Patrick Machado

Insider

First SEC filing: June 3, 2026 · Latest: June 3, 2026

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Insider at Companies where this person is a reporting insider.
Insider transactions Every share this person bought or sold, from Form 4 filings.
Derivatives Options and other derivative holdings reported by this person.
Initial holdings The stakes this person held when they first started reporting.

Insider at

Insider transactions

0 buys (P) 0 sells (S) Net: $0 + 27 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

27 other filings hidden

Date	Ticker	Code	Shares	Price	Value	Owned after	Δ own	A/D	vs now
June 30, 2026	ALMS	A	15,528	—	—	15,528 Direct	—	Acquired	(price as of 2026-08-20)
June 30, 2026	ALMS	A	3,553	—	—	3,553 Direct	—	Acquired	(price as of 2026-08-20)
June 11, 2026	RCUS	A	16,900	—	—	16,900 Direct	—	Acquired	(price as of 2026-08-20)
June 11, 2026	RCUS	A	5,700	—	—	44,300 Direct	+14.77%	Acquired	(price as of 2026-08-20)
June 3, 2026	XENE	A	1,593	—	—	1,593 Direct	—	Acquired	(price as of 2026-08-20)
June 3, 2026	XENE	A	10,507	—	—	10,507 Direct	—	Acquired	(price as of 2026-08-20)
June 1, 2026	XENE	M	2,645	—	—	0 Direct	-100.00%	Disposed	(price as of 2026-08-20)
June 1, 2026	XENE	M	2,645	—	—	2,645 Direct	—	Acquired	(price as of 2026-08-20)
June 5, 2024	XENE	A	15,542	—	—	15,542 Direct	—	Acquired	(price as of 2026-08-20)
June 15, 2023	RCUS	A	19,500	—	—	19,500 Direct	—	Acquired	(price as of 2026-08-20)
June 15, 2023	RCUS	A	6,800	—	—	16,900 Direct	+67.33%	Acquired	(price as of 2026-08-20)
June 2, 2023	XENE	A	18,475	—	—	18,475 Direct	—	Acquired	(price as of 2026-08-20)
June 28, 2022	XENE	A	18,000	—	—	18,000 Direct	—	Acquired	(price as of 2026-08-20)
June 14, 2022	RCUS	A	16,800	—	—	16,800 Direct	—	Acquired	(price as of 2026-08-20)
June 14, 2022	RCUS	A	4,100	—	—	10,100 Direct	+68.33%	Acquired	(price as of 2026-08-20)
June 3, 2021	RCUS	A	14,100	—	—	14,100 Direct	—	Acquired	(price as of 2026-08-20)
June 3, 2021	RCUS	A	3,000	—	—	6,000 Direct	+100.00%	Acquired	(price as of 2026-08-20)
June 3, 2021	XENE	A	10,000	—	—	10,000 Direct	—	Acquired	(price as of 2026-08-20)
Nov. 5, 2020	XENE	A	20,000	—	—	20,000 Direct	—	Acquired	(price as of 2026-08-20)
June 4, 2020	RCUS	A	3,000	—	—	3,000 Direct	—	Acquired	(price as of 2026-08-20)
June 4, 2020	RCUS	A	14,000	—	—	14,000 Direct	—	Acquired	(price as of 2026-08-20)
Dec. 10, 2019	RCUS	A	50,000	—	—	50,000 Direct	—	Acquired	(price as of 2026-08-20)
Jan. 2, 2019	SCYX	A	22,500	—	—	22,500 Direct	—	Acquired	(price as of 2026-08-20)
Jan. 12, 2018	ABUS	P	664,000	$100.00	$66,400,000	1,164,000 Indirect	+132.80%	Acquired	-95.1% (price as of 2026-08-20)
Jan. 2, 2018	SCYX	A	19,989	—	—	19,989 Direct	—	Acquired	(price as of 2026-08-20)
Oct. 16, 2017	ABUS	P	500,000	$100.00	$50,000,000	500,000 Indirect	—	Acquired	-95.1% (price as of 2026-08-20)
June 20, 2017	RCKTW	A	45,000	—	—	45,000 Direct	—	Acquired	(price as of 2026-08-20)
Aug. 17, 2016	RCKTW	A	24,000	—	—	24,000 Direct	—	Acquired	(price as of 2026-08-20)
Sept. 24, 2015	SCYX	A	11,700	—	—	11,700 Direct	—	Acquired	(price as of 2026-08-20)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II)

Options, RSUs and convertible securities reported on Form 4 Table II.

Date	Ticker	Security	Underlying	Exercise price	Expiration	Shares	A/D
June 30, 2026	ALMS	Stock Option (Right to Buy)	Common Stock (15,528)	$28.14	June 29, 2036	15,528	Acquired
June 11, 2026	RCUS	Stock Option (Right to Buy)	Stock Option (Rights to Buy) (16,900)	$23.30	June 10, 2036	16,900	Acquired
June 3, 2026	XENE	Restricted Share Units	Common Shares (1,593)	$0.00	—	1,593	Acquired
June 3, 2026	XENE	Share Option (Right to Buy)	Common Shares (10,507)	$53.46	June 2, 2036	10,507	Acquired
June 1, 2026	XENE	Restricted Share Units	Common Shares (2,645)	—	—	2,645	Disposed
June 5, 2024	XENE	Stock Option (Right to Buy)	Common Shares (15,542)	$38.16	June 4, 2034	15,542	Acquired
June 15, 2023	RCUS	Stock Option (Right to Buy)	Common Stock (19,500)	$19.60	June 14, 2033	19,500	Acquired
June 2, 2023	XENE	Stock Option (Right to Buy)	Common Shares (18,475)	$38.96	June 1, 2033	18,475	Acquired
June 28, 2022	XENE	Stock Option (Right to Buy)	Common Shares (18,000)	$30.11	June 27, 2032	18,000	Acquired
June 14, 2022	RCUS	Stock Option (Right to Buy)	Common Stock (16,800)	$20.62	June 13, 2032	16,800	Acquired
June 3, 2021	RCUS	Stock Option (Right to Buy)	Common Stock (14,100)	$24.79	June 2, 2031	14,100	Acquired
June 3, 2021	XENE	Stock Option (Right to Buy)	Common Shares (10,000)	$18.56	June 2, 2031	10,000	Acquired
Nov. 5, 2020	XENE	Stock Option (Right to Buy)	Common Shares (20,000)	$11.85	Nov. 4, 2030	20,000	Acquired
June 4, 2020	RCUS	Stock Option (Right to Buy)	Common Stock (14,000)	$30.05	June 3, 2030	14,000	Acquired
Dec. 10, 2019	RCUS	Stock Option (right to buy)	Common Stock (50,000)	$8.55	Dec. 9, 2029	50,000	Acquired
Jan. 2, 2019	SCYX	Stock Option (right to buy)	Common Stock (22,500)	$0.54	Jan. 1, 2029	22,500	Acquired
Jan. 12, 2018	ABUS	Series A Participating Convertible Preferred Shares	Common shares, no par value	—	Oct. 16, 2021	664,000	Acquired
Jan. 2, 2018	SCYX	Stock Option (right to buy)	Common Stock (19,989)	$2.28	Jan. 1, 2028	19,989	Acquired
Oct. 16, 2017	ABUS	Series A Participating Convertible Preferred Shares	Common shares, no par value	—	Oct. 16, 2021	500,000	Acquired
June 20, 2017	RCKTW	Stock Options (Right to Buy)	Common Stock (45,000)	$1.80	June 19, 2027	45,000	Acquired
Aug. 17, 2016	RCKTW	Stock Options (Right to Buy)	Common Stock (24,000)	$6.91	Aug. 17, 2026	24,000	Acquired
Sept. 24, 2015	SCYX	Stock Option (right to buy)	Common Stock (11,700)	$6.89	Sept. 23, 2025	11,700	Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 8 holdings

Securities held when first becoming an insider, per SEC Form 3.

Date	Ticker	Security	Shares	Ownership
Oct. 1, 2021	ROIV	Stock Option (Right to Buy)→ Common Shares (170,167)	170,167	Direct
Oct. 1, 2021	ROIV	Stock Option (Right to Buy)→ Common Shares (109,732)	109,732	Direct
Oct. 1, 2021	ROIV	Stock Option (Right to Buy)→ Common Shares (109,732)	109,732	Direct
Oct. 1, 2021	ROIV	Stock Option (Right to Buy)→ Common Shares (109,732)	109,732	Direct
Oct. 1, 2021	ROIV	Stock Option (Right to Buy)→ Common Shares (109,732)	109,732	Direct
Nov. 5, 2020	XENE	No securities are beneficially owned	0	Indirect
Nov. 5, 2020	XENE	No securities are beneficially owned→ N/A [F1]	—	Direct
Oct. 19, 2016	ABUS	Common Shares, no par value	16,013,540	Indirect