SVRA — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| NEA Management Company, LLC | $150 742 986 | 24 471 264 | 10,78% | Actions |
| Bain Capital Life Sciences Investors, LLC | $108 419 826 | 17 600 621 | 7,75% | Actions |
| Venrock Adviser, LLC | $90 835 009 | 14 745 943 | 6,50% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $83 585 040 | 13 569 000 | 5,98% | Actions |
| BlackRock, Inc. | $76 966 107 | 12 494 498 | 5,50% | Actions |
| TCG Crossover Management, LLC | $76 151 183 | 12 362 205 | 5,45% | Actions |
| VANGUARD GROUP INC | $60 551 132 | 10 041 647 | 4,33% | Actions |
| Frazier Life Sciences Management, L.P. | $59 880 448 | 9 720 852 | 4,28% | Actions |
| Polar Capital Holdings Plc | $58 777 402 | 9 541 786 | 4,20% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $48 864 477 | 7 932 545 | 3,49% | Actions |
| Nantahala Capital Management, LLC | $42 977 150 | 6 976 810 | 3,07% | Actions |
| STATE STREET CORP | $40 368 624 | 6 553 348 | 2,89% | Actions |
| MARSHALL WACE, LLP | $38 543 053 | 6 256 989 | 2,76% | Actions |
| RTW INVESTMENTS, LP | $36 666 661 | 5 952 380 | 2,62% | Actions |
| Woodline Partners LP | $26 149 933 | 4 245 119 | 1,87% | Actions |
| ORBIMED ADVISORS LLC | $24 392 984 | 3 959 900 | 1,74% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $23 857 705 | 3 872 133 | 1,71% | Actions |
| Spruce Street Capital LP | $21 267 868 | 3 452 576 | 1,52% | Actions |
| Rosalind Advisors, Inc. | $19 577 225 | 3 178 121 | 1,40% | Actions |
| EMERALD ADVISERS, LLC | $19 394 384 | 3 148 439 | 1,39% | Actions |
| Pictet Asset Management Holding SA | $17 020 419 | 2 763 055 | 1,22% | Actions |
| Vestal Point Capital, LP | $16 755 200 | 2 720 000 | 1,20% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $16 600 042 | 2 694 812 | 1,19% | Actions |
| D. E. Shaw & Co., Inc. | $15 492 388 | 2 514 998 | 1,11% | Actions |
| Affinity Asset Advisors, LLC | $15 474 862 | 2 512 153 | 1,11% | Actions |
| EMERALD MUTUAL FUND ADVISERS TRUST | $14 636 154 | 2 375 999 | 1,05% | Actions |
| NAN FUNG TRINITY (HK) LTD | $11 348 876 | 1 842 350 | 0,81% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $10 076 762 | 1 635 838 | 0,72% | Actions |
| ADAR1 Capital Management, LLC | $8 644 999 | 1 403 409 | 0,62% | Actions |
| SILVERARC CAPITAL MANAGEMENT, LLC | $8 349 627 | 1 355 459 | 0,60% | Actions |
| ALGERT GLOBAL LLC | $8 188 235 | 1 329 259 | 0,59% | Actions |
| NORTHERN TRUST CORP | $8 025 894 | 1 302 905 | 0,57% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7 211 802 | 1 170 747 | 0,52% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $6 412 597 | 1 041 006 | 0,46% | Actions |
| Longaeva Partners L.P. | $6 257 864 | 1 015 887 | 0,45% | Actions |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $6 219 696 | 1 009 691 | 0,44% | Actions |
| SUPERSTRING CAPITAL MANAGEMENT LP | $6 021 154 | 977 460 | 0,43% | Actions |
| DEUTSCHE BANK AG\ | $5 328 129 | 864 956 | 0,38% | Actions |
| GOLDMAN SACHS GROUP INC | $5 108 767 | 829 345 | 0,37% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $4 657 970 | 756 164 | 0,33% | Actions |
| Swedbank AB | $4 409 944 | 715 900 | 0,32% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $4 264 020 | 692 211 | 0,30% | Actions |
| F/m Investments LLC | $4 055 461 | 658 354 | 0,29% | Actions |
| Sio Capital Management, LLC | $3 804 878 | 617 675 | 0,27% | Actions |
| AXA Investment Managers S.A. | $3 760 142 | 1 053 261 | 0,27% | Actions |
| KVP Capital Advisors, LP | $3 728 525 | 605 280 | 0,27% | Actions |
| Integral Health Asset Management, LLC | $3 696 000 | 600 000 | 0,26% | Actions |
| BANK OF AMERICA CORP /DE/ | $3 205 393 | 520 356 | 0,23% | Actions |
| UBS Group AG | $3 160 240 | 513 026 | 0,23% | Actions |
| Moody Aldrich Partners LLC | $2 974 005 | 482 793 | 0,21% | Actions |
| Y-Intercept (Hong Kong) Ltd | $2 529 351 | 410 609 | 0,18% | Actions |
| Bank of New York Mellon Corp | $2 293 779 | 372 367 | 0,16% | Actions |
| MORGAN STANLEY | $2 254 351 | 365 966 | 0,16% | Actions |
| Sofinnova Investments, Inc. | $2 246 940 | 364 763 | 0,16% | Actions |
| Nuveen, LLC | $2 090 205 | 339 319 | 0,15% | Actions |
| Seven Fleet Capital Management LP | $1 904 074 | 309 103 | 0,14% | Actions |
| WEDGE CAPITAL MANAGEMENT L L P/NC | $1 681 669 | 307 998 | 0,12% | Actions |
| CITADEL ADVISORS LLC | $1 608 049 | 261 047 | 0,11% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $1 533 156 | 248 889 | 0,11% | Actions |
| Walleye Capital LLC | $1 532 115 | 248 720 | 0,11% | Actions |
| HighVista Strategies LLC | $1 493 054 | 242 379 | 0,11% | Actions |
| Eversept Partners, LP | $1 259 276 | 204 428 | 0,09% | Actions |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $1 236 693 | 205 090 | 0,09% | Actions |
| Invesco Ltd. | $1 236 220 | 200 685 | 0,09% | Actions |
| RHUMBLINE ADVISERS | $1 146 187 | 186 071 | 0,08% | Actions |
| Swiss National Bank | $1 139 600 | 185 000 | 0,08% | Actions |
| WELLS FARGO & COMPANY/MN | $1 106 108 | 179 563 | 0,08% | Actions |
| FMR LLC | $1 076 387 | 174 738 | 0,08% | Actions |
| CITIGROUP INC | $984 886 | 159 884 | 0,07% | Actions |
| Jain Global LLC | $879 605 | 142 793 | 0,06% | Actions |
| XTX Topco Ltd | $754 662 | 122 510 | 0,05% | Actions |
| GLENMEDE TRUST CO NA | $707 432 | 114 843 | 0,05% | Actions |
| ALLIANCEBERNSTEIN L.P. | $693 638 | 127 040 | 0,05% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $621 766 | 100 936 | 0,04% | Actions |
| DCF Advisers, LLC | $616 000 | 100 000 | 0,04% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $585 921 | 95 117 | 0,04% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $574 728 | 93 300 | 0,04% | Option d'achat |
| Russell Investments Group, Ltd. | $556 309 | 90 310 | 0,04% | Actions |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $554 400 | 90 000 | 0,04% | Actions |
| MetLife Investment Management, LLC | $549 817 | 89 256 | 0,04% | Actions |
| Rafferty Asset Management, LLC | $547 279 | 88 844 | 0,04% | Actions |
| ENVESTNET ASSET MANAGEMENT INC | $531 534 | 86 288 | 0,04% | Actions |
| JPMORGAN CHASE & CO | $518 032 | 85 909 | 0,04% | Actions |
| OPTIMIZE FINANCIAL INC. | $516 276 | 83 811 | 0,04% | Actions |
| Cresset Asset Management, LLC | $513 337 | 83 334 | 0,04% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $494 360 | 80 471 | 0,04% | Actions |
| Birchview Capital, LP | $492 800 | 80 000 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $473 291 | 76 833 | 0,03% | Actions |
| Connor, Clark & Lunn Investment Management Ltd. | $461 236 | 74 876 | 0,03% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $430 492 | 69 885 | 0,03% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $405 427 | 65 816 | 0,03% | Actions |
| Susquehanna Portfolio Strategies, LLC | $388 560 | 63 078 | 0,03% | Actions |
| Virtus Investment Advisers, LLC | $383 183 | 62 205 | 0,03% | Actions |
| Verdad Advisers, LP | $380 435 | 61 759 | 0,03% | Actions |
| Creative Planning | $378 951 | 61 518 | 0,03% | Actions |
| Legal & General Group Plc | $350 819 | 56 951 | 0,03% | Actions |
| FIFTH THIRD BANCORP | $333 595 | 54 155 | 0,02% | Actions |
| Avidity Partners Management LP | $308 000 | 50 000 | 0,02% | Actions |
| Sivia Capital Partners, LLC | $298 760 | 48 500 | 0,02% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $293 450 | 47 638 | 0,02% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $287 841 | 52 718 | 0,02% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $285 824 | 46 400 | 0,02% | Option de vente |
| PROFUND ADVISORS LLC | $285 645 | 46 371 | 0,02% | Actions |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | $283 360 | 46 000 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $280 003 | 45 455 | 0,02% | Actions |
| Jump Financial, LLC | $273 504 | 44 400 | 0,02% | Actions |
| SEI INVESTMENTS CO | $267 523 | 43 429 | 0,02% | Actions |
| CITADEL ADVISORS LLC | $256 872 | 41 700 | 0,02% | Option de vente |
| Police & Firemen's Retirement System of New Jersey | $250 324 | 40 637 | 0,02% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $247 891 | 40 242 | 0,02% | Actions |
| JANUS HENDERSON GROUP PLC | $247 018 | 45 200 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $244 552 | 39 700 | 0,02% | Option d'achat |
| TWO SIGMA INVESTMENTS, LP | $231 906 | 37 647 | 0,02% | Actions |
| BARCLAYS PLC | $230 076 | 37 350 | 0,02% | Actions |
| CITADEL ADVISORS LLC | $217 448 | 35 300 | 0,02% | Option d'achat |
| Squarepoint Ops LLC | $205 054 | 33 288 | 0,01% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $201 678 | 32 740 | 0,01% | Actions |
| China Universal Asset Management Co., Ltd. | $200 902 | 32 614 | 0,01% | Actions |
| STRS OHIO | $199 584 | 32 400 | 0,01% | Actions |
| Graham Capital Management, L.P. | $197 434 | 32 051 | 0,01% | Actions |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $193 714 | 31 447 | 0,01% | Actions |
| Skopos Labs, Inc. | $183 828 | 33 668 | 0,01% | Actions |
| State of New Jersey Common Pension Fund D | $183 673 | 29 817 | 0,01% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $176 835 | 28 707 | 0,01% | Actions |
| Farther Finance Advisors, LLC | $166 665 | 27 056 | 0,01% | Actions |
| ProShare Advisors LLC | $164 798 | 26 753 | 0,01% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $162 784 | 26 426 | 0,01% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $156 741 | 25 445 | 0,01% | Actions |
| WINTON GROUP Ltd | $151 290 | 24 560 | 0,01% | Actions |
| PRUDENTIAL FINANCIAL INC | $151 259 | 24 555 | 0,01% | Actions |
| Orion Porfolio Solutions, LLC | $150 698 | 24 464 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $144 514 | 23 460 | 0,01% | Actions |
| Trexquant Investment LP | $133 980 | 21 750 | 0,01% | Actions |
| Quantinno Capital Management LP | $133 241 | 21 630 | 0,01% | Actions |
| BANK OF MONTREAL /CAN/ | $128 584 | 20 874 | 0,01% | Actions |
| BROWN ADVISORY INC | $128 461 | 20 854 | 0,01% | Actions |
| OPPENHEIMER & CO INC | $104 720 | 17 000 | 0,01% | Actions |
| EntryPoint Capital, LLC | $95 813 | 15 554 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $93 632 | 15 200 | 0,01% | Actions |
| OSAIC HOLDINGS, INC. | $90 885 | 14 754 | 0,01% | Actions |
| INCEPTIONR LLC | $90 392 | 14 674 | 0,01% | Actions |
| XPONANCE LLC | $90 145 | 14 634 | 0,01% | Actions |
| US BANCORP \DE\ | $86 825 | 14 095 | 0,01% | Actions |
| Sanctuary Advisors, LLC | $86 579 | 14 055 | 0,01% | Actions |
| Cubist Systematic Strategies, LLC | $85 991 | 24 087 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $85 532 | 13 885 | 0,01% | Actions |
| Magnetar Financial LLC | $84 392 | 13 700 | 0,01% | Actions |
| MML INVESTORS SERVICES, LLC | $81 552 | 13 239 | 0,01% | Actions |
| JANE STREET GROUP, LLC | $80 696 | 13 100 | 0,01% | Option de vente |
| E Fund Management Co., Ltd. | $77 166 | 12 527 | 0,01% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $75 947 | 12 329 | 0,01% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $73 101 | 11 867 | 0,01% | Actions |
| PRINCIPAL FINANCIAL GROUP INC | $72 060 | 11 698 | 0,01% | Actions |
| Sequoia Financial Advisors, LLC | $69 473 | 11 278 | 0,00% | Actions |
| TWO SIGMA ADVISERS, LP | $64 774 | 10 742 | 0,00% | Actions |
| Granite Investment Partners, LLC | $64 606 | 10 488 | 0,00% | Actions |
| CAPTRUST FINANCIAL ADVISORS | $63 565 | 10 319 | 0,00% | Actions |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $62 592 | 10 161 | 0,00% | Actions |
| Point72 Asia (Singapore) Pte. Ltd. | $60 322 | 16 897 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $56 456 | 9 165 | 0,00% | Actions |
| Point72 (DIFC) Ltd | $52 633 | 14 743 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $40 231 | 6 531 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $35 000 | 5 651 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $26 525 | 4 306 | 0,00% | Actions |
| 1620 INVESTMENT ADVISORS, INC. | $18 480 | 3 000 | 0,00% | Actions |
| COMERICA BANK | $12 693 | 2 105 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $10 842 | 1 760 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $10 091 | 1 638 | 0,00% | Actions |
| Larson Financial Group LLC | $4 873 | 791 | 0,00% | Actions |
| GROUP ONE TRADING LLC | $4 318 | 701 | 0,00% | Actions |
| Sterling Capital Management LLC | $3 308 | 537 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $3 049 | 495 | 0,00% | Actions |
| CWM, LLC | $3 025 | 554 | 0,00% | Actions |
| Optiver Holding B.V. | $2 723 | 442 | 0,00% | Actions |
| GAMMA Investing LLC | $2 519 | 409 | 0,00% | Actions |
| Point72 Europe (London) LLP | $2 203 | 617 | 0,00% | Actions |
| Allworth Financial LP | $1 701 | 276 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $1 386 | 225 | 0,00% | Actions |
| Keating Financial Advisory Services, Inc. | $1 312 | 213 | 0,00% | Actions |
| Quarry LP | $1 109 | 180 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $861 | 146 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $775 | 125 676 | 0,00% | Actions |
| Arax Advisory Partners | $721 | 117 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $616 | 100 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $401 | 65 | 0,00% | Actions |
| SG Americas Securities, LLC | $382 | 61 977 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $289 | 47 | 0,00% | Actions |
| Global Retirement Partners, LLC | $179 | 29 | 0,00% | Actions |
| Sunbelt Securities, Inc. | $136 | 25 | 0,00% | Actions |
| CANADA LIFE ASSURANCE Co | $74 | 11 940 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $37 | 6 | 0,00% | Actions |
| Clearstead Advisors, LLC | $19 | 3 | 0,00% | Actions |
| Pacer Advisors, Inc. | $9 | 1 484 | 0,00% | Actions |
| Covestor Ltd | $0 | 74 | 0,00% | Actions |