LYEL Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

03
Price $9.26
Market Cap (MRQ) $217M
P/E (TTM) -0.6
EPS (TTM) $-16.01
Revenue (TTM) $27.0K
ROE (TTM) -93.3%
52W Range $9–$40

LYEL Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

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Stock splits 1
Ex-date Split Type
June 2, 2025 1-for-20 Reverse

10-Year Performance Revenue, net income, margins and EPS trends

06
Revenue$36.0K
2019-12-31 → 2025-12-31
EPS$-16.06
2019-12-31 → 2025-12-31
Free Cash Flow$-151M
2021-12-31 → 2025-12-31
Net margin-920285.2%
2021-12-31 → 2025-12-31
Valuation & Ratios 07–12

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric 5Y trend LYEL 5Y avg Peer Median Verdict
P/E (TTM) -0.65Y avg ≈-36.5 ≈-36.5 · ·
P/S (TTM) 8024.35Y avg ≈31914.9 ≈31914.9 14.6 Overvalued
P/B (MRQ) 0.95Y avg ≈17.7 ≈17.7 2.9 Undervalued
Price / FCF (TTM) -1.65Y avg ≈-74.4 ≈-74.4 · ·
Price / Cash Flow (TTM) -1.65Y avg ≈-97.5 ≈-97.5 · ·
Price / Tangible Book 0.95Y avg ≈17.7 ≈17.7 · ·

Peer median is calculated on a standardized basis per metric and may not always match the TTM/MRQ basis shown for this stock.

value · ≈ 5Y avg · industry median · verdict relative to median

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

14
Avg Surprise -20.5%
Next Report Nov 09, 2026
PeriodReportEPS ActualEPS EstSurprise
June 30, 2026 Aug 10, 2026 $-1.92 $-2.06 6.7%
March 31, 2026 May 11, 2026 $-1.10 $-2.41 54.4%
Dec. 31, 2025 $-7.50 $-2.28 -229.5%
Sept. 30, 2025 $-2.13 $-2.70 21.0%
June 30, 2025 $-2.89 $-3.65 20.9%
March 31, 2025 $-3.54 $-3.67 3.6%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

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Income Statement 13
Metric Trend 202520242023202220212020
Revenue $36.0K$61.0K$130.0K$85M$11M$8M
R&D Expense ··$183M$159M$139M$182M
SG&A Expense $45M$52M$67M$117M$89M$47M
Operating Expenses $269M$359M$247M$272M$225M$220M
Operating Income $-269M$-359M$-247M$-187M$-215M$-212M
Other Non-op $-18M$5M$2M$2M$-161.0K$2M
Income Tax $0·····
Net Income $-274M$-343M$-235M$-183M$-250M$-204M
EPS (Basic) $-16.06$-26.23$-18.70$-0.74$-1.84$-15.69
EPS (Diluted) $-16.06$-26.23$-18.70$-0.74$-1.84$-15.69
Shares (Basic) 17,093,00013,074,00012,549,000247,080,000135,918,00013,258,000
Shares (Diluted) 17,093,00013,074,00012,549,000247,080,000135,918,00013,258,000
EBITDA $-258M$-339M$-227M$-169M$-201M·
Balance Sheet 21
Metric Trend 202520242023202220212020
Cash & Equivalents $60M$106M$146M$124M$294M$140M
Short-term Investments $187M$265M$401M$517M$321M$472M
Prepaid Expense $14M$9M$8M$11M$11M$5M
Current Assets $261M$380M$555M$651M$626M$618M
PP&E (Net) $35M$48M$103M$123M$120M$77M
PP&E (Gross) $109M$119M$154M$155M$135M$82M
Accum. Depreciation $74M$71M$52M$32M$15M$5M
Other Non-current Assets $5M$5M$4M$5M$3M$3M
Total Assets $340M$491M$750M$938M$1.13B$908M
Accounts Payable $3M$5M$5M$4M$3M$9M
Current Liabilities $49M$54M$35M$37M$47M$49M
Capital Leases $42M$51M$57M$63M$67M$51M
Other Non-current Liabilities $517.0K$3M$4M$4M$5M$532.0K
Total Liabilities $92M$108M$95M$104M$198M$190M
Common Stock $2.0K$1.0K$25.0K$25.0K$24.0K$2.0K
Paid-in Capital $1.87B$1.73B$1.66B$1.61B$1.52B$41M
Retained Earnings $-1.62B$-1.35B$-1.00B$-767M$-584M$-334M
AOCI $242.0K$291.0K$-94.0K$-8M$-2M$256.0K
Stockholders' Equity $248M$383M$655M$833M$930M$-293M
Liabilities + Equity $340M$491M$750M$938M$1.13B$908M
Shares Outstanding 21,251,00014,744,00012,698,00012,479,000242,738,00015,570,000
Cash Flow 13
Metric Trend 202520242023202220212020
D&A $12M$20M$20M$18M$14M$4M
Stock-based Comp $42M$33M$47M$82M$62M$33M
Restructuring ··$6M···
Other Non-cash $71M$128M$4M$-86M$48M·
Operating Cash Flow $-150M$-162M$-164M$-170M$-126M$-161M
CapEx $780.0K$464.0K$3M$24M$66M$51M
Investing Cash Flow $54M$122M$184M$-12M$-122M$-274M
Stock Issued $50M$0$0···
Stock Repurchased ···$0$0$12M
Net Stock Activity $50M··$0$0·
Financing Cash Flow $50M$1M$2M$11M$401M$477M
Net Change in Cash $-46M$-39M$22M$-170M$153M$42M
Free Cash Flow $-151M$-163M$-166M$-194M$-192M·
Profitability 5
Metric Trend 202520242023202220212020
Operating Margin -748344.4%-588123.0%-190006.1%-220.9%-2016.7%·
Net Margin -762355.6%-562285.2%-180486.1%-216.2%-2349.5%·
EBITDA Margin -716291.7%-555941.0%-174429.2%-199.6%-1888.8%·
ROA -66.1%-55.3%-27.8%-17.7%-24.6%·
ROE -100.3%-75.1%-34.7%-22.1%-26.1%·
Liquidity & Solvency 2
Metric Trend 202520242023202220212020
Current Ratio 5.37.116.117.613.4·
Quick Ratio 5.06.915.817.313.2·
Efficiency 1
Metric Trend 202520242023202220212020
Asset Turnover 0.00.00.00.10.0·
Per Share 5
Metric Trend 202520242023202220212020
Book Value / Share $11.68$1.30$2.58$3.34$3.83·
Revenue / Share $0.00$0.00$0.00$0.34$78.36·
Cash Flow / Share $-8.78$-0.62$-0.65$-0.69$-928.86·
Cash / Share $2.83$0.36$0.57$0.50$1.21·
EPS (TTM) $-16.06$-26.23$-18.70$-0.74$-1.84·
Growth Rates 3
Metric Trend 202520242023202220212020
Revenue YoY -41.0%-53.1%-99.9%695.1%37.3%·
Revenue CAGR 3Y -92.5%-82.1%-74.4%···
Revenue CAGR 5Y -65.8%·····
Valuation (TTM) 10
Metric Trend 202520242023202220212020
Revenue TTM $36.0K$61.0K$130.0K$85M$11M·
Net Income TTM $-274M$-343M$-235M$-183M$-250M·
Market Cap $654M$3.77B$9.85B$17.32B$37.58B·
P/E -1.9-0.5-2.1-93.8-84.1·
P/S 18169.661875.675796.7204.53528.2·
P/B 2.69.915.020.840.4·
P / Tangible Book 2.69.915.020.840.4·
P / Cash Flow -4.4-23.2-60.2-102.1-297.6·
P / FCF -4.3-23.2-59.2-89.4-196.0·
Earnings Yield -52.2%-204.9%-48.2%-1.1%-1.2%·

Most recent period on the left · null values shown as ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

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Metric 2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $36.0K $61.0K $130.0K $85M $11M
Operating Margin % -748344.4% -588123.0% -190006.1% -220.9% -2016.7%
Net Income $-274M $-343M $-235M $-183M $-250M
Diluted EPS $-16.06 $-26.23 $-18.70 $-0.74 $-1.84

Institutional owners (13F) 95 filers · $240.0M total · As of June 30, 2026

17

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Holders 95
Value held $240.0M
New positions 26
Exited positions 9
Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
26 (+6 vs prior Q) 9 (+3 vs prior Q) 29 (+4 vs prior Q) 19 (+11 vs prior Q) +67K

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
ARCH Venture Management, LLC $45,525,211 3,247,162 18.97% Shares
MWG Caph Ltd $31,029,810 1,008,116 12.93% Shares
VANGUARD GROUP INC $25,437,516 826,430 10.60% Shares
GSK plc $21,252,859 1,512,659 8.86% Shares
MWG Management Ltd. $16,371,804 1,008,116 6.82% Shares
VANGUARD CAPITAL MANAGEMENT LLC $11,054,175 786,774 4.61% Shares
Orland Properties Ltd $10,603,507 754,698 4.42% Shares
BlackRock, Inc. $10,177,005 724,342 4.24% Shares
Almitas Capital LLC $8,168,768 581,407 3.40% Shares
Foresite Capital Management V, LLC $6,693,223 476,386 2.79% Shares
MILLENNIUM MANAGEMENT LLC $5,162,996 367,473 2.15% Shares
Opaleye Management Inc. $4,833,551 344,025 2.01% Shares
venBio Partners LLC $4,744,643 337,697 1.98% Shares
GEODE CAPITAL MANAGEMENT, LLC $4,365,887 310,636 1.82% Shares
Alphabet Inc. $4,120,247 293,256 1.72% Shares
STATE STREET CORP $2,603,774 185,322 1.08% Shares
HSG Holding Ltd $2,139,801 152,299 0.89% Shares
RENAISSANCE TECHNOLOGIES LLC $1,829,169 130,190 0.76% Shares
NORTHERN TRUST CORP $1,664,925 118,500 0.69% Shares
Qube Research & Technologies Ltd $1,552,961 110,531 0.65% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $1,511,359 107,570 0.63% Shares
MARSHALL WACE, LLP $1,493,516 106,300 0.62% Shares
Velan Capital Investment Management LP $1,475,250 105,000 0.61% Shares
VANGUARD FIDUCIARY TRUST CO $1,307,985 93,095 0.54% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $1,291,069 91,891 0.54% Shares
MIC Capital Management UK LLP $1,222,743 87,028 0.51% Shares
GOLDMAN SACHS GROUP INC $1,219,245 86,779 0.51% Shares
DIMENSIONAL FUND ADVISORS LP $957,066 68,315 0.40% Shares
TWO SIGMA INVESTMENTS, LP $743,624 52,927 0.31% Shares
JANE STREET GROUP, LLC $646,455 46,011 0.27% Shares
Squarepoint Ops LLC $594,624 42,322 0.25% Shares
Ikarian Capital, LLC $577,188 41,081 0.24% Shares
MORGAN STANLEY $520,553 37,050 0.22% Shares
CANADA PENSION PLAN INVESTMENT BOARD $413,225 29,411 0.17% Shares
Point72 Asset Management, L.P. $366,424 26,080 0.15% Shares
UBS Group AG $365,048 25,982 0.15% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $363,895 25,900 0.15% Call option
Bank of New York Mellon Corp $346,656 24,673 0.14% Shares
AMERICAN CENTURY COMPANIES INC $344,787 24,540 0.14% Shares
Jump Financial, LLC $308,482 21,956 0.13% Shares
Clearstead Advisors, LLC $280,410 19,958 0.12% Shares
EntryPoint Capital, LLC $272,710 19,410 0.11% Shares
CITADEL ADVISORS LLC $262,665 18,695 0.11% Shares
BRIDGEWAY CAPITAL MANAGEMENT, LLC $252,900 18,000 0.11% Shares
CITADEL ADVISORS LLC $251,495 17,900 0.10% Put option
Susquehanna Portfolio Strategies, LLC $251,144 17,875 0.10% Shares
CITADEL ADVISORS LLC $238,850 17,000 0.10% Call option
Allspring Global Investments Holdings, LLC $226,837 16,145 0.09% Shares
RHUMBLINE ADVISERS $217,234 15,462 0.09% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $199,510 14,200 0.08% Put option

Show all 95 institutional owners →

Company insiders 25 insiders · 14 officers · 11 directors

19
Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Lynn Seely President and CEO Aug. 21, 2026 S 63,899 0 6 $-353,079
Elizabeth Homans Chief Executive Officer March 16, 2022 A · 0 0 $0
Charles W. Newton Chief Financial Officer Aug. 21, 2025 S 15,306 0 0 $0
Stephen J. Hill Chief Operating Officer Aug. 21, 2026 S 16,816 0 6 $-51,290
Jarrad Mattieu Aguirre Chief Medical Officer Sept. 10, 2026 A · 0 0 $0
David Shook Chief Medical Officer Sept. 10, 2026 S 20,423 0 2 $-31,339
Gary K. Lee Chief Scientific Officer Aug. 21, 2026 S 16,220 0 6 $-71,695
Veronica Sanchez Bulis VP, Corporate Controller Aug. 10, 2026 S 14,799 0 6 $-96,909
Smital Shah Chief Fin. and Bus. Officer March 9, 2026 A · 0 0 $0
Mark A Meltz General Counsel Feb. 10, 2026 A · 0 0 $0
Matthew Lang Chief Business Officer Feb. 10, 2025 A 162,500 0 0 $0
Tina M. Albertson Chief Medical Officer Feb. 24, 2023 A · 0 0 $0
Rahsaan Thompson Chief Legal Officer Feb. 24, 2023 A · 0 0 $0
Heather D Turner Chief General Counsel March 16, 2022 A · 0 0 $0
Mark Bachleda Director June 10, 2026 A · 0 0 $0
Elizabeth G Nabel Director June 10, 2026 A · 0 0 $0
Richard Klausner Director June 10, 2026 A 843,365 0 0 $0
Sumant Ramachandra Director June 10, 2026 A 200,000 0 0 $0
Cathy Friedman Director June 10, 2026 A 236,370 0 0 $0
Otis W Brawley Director June 10, 2026 A 35,640 0 0 $0
William Jl Rieflin Director June 10, 2026 A · 0 0 $0
Hans Edgar Bishop Director June 14, 2024 A 4,685,614 0 0 $0
Robert Nelsen Director June 14, 2024 A 18,206,358 0 0 $0
Innovative Cellular Therapeutics Holdings Ltd 10% owner July 27, 2026 J 2,818,980 0 2 $-274
GSK plc · June 21, 2021 C 30,253,189 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

ETF ownership Held by 16 ETFs

20

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
IWC · iShares Trust 0.03% 32,319 SH Sept. 11, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.02% 1,674 SH Oct. 1, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.01% 8,183 SH Aug. 19, 2026 Daily
IBB · iShares Trust 0.01% 57,662 SH Sept. 11, 2026 Daily
RSSL · Global X Funds 0.00% 4,474 NS July 31, 2026 N-PORT
IWM · iShares Trust 0.00% 222,823 SH Sept. 11, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.00% 9,045 SH Oct. 1, 2026 Daily
DCOR · Dimensional ETF Trust 0.00% 1,961 NS July 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.00% 1,736 NS July 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 163,755 SH Aug. 19, 2026 Daily
VTI · VANGUARD INDEX FUNDS 0.00% 604,461 SH Aug. 19, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.00% 54,398 SH Aug. 19, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 1,151 SH Aug. 19, 2026 Daily
DFAC · Dimensional ETF Trust 0.00% 409 NS July 31, 2026 N-PORT
VHT · VANGUARD WORLD FUND 0.00% 28,159 SH Aug. 19, 2026 Daily
IWN · iShares Trust · 89,130 SH Sept. 11, 2026 Daily

LYEL Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

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rating · 14 analysts BUY
Median target $41.50 +348.2%
4 28.6% Strong Buy
8 57.1% Buy
1 7.1% Hold
1 7.1% Sell
0 0.0% Strong Sell

12-Month Price Target

8 analysts · 2026-10-02

Mean target $37.88 +309.0%

← Below all targets Current price $9.26
Low$12.00 Mean$37.88 High$49.00

Peer comparison (GICS sub-industry) Key metrics vs sector peers

22

FY basis, prices as of each company's last fiscal year-end close.

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
LYEL $654M -1.9 -41.0% -762355.6% -100.3% ·
CAMP $318M -2.3 436.5% -2298.5% -183.4% ·
EVMN $540M -1.5 85.7% -529.8% -401.2% ·
AKBA $427M -80.5 47.5% -2.3% -17.3% ·
IVVD $697M -8.2 110.5% -98.2% -36.9% ·
MGNX $102M -1.4 -0.31% -49.9% -87.0% ·
KROS $398M 8.9 · 35.7% 17.2% ·
RNAC $188M -1.4 -92.8% -4658.6% 202.4% ·
SION $1.84B -21.9 · · -23.4% ·

My Metrics Your personal watchlist — selected rows from Full Fundamentals

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Source: SEC 10-Q filed Aug 6, 2026