| RA CAPITAL MANAGEMENT, L.P. |
$26934527 |
13011849 |
12.42% |
股份
|
| venBio Partners LLC |
$26671201 |
12884638 |
12.29% |
股份
|
| BlackRock, Inc. |
$15317028 |
7399530 |
7.06% |
股份
|
| Redmile Group, LLC |
$15302483 |
7392504 |
7.05% |
股份
|
| Blackstone Inc. |
$13648634 |
6593543 |
6.29% |
股份
|
| Driehaus Capital Management LLC |
$12472247 |
6025240 |
5.75% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$11891647 |
5744757 |
5.48% |
股份
|
| TCG Crossover Management, LLC |
$11706858 |
5655487 |
5.40% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$10295013 |
4973436 |
4.75% |
股份
|
| Vivo Capital, LLC |
$6592356 |
3184713 |
3.04% |
股份
|
| MARSHALL WACE, LLP |
$6357997 |
3071496 |
2.93% |
股份
|
| 5AM Venture Management, LLC |
$6328663 |
3057325 |
2.92% |
股份
|
| Almitas Capital LLC |
$6082552 |
2938431 |
2.80% |
股份
|
| ORBIMED ADVISORS LLC |
$5933150 |
2866256 |
2.74% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$5771224 |
2787809 |
2.66% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4508824 |
2178176 |
2.08% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$3195240 |
1543594 |
1.47% |
股份
|
| STATE STREET CORP |
$3102733 |
1498905 |
1.43% |
股份
|
| JPMORGAN CHASE & CO |
$2298401 |
1044728 |
1.06% |
股份
|
| NORTHERN TRUST CORP |
$1936835 |
935669 |
0.89% |
股份
|
| VANGUARD GROUP INC |
$1842962 |
1630940 |
0.85% |
股份
|
| Ensign Peak Advisors, Inc |
$1677315 |
810297 |
0.77% |
股份
|
| Nantahala Capital Management, LLC |
$1552500 |
750000 |
0.72% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1550904 |
749229 |
0.71% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1539026 |
743491 |
0.71% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1536625 |
742331 |
0.71% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1249860 |
603797 |
0.58% |
股份
|
| ADAR1 Capital Management, LLC |
$1104676 |
533660 |
0.51% |
股份
|
| UBS Group AG |
$958292 |
462943 |
0.44% |
股份
|
| TWO SIGMA ADVISERS, LP |
$802752 |
710400 |
0.37% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$499104 |
241113 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$493585 |
238447 |
0.23% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$467969 |
226072 |
0.22% |
股份
|
| Atom Investors LP |
$454121 |
219382 |
0.21% |
股份
|
| IEQ CAPITAL, LLC |
$363041 |
175382 |
0.17% |
股份
|
| MORGAN STANLEY |
$326798 |
157873 |
0.15% |
股份
|
| Invesco Ltd. |
$310341 |
149923 |
0.14% |
股份
|
| Nuveen, LLC |
$297345 |
143645 |
0.14% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$254935 |
123157 |
0.12% |
股份
|
| RHUMBLINE ADVISERS |
$223350 |
107902 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$222376 |
107428 |
0.10% |
股份
|
| WELLS FARGO & COMPANY/MN |
$206847 |
99926 |
0.10% |
股份
|
| Verdad Advisers, LP |
$170154 |
82200 |
0.08% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$157386 |
76032 |
0.07% |
股份
|
| Graham Capital Management, L.P. |
$154879 |
74821 |
0.07% |
股份
|
| XTX Topco Ltd |
$144190 |
69657 |
0.07% |
股份
|
| MetLife Investment Management, LLC |
$134465 |
64959 |
0.06% |
股份
|
| CITIGROUP INC |
$104815 |
50635 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$102842 |
49682 |
0.05% |
股份
|
| Squarepoint Ops LLC |
$97019 |
46869 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$89089 |
43038 |
0.04% |
股份
|
| AXQ CAPITAL, LP |
$83945 |
40553 |
0.04% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$80773 |
38011 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$74934 |
36200 |
0.03% |
买入期权
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$68517 |
33100 |
0.03% |
股份
|
| BARCLAYS PLC |
$68070 |
32884 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$65872 |
31822 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$64164 |
30997 |
0.03% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$52812 |
26340 |
0.02% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$52799 |
25507 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$51336 |
24800 |
0.02% |
买入期权
|
| HC Advisors, LLC |
$47403 |
22900 |
0.02% |
股份
|
| Callan Family Office, LLC |
$46407 |
22419 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$44424 |
21461 |
0.02% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$44368 |
21434 |
0.02% |
股份
|
| CAXTON CORP |
$43358 |
20946 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$40208 |
19424 |
0.02% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$38190 |
18451 |
0.02% |
股份
|
| Bronte Capital Management Pty Ltd. |
$37457 |
18095 |
0.02% |
股份
|
| JSF Financial, LLC |
$36225 |
17500 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$34395 |
16616 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$33917 |
16385 |
0.02% |
股份
|
| MONETA GROUP INVESTMENT ADVISORS LLC |
$31456 |
15196 |
0.01% |
股份
|
| ProShare Advisors LLC |
$29238 |
14125 |
0.01% |
股份
|
| FMR LLC |
$27411 |
13242 |
0.01% |
股份
|
| Lido Advisors, LLC |
$27365 |
13220 |
0.01% |
股份
|
| Abel Hall, LLC |
$26353 |
12731 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$25875 |
12500 |
0.01% |
股份
|
| Beacon Pointe Advisors, LLC |
$25875 |
12500 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$25449 |
13907 |
0.01% |
股份
|
| Legal & General Group Plc |
$21700 |
10483 |
0.01% |
股份
|
| HSBC HOLDINGS PLC |
$21574 |
10105 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$21522 |
10397 |
0.01% |
股份
|
| XPONANCE LLC |
$21071 |
10179 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$20269 |
9792 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$17859 |
8628 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$14687 |
8025 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$13000 |
6156 |
0.01% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$3076 |
1486 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$2713 |
1313490 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2289 |
1106 |
0.00% |
股份
|
| Bradley & Co. Private Wealth Management, LLC |
$2070 |
1000 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1873 |
905 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$856 |
413545 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$785 |
379 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$207 |
100 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$186 |
89779 |
0.00% |
股份
|
| CWM, LLC |
$130 |
65 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$75 |
36 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$29 |
14 |
0.00% |
股份
|