KOD — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | $776 051 487 | 19 919 186 | 34,05% | Actions |
| BlackRock, Inc. | $161 113 431 | 4 135 355 | 7,07% | Actions |
| STATE STREET CORP | $94 260 486 | 2 419 417 | 4,14% | Actions |
| GOLDMAN SACHS GROUP INC | $90 231 905 | 2 316 014 | 3,96% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $70 308 463 | 1 804 632 | 3,09% | Actions |
| BRAIDWELL LP | $69 633 909 | 1 787 318 | 3,06% | Actions |
| VANGUARD GROUP INC | $64 682 524 | 2 313 395 | 2,84% | Actions |
| RTW INVESTMENTS, LP | $57 969 909 | 1 487 934 | 2,54% | Actions |
| Boxer Capital Management, LLC | $57 567 296 | 1 477 600 | 2,53% | Actions |
| TCG Crossover Management, LLC | $56 318 161 | 1 445 538 | 2,47% | Actions |
| JANUS HENDERSON GROUP PLC | $50 539 675 | 1 325 457 | 2,22% | Actions |
| ICONIQ Capital, LLC | $49 345 294 | 1 266 563 | 2,17% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $41 420 974 | 1 062 955 | 1,82% | Actions |
| Ikarian Capital, LLC | $41 287 080 | 1 059 730 | 1,81% | Actions |
| Artisan Partners Limited Partnership | $37 714 722 | 968 037 | 1,66% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $30 919 164 | 793 613 | 1,36% | Actions |
| Board of Trustees of The Leland Stanford Junior University | $26 951 242 | 691 767 | 1,18% | Actions |
| SILVERARC CAPITAL MANAGEMENT, LLC | $21 282 134 | 546 256 | 0,93% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $20 758 628 | 532 819 | 0,91% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $19 480 000 | 500 000 | 0,85% | Actions |
| Squadron Capital Management LLC | $19 480 000 | 500 000 | 0,85% | Actions |
| TWO SIGMA INVESTMENTS, LP | $18 428 119 | 473 001 | 0,81% | Actions |
| MORGAN STANLEY | $16 948 748 | 435 029 | 0,74% | Actions |
| BANK OF AMERICA CORP /DE/ | $14 949 303 | 383 709 | 0,66% | Actions |
| BOONE CAPITAL MANAGEMENT LLC | $14 727 270 | 378 010 | 0,65% | Actions |
| NORTHERN TRUST CORP | $14 291 579 | 366 827 | 0,63% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $13 949 862 | 358 056 | 0,61% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $12 174 462 | 312 595 | 0,53% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $11 375 112 | 291 969 | 0,50% | Actions |
| FMR LLC | $10 791 298 | 276 984 | 0,47% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $10 344 815 | 265 524 | 0,45% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9 346 504 | 239 900 | 0,41% | Option d'achat |
| DIADEMA PARTNERS LP | $8 497 838 | 218 117 | 0,37% | Actions |
| Ikarian Capital, LLC | $8 481 592 | 217 700 | 0,37% | Option d'achat |
| D. E. Shaw & Co., Inc. | $8 232 248 | 211 300 | 0,36% | Actions |
| DIADEMA PARTNERS LP | $7 663 432 | 196 700 | 0,34% | Option d'achat |
| TD Asset Management Inc | $7 563 383 | 194 132 | 0,33% | Actions |
| PFM Health Sciences, LP | $7 531 552 | 193 315 | 0,33% | Actions |
| UBS Group AG | $7 406 880 | 190 115 | 0,33% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $7 371 232 | 189 200 | 0,32% | Actions |
| ALGERT GLOBAL LLC | $7 265 105 | 186 476 | 0,32% | Actions |
| Nuveen, LLC | $6 807 481 | 174 730 | 0,30% | Actions |
| CITADEL ADVISORS LLC | $6 137 135 | 157 524 | 0,27% | Actions |
| Squarepoint Ops LLC | $5 886 778 | 151 098 | 0,26% | Actions |
| Ghisallo Capital Management LLC | $5 844 000 | 150 000 | 0,26% | Actions |
| DIADEMA PARTNERS LP | $5 723 224 | 146 900 | 0,25% | Option de vente |
| Bruce & Co., Inc. | $5 649 200 | 145 000 | 0,25% | Actions |
| FEDERATED HERMES, INC. | $5 612 772 | 144 065 | 0,25% | Actions |
| PRUDENTIAL FINANCIAL INC | $4 694 485 | 120 495 | 0,21% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $4 444 907 | 114 089 | 0,20% | Actions |
| Bank of New York Mellon Corp | $4 360 988 | 111 935 | 0,19% | Actions |
| CITADEL ADVISORS LLC | $4 266 120 | 109 500 | 0,19% | Option d'achat |
| WELLS FARGO & COMPANY/MN | $3 928 921 | 100 845 | 0,17% | Actions |
| CITADEL ADVISORS LLC | $3 884 312 | 99 700 | 0,17% | Option de vente |
| Harvest Investment Services, LLC | $3 812 080 | 97 846 | 0,17% | Actions |
| Point72 Asset Management, L.P. | $3 802 379 | 97 597 | 0,17% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $3 775 146 | 96 898 | 0,17% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $3 662 824 | 94 015 | 0,16% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3 631 072 | 93 200 | 0,16% | Option de vente |
| VICTORY CAPITAL MANAGEMENT INC | $3 491 206 | 89 610 | 0,15% | Actions |
| RIA Advisory Group LLC | $3 398 442 | 87 229 | 0,15% | Actions |
| JPMORGAN CHASE & CO | $3 383 429 | 87 824 | 0,15% | Actions |
| Caption Management, LLC | $3 186 928 | 81 800 | 0,14% | Option d'achat |
| SPHERA FUNDS MANAGEMENT LTD. | $3 186 772 | 81 796 | 0,14% | Actions |
| Atom Investors LP | $2 993 803 | 76 843 | 0,13% | Actions |
| STEMPOINT CAPITAL LP | $2 955 973 | 75 872 | 0,13% | Actions |
| Invesco Ltd. | $2 901 156 | 74 465 | 0,13% | Actions |
| TWO SIGMA ADVISERS, LP | $2 882 676 | 103 100 | 0,13% | Actions |
| Qube Research & Technologies Ltd | $2 882 183 | 73 978 | 0,13% | Actions |
| FRANKLIN RESOURCES INC | $2 769 900 | 71 096 | 0,12% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $2 639 812 | 67 757 | 0,12% | Actions |
| ExodusPoint Capital Management, LP | $2 636 501 | 67 672 | 0,12% | Actions |
| Pictet Asset Management Holding SA | $2 497 778 | 66 015 | 0,11% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $2 446 688 | 62 800 | 0,11% | Option d'achat |
| CITIGROUP INC | $2 430 325 | 62 380 | 0,11% | Actions |
| Swiss National Bank | $2 415 520 | 62 000 | 0,11% | Actions |
| Persistent Asset Partners Ltd | $2 183 786 | 56 052 | 0,10% | Actions |
| Emerald Investment Advisers, LLC | $2 167 384 | 55 631 | 0,10% | Actions |
| DEUTSCHE BANK AG\ | $2 156 320 | 55 347 | 0,09% | Actions |
| Jain Global LLC | $2 151 098 | 55 213 | 0,09% | Actions |
| Resolute Capital Asset Partners LLC | $2 001 960 | 51 385 | 0,09% | Actions |
| RHUMBLINE ADVISERS | $1 955 700 | 50 198 | 0,09% | Actions |
| Informed Momentum Co LLC | $1 894 157 | 48 618 | 0,08% | Actions |
| Balyasny Asset Management L.P. | $1 809 536 | 46 446 | 0,08% | Actions |
| ALLIANCEBERNSTEIN L.P. | $1 800 026 | 47 220 | 0,08% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 717 123 | 44 074 | 0,08% | Actions |
| JANE STREET GROUP, LLC | $1 706 448 | 43 800 | 0,07% | Option d'achat |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1 667 788 | 43 751 | 0,07% | Actions |
| Rafferty Asset Management, LLC | $1 619 294 | 41 563 | 0,07% | Actions |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $1 585 672 | 40 700 | 0,07% | Actions |
| HighVista Strategies LLC | $1 581 387 | 40 590 | 0,07% | Actions |
| POLEN CAPITAL MANAGEMENT LLC | $1 381 872 | 35 469 | 0,06% | Actions |
| Russell Investments Group, Ltd. | $1 358 566 | 34 870 | 0,06% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1 335 977 | 34 291 | 0,06% | Actions |
| PANAGORA ASSET MANAGEMENT INC | $1 332 042 | 34 190 | 0,06% | Actions |
| Caption Management, LLC | $1 297 368 | 33 300 | 0,06% | Option de vente |
| MILLENNIUM MANAGEMENT LLC | $1 213 760 | 31 154 | 0,05% | Actions |
| Vanguard Global Advisers, LLC | $1 192 955 | 30 620 | 0,05% | Actions |
| Trexquant Investment LP | $1 171 332 | 30 065 | 0,05% | Actions |
| Engineers Gate Manager LP | $1 150 762 | 29 537 | 0,05% | Actions |
| Legal & General Group Plc | $1 141 880 | 29 309 | 0,05% | Actions |
| XTX Topco Ltd | $1 140 009 | 29 261 | 0,05% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $986 390 | 25 318 | 0,04% | Actions |
| Aries Wealth Management | $974 000 | 25 000 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $947 079 | 24 309 | 0,04% | Actions |
| State of Wyoming | $905 586 | 23 244 | 0,04% | Actions |
| MetLife Investment Management, LLC | $895 418 | 22 983 | 0,04% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $888 476 | 22 956 | 0,04% | Actions |
| BARCLAYS PLC | $819 717 | 21 040 | 0,04% | Actions |
| PROFUND ADVISORS LLC | $819 524 | 21 035 | 0,04% | Actions |
| Y-Intercept (Hong Kong) Ltd | $723 137 | 18 561 | 0,03% | Actions |
| OPTIMIZE FINANCIAL INC. | $692 202 | 17 767 | 0,03% | Actions |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $682 774 | 17 525 | 0,03% | Actions |
| Artia Global Partners LP | $663 060 | 17 019 | 0,03% | Actions |
| SEI INVESTMENTS CO | $620 547 | 15 928 | 0,03% | Actions |
| Vanguard Personalized Indexing Management, LLC | $606 296 | 15 562 | 0,03% | Actions |
| Palumbo Wealth Management LLC | $605 478 | 15 541 | 0,03% | Actions |
| SIMPLEX TRADING, LLC | $569 205 | 14 610 | 0,02% | Actions |
| Brevan Howard Capital Management LP | $546 336 | 14 023 | 0,02% | Actions |
| Edgestream Partners, L.P. | $527 207 | 13 532 | 0,02% | Actions |
| Continuum Advisory, LLC | $520 194 | 13 352 | 0,02% | Actions |
| FRED ALGER MANAGEMENT, LLC | $501 220 | 12 865 | 0,02% | Actions |
| LPL Financial LLC | $491 753 | 12 622 | 0,02% | Actions |
| Cerity Partners LLC | $488 871 | 12 548 | 0,02% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $478 702 | 12 287 | 0,02% | Actions |
| Campbell & CO Investment Adviser LLC | $476 442 | 12 229 | 0,02% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $460 624 | 11 823 | 0,02% | Actions |
| Quantinno Capital Management LP | $453 066 | 11 629 | 0,02% | Actions |
| Creative Planning | $445 430 | 11 433 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $422 755 | 10 851 | 0,02% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $404 989 | 10 395 | 0,02% | Actions |
| State of New Jersey Common Pension Fund D | $389 561 | 9 999 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $388 003 | 9 959 | 0,02% | Actions |
| Virtus Investment Advisers, LLC | $374 250 | 9 606 | 0,02% | Actions |
| STIFEL FINANCIAL CORP | $369 193 | 9 476 | 0,02% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $360 926 | 9 264 | 0,02% | Actions |
| Skopos Labs, Inc. | $346 473 | 9 089 | 0,02% | Actions |
| Persistent Asset Partners Ltd | $344 930 | 372 | 0,02% | Option de vente |
| ARIZONA STATE RETIREMENT SYSTEM | $332 446 | 8 533 | 0,01% | Actions |
| ALLSTATE CORP | $327 615 | 8 409 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $319 472 | 8 200 | 0,01% | Actions |
| NORGES BANK | $298 083 | 7 651 | 0,01% | Actions |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $287 914 | 7 390 | 0,01% | Actions |
| J. Goldman & Co LP | $284 759 | 7 309 | 0,01% | Actions |
| ProShare Advisors LLC | $280 784 | 7 207 | 0,01% | Actions |
| AMERICAN CENTURY COMPANIES INC | $255 032 | 6 546 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $249 344 | 6 400 | 0,01% | Actions |
| MANGROVE PARTNERS IM, LLC | $239 565 | 6 149 | 0,01% | Actions |
| PSP Research LLC | $233 760 | 6 000 | 0,01% | Actions |
| HSBC HOLDINGS PLC | $232 415 | 6 004 | 0,01% | Actions |
| E Fund Management Co., Ltd. | $228 345 | 5 861 | 0,01% | Actions |
| Persistent Asset Partners Ltd | $215 919 | 502 | 0,01% | Option d'achat |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $206 605 | 5 303 | 0,01% | Actions |
| VARCOV Co. | $204 696 | 5 254 | 0,01% | Actions |
| GROUP ONE TRADING LLC | $153 580 | 3 942 | 0,01% | Actions |
| Mitsubishi UFJ Trust & Banking Corp | $145 827 | 3 743 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $139 204 | 3 573 | 0,01% | Actions |
| CWM, LLC | $131 476 | 3 449 | 0,01% | Actions |
| ROYAL BANK OF CANADA | $131 000 | 3 362 | 0,01% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $126 567 | 3 248 611 | 0,01% | Actions |
| Tower Research Capital LLC (TRC) | $115 360 | 2 961 | 0,01% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $113 023 | 2 901 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $109 049 | 2 799 | 0,00% | Actions |
| Bayforest Capital Ltd | $105 932 | 2 719 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $96 582 | 2 479 | 0,00% | Actions |
| T. Rowe Price Investment Management, Inc. | $57 546 | 1 477 033 | 0,00% | Actions |
| STRS OHIO | $50 648 | 1 300 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $50 414 | 1 294 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $47 414 | 1 217 | 0,00% | Actions |
| Point72 (DIFC) Ltd | $41 183 | 2 516 | 0,00% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $39 622 | 1 017 | 0,00% | Actions |
| Activest Wealth Management | $38 999 | 1 001 | 0,00% | Actions |
| GAMMA Investing LLC | $34 752 | 892 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $27 876 | 730 | 0,00% | Actions |
| FIFTH THIRD BANCORP | $27 496 | 706 | 0,00% | Actions |
| V-Square Quantitative Management LLC | $26 960 | 692 | 0,00% | Actions |
| Larson Financial Group LLC | $25 675 | 659 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $24 895 | 639 | 0,00% | Actions |
| Spire Wealth Management | $24 662 | 633 | 0,00% | Actions |
| Physician Wealth Advisors, Inc. | $23 766 | 610 | 0,00% | Actions |
| Ameritas Advisory Services, LLC | $20 727 | 532 | 0,00% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $17 610 | 452 | 0,00% | Actions |
| Allworth Financial LP | $15 000 | 385 | 0,00% | Actions |
| Versant Capital Management, Inc | $14 454 | 371 | 0,00% | Actions |
| TOKIO MARINE ASSET MANAGEMENT CO LTD | $13 285 | 341 | 0,00% | Actions |
| Accent Capital Management, LLC | $8 844 | 227 | 0,00% | Actions |
| Arax Advisory Partners | $7 247 | 186 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $5 922 | 152 | 0,00% | Actions |
| AlphaQuest LLC | $5 872 | 210 | 0,00% | Actions |
| Sterling Capital Management LLC | $5 376 | 138 | 0,00% | Actions |
| Fortitude Family Office, LLC | $2 961 | 76 | 0,00% | Actions |
| Bare Financial Services, Inc | $1 714 | 44 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 636 | 42 | 0,00% | Actions |
| FINANCIAL CONSULATE, INC | $1 169 | 30 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $1 072 | 27 525 | 0,00% | Actions |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $990 | 25 419 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $818 | 21 | 0,00% | Actions |
| SG Americas Securities, LLC | $781 | 20 057 | 0,00% | Actions |
| Parkside Financial Bank & Trust | $585 | 15 | 0,00% | Actions |
| True Wealth Design, LLC | $507 | 13 | 0,00% | Actions |
| Quarry LP | $468 | 12 | 0,00% | Actions |
| Keating Financial Advisory Services, Inc. | $390 | 10 | 0,00% | Actions |
| Axiom Investment Management LLC | $390 | 10 | 0,00% | Actions |
| Global Retirement Partners, LLC | $273 | 7 | 0,00% | Actions |
| Smartleaf Asset Management LLC | $253 | 6 | 0,00% | Actions |
| IFP Advisors, Inc | $234 | 6 | 0,00% | Actions |
| Essential Partners LLC | $195 | 5 | 0,00% | Actions |
| CANADA LIFE ASSURANCE Co | $192 | 4 951 | 0,00% | Actions |
| Stone House Investment Management, LLC | $156 | 4 | 0,00% | Actions |
| Hughes Financial Services, LLC | $78 | 2 | 0,00% | Actions |
| ACADIAN ASSET MANAGEMENT LLC | $54 | 1 415 | 0,00% | Actions |
| KBC Group NV | $40 | 1 014 | 0,00% | Actions |
| Pacer Advisors, Inc. | $27 | 694 | 0,00% | Actions |
| Avion Wealth | $13 | 352 | 0,00% | Actions |
| Covestor Ltd | $1 | 17 | 0,00% | Actions |