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UPB NASDAQ US

Upstream Bio, Inc. - Common Stock

Healthcare · Biotechnology Website · IPO Oct 2024
$9.50
▲ +$0.19 (+2.04%)
Vol 538K
3
Quality Score
fail
Mkt Cap
$1.5B
ROE
-28.7%
Margin
-4366.8%
D/E
0.00
Beta
0.60
52W
$5–$33

Wall Street Consensus

12 analysts · Apr 2026
2
Strong Buy
8
Buy
2
Hold
0
Sell
0
Strong Sell
83.3%
Buy Rating

Price Chart

Earnings

Beat rate: 20.0%
Quarter EPS Est EPS Act Surprise
Dec 2025 $-0.71 $-0.79 $-0.08
Sep 2025 $-0.79 $-0.63 +$0.16
Jun 2025 $-0.62 $-0.74 $-0.12
Mar 2025 $-0.49 $-0.51 $-0.02

Quarterly Revenue & Earnings

Quarter 2024-0… 2024-1… 2025-0… 2025-0… 2025-0…
Revenue $607K $613K $566K $937K $683K
Net Income -$16.0M -$21.2M -$27.3M -$40.0M -$33.7M

Fundamentals Trend

Metric 2025-06-30 2025-09-02 2025-10-02 2025-11-03 2025-12-03 2026-01-02
ROE (TTM) -27.1% -27.1% -27.1% -27.1% -28.7% -28.7%
P/E (TTM)
Net Margin -4265.3% -3836.6% -3836.6% -3836.6% -4366.8% -4366.8%
Gross Margin
D/E Ratio 0.00 0.00 0.00 0.00 0.00 0.00
Current Ratio 38.27 38.27 38.27 38.27 32.67 32.67

Key Ratios

ROA (TTM)
-27.9%
P/S (TTM)
524.17
P/B
1.9
EPS (TTM)
$-2.29
52W High
$33.00
52W Low
$5.14
$5.14 52-Week Range $33.00

Financial Health

Free Cash Flow
-$22.3M
Net Debt
-$70.7M
Cash
$72.2M
Total Debt
$1.4M
As of Sep 30, 2025

How does UPB compare to Biotechnology peers?

Peer group: Micro-cap Biotechnology (All) · 528 companies

UPB valuation vs Biotechnology peers

P/E ratio
0% below peers (18.8)
vs Peers
vs Industry
Undervalued
P/S ratio
524.2
3979% above peers (12.9)
vs Peers
vs Industry
Overvalued
P/B ratio
1.9
24% below peers (2.5)
vs Peers
vs Industry
Pricier
Div yield
0% below peers (0.0%)
vs Peers
vs Industry
Low yield

UPB profitability vs Biotechnology peers

ROE
-28.7%
57% above peers (-67.3%)
vs Peers
vs Industry
Top tier
Net margin
-4366.8%
1423% below peers (-286.8%)
vs Peers
vs Industry
Weak
Gross margin
0% below peers (78.6%)
vs Peers
vs Industry
In line
ROA
-27.9%
40% above peers (-46.7%)
vs Peers
vs Industry
Below avg

UPB financial health vs Biotechnology peers

D/E ratio
0.0
0% below peers (0.0)
vs Peers
vs Industry
Low debt
Current ratio
32.7
636% above peers (4.4)
vs Peers
vs Industry
Strong liquidity
Beta
0.6
38% below peers (1.0)
vs Peers
vs Industry
More volatile

UPB fundamentals radar

UPB Peer median Industry

UPB profitability vs leverage

Bubble size = market cap · X = net margin · Y = D/E ratio

UPB vs peers: key metrics