GLSI Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $16.98
Market Cap (MRQ) $249M
P/E -11.9
EPS $-1.43
ROE -2159.7%
52W Range $8–$33

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10-Year Performance Revenue, net income, margins and EPS trends

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EPS$-1.43
2022-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend GLSI 5Y avg Peer Median Verdict
P/E -11.95Y avg ≈-16.0 ≈-16.0 · ·
P/B (MRQ) 80.05Y avg ≈235.9 ≈235.9 1.4 Overvalued
Price / Cash Flow -24.55Y avg ≈-25.7 ≈-25.7 · ·
Price / Tangible Book 687.45Y avg ≈191.1 ≈191.1 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

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Avg Surprise -40.4%
Next Report Nov 12, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 12, 2026 $-0.27 $-0.34 19.8%
March 31, 2026 Jun 4, 2026 $-0.39 $-0.34 -15.9%
Dec. 31, 2025 Jun 1, 2026 $-0.58 $-0.33 -77.7%
Sept. 30, 2025 $-0.30 $-0.30 0.30%
June 30, 2025 $-0.30 $-0.24 -22.5%
March 31, 2025 $-0.25 $-0.24 -2.1%
Dec. 31, 2024 $-0.61 $-0.21 -184.8%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

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Income Statement 11
Metric Trend 2025202420232022202120202019
R&D Expense $17M$15M$8M$6M$4M$1M$3M
SG&A Expense $2M$2M$2M$2M$1M$806.2K$818.9K
Operating Expenses $19M$18M$9M$8M$5M$2M$3M
Operating Income $-19M$-18M$-9M$-8M$-5M$-2M$-3M
Interest Income $89.7K$223.0K$436.1K$215.0K$27.4K$832·
Net Income $-19M$-17M$-9M$-8M$-5M$-2M$-3M
EPS (Basic) $-1.43$-1.34$-0.69$-0.61$-0.35··
EPS (Diluted) $-1.43$-1.34$-0.69$-0.61···
Shares (Basic) 13,534,99413,014,58512,848,165····
Shares (Diluted) 13,534,99413,014,58512,848,16512,913,848···
EBITDA $-19M$-16M$-9M$-8M·$-2M·
Balance Sheet 13
Metric Trend 2025202420232022202120202019
Cash & Equivalents $6M$4M$7M$13M$27M$29M$6.8K
Current Assets $6M$4M···$29M$6.8K
Intangibles ·$1.8K$5.4K$9.0K$12.6K$16.2K$19.8K
Total Assets $6M$4M$7M$13M$27M$29M$26.7K
Accounts Payable $5M$3M$256.3K$220.8K$220.8K$711.0K$730.3K
Current Liabilities $6M$3M$294.4K$262.9K$385.2K$1M$1M
Total Liabilities $6M$3M$294.4K$262.9K$385.2K$1M$1M
Common Stock $14.3K$13.2K$12.8K$12.8K$13.1K$12.7K$8.5K
Paid-in Capital ·····$57M$26M
Retained Earnings $-87M$-68M$-50M$-41M$-34M$-29M$-27M
Stockholders' Equity $353.2K$908.6K$7M$13M$27M$28M$-1M
Liabilities + Equity $6M$4M$7M$13M$27M$29M$26.7K
Shares Outstanding 14,298,44613,152,72912,848,16512,848,16513,147,82912,703,5418,458,048
Cash Flow 7
Metric Trend 2025202420232022202120202019
Stock-based Comp $7M$7M$2M$2M$660.6K$678.0K$194.9K
Operating Cash Flow $-10M$-7M$-6M$-6M$-4M$-1M$-293.3K
Stock Issued ····$3M$30M·
Stock Repurchased ···$8M···
Net Stock Activity ···$-8M·$30M·
Financing Cash Flow $12M$4M·$-8M$3M$30M$215.0K
Net Change in Cash $2M$-3M$-6M$-14M$-1M$29M$-78.3K
Profitability 2
Metric Trend 2025202420232022202120202019
ROA -376.9%-284.8%-86.9%-38.5%·-13.0%·
ROE -2159.7%-420.1%-114.3%-54.7%·-11.5%·
Liquidity & Solvency 2
Metric Trend 2025202420232022202120202019
Current Ratio 1.1····27.4·
Quick Ratio 1.12.623.751.2·27.4·
Per Share 4
Metric Trend 2025202420232022202120202019
Book Value / Share $0.02$0.19$0.52$1.03·$2.18·
Cash Flow / Share $-0.73$-0.56$-0.50····
Cash / Share $0.43$0.31$0.54$1.05·$2.26·
EPS (TTM) $-1.43$-1.21$-0.69$-0.61···
Valuation (TTM) 7
Metric Trend 2025202420232022202120202019
Net Income TTM $-19M$-16M$-9M$-8M$-5M$-2M·
Market Cap $300M$148M$135M$195M·$463M·
P/E -14.7-9.3-15.2-24.9···
P/B 850.558.320.214.8·16.8·
P / Tangible Book 850.558.320.214.811.916.8·
P / Cash Flow -30.3-20.3-20.9-31.5·-401.8·
Earnings Yield -6.8%-10.8%-6.6%-4.0%···

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

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Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-19M $-17M $-9M $-8M $-5M
Diluted EPS $-1.43 $-1.34 $-0.69 $-0.61 ·

Institutional owners (13F) 60 filers · $45.3M total · As of June 30, 2026

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Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 60
Value held $45.3M
New positions 6
Exited positions 11
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
6 (-18 vs prior Q) 11 (+2 vs prior Q) 24 (+6 vs prior Q) 15 (+3 vs prior Q) -26K

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
BlackRock, Inc. $11,398,136 485,854 25.14% Shares
VANGUARD CAPITAL MANAGEMENT LLC $6,526,337 278,190 14.39% Shares
VANGUARD GROUP INC $6,232,071 296,624 13.74% Shares
GEODE CAPITAL MANAGEMENT, LLC $3,946,578 168,179 8.70% Shares
STATE STREET CORP $3,356,798 143,086 7.40% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $1,896,999 80,861 4.18% Shares
NORTHERN TRUST CORP $1,882,148 80,228 4.15% Shares
Bank of New York Mellon Corp $1,123,733 47,900 2.48% Shares
VANGUARD FIDUCIARY TRUST CO $1,078,339 45,965 2.38% Shares
MORGAN STANLEY $1,019,267 43,447 2.25% Shares
GOLDMAN SACHS GROUP INC $922,658 39,329 2.03% Shares
Russell Investments Group, Ltd. $805,939 34,353 1.78% Shares
JANE STREET GROUP, LLC $649,701 27,694 1.43% Shares
UBS Group AG $549,175 23,409 1.21% Shares
STATE OF WISCONSIN INVESTMENT BOARD $531,111 22,639 1.17% Shares
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ $420,450 17,922 0.93% Shares
STRS OHIO $417,588 17,800 0.92% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $401,119 17,098 0.88% Shares
Vanguard Global Advisers, LLC $278,494 11,871 0.61% Shares
Ancora Advisors LLC $251,960 10,740 0.56% Shares
STIFEL FINANCIAL CORP $235,141 10,023 0.52% Shares
RAYMOND JAMES FINANCIAL INC $214,354 9,137 0.47% Shares
RHUMBLINE ADVISERS $196,750 8,387 0.43% Shares
WELLS FARGO & COMPANY/MN $144,138 6,144 0.32% Shares
DEUTSCHE BANK AG\ $125,535 5,351 0.28% Shares
FMR LLC $93,744 3,996 0.21% Shares
CITIGROUP INC $74,884 3,192 0.17% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $72,773 3,102 0.16% Shares
JPMORGAN CHASE & CO $67,564 2,906 0.15% Shares
JONES FINANCIAL COMPANIES LLLP $67,320 3,400 0.15% Shares
Police & Firemen's Retirement System of New Jersey $64,937 2,768 0.14% Shares
NFSG Corp $49,266 2,100 0.11% Shares
Tower Research Capital LLC (TRC) $42,017 1,791 0.09% Shares
BNP PARIBAS FINANCIAL MARKETS $37,466 1,597 0.08% Shares
Farther Finance Advisors, LLC $30,498 1,300 0.07% Shares
NEW YORK STATE COMMON RETIREMENT FUND $28,152 1,200 0.06% Shares
BARCLAYS PLC $19,941 850 0.04% Shares
Legal & General Group Plc $18,510 789 0.04% Shares
NISA INVESTMENT ADVISORS, LLC $18,182 775 0.04% Shares
Ameritas Investment Partners, Inc. $13,724 585 0.03% Shares
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $12,514 521 0.03% Shares
ROYAL BANK OF CANADA $8,000 351 0.02% Shares
Washington Trust Advisors, Inc. $4,692 200 0.01% Shares
Optiver Holding B.V. $2,252 96 0.00% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $2,111 90 0.00% Shares
Geneos Wealth Management Inc. $2,064 88 0.00% Shares
GAMMA Investing LLC $1,361 58 0.00% Shares
CWM, LLC $1,249 52 0.00% Shares
North Star Investment Management Corp. $1,196 51 0.00% Shares
Arax Advisory Partners $633 27 0.00% Shares

Show all 60 institutional owners →

Activists & 5%+ owners 2 positions

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Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
David McWilliams Nov. 30, 2020 · Initial filing Passive investment SEC
Snehal Patel, Snehal Patel IRA, Kinnary Patel IRA, Patel Family Trust 1, Patel Family Trust 2, Patel Family Trust 3 Oct. 13, 2020 · Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Company insiders 8 insiders · 3 officers · 5 directors

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Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Snehal Patel CEO and CFO July 29, 2026 P 5,611,402 13 0 $586,328
Frank Joseph Daugherty Chief Medical Officer Dec. 24, 2024 A 90,121 0 0 $0
Jaye Thompson VP Clinical Reg Affairs Dec. 24, 2024 A 264,148 0 0 $0
Kenneth Hallock Director Dec. 24, 2024 A 397,304 0 0 $0
Eric Rothe Director Dec. 24, 2024 A 313,226 0 0 $0
David Mcwilliams Director Dec. 24, 2024 A 620,301 0 0 $0
Patel Panjaj Amrit 10% owner Nov. 10, 2020 J 0 0 0 $0
Kinnary Patel 10% owner Sept. 29, 2020 M 129,400 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 11 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
VFMO · VANGUARD WELLINGTON FUND 0.04% 34,273 SH Aug. 19, 2026 Daily
IWC · iShares Trust 0.02% 23,401 SH Sept. 11, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.01% 6,984 SH Aug. 19, 2026 Daily
IWO · iShares Trust 0.01% 63,269 SH Sept. 11, 2026 Daily
OMFS · Invesco Exchange-Traded Self-Indexe… 0.01% 762 SH Oct. 2, 2026 Daily
IWM · iShares Trust 0.00% 177,348 SH Sept. 11, 2026 Daily
RSSL · Global X Funds 0.00% 3,196 NS July 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 72,268 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 199,015 SH Aug. 19, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.00% 39,061 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 543 SH Aug. 19, 2026 Daily

GLSI Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

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rating · 8 analysts BUY
Median target $57.00 +235.7%
2 25.0% Strong Buy
5 62.5% Buy
1 12.5% Hold
0 0.0% Sell
0 0.0% Strong Sell

12-Month Price Target

2 analysts · 2026-10-04

Mean target $57.00 +235.7%

← Below all targets Current price $16.98
Low$45.00 Mean$57.00 High$69.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

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FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
GLSI $300M -14.7 · · -2159.7% ·
IMRX · -5.2 · · -45.3% ·
ANIK $133M -12.6 -5.9% -9.6% -7.5% 56.6%
STRO $99M -0.5 65.2% -186.5% 232.2% ·
PALI $375M -7.8 · · -25.4% ·
EVMN $540M -1.5 85.7% -529.8% -401.2% ·
QTTB $43M 1.4 · 55.5% 200.3% ·
AKBA $427M -80.5 47.5% -2.3% -17.3% ·
CAMP $318M -2.3 436.5% -2298.5% -183.4% ·

Latest News Recent headlines mentioning this company

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Source: SEC 10-Q filed Aug 11, 2026