,451 | 5,939,755 | 5,937,291 | 4,198,326 | -7,109,624 | 3,735,176 | 3,731,571 | 3,260,484 | -2,303,896 | 1,732,783 | |
| EBITDA | $-4M | $-3M | · | $-3M | $-3M | $-4M | · | $-4M | $-4M | $-3M | · | $-4M | $-4M | $410 | · | · |
Balance Sheet 18
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $41M | $46M | $15M | $14M | $17M | $19M | $23M | $26M | $29M | $32M | $22M | $25M | $28M | $31M | $29M | $33M | |
| Prepaid Expense | $679.7K | $779.2K | $961.9K | $225.9K | $395.0K | $558.7K | $726.3K | $234.2K | $865.1K | $698.9K | $914.3K | $286.3K | $953.7K | $1M | $1M | $361.2K | |
| Current Assets | $42M | $47M | $16M | $14M | $17M | $20M | $24M | $26M | $30M | $33M | $23M | $26M | $29M | $32M | $30M | $33M | |
| PP&E (Net) | $64.0K | $54.4K | $59.8K | $65.2K | $70.7K | $76.1K | $81.5K | $87.0K | $92.4K | $90.2K | $88.4K | $86.2K | $1.7K | $1.9K | $2.3K | $12.2K | |
| PP&E (Gross) | · | · | $154.0K | · | · | · | $154.0K | · | · | · | $138.5K | · | · | · | $45.4K | · | |
| Accum. Depreciation | · | · | $94.2K | · | · | · | $72.4K | · | · | · | $50.1K | · | · | · | $43.1K | · | |
| Other Non-current Assets | $271.2K | $271.2K | $271.2K | $271.2K | $271.2K | $271.2K | $281.7K | $281.7K | $271.2K | · | · | · | · | · | · | $29.4K | |
| Total Assets | $42M | $48M | $16M | $14M | $17M | $20M | $24M | $27M | $30M | $33M | $23M | $26M | $29M | $32M | $30M | $34M | |
| Accounts Payable | $935.1K | $3M | $713.7K | $641.3K | $1M | $1M | $1M | $1M | $964.3K | $1M | $2M | $862.6K | $1M | $826.0K | $842.8K | $1M | |
| Current Liabilities | $3M | $5M | $3M | $3M | $3M | $3M | $3M | $4M | $3M | $3M | $4M | $4M | $4M | $4M | $3M | $4M | |
| Total Liabilities | · | · | · | · | · | · | · | · | · | · | · | · | $4M | $4M | · | $4M | |
| Common Stock | $12.4K | $12.0K | $8.2K | $6.0K | $5.8K | $5.5K | $5.5K | $5.4K | $5.4K | $5.4K | $3.7K | $3.7K | $3.7K | $3.7K | $2.7K | $52.2K | |
| Paid-in Capital | $390M | $390M | $357M | $353M | $352M | $351M | $351M | $351M | $351M | $350M | $336M | $336M | $335M | $335M | $330M | $328M | |
| Retained Earnings | $-341M | $-337M | $-334M | $-331M | $-328M | $-325M | $-321M | $-318M | $-314M | $-311M | $-308M | $-305M | $-301M | $-298M | $-294M | $-291M | |
| AOCI | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-11M | $-10M | |
| Stockholders' Equity | $38M | $42M | $12M | $11M | $13M | $16M | $19M | $22M | $26M | $29M | $17M | $20M | $23M | $26M | $26M | $27M | |
| Liabilities + Equity | $42M | $48M | $16M | $14M | $17M | $20M | $24M | $27M | $30M | $33M | $23M | $26M | $29M | $32M | $30M | $34M | |
| Shares Outstanding | 12,391,136 | 11,982,776 | 8,192,538 | 5,979,292 | 5,752,175 | 5,512,656 | 5,481,055 | 5,434,903 | 5,430,215 | 5,430,215 | 3,736,673 | 3,736,673 | 3,731,571 | 3,731,571 | 2,655,269 | 52,237,885 |
Cash Flow 9
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $5.7K | $5.4K | $5.4K | $5.4K | $5.4K | $5.4K | $5.4K | $5.4K | $5.3K | $6.2K | $5.0K | $1.4K | $224 | $410 | $-2.4K | $122 | |
| Other Non-cash | · | $525.8K | · | · | · | $296.1K | · | · | · | $-1M | · | · | · | $1M | · | · | |
| Operating Cash Flow | $-3M | $-3M | $-3M | $-3M | $-3M | $-4M | $-4M | $-2M | $-4M | $-4M | $-4M | $-2M | $-3M | $-3M | $-4M | $-7M | |
| CapEx | · | · | · | · | · | · | $0 | $0 | $7.5K | $8.0K | $7.2K | · | · | · | · | · | |
| Investing Cash Flow | · | · | · | · | · | · | $0 | $0 | $-7.5K | $-8.0K | $-7.2K | · | · | · | · | · | |
| Stock Issued | $500.1K | $35M | $4M | $375.4K | $399.8K | $59.2K | $140.8K | $0 | $0 | $16M | $0 | $0 | $0 | $6M | $98.5K | · | |
| Net Stock Activity | · | $35M | · | · | · | $59.2K | · | · | · | $16M | · | · | · | $6M | · | · | |
| Financing Cash Flow | $-2M | $35M | $4M | $357.9K | $384.9K | $55.8K | $134.4K | $-1.2K | $-21.1K | $15M | $0 | $0 | $0 | $5M | $98.5K | · | |
| Free Cash Flow | · | · | · | · | · | · | · | · | · | $-4M | · | · | · | · | · | · |
Profitability 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -12.0% | -9.7% | · | -14.4% | -13.7% | -14.7% | · | -14.4% | -11.8% | -8.6% | · | -10.8% | -9.4% | -10.6% | · | -8.4% | |
| ROE | -13.8% | -11.5% | · | -18.1% | -16.6% | -17.7% | · | -17.9% | -14.2% | -10.1% | · | -13.7% | 52.7% | -12.5% | · | -10.1% |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 13.6 | 8.9 | · | 5.2 | 5.3 | 5.9 | · | 7.3 | 9.6 | 11.2 | · | 6.2 | 7.2 | 7.6 | · | 8.4 | |
| Quick Ratio | 13.3 | 8.8 | · | 5.1 | 5.2 | 5.7 | · | 7.2 | 9.3 | 10.9 | · | 6.1 | 7.0 | 7.3 | · | 8.3 |
Valuation (TTM) 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-13M | $-13M | · | $-14M | $-14M | $-14M | · | $-13M | $-13M | $-14M | · | $-15M | $-110M | $-115M | · | $-120M | |
| Market Cap | $10M | $9M | · | $9M | $10M | $11M | · | $15M | $22M | $36M | · | $16M | $12M | $17M | · | $679M | |
| P/E | -0.6 | -0.4 | · | -0.6 | -0.7 | -0.8 | · | -1.0 | -1.4 | -1.8 | · | -0.8 | -0.0 | -0.0 | · | -0.1 | |
| P/B | 0.3 | 0.2 | · | 0.8 | 0.7 | 0.7 | · | 0.7 | 0.9 | 1.3 | · | 0.8 | 0.5 | 0.6 | · | 25.5 | |
| P / Tangible Book | 0.3 | 0.2 | · | 0.8 | 0.7 | 0.7 | · | 0.7 | 0.9 | 1.3 | · | 0.8 | 0.5 | 0.6 | · | 25.5 | |
| P / Cash Flow | · | -3.3 | · | · | · | -3.1 | · | · | · | -9.2 | · | · | · | -5.6 | · | · | |
| P / FCF | · | · | · | · | · | · | · | · | · | -9.2 | · | · | · | · | · | · | |
| Earnings Yield | -160.8% | -246.4% | · | -155.9% | -142.6% | -125.0% | · | -100.0% | -73.2% | -55.9% | · | -129.4% | -2896.8% | -2198.9% | · | -744.1% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Net Income | $-13M | $-13M | $-14M | $-113M | $-37M |
| Diluted EPS | $-1.93 | $-2.35 | $-3.95 | $-67.99 | $-34.88 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Current Ratio | 5.6 | 7.0 | 5.1 | — | — |
| Quick Ratio | 5.3 | 6.8 | 4.9 | — | — |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | — | $-14M | $-12M | — | — |
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Institutional owners (13F) 29 filers · $1.2M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 10 (+5 vs prior Q) | 2 (-3 vs prior Q) | 3 (-1 vs prior Q) | 4 (+1 vs prior Q) | +185K |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Vestal Point Capital, LP | $280,805 | 350,000 | 23.94% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $216,621 | 270,000 | 18.47% | Shares |
| Nantahala Capital Management, LLC | $165,081 | 205,760 | 14.08% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $84,883 | 105,800 | 7.24% | Shares |
| AIGH Capital Management LLC | $80,468 | 100,297 | 6.86% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $58,579 | 73,007 | 4.99% | Shares |
| CITADEL ADVISORS LLC | $47,015 | 58,600 | 4.01% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $36,273 | 45,211 | 3.09% | Shares |
| DIADEMA PARTNERS LP | $36,029 | 44,907 | 3.07% | Shares |
| VANGUARD GROUP INC | $32,810 | 38,464 | 2.80% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $30,848 | 38,464 | 2.63% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $28,032 | 34,939 | 2.39% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $18,351 | 22,882 | 1.56% | Shares |
| LPL Financial LLC | $12,879 | 16,052 | 1.10% | Shares |
| HighTower Advisors, LLC | $11,123 | 13,864 | 0.95% | Shares |
| NORTHERN TRUST CORP | $10,996 | 13,705 | 0.94% | Shares |
| Persistent Asset Partners Ltd | $9,218 | 11,490 | 0.79% | Shares |
| XTX Topco Ltd | $8,476 | 10,565 | 0.72% | Shares |
| Tower Research Capital LLC (TRC) | $2,880 | 3,590 | 0.25% | Shares |
| GROUP ONE TRADING LLC | $463 | 577 | 0.04% | Shares |
| BARCLAYS PLC | $379 | 473 | 0.03% | Shares |
| OSAIC HOLDINGS, INC. | $236 | 295 | 0.02% | Shares |
| WealthCollab, LLC | $127 | 158 | 0.01% | Shares |
| MORGAN STANLEY | $64 | 80 | 0.01% | Shares |
| BlackRock, Inc. | $57 | 71 | 0.00% | Shares |
| Integrated Wealth Concepts LLC | $36 | 46 | 0.00% | Shares |
| FMR LLC | $36 | 45 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $13 | 16 | 0.00% | Shares |
| UBS Group AG | $2 | 3 | 0.00% | Shares |
Company insiders 23 insiders · 8 officers · 17 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Oren Gilad | President/CEO | March 12, 2026 A | 393,895 | 2 | 0 | $49,901 |
| John P. Hamill | SrVP/CFO/Prin Fin & Acct Ofcr | March 31, 2026 P | 43,528 | 3 | 0 | $35,965 |
| Scott M Coiante | SVP, Chief Financial Officer | July 28, 2022 A | 145,065 | 0 | 0 | $0 |
| Gregory Alan Korbel | SVP, Chief Operating Officer | July 28, 2022 A | 45,762 | 0 | 0 | $0 |
| Nadeem Q. Mirza | Chief Medical Officer | May 1, 2024 A | 6,730 | 0 | 0 | $0 |
| Eyal C. Attar | SVP, Chief Medical Officer | June 3, 2022 F | 57,233 | 0 | 0 | $0 |
| Lars B. Abrahmsen | SVP, Chief Scientific Officer | March 10, 2022 A | 43,700 | 0 | 0 | $0 |
| Gregory S. Wessels | SVP, Chief Commercial Officer | Feb. 25, 2021 A | 16,000 | 0 | 0 | $0 |
| Rifat Pamukcu | Director | June 16, 2026 A | 8,581 | 0 | 0 | $0 |
| Marc Duey | Director | June 16, 2026 A | 259,290 | 1 | 0 | $24,892 |
| Gabriela Gruia | Director | June 16, 2026 A | 4,180 | 0 | 0 | $0 |
| Bernd R. Seizinger | Director | June 16, 2026 A | 48,910 | 0 | 0 | $0 |
| Michael Grissinger | Director | June 16, 2026 A | 6,024 | 0 | 0 | $0 |
| Richard Peters | Director | June 16, 2026 A | 6,254 | 1 | 0 | $100,371 |
| Jean-Pierre Bizzari | Director | June 16, 2026 A | 4,180 | 0 | 0 | $0 |
| John B Henneman III | Director | June 16, 2026 A | 13,364 | 0 | 0 | $0 |
| Christian S Schade | Director | July 28, 2022 A | 259,246 | 0 | 0 | $0 |
| Michael Aaron Kelly | Director | Sept. 28, 2020 A | — | 0 | 0 | $0 |
| Jonathan Hepple | Director | June 30, 2020 A | — | 0 | 0 | $0 |
| Johan Christenson | Director | June 30, 2020 A | 2,366,104 | 0 | 0 | $0 |
| Scott M. Rocklage | Director | June 30, 2020 A | 75,965 | 0 | 0 | $0 |
| Fouad Namouni | Director | June 26, 2020 A | — | 0 | 0 | $0 |
| Guido Magni | Director | Oct. 7, 2019 P | 6,500 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 2 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| HealthCap VII, L.P., HealthCap VII GP S.A. ×4 filings | Nov. 15, 2022 | — | Initial filing | — | SEC |
| 5AM Ventures IV, L.P., 5AM Co-Investors IV, L.P., 5AM Partners IV, LLC, 5AM Opportunities I, L.P., 5AM Opportunities I (GP), LLC, Dr. John D. Diekman, Andrew J. Schwab, Dr. Scott M. Rocklage ×6 filings | Feb. 16, 2021 | — | Initial filing | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 1 ETF
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| VXF · VANGUARD INDEX FUNDS | 0.00% | 22,882 SH | Aug. 8, 2026 | Daily |