RIGL Rigel Pharmaceuticals, Inc. - Common Stock
$45.00
Price · Aug 19, 2026
Fundamentals as of Aug 4, 2026
52W Range
$25–$52
73% of range
Analyst Rating
STRONG BUY
11 analysts
Price Target
$61
+36% upside
P/E (TTM)
2.3
ROE
155.1%
Net Profit Margin
124.7%
RIGL Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$45.00
Market Cap
$824M
P/E (TTM)
2.3
EPS (TTM)
$19.48
Revenue (TTM)
$294M
Div Yield
—
ROE
155.1%
Debt/Equity
—
52W Range
$25 – $52
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
$294M
2016-12-31
→
2025-12-31
EPS
$19.48
2019-12-31
→
2025-12-31
Free Cash Flow
—
2016-12-31
→
2022-12-31
Margins
124.7%
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
RIGL
Peer Median
P/E (TTM)
2.3
68.0
P/S (TTM)
2.8
20.6
P/B
2.1
3.2
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
RIGL
Peer Median
Operating Margin
42.6%
—
Net Profit Margin
124.7%
-94.7%
ROA
108.3%
-25.6%
ROE
155.1%
-30.9%
ROIC
96.5%
—
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
RIGL
Peer Median
Current Ratio
2.4
9.3
Quick Ratio
2.1
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
RIGL
Peer Median
Revenue YoY
64.1%
—
Revenue CAGR 3Y
34.8%
—
Revenue CAGR 5Y
22.1%
—
EPS YoY
1867.7%
—
Net Income YoY
1999.1%
—
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
RIGL
Peer Median
RIGL Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
11 analysts
- Strong Buy 4 36.4%
- Buy 4 36.4%
- Hold 3 27.3%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
5 analysts · 2026-08-17
Median
$55.00
Mean
$61.20
Now
$45.00
Low
$40.00
High
$85.00
Median target
$55.00
+22.2%
Mean target
$61.20
+36.0%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
0.26%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| June 30, 2026 | $0.88 | $0.63 | 0.25% |
| March 31, 2026 | $0.44 | $0.78 | -0.34% |
| Dec. 31, 2025 | $1.15 | $1.27 | -0.12% |
| Sept. 30, 2025 | $1.46 | $0.87 | 0.59% |
| June 30, 2025 | $3.28 | $2.63 | 0.65% |
| March 31, 2025 | $0.63 | $0.09 | 0.54% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| RIGL | $784M | 2.2 | 64.1% | 124.7% | 155.1% | — |
| OLMA | $2.03B | -13.4 | — | — | -39.4% | — |
| IMMX | $277M | -5.9 | — | — | -59.8% | — |
| FTH | — | — | — | — | — | — |
| ACHV | — | -4.0 | — | — | — | — |
| FDMT | $432M | -3.1 | 230194.6% | -164.4% | -30.2% | — |
| AURA | $347M | -3.1 | -29.7% | -1601.4% | -68.2% | — |
| MNPR | — | — | — | — | — | — |
| RGNX | $733M | -3.8 | 104.5% | -113.8% | -122.5% | — |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 16
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $294M | $179M | $117M | $120M | $149M | $109M | $59M | $45M | $4M | $20M | |
| Cost of Revenue | $20M | $19M | $7M | $2M | $1M | $895.0K | $906.0K | $287.0K | · | · | |
| R&D Expense | $33M | $23M | $25M | · | · | · | · | · | · | · | |
| SG&A Expense | $116M | $113M | $106M | $112M | $92M | $77M | $75M | $70M | $38M | $21M | |
| Operating Expenses | $169M | $155M | $137M | $176M | $162M | $138M | $128M | $117M | $84M | $90M | |
| Operating Income | $125M | $24M | $-20M | $-56M | $-12M | $-29M | $-69M | $-73M | $-80M | $-70M | |
| Interest Expense | · | $8M | $7M | $4M | $5M | $1M | $335.0K | · | · | · | |
| Interest Income | $4M | $2M | $2M | $684.0K | $47.0K | $582.0K | $3M | $2M | $892.0K | $437.0K | |
| Pretax Income | $122M | $18M | $-25M | $-59M | $-17M | $-30M | $-67M | · | · | · | |
| Income Tax | $-245M | $881.0K | $0 | · | $605.0K | · | · | $0 | $0 | $0 | |
| Net Income | $367M | $17M | $-25M | $-59M | $-18M | $-30M | $-67M | $-70M | $-78M | $-69M | |
| EPS (Basic) | $20.40 | $0.99 | $-1.44 | $-3.44 | $-0.11 | $-0.18 | $-0.40 | · | · | · | |
| EPS (Diluted) | $19.48 | $0.99 | $-1.44 | $-3.44 | $-0.11 | $-0.18 | $-0.40 | · | · | · | |
| Shares (Basic) | 17,987,000 | 17,579,000 | 17,401,000 | 17,049,000 | 170,492,000 | 168,754,000 | 167,400,000 | · | · | · | |
| Shares (Diluted) | 18,840,000 | 17,687,000 | 17,401,000 | 17,049,000 | 170,492,000 | 168,754,000 | 167,400,000 | · | · | · | |
| EBITDA | $128M | $26M | $-19M | $-55M | $-11M | $-28M | $-68M | $-72M | · | $-69M |
Balance Sheet 26
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $41M | $57M | $33M | $24M | $19M | $30M | $23M | $76M | $38M | $18M | |
| Short-term Investments | $114M | $21M | $24M | $34M | $106M | $27M | $76M | $52M | $77M | $57M | |
| Receivables | $52M | $42M | $31M | $40M | $15M | $16M | $10M | $4M | $0 | $0 | |
| Inventory | $12M | $6M | $6M | $9M | $7M | $2M | $1M | $894.0K | · | · | |
| Prepaid Expense | $22M | $10M | $6M | $8M | $7M | $14M | $9M | $3M | $2M | $1M | |
| Other Current Assets | $5M | $5M | · | · | · | · | · | · | · | · | |
| Current Assets | $240M | $135M | $99M | $116M | $154M | $89M | $119M | $137M | $117M | $76M | |
| PP&E (Net) | $30.0K | $92.0K | $165.0K | $857.0K | $2M | $3M | $2M | $1M | $875.0K | $1M | |
| PP&E (Gross) | $347.0K | $353.0K | $2M | $12M | $17M | $16M | $15M | $14M | $13M | $20M | |
| Accum. Depreciation | $317.0K | $261.0K | $2M | $11M | $15M | $14M | $13M | $13M | $12M | $19M | |
| Intangibles | $25M | $27M | $14M | $15M | · | · | · | · | · | · | |
| Other Non-current Assets | $2M | $2M | $3M | $640.0K | $974.0K | $824.0K | $696.0K | $735.0K | $803.0K | $764.0K | |
| Total Assets | $514M | $164M | $117M | $134M | $167M | $110M | $148M | $139M | $119M | $78M | |
| Accounts Payable | $7M | $3M | $7M | $23M | $4M | $4M | $4M | $6M | $3M | $6M | |
| Accrued Liabilities | · | · | · | · | $4M | $4M | $3M | · | · | · | |
| Current Liabilities | $99M | $63M | $53M | $65M | $64M | $41M | $58M | $28M | $18M | $23M | |
| Capital Leases | $395.0K | $0 | $285.0K | $972.0K | $759.0K | $11M | $19M | · | · | · | |
| Other Non-current Liabilities | $0 | $40M | $40M | $42M | $53M | $5M | $5M | · | $38.0K | $2.0K | |
| Total Liabilities | $122M | $161M | $146M | $148M | $137M | · | · | · | · | · | |
| Long-term Debt | $52M | $60M | $60M | $40M | $20M | $20M | $10M | · | · | · | |
| Common Stock | $18.0K | $18.0K | $17.0K | $174.0K | $172.0K | $169.0K | $168.0K | $167.0K | $147.0K | $100.0K | |
| Retained Earnings | $-1.02B | $-1.39B | $-1.41B | $-1.38B | $-1.32B | $-1.31B | $-1.28B | $-1.21B | $-1.14B | $-1.06B | |
| AOCI | $181.0K | $10.0K | $8.0K | $-153.0K | $-102.0K | $-4.0K | $23.0K | $-24.0K | $-82.0K | $-18.0K | |
| Stockholders' Equity | $391M | $3M | $-29M | $-14M | $30M | $34M | $54M | $110M | $101M | $55M | |
| Liabilities + Equity | $514M | $164M | $117M | $134M | $167M | $110M | $148M | $139M | $119M | $78M | |
| Shares Outstanding | 18,310,934 | 17,710,216 | 17,482,513 | 173,398,645 | 171,602,226 | 169,316,782 | 167,987,850 | 167,171,505 | 146,814,906 | 99,269,418 |
Cash Flow 16
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $2M | $2M | $1M | $998.0K | $1M | $706.0K | $683.0K | $594.0K | $465.0K | $941.0K | |
| Stock-based Comp | $13M | $12M | $9M | $12M | $9M | $7M | $9M | $8M | $6M | $7M | |
| Deferred Tax | $-246M | $0 | $0 | · | · | · | · | · | · | · | |
| Amort. of Intangibles | $2M | $2M | $1M | $100.0K | · | · | · | · | · | · | |
| Restructuring | · | · | · | $1M | $4M | · | · | · | · | $6M | |
| Other Non-cash | $-61M | $-635.0K | $9M | $-29M | $13M | $-30M | $16M | $3M | · | · | |
| Operating Cash Flow | $76M | $31M | $-6M | $-74M | $6M | $-52M | $-42M | $-59M | $-78M | $-76M | |
| CapEx | · | · | · | $450.0K | $627.0K | $1M | $1M | $1M | $164.0K | $804.0K | |
| Investing Cash Flow | $-92M | $4M | $-4M | $73M | $-80M | $47M | $-24M | $25M | $-19M | $25M | |
| Stock Issued | · | · | · | · | · | · | · | $67M | $114M | $24M | |
| Net Stock Activity | · | · | · | · | · | · | · | $67M | · | $30M | |
| Financing Cash Flow | $601.0K | $-12M | $18M | $7M | $63M | $13M | $11M | $72M | $118M | $25M | |
| Net Change in Cash | · | · | · | · | · | · | · | $38M | $21M | $-26M | |
| Taxes Paid | $1M | $331.0K | $81.0K | · | · | · | · | · | · | · | |
| Free Cash Flow | · | · | · | $-74M | $5M | $-53M | $-43M | $-60M | · | $-77M | |
| Levered FCF | · | · | · | · | $221.1K | · | · | · | · | · |
Profitability 7
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | 42.6% | 13.5% | -17.5% | -46.2% | -8.4% | -26.7% | -116.5% | -163.3% | · | · | |
| Net Margin | 124.7% | 9.8% | -21.5% | -48.7% | -12.0% | -27.4% | -112.8% | -158.3% | · | · | |
| Pretax Margin | 41.4% | 10.2% | -21.5% | -48.7% | -11.6% | · | · | · | · | · | |
| EBITDA Margin | 43.5% | 14.7% | -16.5% | -45.4% | -7.6% | -26.0% | -115.4% | -162.0% | · | · | |
| ROA | 108.3% | 12.4% | -20.0% | -38.8% | -12.9% | -23.1% | -46.7% | -54.6% | · | · | |
| ROE | 155.1% | -308.2% | 83.0% | 350.2% | -44.8% | -70.0% | -109.0% | -66.1% | · | · | |
| ROIC | 96.5% | 700.5% | · | · | -42.6% | · | · | · | · | · |
Liquidity & Solvency 3
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 2.4 | 2.1 | 1.9 | 1.8 | 2.4 | 2.2 | 2.0 | 4.9 | · | 3.4 | |
| Quick Ratio | 2.1 | 1.9 | 1.6 | 1.5 | 2.2 | 1.8 | 1.9 | 4.8 | · | 3.3 | |
| Interest Coverage | · | 3.1 | -3.0 | -15.0 | -2.6 | -21.4 | -206.2 | · | · | · |
Efficiency 3
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.9 | 1.3 | 0.9 | 0.8 | 1.1 | 0.8 | 0.4 | 0.3 | · | · | |
| Inventory Turnover | 2.2 | 3.2 | 1.0 | 0.2 | 0.3 | 0.6 | 0.8 | 0.6 | · | · | |
| Receivables Turnover | 6.3 | 5.0 | 3.3 | 4.3 | 9.5 | 8.3 | 8.4 | 21.8 | · | · |
Growth Rates 5
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue YoY | 64.1% | 53.4% | -2.8% | -19.4% | 37.4% | · | · | · | · | · | |
| Revenue CAGR 3Y | 34.8% | 6.3% | 2.5% | · | · | · | · | · | · | · | |
| Revenue CAGR 5Y | 22.1% | · | · | · | · | · | · | · | · | · | |
| EPS YoY | 1867.7% | · | · | · | · | · | · | · | · | · | |
| Net Income YoY | 1999.1% | · | · | · | · | · | · | · | · | · |
Valuation (TTM) 10
| Metric | Trend | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $294M | $179M | $117M | $120M | $149M | $109M | $59M | $45M | $4M | $20M | |
| Net Income TTM | $367M | $17M | $-25M | $-59M | $-18M | $-30M | $-67M | $-70M | $-78M | $-69M | |
| Market Cap | $784M | $298M | $2.53B | $2.60B | $4.55B | $5.93B | $3.59B | $3.84B | · | $2.36B | |
| P/E | 2.2 | 17.0 | -10.1 | -4.4 | -240.9 | -194.4 | -53.5 | · | · | · | |
| P/S | 2.7 | 1.7 | 21.7 | 21.6 | 30.5 | 54.6 | 60.6 | 86.4 | · | 115.9 | |
| P/B | 2.0 | 90.6 | -88.5 | -191.0 | 149.7 | 174.2 | 66.8 | 35.0 | · | 42.9 | |
| P / Tangible Book | 2.1 | · | · | · | 149.7 | 174.2 | · | · | · | · | |
| P / Cash Flow | 10.4 | 9.5 | -441.4 | -35.3 | 773.6 | -113.6 | -86.6 | -65.4 | · | -31.1 | |
| P / FCF | · | · | · | -35.0 | 866.0 | -110.9 | -83.7 | -64.2 | · | -30.8 | |
| Earnings Yield | 45.5% | 5.9% | -9.9% | -22.9% | -0.42% | -0.51% | -1.9% | · | · | · |
Income Statement 16
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $79M | $59M | $70M | $69M | $102M | $53M | $58M | $55M | $37M | $30M | $36M | $28M | $27M | $26M | $51M | $22M | |
| Cost of Revenue | $9M | $5M | $6M | $5M | $5M | $4M | $6M | $8M | $3M | $2M | $4M | $1M | $1M | $977.0K | $342.0K | $250.0K | |
| R&D Expense | $14M | $12M | · | · | $7M | $8M | · | · | · | · | · | · | · | · | · | · | |
| SG&A Expense | $33M | $31M | $30M | $29M | $29M | $28M | $30M | $27M | $28M | $28M | $27M | $25M | $26M | $28M | $32M | $26M | |
| Operating Expenses | $55M | $47M | $47M | $41M | $41M | $41M | $41M | $41M | $36M | $36M | $34M | $33M | $32M | $39M | $49M | $41M | |
| Operating Income | $24M | $12M | $23M | $28M | $61M | $13M | $17M | $14M | $447.0K | $-7M | $2M | $-4M | $-5M | $-13M | $2M | $-18M | |
| Interest Expense | · | · | · | $2M | $2M | $2M | · | $2M | $2M | $2M | · | $2M | $2M | $1M | $1M | $826.0K | |
| Interest Income | $789.0K | $1M | $1M | $1M | $753.0K | $591.0K | $522.0K | $425.0K | $552.0K | $593.0K | $678.0K | $672.0K | $529.0K | $393.0K | $429.0K | $192.0K | |
| Pretax Income | $24M | $12M | $23M | $28M | $60M | $12M | $15M | $12M | $-1M | $-8M | · | · | · | · | $1M | $-19M | |
| Income Tax | $6M | $3M | $-245M | $-280.0K | $369.0K | $65.0K | $881.0K | $0 | $0 | $0 | · | · | · | · | · | $0 | |
| Net Income | $17M | $9M | $268M | $28M | $60M | $11M | $14M | $12M | $-1M | $-8M | $737.0K | $-6M | $-7M | $-14M | $1M | $-19M | |
| EPS (Basic) | $0.93 | $0.47 | $14.88 | $1.55 | $3.33 | $0.64 | $0.81 | $0.71 | $-0.06 | $-0.47 | $-0.65 | $-0.33 | $-0.38 | $-0.08 | $-3.09 | $-0.11 | |
| EPS (Diluted) | $0.88 | $0.44 | $14.11 | $1.46 | $3.28 | $0.63 | $0.82 | $0.70 | $-0.06 | $-0.47 | $-0.65 | $-0.33 | $-0.38 | $-0.08 | $-3.09 | $-0.11 | |
| Shares (Basic) | 18,541,000 | 18,412,000 | -35,744,000 | 18,038,000 | 17,885,000 | 17,808,000 | -35,090,000 | 17,600,000 | 17,549,000 | 17,520,000 | -190,959,000 | 17,436,000 | 17,356,000 | 173,568,000 | -499,708,000 | 172,836,000 | |
| Shares (Diluted) | 19,570,000 | 19,686,000 | -36,647,000 | 19,156,000 | 18,162,000 | 18,169,000 | -35,030,000 | 17,648,000 | 17,549,000 | 17,520,000 | -190,959,000 | 17,436,000 | 17,356,000 | 173,568,000 | -499,708,000 | 172,836,000 | |
| EBITDA | $24M | $12M | · | $28M | $61M | $13M | · | $14M | $447.0K | $-7M | · | $-4M | $-5M | $-12M | · | $-18M |
Balance Sheet 25
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $61M | $24M | $41M | $49M | $53M | $46M | $57M | $52M | $36M | $26M | · | $45M | $49M | $40M | · | $30M | |
| Short-term Investments | $35M | $122M | $114M | $89M | $55M | $31M | $21M | $9M | $13M | $24M | · | $17M | $16M | $18M | · | $52M | |
| Receivables | $56M | $50M | $52M | $46M | $40M | $42M | $42M | $31M | $29M | $28M | · | $24M | $21M | $29M | · | $16M | |
| Inventory | $14M | $12M | $12M | $13M | $10M | $5M | $6M | $5M | $8M | $7M | · | $6M | $11M | $11M | · | $7M | |
| Prepaid Expense | $20M | $26M | $22M | $19M | $17M | $23M | $10M | $10M | $9M | $9M | · | $3M | $5M | $8M | · | $6M | |
| Other Current Assets | $5M | $7M | $5M | $6M | $5M | $6M | $5M | · | · | · | · | · | · | · | · | · | |
| Current Assets | $186M | $234M | $240M | $215M | $175M | $147M | $135M | $106M | $95M | $92M | · | $95M | $101M | $107M | · | $110M | |
| PP&E (Net) | · | · | $30.0K | $54.0K | $57.0K | $76.0K | $92.0K | $99.0K | $115.0K | $140.0K | · | $190.0K | $215.0K | $294.0K | · | $2M | |
| PP&E (Gross) | · | · | $347.0K | · | · | · | $353.0K | · | · | · | · | · | · | · | · | · | |
| Accum. Depreciation | · | · | $317.0K | · | · | · | $261.0K | · | · | · | · | · | · | · | · | · | |
| Intangibles | $94M | $24M | $25M | $25M | $26M | $27M | $27M | $28M | $28M | $29M | · | · | · | · | · | · | |
| Other Non-current Assets | $3M | $2M | $2M | $1M | $4M | $2M | $2M | $5M | $5M | $4M | · | $5M | $541.0K | $542.0K | · | $484.0K | |
| Total Assets | $521M | $505M | $514M | $243M | $207M | $176M | $164M | $139M | $128M | $127M | · | $115M | $117M | $124M | · | $116M | |
| Accounts Payable | $4M | $4M | $7M | $4M | $7M | $4M | $3M | $4M | $6M | $9M | · | $8M | $5M | $6M | · | $3M | |
| Current Liabilities | $96M | $89M | $99M | $94M | $87M | $67M | $63M | $54M | $59M | $73M | · | $48M | $44M | $46M | · | $47M | |
| Capital Leases | $58.0K | $228.0K | $395.0K | $556.0K | $714.0K | $864.0K | $0 | · | · | $100.0K | · | $466.0K | $628.0K | $802.0K | · | · | |
| Other Non-current Liabilities | · | · | $0 | · | · | $40M | $40M | $40M | $40M | $40M | · | $39M | $41M | $42M | · | $49M | |
| Total Liabilities | $96M | $105M | $122M | $125M | $125M | $157M | $161M | $154M | $158M | $158M | · | $147M | $145M | $148M | · | · | |
| Long-term Debt | · | $45M | $52M | $60M | $60M | $60M | · | $60M | $60M | $60M | · | $60M | $60M | $60M | · | $40M | |
| Common Stock | $18.0K | $18.0K | $18.0K | $18.0K | $18.0K | $18.0K | $18.0K | $17.0K | $17.0K | $175.0K | · | $175.0K | $175.0K | $174.0K | · | $173.0K | |
| Retained Earnings | $-997M | $-1.01B | $-1.02B | $-1.29B | $-1.32B | $-1.38B | $-1.39B | $-1.40B | $-1.42B | $-1.42B | · | $-1.41B | $-1.40B | $-1.40B | · | $-1.38B | |
| AOCI | $-148.0K | $-128.0K | $181.0K | $96.0K | $6.0K | $-2.0K | $10.0K | $11.0K | $-9.0K | $-5.0K | · | $-15.0K | $-25.0K | $-27.0K | · | $-286.0K | |
| Stockholders' Equity | $425M | $400M | $391M | $118M | $82M | $19M | $3M | $-15M | $-30M | $-32M | $-29M | $-32M | $-28M | $-24M | $-14M | $-20M | |
| Liabilities + Equity | $521M | $505M | $514M | $243M | $207M | $176M | $164M | $139M | $128M | $127M | · | $115M | $117M | $124M | · | $116M | |
| Shares Outstanding | · | · | 18,310,934 | · | · | · | 17,710,216 | · | · | · | · | · | · | · | · | · |
Cash Flow 10
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $848.0K | $597.0K | $601.0K | $603.0K | $607.0K | $604.0K | $604.0K | $611.0K | $613.0K | $400.0K | $293.0K | $292.0K | $296.0K | $357.0K | $284.0K | $240.0K | |
| Stock-based Comp | $7M | $3M | $3M | $3M | $3M | $3M | $2M | $3M | $3M | $5M | $2M | $2M | $2M | $3M | $4M | $3M | |
| Amort. of Intangibles | · | $600.0K | $600.0K | $600.0K | $600.0K | $600.0K | $500.0K | $600.0K | $600.0K | $400.0K | $200.0K | $300.0K | $300.0K | $300.0K | · | · | |
| Other Non-cash | · | $-10M | · | · | · | $-16M | · | · | · | $-2M | · | · | · | $6M | · | · | |
| Operating Cash Flow | $31M | $3M | $22M | $24M | $31M | $-893.0K | $15M | $22M | $302.0K | $-5M | $-6M | $-1M | $6M | $-4M | $-22M | $-13M | |
| CapEx | · | · | · | · | · | · | · | · | · | · | · | · | · | · | · | $189.0K | |
| Investing Cash Flow | $17M | $-8M | $-25M | $-33M | $-23M | $-11M | $-11M | $4M | $11M | $313.0K | $-7M | $-1M | $3M | $777.0K | $19M | $10M | |
| Stock Repurchased | $511.0K | $4M | · | · | $0 | $0 | · | · | · | · | · | · | · | · | · | · | |
| Net Stock Activity | · | $-4M | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Financing Cash Flow | $-12M | $-11M | $-5M | $4M | $418.0K | $484.0K | $1M | $-10M | $-752.0K | $-3M | $486.0K | $-869.0K | $-373.0K | $19M | $-2M | $6M |
Profitability 7
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | 29.9% | 20.2% | · | 40.9% | 60.1% | 23.9% | · | 25.4% | 1.2% | -23.6% | · | -15.9% | -19.6% | -48.8% | · | -82.1% | |
| Net Margin | 22.0% | 14.7% | · | 40.2% | 58.6% | 21.5% | · | 22.5% | -2.8% | -27.9% | · | -20.2% | -24.6% | -51.9% | · | -85.0% | |
| Pretax Margin | 30.0% | 19.8% | · | 39.8% | 59.0% | 21.6% | · | · | · | · | · | · | · | · | · | -85.0% | |
| EBITDA Margin | 29.9% | 21.2% | · | 40.9% | 60.1% | 25.1% | · | 25.4% | 1.2% | -22.2% | · | -15.9% | -19.6% | -47.4% | · | -82.1% | |
| ROA | 4.8% | 2.5% | · | 14.6% | 35.6% | 7.6% | · | 9.8% | -0.84% | -6.6% | · | -4.9% | -5.4% | -9.9% | · | -12.6% | |
| ROE | 6.8% | 4.1% | · | 54.2% | 229.2% | -174.7% | · | -53.5% | 3.5% | 29.5% | · | 22.0% | 41.5% | 155.1% | · | -127.6% | |
| ROIC | 4.1% | 2.2% | · | 24.4% | 74.1% | 68.4% | · | · | · | · | · | · | · | · | · | 92.8% |
Liquidity & Solvency 3
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 1.9 | 2.6 | · | 2.3 | 2.0 | 2.2 | · | 2.0 | 1.6 | 1.3 | · | 2.0 | 2.3 | 2.4 | · | 2.3 | |
| Quick Ratio | 1.6 | 2.2 | · | 1.9 | 1.7 | 1.8 | · | 1.7 | 1.3 | 1.1 | · | 1.8 | 1.9 | 1.9 | · | 2.1 | |
| Interest Coverage | · | · | · | 15.0 | 32.6 | 6.9 | · | 6.8 | 0.2 | -3.7 | · | -2.4 | -2.8 | -10.6 | · | -22.3 |
Efficiency 3
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.2 | 0.2 | · | 0.4 | 0.6 | 0.4 | · | 0.4 | 0.3 | 0.2 | · | 0.2 | 0.2 | 0.2 | · | 0.1 | |
| Inventory Turnover | 0.7 | 0.6 | · | 0.5 | 0.5 | 0.8 | · | 1.5 | 0.3 | 0.2 | · | 0.2 | 0.1 | 0.1 | · | 0.0 | |
| Receivables Turnover | 1.6 | 1.3 | · | 1.8 | 3.0 | 1.5 | · | 2.0 | 1.5 | 1.0 | · | 1.4 | 1.4 | 1.2 | · | 1.5 |
Valuation (TTM) 4
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $309M | $283M | · | $280M | $247M | $175M | · | $150M | $121M | $111M | · | $104M | $105M | $95M | · | $91M | |
| Net Income TTM | $113M | $108M | · | $111M | $82M | $15M | · | $-3M | $-22M | $-34M | · | $-45M | $-53M | $-74M | · | $-81M | |
| P/E | 6.5 | 4.7 | · | 4.7 | 4.1 | 22.5 | · | -101.1 | -6.6 | -11.7 | · | -12.0 | -19.8 | -30.7 | · | -25.1 | |
| Earnings Yield | 15.5% | 21.5% | · | 21.4% | 24.3% | 4.5% | · | -0.99% | -15.1% | -8.5% | · | -8.3% | -5.0% | -3.3% | · | -4.0% |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Revenue | $294M | $179M | $117M | $120M | $149M |
| Operating Margin % | 42.6% | 13.5% | -17.5% | -46.2% | -8.4% |
| Net Income | $367M | $17M | $-25M | $-59M | $-18M |
| Diluted EPS | $19.48 | $0.99 | $-1.44 | $-3.44 | $-0.11 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Current Ratio | 2.4 | 2.1 | 1.9 | 1.8 | 2.4 |
| Quick Ratio | 2.1 | 1.9 | 1.6 | 1.5 | 2.2 |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Free Cash Flow | — | — | — | $-74M | $5M |
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Institutional owners (13F) 171 filers · $452.8M total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 37 (+20 vs prior Q) | 23 (-21 vs prior Q) | 43 (-25 vs prior Q) | 59 (+11 vs prior Q) | +508K |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Soleus Capital Management, L.P. | $72,117,876 | 1,843,504 | 15.93% | Shares |
| ARMISTICE CAPITAL, LLC | $65,408,640 | 1,672,000 | 14.44% | Shares |
| STATE STREET CORP | $40,684,565 | 1,039,994 | 8.98% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $30,713,386 | 785,107 | 6.78% | Shares |
| AMERICAN CENTURY COMPANIES INC | $29,016,008 | 741,718 | 6.41% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $16,233,871 | 414,860 | 3.59% | Shares |
| CM Management, LLC | $9,780,000 | 250,000 | 2.16% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $9,143,439 | 233,728 | 2.02% | Shares |
| D. E. Shaw & Co., Inc. | $8,343,357 | 213,276 | 1.84% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $8,288,120 | 211,864 | 1.83% | Shares |
| TWO SIGMA INVESTMENTS, LP | $8,120,451 | 207,578 | 1.79% | Shares |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $7,628,000 | 195,000 | 1.68% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6,049,008 | 154,627 | 1.34% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $5,705,496 | 145,846 | 1.26% | Shares |
| GOLDMAN SACHS GROUP INC | $5,507,079 | 140,774 | 1.22% | Shares |
| VANGUARD GROUP INC | $5,228,301 | 122,071 | 1.15% | Shares |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $5,131,644 | 131,177 | 1.13% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $4,875,134 | 124,620 | 1.08% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $4,858,078 | 124,184 | 1.07% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $4,762,195 | 121,733 | 1.05% | Shares |
| BANK OF AMERICA CORP /DE/ | $4,448,962 | 113,726 | 0.98% | Shares |
| GLOBEFLEX CAPITAL L P | $4,407,729 | 112,672 | 0.97% | Shares |
| CenterBook Partners LP | $4,286,574 | 109,575 | 0.95% | Shares |
| FMR LLC | $3,759,432 | 96,100 | 0.83% | Shares |
| RITHOLTZ WEALTH MANAGEMENT | $3,694,884 | 94,450 | 0.82% | Shares |
| JANUS HENDERSON GROUP PLC | $3,674,114 | 135,877 | 0.81% | Shares |
| MILLENNIUM MANAGEMENT LLC | $3,665,114 | 93,689 | 0.81% | Shares |
| FIRST TRUST ADVISORS LP | $3,182,099 | 81,342 | 0.70% | Shares |
| Empowered Funds, LLC | $3,097,678 | 79,184 | 0.68% | Shares |
| Brandywine Global Investment Management, LLC | $3,065,343 | 71,570 | 0.68% | Shares |
| FRANKLIN RESOURCES INC | $2,831,114 | 72,370 | 0.63% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2,687,544 | 68,700 | 0.59% | Call option |
| Squarepoint Ops LLC | $2,607,661 | 66,658 | 0.58% | Shares |
| BlackRock, Inc. | $2,389,410 | 61,079 | 0.53% | Shares |
| BURNEY CO/ | $2,181,683 | 55,769 | 0.48% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $2,159,424 | 55,200 | 0.48% | Shares |
| OMERS ADMINISTRATION Corp | $2,030,328 | 51,900 | 0.45% | Shares |
| PRINCIPAL FINANCIAL GROUP INC | $2,017,066 | 51,561 | 0.45% | Shares |
| Woodline Partners LP | $1,956,000 | 50,000 | 0.43% | Shares |
| Connor, Clark & Lunn Investment Management Ltd. | $1,920,636 | 49,096 | 0.42% | Shares |
| SEGALL BRYANT & HAMILL, LLC | $1,794,747 | 45,878 | 0.40% | Shares |
| Inspire Investing, LLC | $1,727,613 | 63,891 | 0.38% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,635,216 | 41,800 | 0.36% | Put option |
| WELLS FARGO & COMPANY/MN | $1,528,927 | 39,083 | 0.34% | Shares |
| ALPS ADVISORS INC | $1,488,633 | 38,053 | 0.33% | Shares |
| Bank of New York Mellon Corp | $1,393,963 | 35,633 | 0.31% | Shares |
| Virtus Investment Advisers, LLC | $1,384,848 | 35,400 | 0.31% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $1,370,334 | 35,029 | 0.30% | Shares |
| Trexquant Investment LP | $1,312,945 | 33,562 | 0.29% | Shares |
| SIERRA SUMMIT ADVISORS LLC | $1,246,990 | 31,876 | 0.28% | Shares |
| CITIGROUP INC | $1,232,436 | 31,504 | 0.27% | Shares |
| CREDIT AGRICOLE S A | $1,126,656 | 28,800 | 0.25% | Shares |
| RHUMBLINE ADVISERS | $1,016,483 | 25,984 | 0.22% | Shares |
| CITADEL ADVISORS LLC | $962,352 | 24,600 | 0.21% | Call option |
| Vanguard Global Advisers, LLC | $949,247 | 24,265 | 0.21% | Shares |
| Engineers Gate Manager LP | $933,638 | 23,866 | 0.21% | Shares |
| AXA Investment Managers S.A. | $923,388 | 32,594 | 0.20% | Shares |
| DIADEMA PARTNERS LP | $892,562 | 22,816 | 0.20% | Shares |
| ALLIANCEBERNSTEIN L.P. | $866,172 | 32,033 | 0.19% | Shares |
| MARSHALL WACE, LLP | $863,770 | 22,080 | 0.19% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $847,730 | 21,670 | 0.19% | Shares |
| STRS OHIO | $813,696 | 20,800 | 0.18% | Shares |
| Man Group plc | $813,540 | 20,796 | 0.18% | Shares |
| Quantinno Capital Management LP | $802,116 | 20,504 | 0.18% | Shares |
| HSBC HOLDINGS PLC | $744,752 | 18,577 | 0.16% | Shares |
| CANADA PENSION PLAN INVESTMENT BOARD | $735,456 | 18,800 | 0.16% | Shares |
| Rafferty Asset Management, LLC | $707,094 | 18,075 | 0.16% | Shares |
| DEUTSCHE BANK AG\ | $702,478 | 17,957 | 0.16% | Shares |
| MACKENZIE FINANCIAL CORP | $701,109 | 17,922 | 0.15% | Shares |
| TWO SIGMA ADVISERS, LP | $693,760 | 16,198 | 0.15% | Shares |
| Aquatic Capital Management LLC | $674,155 | 17,233 | 0.15% | Shares |
| CITADEL ADVISORS LLC | $668,952 | 17,100 | 0.15% | Put option |
| WELLINGTON MANAGEMENT GROUP LLP | $632,062 | 16,157 | 0.14% | Shares |
| BOKF, NA | $598,771 | 15,306 | 0.13% | Shares |
| NJ State Employees Deferred Compensation Plan | $566,600 | 20,000 | 0.13% | Shares |
| Pale Fire Capital SE | $557,538 | 14,252 | 0.12% | Shares |
| AVIVA PLC | $529,607 | 13,538 | 0.12% | Shares |
| BARCLAYS PLC | $524,091 | 13,397 | 0.12% | Shares |
| Graham Capital Management, L.P. | $471,396 | 12,050 | 0.10% | Shares |
| MetLife Investment Management, LLC | $447,063 | 11,428 | 0.10% | Shares |
| OSAIC HOLDINGS, INC. | $436,075 | 11,151 | 0.10% | Shares |
| Nuveen Asset Management, LLC | $387,751 | 23,053 | 0.09% | Shares |
| WOLVERINE TRADING, LLC | $376,625 | 13,100 | 0.08% | Call option |
| PROFUND ADVISORS LLC | $358,887 | 9,174 | 0.08% | Shares |
| PRUDENTIAL FINANCIAL INC | $337,527 | 8,628 | 0.07% | Shares |
| Advantage Alpha Capital Partners LP | $334,407 | 11,804 | 0.07% | Shares |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $296,099 | 7,569 | 0.07% | Shares |
| JANE STREET GROUP, LLC | $285,576 | 7,300 | 0.06% | Call option |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $280,177 | 7,162 | 0.06% | Shares |
| Invesco Ltd. | $277,126 | 7,084 | 0.06% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $275,248 | 7,036 | 0.06% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $243,053 | 6,213 | 0.05% | Shares |
| Caprock Group, LLC | $238,828 | 6,105 | 0.05% | Shares |
| Jump Financial, LLC | $238,632 | 6,100 | 0.05% | Shares |
| Persistent Asset Partners Ltd | $227,718 | 5,821 | 0.05% | Shares |
| Police & Firemen's Retirement System of New Jersey | $227,600 | 5,818 | 0.05% | Shares |
| Nuveen, LLC | $226,231 | 5,783 | 0.05% | Shares |
| Russell Investments Group, Ltd. | $210,504 | 5,381 | 0.05% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $133,908 | 3,423 | 0.03% | Shares |
| MORGAN STANLEY | $131,678 | 3,366 | 0.03% | Shares |
Company insiders 41 insiders · 19 officers · 21 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Raul R Rodriguez | CEO, President | June 17, 2026 A | 279,593 | 0 | 0 | $0 |
| James M Gower | CEO & Board Chairman | Feb. 27, 2014 A | 180,676 | 0 | 0 | $0 |
| Dean L Schorno | EVP & Chief Financial Officer | June 17, 2026 A | 78,790 | 0 | 0 | $0 |
| Ryan D Maynard | EVP & CFO | Nov. 3, 2017 M | 0 | 0 | 0 | $0 |
| James H Welch | CFO, VP & Secretary | Jan. 25, 2006 A | 3,757 | 0 | 0 | $0 |
| Lisa Rojkjaer | EVP, Chief Medical Officer | June 17, 2026 A | 34,003 | 0 | 0 | $0 |
| David A Santos | EVP, Chief Commercial Officer | June 17, 2026 A | 61,996 | 0 | 0 | $0 |
| Raymond J. Furey | EVP, GC, CCO & Corp Sec | June 17, 2026 A | 50,936 | 0 | 0 | $0 |
| Wolfgang Dummer | EVP & CMO | Feb. 2, 2023 S | 72,459 | 0 | 0 | $0 |
| Dolly Vance | EVP Corp. Affairs, G.C., Sect. | Sept. 14, 2022 A | 575 | 0 | 0 | $0 |
| Nelson Cabatuan | VP,Finance & Princ.Acctg. Off. | May 14, 2020 A | 58 | 0 | 0 | $0 |
| Eldon C. Mayer III | EVP & Chief Commercial Officer | Nov. 18, 2019 A | 215,000 | 0 | 0 | $0 |
| Joseph Lasaga | Sr.VP Bus.Dev.Alliance Mgmt. | Nov. 18, 2019 A | — | 0 | 0 | $0 |
| Esteban Masuda | Sr. VP Research | Nov. 18, 2019 S | — | 0 | 0 | $0 |
| Stacy Markel | EVP Human Resources | March 20, 2019 A | — | 0 | 0 | $0 |
| Anne-Marie Duliege | EVP & Chief Medical Officer | March 20, 2019 A | 0 | 0 | 0 | $0 |
| Donald G Payan | EVP, Pres. Discovery&Research | Aug. 30, 2016 S | 53,031 | 0 | 0 | $0 |
| Elliot B Grossbard | EVP, CMO | Jan. 26, 2016 A | 2,000 | 0 | 0 | $0 |
| Robin D G Cooper | Sr. V.P. Pharmaceutical Scs. | Jan. 31, 2008 A | 9,000 | 0 | 0 | $0 |
| Kamil Ali-Jackson | Director | June 22, 2026 S | 10,125 | 0 | 2 | $-160,425 |
| Alison L. Hannah | Director | May 15, 2026 A | 16,375 | 0 | 0 | $0 |
| Mark W Frohlich | Director | May 15, 2026 A | 7,000 | 0 | 0 | $0 |
| Jane Wasman | Director | May 15, 2026 A | 18,250 | 0 | 0 | $0 |
| Anthony Gregg Lapointe | Director | May 15, 2026 A | 18,250 | 0 | 0 | $0 |
| MILLER MICHAEL PATRICK | Director | May 15, 2026 A | 5,937 | 0 | 0 | $0 |
| Walter H Moos | Director | May 15, 2026 A | 18,472 | 0 | 1 | $-145,440 |
| Brian L. Kotzin | Director | May 25, 2024 A | 100,000 | 0 | 0 | $0 |
| LYONS GARY A | Director | May 26, 2023 A | 75,000 | 0 | 0 | $0 |
| Keith Katkin | Director | May 19, 2021 A | 25,000 | 0 | 0 | $0 |
| Bradford S Goodwin | Director | May 19, 2021 A | 35,000 | 0 | 0 | $0 |
| Peter S Ringrose | Director | May 17, 2018 A | — | 0 | 0 | $0 |
| SHERWIN STEPHEN A | Director | May 11, 2016 A | — | 0 | 0 | $0 |
| Hollings Renton | Director | May 15, 2013 A | — | 0 | 0 | $0 |
| Jean Deleage | Director | May 28, 2010 A | 697 | 0 | 0 | $0 |
| Alan D Frazier | Director | Aug. 7, 2006 A | 10,905 | 0 | 0 | $0 |
| Nicholas J Simon III | Director | June 3, 2005 A | 0 | 0 | 0 | $0 |
| Dennis Henner | Director | Jan. 5, 2005 S | 0 | 0 | 0 | $0 |
| Michael Steinmetz | 10% owner | Aug. 2, 2004 S | 1,833,597 | 0 | 0 | $0 |
| Nicholas Galakatos | 10% owner | July 2, 2004 S | 1,833,597 | 0 | 0 | $0 |
| Luke Evnin | 10% owner | July 2, 2004 S | 1,833,597 | 0 | 0 | $0 |
| ANSBERT GADICKE | 10% owner | July 2, 2004 J | 0 | 0 | 0 | $0 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 5 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| Undisclosed reporting person, Undisclosed reporting person, Undisclosed reporting person | Jan. 27, 2005 | — | Initial filing | Passive investment | SEC |
| I.R.S.Identification Nos. of above persons (entities only). FRAZIER HEALTHCARE II, L.P., I.R.S.Identification Nos. of above persons (entities only). FHM II, L.L.C., I.R.S.Identification Nos. of above persons (entities only). FRAZIER HEALTHCARE IV, L.P., I.R.S.Identification Nos. of above persons (entities only). FRAZIER AFFILIATES IV, L.P.., I.R.S.Identification Nos. of above persons (entities only). FHM IV, L.P., I.R.S.Identification Nos. of above persons (entities only). FHM IV, L.L.C., I.R.S.Identification Nos. of above persons (entities only). FRAZIER MANAGEMENT, L.L.C., I.R.S.Identification Nos. of above persons (entities only). FRAZIER & COMPANY, INC., I.R.S.Identification Nos. of above persons (entities only). ALAN D. FRAZIER | April 14, 2004 | — | Initial filing | Passive investment | SEC |
| Undisclosed reporting person, Undisclosed reporting person, Undisclosed reporting person, Undisclosed reporting person | July 7, 2003 | — | Initial filing | Board campaign | SEC |
| MPM BioVentures III, L.P., MPM BioVentures III-QP, L.P., MPM BioVentures III Parallel Fund, L.P., MPM BioVentures III GmbH & Co. Beteiligungs KG, MPM Asset Management Investors 2003 BVIII, LLC, MPM BioEquities Master Fund, L.P., MPM BioVentures III GP, LP, MPM BioVentures III LLC, MPM BioEquities GP, LP, MPM BioEquities GP, LLC, Luke Evnin, Ansbert Gadicke, Nicholas Galakatos, Dennis Henner, Robert Liptak, Nick Simon, III, Michael Steinmetz, Kurt von Emster, Kurt Wheeler | July 7, 2003 | — | Initial filing | Board campaign | SEC |
| MPM Bio Ventures III, L.P., MPM Bio Ventures III-QP, L.P., MPM Bio Ventures III Parallel Fund, L.P., MPM Bio Ventures III GmbH & Co. Beteiligungs KG, MPM Asset Management Investors 2003 BVIII, LLC, MPM BioEquities Master Fund, L.P., MPM Bio Ventures III GP, L.P., MPM Bio Ventures III LLC, MPM BioEquities GP, L.P., MPM BioEquities GP, LLC, Luke Evnin, Ansbert Gadicke, Nicholas Galakatos, Dennis Henner, Robert Liptak, Nicholas Simon, III, Michael Steinmetz, Kurt von Emster, Kurt Wheeler | May 14, 2003 | — | Initial filing | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 52 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| AFSM · First Trust Exchange-Traded Fund VI… | 0.53% | 17,221 NS | May 31, 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0.52% | 6,766 NS | April 30, 2026 | N-PORT |
| BRNY · EA Series Trust | 0.45% | 86,788 NS | April 30, 2026 | N-PORT |
| SBIO · ALPS ETF Trust | 0.36% | 19,042 NS | May 31, 2026 | N-PORT |
| JSML · Janus Detroit Street Trust | 0.34% | 37,605 NS | April 30, 2026 | N-PORT |
| JSMD · Janus Detroit Street Trust | 0.30% | 102,534 NS | April 30, 2026 | N-PORT |
| BFOR · ALPS ETF Trust | 0.27% | 19,079 NS | May 31, 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0.23% | 40,551 NS | April 30, 2026 | N-PORT |
| JPSE · J.P. Morgan Exchange-Traded Fund Tr… | 0.15% | 30,071 NS | April 30, 2026 | N-PORT |
| CALF · Pacer Funds Trust | 0.10% | 113,280 NS | April 30, 2026 | N-PORT |
| PSC · Principal Exchange-Traded Funds | 0.09% | 50,972 NS | June 30, 2026 | N-PORT |
| GSSC · Goldman Sachs ETF Trust | 0.07% | 23,773 NS | May 31, 2026 | N-PORT |
| AVUV · AMERICAN CENTURY ETF TRUST | 0.07% | 594,889 NS | May 31, 2026 | N-PORT |
| BIB · ProShares Trust | 0.03% | 672 NS | May 31, 2026 | N-PORT |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.02% | 20,787 NS | May 31, 2026 | N-PORT |
| RSSL · Global X Funds | 0.02% | 7,831 NS | April 30, 2026 | N-PORT |
| ITWO · ProShares Trust | 0.01% | 843 NS | May 31, 2026 | N-PORT |
| DFAS · Dimensional ETF Trust | 0.01% | 58,389 NS | April 30, 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.01% | 89,359 NS | May 31, 2026 | N-PORT |
| UWM · ProShares Trust | 0.01% | 659 NS | May 31, 2026 | N-PORT |
| AVSU · AMERICAN CENTURY ETF TRUST | 0.01% | 1,135 NS | May 31, 2026 | N-PORT |
| URTY · ProShares Trust | 0.01% | 665 NS | May 31, 2026 | N-PORT |
| DXUV · Dimensional ETF Trust | 0.01% | 700 NS | April 30, 2026 | N-PORT |
| AVUS · AMERICAN CENTURY ETF TRUST | 0.00% | 18,569 NS | May 31, 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.00% | 677 NS | May 31, 2026 | N-PORT |
| HDG · ProShares Trust | 0.00% | 17 NS | May 31, 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 2,458 NS | April 30, 2026 | N-PORT |
| DFAC · Dimensional ETF Trust | 0.00% | 17,507 NS | April 30, 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0.00% | 3,011 NS | April 30, 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0.00% | 5,798 NS | April 30, 2026 | N-PORT |
| SCHB · SCHWAB STRATEGIC TRUST | 0.00% | 10,304 NS | May 31, 2026 | N-PORT |
| DFUV · Dimensional ETF Trust | 0.00% | 112 NS | April 30, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | — | — | July 15, 2026 | Daily |
| VTI · VANGUARD INDEX FUNDS | — | — | July 15, 2026 | Daily |
| VFMO · VANGUARD WELLINGTON FUND | — | — | July 30, 2026 | Daily |
| VFMF · VANGUARD WELLINGTON FUND | — | — | July 30, 2026 | Daily |
| VTWO · VANGUARD SCOTTSDALE FUNDS | — | — | July 15, 2026 | Daily |
| VTWV · VANGUARD SCOTTSDALE FUNDS | — | — | July 15, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | — | — | July 15, 2026 | Daily |
| ITOT · iShares Trust | — | — | Aug. 5, 2026 | Daily |
| IWV · iShares Trust | — | — | Aug. 18, 2026 | Daily |
| IWN · iShares Trust | — | — | Aug. 17, 2026 | Daily |
| IWM · iShares Trust | — | — | Aug. 18, 2026 | Daily |
| IBB · iShares Trust | — | — | Aug. 18, 2026 | Daily |
| IWC · iShares Trust | — | — | Aug. 18, 2026 | Daily |
| PRFZ · Invesco Exchange-Traded Fund Trust | — | — | July 13, 2026 | Daily |
| OMFS · Invesco Exchange-Traded Self-Indexe… | — | — | July 13, 2026 | Daily |
| VHT · VANGUARD WORLD FUND | — | — | July 20, 2026 | Daily |
| IDNA · iShares Trust | — | — | Aug. 12, 2026 | Daily |
| TECB · iShares Trust | — | — | Aug. 5, 2026 | Daily |