PHAT — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | $135 261 406 | 12 466 489 | 16,52% | Actions |
| Medicxi Ventures Management (Jersey) Ltd | $80 990 606 | 7 464 572 | 9,89% | Actions |
| VANGUARD GROUP INC | $52 709 931 | 3 177 211 | 6,44% | Actions |
| BlackRock, Inc. | $49 097 648 | 4 525 129 | 6,00% | Actions |
| Invesco Ltd. | $43 722 581 | 4 029 731 | 5,34% | Actions |
| Carlyle Group Inc. | $37 940 367 | 3 496 808 | 4,63% | Actions |
| MILLENNIUM MANAGEMENT LLC | $36 627 799 | 3 375 834 | 4,47% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $28 827 842 | 2 656 944 | 3,52% | Actions |
| FRANKLIN RESOURCES INC | $21 383 482 | 1 970 828 | 2,61% | Actions |
| NEA Management Company, LLC | $21 267 834 | 1 960 169 | 2,60% | Actions |
| 683 Capital Management, LLC | $20 072 501 | 1 850 000 | 2,45% | Actions |
| GOLDMAN SACHS GROUP INC | $19 291 647 | 1 778 032 | 2,36% | Actions |
| STATE STREET CORP | $17 211 605 | 1 586 323 | 2,10% | Actions |
| Catalys Pacific, LLC | $16 208 316 | 1 493 854 | 1,98% | Actions |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $15 871 000 | 1 462 738 | 1,94% | Actions |
| WASATCH ADVISORS LP | $14 897 577 | 1 340 916 | 1,82% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $14 277 589 | 1 315 687 | 1,74% | Actions |
| Ensign Peak Advisors, Inc | $11 413 256 | 1 051 913 | 1,39% | Actions |
| Propel Bio Management, LLC | $11 396 384 | 1 050 358 | 1,39% | Actions |
| Point72 Asset Management, L.P. | $11 090 794 | 1 022 193 | 1,35% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $8 643 446 | 796 631 | 1,06% | Actions |
| SummitTX Capital, L.P. | $8 566 618 | 789 550 | 1,05% | Actions |
| HSBC HOLDINGS PLC | $7 701 936 | 709 695 | 0,94% | Actions |
| MARSHALL WACE, LLP | $7 227 078 | 666 090 | 0,88% | Actions |
| EcoR1 Capital, LLC | $6 781 250 | 625 000 | 0,83% | Actions |
| PERCEPTIVE ADVISORS LLC | $5 772 200 | 532 000 | 0,70% | Actions |
| TWO SIGMA INVESTMENTS, LP | $5 631 975 | 519 076 | 0,69% | Actions |
| CITADEL ADVISORS LLC | $5 216 680 | 480 800 | 0,64% | Option d'achat |
| NORTHERN TRUST CORP | $4 972 565 | 458 301 | 0,61% | Actions |
| StepStone Group LP | $4 689 364 | 422 085 | 0,57% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4 547 170 | 419 094 | 0,56% | Actions |
| Woodline Partners LP | $4 004 214 | 369 052 | 0,49% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $3 847 117 | 354 573 | 0,47% | Actions |
| AMERIPRISE FINANCIAL INC | $3 189 673 | 293 979 | 0,39% | Actions |
| JPMORGAN CHASE & CO | $2 991 978 | 275 251 | 0,37% | Actions |
| Simplify Asset Management Inc. | $2 704 547 | 249 267 | 0,33% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $2 456 440 | 226 400 | 0,30% | Actions |
| JANE STREET GROUP, LLC | $2 307 860 | 212 706 | 0,28% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2 281 755 | 210 300 | 0,28% | Option d'achat |
| UBS Group AG | $2 219 618 | 204 573 | 0,27% | Actions |
| NewEdge Advisors, LLC | $2 212 988 | 203 962 | 0,27% | Actions |
| Avidity Partners Management LP | $2 170 000 | 200 000 | 0,27% | Actions |
| MORGAN STANLEY | $2 169 013 | 199 909 | 0,26% | Actions |
| Jump Financial, LLC | $2 081 746 | 191 866 | 0,25% | Actions |
| Opaleye Management Inc. | $2 013 641 | 185 589 | 0,25% | Actions |
| CITADEL ADVISORS LLC | $2 006 176 | 184 901 | 0,25% | Actions |
| Trexquant Investment LP | $1 886 641 | 173 884 | 0,23% | Actions |
| Jones Hill Capital LP | $1 752 123 | 161 486 | 0,21% | Actions |
| Bank of New York Mellon Corp | $1 652 595 | 152 313 | 0,20% | Actions |
| WELLS FARGO & COMPANY/MN | $1 649 221 | 152 002 | 0,20% | Actions |
| BANK OF AMERICA CORP /DE/ | $1 638 513 | 151 015 | 0,20% | Actions |
| XTX Topco Ltd | $1 473 777 | 135 832 | 0,18% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $1 463 677 | 134 901 | 0,18% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $1 435 281 | 132 284 | 0,18% | Actions |
| DIADEMA PARTNERS LP | $1 409 958 | 129 950 | 0,17% | Actions |
| Nuveen, LLC | $1 379 328 | 127 127 | 0,17% | Actions |
| SIG BROKERAGE, LP | $1 345 400 | 124 000 | 0,16% | Option d'achat |
| Engineers Gate Manager LP | $1 283 088 | 118 257 | 0,16% | Actions |
| Virtus Investment Advisers, LLC | $1 216 708 | 112 139 | 0,15% | Actions |
| Russell Investments Group, Ltd. | $1 114 879 | 102 754 | 0,14% | Actions |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $1 105 968 | 101 745 | 0,14% | Actions |
| Stratos Wealth Partners, LTD. | $1 085 000 | 100 000 | 0,13% | Actions |
| Swiss National Bank | $1 071 980 | 98 800 | 0,13% | Actions |
| D. E. Shaw & Co., Inc. | $1 037 911 | 95 660 | 0,13% | Actions |
| GILDER GAGNON HOWE & CO LLC | $956 254 | 88 134 | 0,12% | Actions |
| Stonepine Capital Management, LLC | $922 358 | 85 010 | 0,11% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $838 879 | 77 316 | 0,10% | Actions |
| JANE STREET GROUP, LLC | $837 620 | 77 200 | 0,10% | Option d'achat |
| Campbell & CO Investment Adviser LLC | $746 035 | 68 759 | 0,09% | Actions |
| Penn Mutual Asset Management | $681 402 | 62 802 | 0,08% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $675 771 | 62 283 | 0,08% | Actions |
| RHUMBLINE ADVISERS | $654 740 | 60 346 | 0,08% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $619 804 | 55 788 | 0,08% | Actions |
| Birchview Capital, LP | $596 750 | 55 000 | 0,07% | Actions |
| CITIGROUP INC | $574 453 | 52 945 | 0,07% | Actions |
| STIFEL FINANCIAL CORP | $573 228 | 52 832 | 0,07% | Actions |
| Creative Planning | $572 337 | 52 750 | 0,07% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $561 889 | 51 787 | 0,07% | Actions |
| ALLIANCEBERNSTEIN L.P. | $547 612 | 49 290 | 0,07% | Actions |
| DEUTSCHE BANK AG\ | $544 725 | 50 205 | 0,07% | Actions |
| Pale Fire Capital SE | $539 386 | 49 713 | 0,07% | Actions |
| NOMURA HOLDINGS INC | $532 735 | 49 100 | 0,07% | Option de vente |
| Man Group plc | $528 167 | 48 679 | 0,06% | Actions |
| RAYMOND JAMES FINANCIAL INC | $521 061 | 48 024 | 0,06% | Actions |
| Persistent Asset Partners Ltd | $517 143 | 47 663 | 0,06% | Actions |
| AlphaQuest LLC | $468 668 | 28 250 | 0,06% | Actions |
| ADAR1 Capital Management, LLC | $465 465 | 42 900 | 0,06% | Actions |
| Quantbot Technologies LP | $463 892 | 42 755 | 0,06% | Actions |
| BARCLAYS PLC | $453 280 | 41 777 | 0,06% | Actions |
| NOMURA HOLDINGS INC | $434 000 | 40 000 | 0,05% | Actions |
| Y-Intercept (Hong Kong) Ltd | $432 318 | 39 845 | 0,05% | Actions |
| Fiduciary Trust Co | $387 681 | 35 731 | 0,05% | Actions |
| Nebula Research & Development LLC | $363 816 | 37 937 | 0,04% | Actions |
| ALLSTATE CORP | $356 694 | 32 875 | 0,04% | Actions |
| Legal & General Group Plc | $355 207 | 32 738 | 0,04% | Actions |
| Squarepoint Ops LLC | $342 806 | 31 595 | 0,04% | Actions |
| CITADEL ADVISORS LLC | $337 435 | 31 100 | 0,04% | Option de vente |
| VANGUARD ASSET MANAGEMENT, Ltd | $309 290 | 28 506 | 0,04% | Actions |
| MetLife Investment Management, LLC | $304 961 | 28 107 | 0,04% | Actions |
| Kera Capital Partners, Inc. | $291 062 | 26 826 | 0,04% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $280 342 | 25 838 | 0,03% | Actions |
| Caption Management, LLC | $260 400 | 24 000 | 0,03% | Option d'achat |
| Caption Management, LLC | $260 400 | 24 000 | 0,03% | Option de vente |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $245 720 | 22 647 | 0,03% | Actions |
| COMMONWEALTH EQUITY SERVICES, LLC | $244 500 | 22 535 | 0,03% | Actions |
| Summit Financial Wealth Advisors, LLC | $240 252 | 22 143 | 0,03% | Actions |
| JANUS HENDERSON GROUP PLC | $239 403 | 21 500 | 0,03% | Actions |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $236 198 | 18 731 | 0,03% | Actions |
| Vanguard Global Advisers, LLC | $225 344 | 20 769 | 0,03% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $220 255 | 20 300 | 0,03% | Option de vente |
| INSPIRION WEALTH ADVISORS, LLC | $209 794 | 19 914 | 0,03% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $192 316 | 17 725 | 0,02% | Actions |
| State of Wyoming | $191 383 | 17 639 | 0,02% | Actions |
| PROFUND ADVISORS LLC | $187 455 | 17 277 | 0,02% | Actions |
| Jain Global LLC | $178 341 | 16 437 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $175 206 | 16 148 | 0,02% | Actions |
| State of New Jersey Common Pension Fund D | $172 775 | 15 924 | 0,02% | Actions |
| Pathstone Holdings, LLC | $162 750 | 15 000 | 0,02% | Actions |
| LAZARD ASSET MANAGEMENT LLC | $159 180 | 14 671 | 0,02% | Actions |
| Brevan Howard Capital Management LP | $158 399 | 14 599 | 0,02% | Actions |
| KLP KAPITALFORVALTNING AS | $151 900 | 14 000 | 0,02% | Actions |
| GROUP ONE TRADING LLC | $150 609 | 13 881 | 0,02% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $147 896 | 13 631 | 0,02% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $147 441 | 13 589 | 0,02% | Actions |
| Rafferty Asset Management, LLC | $138 403 | 12 756 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $137 719 | 12 693 | 0,02% | Actions |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | $130 200 | 12 000 | 0,02% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $123 560 | 11 388 | 0,02% | Actions |
| Vanguard Investments Australia, Ltd. | $122 345 | 11 276 | 0,01% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $116 855 | 10 770 | 0,01% | Actions |
| Allworth Financial LP | $113 307 | 10 443 | 0,01% | Actions |
| Private Advisor Group, LLC | $110 453 | 10 180 | 0,01% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $94 308 | 8 692 | 0,01% | Actions |
| FMR LLC | $89 290 | 8 230 | 0,01% | Actions |
| Kera Capital Partners, Inc. | $54 250 | 5 000 | 0,01% | Option d'achat |
| Fulcrum Asset Management LLP | $48 458 | 4 458 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $48 424 | 4 463 | 0,01% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $45 560 | 4 250 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $38 702 | 3 567 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $28 515 | 2 628 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $24 749 | 2 281 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $24 000 | 2 258 | 0,00% | Actions |
| HUNTINGTON NATIONAL BANK | $23 610 | 2 176 | 0,00% | Actions |
| GW&K Investment Management, LLC | $23 510 | 2 166 838 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $21 049 | 1 940 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $20 799 | 1 917 | 0,00% | Actions |
| CWM, LLC | $20 709 | 1 864 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $18 109 | 1 669 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $15 884 | 1 464 | 0,00% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $9 722 | 896 | 0,00% | Actions |
| Sterling Capital Management LLC | $8 203 | 756 | 0,00% | Actions |
| Larson Financial Group LLC | $7 942 | 732 | 0,00% | Actions |
| Aster Capital Management (DIFC) Ltd | $5 512 | 508 | 0,00% | Actions |
| MassMutual Private Wealth & Trust, FSB | $4 633 | 427 | 0,00% | Actions |
| GAMMA Investing LLC | $4 340 | 400 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $3 711 | 342 | 0,00% | Actions |
| US BANCORP \DE\ | $3 005 | 277 | 0,00% | Actions |
| Truvestments Capital LLC | $2 441 | 225 | 0,00% | Actions |
| FIFTH THIRD BANCORP | $2 365 | 218 | 0,00% | Actions |
| Lindbrook Capital, LLC | $1 593 | 254 | 0,00% | Actions |
| Quarry LP | $1 378 | 127 | 0,00% | Actions |
| Parallel Advisors, LLC | $1 085 | 100 | 0,00% | Actions |
| Optiver Holding B.V. | $976 | 90 | 0,00% | Actions |
| True Wealth Design, LLC | $955 | 88 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $879 | 81 | 0,00% | Actions |
| KBC Group NV | $837 | 77 139 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $714 | 65 722 | 0,00% | Actions |
| Arax Advisory Partners | $456 | 42 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $327 | 30 138 | 0,00% | Actions |
| ELEVATION WEALTH PARTNERS, LLC | $217 | 20 | 0,00% | Actions |
| HAP Trading, LLC | $90 | 150 000 | 0,00% | Option de vente |
| Stone House Investment Management, LLC | $87 | 8 | 0,00% | Actions |
| CANADA LIFE ASSURANCE Co | $74 | 6 818 | 0,00% | Actions |
| Clearstead Advisors, LLC | $55 | 5 | 0,00% | Actions |
| Strategic Wealth Advisors LLC | $16 | 1 000 | 0,00% | Actions |
| Covestor Ltd | $0 | 29 | 0,00% | Actions |