AKBA Akebia Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$0.89
Price · Aug 24, 2026
Fundamentals as of Aug 5, 2026

AKBA Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$0.89
Market Cap
$237M
P/E (TTM)
-44.7
EPS (TTM)
$-0.02
Revenue (TTM)
$236M
Div Yield
ROE
-17.3%
Debt/Equity
1.5
52W Range
$1 – $3

AKBA Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $236M
6-point trend, -19.8%
2020-12-31 2025-12-31
EPS $-0.02
6-point trend, +99.3%
2020-12-31 2025-12-31
Free Cash Flow $68M
6-point trend, +161.2%
2020-12-31 2025-12-31
Margins -2.3%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
AKBA
Peer Median
P/E (TTM)
5-point trend, -5955.4%
-44.7
88.5
P/S (TTM)
5-point trend, +28.6%
1.0
1.7
P/B
5-point trend, +682.6%
7.3
3.6
EV / EBITDA
5-point trend, +1740.9%
4.3
Price / FCF
5-point trend, +268.5%
3.5

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
AKBA
Peer Median
Operating Margin
5-point trend, +108.0%
10.0%
Net Profit Margin
5-point trend, +98.3%
-2.3%
-35.8%
ROA
5-point trend, +96.7%
-1.8%
-38.8%
ROE
5-point trend, +87.2%
-17.3%
-61.0%
ROIC
3-point trend, +138.1%
41.7%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
AKBA
Peer Median
Debt / Equity
5-point trend, +280.2%
1.5
0.0
Current Ratio
5-point trend, -21.8%
1.6
3.9
Quick Ratio
5-point trend, +4.2%
1.4

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
AKBA
Peer Median
Revenue YoY
5-point trend, +11.6%
47.5%
Revenue CAGR 3Y
5-point trend, +11.6%
-6.9%
Revenue CAGR 5Y
5-point trend, +11.6%
-4.3%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
AKBA
Peer Median
EPS (Diluted)
5-point trend, +98.8%
$-0.02

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
AKBA
Peer Median

AKBA Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 11 analysts
  • Strong Buy 5 45.5%
  • Buy 5 45.5%
  • Hold 1 9.1%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

5 analysts · 2026-08-22
Median target $4.00 +351.9%
Mean target $3.80 +329.3%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.02%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.03 $-0.04 0.01%
March 31, 2026 $-0.03 $-0.03 -0.00%
Dec. 31, 2025 $-0.05 $-0.03 -0.02%
Sept. 30, 2025 $0.00 $-0.02 0.02%
June 30, 2025 $0.00 $-0.02 0.02%
March 31, 2025 $0.03 $-0.05 0.08%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
AKBA $427M -80.5 47.5% -2.3% -17.3%
MGNX $102M -1.4 -0.31% -49.9% -87.0%
PYXS $72M -0.9 -14.2% -574.5% -112.9%
CNXU
ALEC $172M -1.1 -79.1% -679.2% -280.7%
EBS $644M 13.3 -28.8% 7.1% 9.9%
GLSI $300M -14.7 -2159.7%
SION $1.84B -21.9 -23.4%
DTIL $100M -1.2 -50.1% -133.4% -72.4%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +236196000.00 $236M $160M $195M $292M $212M $295M $335M $208M $181M $2M $0 $0
Cost of Revenue 8-point trend, +408.0% $39M $63M $74M $86M $151M $296M $145M $8M · · · ·
R&D Expense 12-point trend, +168.1% $62M $38M $63M $130M $148M $218M $323M $291M $231M $116M $43M $23M
SG&A Expense 12-point trend, +632.3% $107M $107M $100M $139M $174M $154M $149M $87M $27M $22M $18M $15M
Operating Expenses 12-point trend, +356.6% $173M $147M $167M $288M $325M $376M $476M $378M $258M $138M $62M $38M
Operating Income 12-point trend, +161.9% $23M $-50M $-46M $-81M $-265M $-378M $-286M $-178M $-77M $-136M $-62M $-38M
Interest Income 3-point trend, +337.4% · · · · · · · · · $901.0K $510.0K $206.0K
Other Non-op 12-point trend, -91.7% $58.0K $94.0K $887.0K $3M $2M $2M $-794.0K $81.0K $204.0K $-188.0K $287.0K $700.0K
Pretax Income 10-point trend, +97.3% $-4M $-69M $-52M $-94M $-282M $-385M $-286M $-172M $-74M $-136M · ·
Income Tax 8-point trend, +105.7% $2M $0 $0 $0 $0 $0 $-7M $-28M · · · ·
Net Income 12-point trend, +85.6% $-5M $-69M $-52M $-94M $-282M $-385M $-280M $-144M $-74M $-136M $-61M $-37M
EPS (Basic) 7-point trend, +99.2% $-0.02 $-0.33 $-0.28 $-0.52 $-1.70 $-2.78 $-2.36 · · · · ·
EPS (Diluted) 7-point trend, +99.2% $-0.02 $-0.33 $-0.28 $-0.52 $-1.70 $-2.78 $-2.36 · · · · ·
Shares (Basic) 7-point trend, +117.2% 257,157,782 210,946,658 187,465,448 182,782,680 165,949,695 138,463,152 118,395,919 · · · · ·
Shares (Diluted) 7-point trend, +117.2% 257,157,782 210,946,658 187,465,448 182,782,680 165,949,695 138,463,152 118,395,919 · · · · ·
EBITDA 12-point trend, +161.9% $23M $-50M $-46M $-79M $-263M $-374M $-284M $-177M $-79M $-136M $-62M $-38M
Balance Sheet 29
Annual Balance Sheet data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +463.9% $185M $52M $43M $90M $150M $229M $147M $105M $70M $187M $50M $33M
Short-term Investments 4-point trend, +225.2% · · · · · · · · $248M $73M $89M $76M
Receivables 11-point trend, +97881.2% $47M $34M $39M $40M $52M $27M $39M $17M $34M $34M · $48.0K
Inventory 8-point trend, -86.3% $16M $16M $16M $22M $37M $61M $116M $114M · · · ·
Prepaid Expense 12-point trend, +250.2% $5M $11M $20M $33M $33M $15M $7M $16M $6M $2M $3M $2M
Other Current Assets 4-point trend, -78.1% $4M $7M $6M $17M · · · · · · · ·
Current Assets 12-point trend, +129.0% $253M $114M $118M $185M $271M $371M $310M $468M $358M $296M $141M $110M
PP&E (Net) 12-point trend, +481.9% $1M $2M $4M $5M $7M $9M $10M $8M $4M $3M $540.0K $210.0K
PP&E (Gross) 9-point trend, +5468.2% · · · $15M $14M $14M $14M $10M $5M $3M $687.0K $261.0K
Accum. Depreciation 9-point trend, +18172.5% · · · $9M $8M $6M $4M $2M $1M $442.0K $147.0K $51.0K
Goodwill 8-point trend, +7.2% $59M $59M $59M $59M $59M $55M $55M $55M · · · ·
Intangibles 7-point trend, -100.0% · $0 $36M $72M $108M $144M $291M $328M · · · ·
Other Non-current Assets 12-point trend, +19467.5% $60M $37M $12M $5M $50M $38M $76M $137M $2M $1M $1M $305.0K
Total Assets 12-point trend, +239.3% $377M $221M $242M $356M $529M $644M $771M $997M $364M $300M $143M $111M
Accounts Payable 12-point trend, +948.2% $21M $15M $15M $18M $34M $41M $39M $43M $7M $2M $2M $2M
Accrued Liabilities 12-point trend, +2402.4% $122M $63M $68M $76M $109M $131M $129M $151M $52M $30M $10M $5M
Current Liabilities 12-point trend, +2266.6% $163M $81M $100M $130M $261M $187M $208M $266M $141M $114M $12M $7M
Capital Leases 7-point trend, -100.0% $0 $4M $9M $29M $34M $25M $28M · · · · ·
Other Non-current Liabilities 12-point trend, +5596.9% $2M $5M $9M $16M $84M $61M $30M $30M $22.0K $27.0K $5.0K $32.0K
Total Liabilities 12-point trend, +4872.6% $344M $270M $272M $351M $455M $397M $376M $361M $242M $232M $12M $7M
Long-term Debt 7-point trend, -36.3% $48M $39M $35M $66M $98M $96M $76M · · · · ·
Total Debt 6-point trend, -36.3% $48M $39M $35M · $98M $96M $76M · · · · ·
Common Stock 12-point trend, +2000.00 $2.0K $2.0K $2.0K $2.0K $1.0K $1.0K $1.0K $1.0K $0 $0 $0 $0
Retained Earnings 12-point trend, -1572.4% $-1.68B $-1.68B $-1.61B $-1.56B $-1.46B $-1.18B $-794M $-514M $-371M $-297M $-161M $-101M
Treasury Stock Flat — no change across 2 periods · · · · · · · · · · $162.0K $162.0K
AOCI 12-point trend, +110.7% $6.0K $6.0K $6.0K $6.0K $6.0K $13.0K $0 $-261.0K $-442.0K $-42.0K $-234.0K $-56.0K
Stockholders' Equity 12-point trend, -68.7% $33M $-49M $-31M $5M $74M $244M $393M $636M $123M $68M $131M $104M
Liabilities + Equity 12-point trend, +239.3% $377M $221M $242M $356M $529M $644M $771M $997M $364M $300M $143M $111M
Shares Outstanding 12-point trend, +1203.0% 265,424,818 224,848,992 194,582,539 184,135,714 177,000,963 148,074,085 121,674,568 116,887,518 47,612,619 38,615,709 30,662,218 20,370,624
Cash Flow 17
Annual Cash Flow data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
D&A 9-point trend, +3275.5% · · · $2M $2M $2M $2M $899.0K $617.0K $296.0K $96.0K $49.0K
Stock-based Comp 12-point trend, +87.7% $11M $8M $9M $18M $23M $24M $12M $19M $9M $6M $5M $6M
Deferred Tax 12-point trend, +0.00 $0 $0 $0 $0 $0 $0 $-7M $-28M $0 $0 $0 $0
Amort. of Intangibles 8-point trend, -100.0% $0 $36M $36M $36M $36M $33M $36M $2M · · · ·
Restructuring 6-point trend, +0.00 $0 $58.0K $181.0K $16M $0 $0 · · · · · ·
Other Non-cash 7-point trend, -99.2% · · · $2M $5M $247M $15M $55M $11M $188M · ·
Operating Cash Flow 12-point trend, +347.4% $68M $-41M $-23M $-73M $-253M $-110M $-257M $-97M $-56M $58M $-52M $-27M
CapEx 12-point trend, +27.1% $291.0K $33.0K $0 $114.0K $59.0K $317.0K $7M $2M $2M $3M $414.0K $229.0K
Investing Cash Flow 10-point trend, -162.4% $-8M $-33.0K $0 $-114.0K $40M $-40M $211M $37M $-177M $13M · ·
Debt Issued 5-point trend, +0.00 · · · $0 $0 $20M $78M $0 · · · ·
Net Debt Issued 4-point trend, -100.0% · · · $0 $0 $20M $78M · · · · ·
Stock Issued 3-point trend, +349.0% · · · · · · · $468M $373M · · $104M
Stock Repurchased · · · · · · · · · · · $162.0K
Net Stock Activity 3-point trend, +349.7% · · · · · · · $468M $373M · · $104M
Financing Cash Flow 10-point trend, +8.9% $73M $50M $-25M $15M $134M $232M $89M $97M $116M $67M · ·
Net Change in Cash 12-point trend, +1050.0% $133M $9M $-49M $-59M $-79M $81M $43M $36M $-117M $138M $17M $12M
Free Cash Flow 12-point trend, +344.3% $68M $-41M $-23M $-73M $-253M $-111M $-264M $-99M $-58M $55M $-53M $-28M
Profitability 7
Annual Profitability data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 8-point trend, +111.6% 10.0% -31.5% -23.8% -27.6% -124.2% -127.5% -85.5% -85.8% · · · ·
Net Margin 8-point trend, +96.7% -2.3% -43.3% -26.7% -32.2% -132.4% -129.8% -83.5% -69.1% · · · ·
Pretax Margin 8-point trend, +98.1% -1.6% -43.3% -26.7% -32.2% -132.4% -129.8% -85.5% -82.8% · · · ·
EBITDA Margin 8-point trend, +111.7% 10.0% -31.5% -23.8% -27.1% -123.3% -126.8% -84.8% -85.3% · · · ·
ROA 11-point trend, +96.5% -1.8% -30.0% -19.9% · -48.4% -54.2% -31.6% -21.1% -23.2% -61.3% -47.8% -50.8%
ROE 11-point trend, -105.4% -17.3% 139.4% 148.3% · -264.8% -135.6% -64.9% -36.9% -82.1% -136.3% -51.7% 322.1%
ROIC 5-point trend, +278.4% 41.7% · · · -152.5% -109.4% -59.4% -23.4% · · · ·
Liquidity & Solvency 4
Annual Liquidity & Solvency data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, -90.3% 1.6 1.4 1.2 · 1.1 2.0 1.5 1.8 2.5 2.6 11.9 16.0
Quick Ratio 11-point trend, -91.0% 1.4 1.1 0.8 · 0.8 1.4 0.9 0.5 2.4 2.3 11.7 15.8
Debt / Equity 6-point trend, +670.6% 1.5 -0.8 -1.1 · 1.3 0.4 0.2 · · · · ·
LT Debt / Equity 6-point trend, +670.6% 1.5 -0.8 -0.6 · 0.0 0.4 0.2 · · · · ·
Efficiency 3
Annual Efficiency data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 9-point trend, +0.79 0.8 0.7 0.7 · 0.4 0.4 0.4 0.3 · · 0.0 0.0
Inventory Turnover 7-point trend, +2164.9% 2.5 4.0 4.1 · 3.1 3.3 0.9 0.1 · · · ·
Receivables Turnover 8-point trend, +5.80 5.8 4.3 6.7 · 5.5 9.0 12.1 8.2 · · · 0.0
Per Share 5
Annual Per Share data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, -97.6% $0.12 $-0.22 $-0.16 · $0.43 $1.67 $3.24 $5.44 $2.51 $1.76 $4.27 $5.11
Revenue / Share 5-point trend, -28.6% $0.92 $0.76 $1.04 $1.60 $1.29 · · · · · · ·
Cash Flow / Share 5-point trend, +117.3% $0.26 $-0.19 $-0.12 $-0.40 $-1.52 · · · · · · ·
Cash / Share 11-point trend, -56.7% $0.70 $0.23 $0.22 · $0.85 $1.54 $1.21 $0.90 $1.47 $4.85 $1.62 $1.61
EPS (TTM) 9-point trend, +98.9% $-0.02 $-0.33 $-0.28 $-0.52 $-1.70 $-2.78 $-2.36 $-1.86 $-1.86 · · ·
Growth Rates 3
Annual Growth Rates data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +268.5% 47.5% -17.7% -33.5% 38.2% -28.2% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +46.7% -6.9% -8.9% -12.9% · · · · · · · · ·
Revenue CAGR 5Y -4.3% · · · · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for AKBA
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +236196000.00 $236M $160M $195M $292M $212M $295M $335M $208M $181M $2M $0 $0
Net Income TTM 12-point trend, +85.6% $-5M $-69M $-52M $-94M $-282M $-385M $-280M $-144M $-74M $-136M $-61M $-37M
Market Cap 11-point trend, +80.2% $427M $427M $241M · $400M $415M $769M $646M $708M $402M $396M $237M
Enterprise Value 6-point trend, -58.3% $291M $414M $233M · $348M $282M $697M · · · · ·
P/E 9-point trend, -906.9% -80.5 -5.8 -4.4 -1.1 -1.3 -1.0 -2.7 -3.0 -8.0 · · ·
P/S 9-point trend, -99.3% 1.8 2.7 1.2 · 1.9 1.4 2.3 3.1 3.9 261.9 · ·
P/B 11-point trend, +475.2% 13.1 -8.7 -7.9 · 5.2 1.7 1.9 1.0 5.9 5.9 3.0 2.3
P / Tangible Book · · · · · 9.2 · · · · · ·
P / Cash Flow 11-point trend, +172.8% 6.3 -10.5 -10.3 · -1.6 -3.8 -3.0 -6.6 -12.6 6.9 -7.6 -8.6
P / FCF 11-point trend, +173.8% 6.3 -10.5 -10.3 · -1.6 -3.7 -2.9 -6.5 -12.3 7.3 -7.5 -8.6
EV / EBITDA 6-point trend, +604.0% 12.4 -8.2 -5.0 · -1.3 -0.8 -2.5 · · · · ·
EV / FCF 6-point trend, +262.6% 4.3 -10.2 -10.0 · -1.4 -2.5 -2.6 · · · · ·
EV / Revenue 6-point trend, -40.9% 1.2 2.6 1.2 · 1.6 1.0 2.1 · · · · ·
Earnings Yield 9-point trend, +90.1% -1.2% -17.4% -22.6% -90.1% -75.2% -99.3% -37.3% -33.6% -12.5% · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312023-03-312022-12-31
Revenue $236M$160M$195M$292M
Operating Margin % 10.0%-31.5%-23.8%-27.6%
Net Income $-5M$-69M$-52M$-94M
Diluted EPS $-0.02$-0.33$-0.28$-0.52
Balance Sheet
2025-12-312024-12-312023-12-312023-03-312022-12-31
Debt / Equity 1.5-0.8-1.1
Current Ratio 1.61.41.2
Quick Ratio 1.41.10.8
Cash Flow
2025-12-312024-12-312023-12-312023-03-312022-12-31
Free Cash Flow $68M$-41M$-23M$-73M

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Institutional owners (13F) 184 filers · $87.7M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
39 (+4 vs prior Q) 35 (+9 vs prior Q) 63 (+18 vs prior Q) 36 (-14 vs prior Q) -3.7M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
VANGUARD CAPITAL MANAGEMENT LLC $12,907,243 11,322,143 14.72% Shares
SATTER MANAGEMENT CO., L.P. $10,921,021 5,747,906 12.45% Shares
GEODE CAPITAL MANAGEMENT, LLC $6,557,737 5,750,625 7.48% Shares
STATE STREET CORP $6,145,572 5,390,853 7.01% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $4,871,250 4,273,026 5.55% Shares
MILLENNIUM MANAGEMENT LLC $3,644,130 3,196,605 4.15% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $2,888,734 2,533,977 3.29% Shares
GOLDMAN SACHS GROUP INC $2,779,842 2,438,458 3.17% Shares
TWO SIGMA INVESTMENTS, LP $2,777,807 2,436,673 3.17% Shares
VANGUARD GROUP INC $2,715,740 1,686,795 3.10% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $2,622,499 2,300,438 2.99% Shares
Nantahala Capital Management, LLC $2,280,000 2,000,000 2.60% Shares
VANGUARD FIDUCIARY TRUST CO $2,176,029 1,908,797 2.48% Shares
FMR LLC $2,132,467 1,870,585 2.43% Shares
Qube Research & Technologies Ltd $2,028,866 1,779,707 2.31% Shares
RENAISSANCE TECHNOLOGIES LLC $1,395,318 1,223,963 1.59% Shares
CITIGROUP INC $1,265,009 1,109,657 1.44% Shares
MANGROVE PARTNERS IM, LLC $760,328 666,954 0.87% Shares
AMERIPRISE FINANCIAL INC $703,205 616,846 0.80% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $672,396 589,821 0.77% Shares
TWO SIGMA ADVISERS, LP $643,918 399,949 0.73% Shares
CHOREO, LLC $641,162 562,423 0.73% Shares
Quantinno Capital Management LP $640,820 562,123 0.73% Shares
Creative Planning $622,144 545,740 0.71% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $606,265 531,813 0.69% Shares
MORGAN STANLEY $584,591 512,799 0.67% Shares
PANAGORA ASSET MANAGEMENT INC $531,832 466,519 0.61% Shares
ALLIANCEBERNSTEIN L.P. $493,325 354,910 0.56% Shares
Eversept Partners, LP $486,888 427,095 0.56% Shares
BANK OF AMERICA CORP /DE/ $473,308 415,182 0.54% Shares
CANADA PENSION PLAN INVESTMENT BOARD $368,904 323,600 0.42% Shares
VIRTUS ADVISERS, LLC $359,940 315,737 0.41% Shares
RHUMBLINE ADVISERS $350,544 307,503 0.40% Shares
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO $336,186 294,900 0.38% Shares
ALPS ADVISORS INC $310,379 272,262 0.35% Shares
DIMENSIONAL FUND ADVISORS LP $307,391 269,641 0.35% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $304,722 267,300 0.35% Put option
FRANKLIN RESOURCES INC $286,156 251,014 0.33% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $279,072 244,800 0.32% Call option
Vanguard Global Advisers, LLC $251,440 220,561 0.29% Shares
Graham Capital Management, L.P. $236,845 207,759 0.27% Shares
Bank of New York Mellon Corp $227,323 199,406 0.26% Shares
Wealthspire Advisors, LLC $205,203 180,002 0.23% Shares
CITADEL ADVISORS LLC $190,608 167,200 0.22% Put option
BlackRock, Inc. $189,909 166,587 0.22% Shares
Nuveen Asset Management, LLC $186,464 98,139 0.21% Shares
Man Group plc $177,151 155,396 0.20% Shares
Mariner, LLC $175,851 154,256 0.20% Shares
MetLife Investment Management, LLC $174,281 152,878 0.20% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $157,464 112,474 0.18% Shares
Russell Investments Group, Ltd. $143,655 126,014 0.16% Shares
BARCLAYS PLC $139,430 122,307 0.16% Shares
VIRGINIA RETIREMENT SYSTEMS ET Al $136,850 85,000 0.16% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $135,666 119,005 0.15% Shares
MERCER GLOBAL ADVISORS INC /ADV $127,402 111,756 0.15% Shares
Invesco Ltd. $116,967 102,603 0.13% Shares
GROUP ONE TRADING LLC $115,841 101,615 0.13% Shares
Fiduciary Trust Co $114,000 100,000 0.13% Shares
CITADEL ADVISORS LLC $110,580 97,000 0.13% Call option
LPL Financial LLC $108,888 95,516 0.12% Shares
IEQ CAPITAL, LLC $105,312 92,379 0.12% Shares
Jain Global LLC $104,214 91,416 0.12% Shares
Focus Partners Wealth $92,280 80,948 0.11% Shares
BNP PARIBAS FINANCIAL MARKETS $91,133 79,941 0.10% Shares
NEW YORK STATE COMMON RETIREMENT FUND $90,174 79,100 0.10% Shares
Headlands Technologies LLC $88,911 77,992 0.10% Shares
Abel Hall, LLC $85,999 75,438 0.10% Shares
SEI INVESTMENTS CO $84,797 74,383 0.10% Shares
D. E. Shaw & Co., Inc. $82,699 72,543 0.09% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $81,957 71,892 0.09% Shares
OSAIC HOLDINGS, INC. $79,715 69,926 0.09% Shares
Police & Firemen's Retirement System of New Jersey $78,757 69,085 0.09% Shares
Brevan Howard Capital Management LP $72,675 63,750 0.08% Shares
CITADEL ADVISORS LLC $72,243 63,371 0.08% Shares
INTECH INVESTMENT MANAGEMENT LLC $70,931 62,220 0.08% Shares
Squarepoint Ops LLC $67,747 59,427 0.08% Shares
CWA Asset Management Group, LLC $67,260 59,000 0.08% Shares
RAYMOND JAMES FINANCIAL INC $65,585 57,531 0.07% Shares
WELLINGTON MANAGEMENT GROUP LLP $63,105 55,355 0.07% Shares
Arax Advisory Partners $62,700 54,999 0.07% Shares
VOYA INVESTMENT MANAGEMENT LLC $61,941 54,334 0.07% Shares
CAPTRUST FINANCIAL ADVISORS $61,567 54,006 0.07% Shares
JANE STREET GROUP, LLC $59,280 52,000 0.07% Call option
PDS Planning, Inc $57,000 50,000 0.06% Shares
Nuveen, LLC $56,925 49,934 0.06% Shares
UBS Group AG $52,834 46,346 0.06% Shares
PRUDENTIAL FINANCIAL INC $50,028 43,884 0.06% Shares
NORTHERN TRUST CORP $46,146 40,479 0.05% Shares
TWO SIGMA SECURITIES, LLC $45,753 40,134 0.05% Shares
EP Wealth Advisors, LLC $44,059 38,648 0.05% Shares
HighTower Advisors, LLC $43,968 38,568 0.05% Shares
Gotham Asset Management, LLC $41,100 36,053 0.05% Shares
Scientech Research LLC $40,117 35,190 0.05% Shares
Empirical Asset Management, LLC $39,900 35,000 0.05% Shares
ProShare Advisors LLC $38,572 33,836 0.04% Shares
NEUBERGER BERMAN GROUP LLC $37,783 33,143 0.04% Shares
CWM, LLC $36,332 26,138 0.04% Shares
Tower Research Capital LLC (TRC) $35,706 31,321 0.04% Shares
VICTORY CAPITAL MANAGEMENT INC $34,394 30,170 0.04% Shares
Sonora Investment Management Group, LLC $32,760 12,000 0.04% Shares

Company insiders 29 insiders · 9 officers · 17 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Erik Ostrowski SVP, CFO, CBO & Treasurer June 29, 2026 S 616,616 0 1 $-62,181
David A Spellman SVP, CFO and Treasurer June 30, 2020 A 0 0 $0
Jason Amello SVP, CFO & Treasurer April 11, 2019 D 118,618 0 0 $0
Rita Jain SVP, Chief Medical Officer April 11, 2019 D 96,332 0 0 $0
Michel Dahan SVP, Chief Business Officer April 11, 2019 D 146,932 0 0 $0
Nicole R. Hadas SVP, CLO & Secretary April 11, 2019 D 154,806 0 0 $0
Karen L Tubridy SVP, Chief Development Officer April 11, 2019 D 55,324 0 0 $0
Bradley Maroni SVP and Chief Medical Officer Feb. 22, 2016 A 38,859 0 0 $0
Robert Shalwitz Chief Medical Officer May 14, 2014 A 264,556 0 0 $0
Ron Frieson Director June 17, 2026 A 165,200 0 0 $0
Myles Wolf Director June 17, 2026 A 169,081 0 0 $0
Cynthia Smith Director June 17, 2026 A 196,633 0 0 $0
Adrian Adams Director June 17, 2026 A 236,200 0 0 $0
Michael W Rogers Director June 17, 2026 A 197,429 0 0 $0
Leanne M Zumwalt Director June 17, 2026 A 145,100 0 0 $0
Jodie Pope Morrison Director Dec. 12, 2018 A 44,919 0 0 $0
Mark J Enyedy Director Dec. 12, 2018 A 3,743 0 0 $0
Michael Thomas Heffernan Director Dec. 12, 2018 A 7,486 0 0 $0
Steven C Gilman Director Dec. 12, 2018 A 10,231 0 0 $0
Satter Muneer A Director July 5, 2017 P 3,037,042 0 0 $0
Duane Nash Director Oct. 2, 2015 S 31,609 0 0 $0
Anupam Dalal Director June 10, 2015 A 0 0 $0
Michael D. Clayman Director June 10, 2015 A 0 0 $0
Ronald C Renaud JR Director June 10, 2015 A 5,000 0 0 $0
Maxine Gowen Director June 10, 2015 A 1,300 0 0 $0
Michael S Wyzga Director June 10, 2015 A 1,500 0 0 $0
John P. Butler Aug. 6, 2026 M 3,718,564 0 0 $0
Novo Holdings A/S March 25, 2014 C 1,516,387 0 0 $0
Novartis Bioventures Ltd March 25, 2014 C 3,405,764 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 5 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Muneer A. Satter (2) ×3 filings Jan. 11, 2019 Initial filing M&A / sale SEC
Nantahala Capital Management, LLC, Wilmot B. Harkey, Daniel Mack ×2 filings Dec. 21, 2018 Initial filing Passive investment SEC
Vifor (International) Ltd., Vifor Pharma Ltd. ×2 filings Aug. 10, 2017 Initial filing SEC
Kearny Venture Partners, L.P. (“KVP”), Kearny Venture Partners Entrepreneurs’ Fund, L.P. (“KVPE”), Thomas Weisel Healthcare Venture Partners, L.P. (“TWHVP”), Kearny Venture Associates, L.L.C. (“KVA”), Caley Castelein (“Castelein”), Richard Spalding (“Spalding”), James Shapiro (“Shapiro”) ×2 filings Jan. 20, 2016 Initial filing SEC
Novo A/S ×3 filings Nov. 18, 2015 Initial filing SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 31 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
QQQS · Invesco Exchange-Traded Fund Trust … 0.44% 109,760 SH Aug. 21, 2026 Daily
SBIO · ALPS ETF Trust 0.17% 276,121 NS May 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.09% 352,079 NS April 30, 2026 N-PORT
IWC · iShares Trust 0.05% 891,009 SH Aug. 21, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.03% 326,417 NS May 31, 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0.02% 249,458 SH Aug. 19, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.01% 449,603 SH Aug. 21, 2026 Daily
IWO · iShares Trust 0.01% 2,169,896 SH Aug. 21, 2026 Daily
RSSL · Global X Funds 0.01% 111,420 NS April 30, 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 1,485,665 SH Aug. 19, 2026 Daily
IWM · iShares Trust 0.01% 6,688,188 SH Aug. 21, 2026 Daily
ITWO · ProShares Trust 0.01% 11,916 NS May 31, 2026 N-PORT
RB · ProShares Trust 0.01% 74 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.01% 1,262,655 NS May 31, 2026 N-PORT
UWM · ProShares Trust 0.00% 9,319 NS May 31, 2026 N-PORT
URTY · ProShares Trust 0.00% 9,423 NS May 31, 2026 N-PORT
IWN · iShares Trust 0.00% 338,633 SH Aug. 21, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 11,769 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.00% 237 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 365,352 SH Aug. 21, 2026 Daily
DFAC · Dimensional ETF Trust 0.00% 108,459 NS April 30, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.00% 6,918 NS April 30, 2026 N-PORT
IWV · iShares Trust 0.00% 45,806 SH Aug. 21, 2026 Daily
DFAU · Dimensional ETF Trust 0.00% 6,798 NS April 30, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 11,776 NS April 30, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 3,164,884 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 7,912,283 SH Aug. 19, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.00% 24,210 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 20,230 SH Aug. 19, 2026 Daily
VHT · VANGUARD WORLD FUND 0.00% 754,414 SH Aug. 19, 2026 Daily
SMLF · iShares Trust 621,529 SH Aug. 21, 2026 Daily