| EVENTIDE ASSET MANAGEMENT, LLC |
$98053951 |
6253673 |
11.85% |
股份
|
| Soleus Capital Management, L.P. |
$68849498 |
4393714 |
8.32% |
股份
|
| VANGUARD GROUP INC |
$67589712 |
2218238 |
8.17% |
股份
|
| MORGAN STANLEY |
$66861101 |
4266822 |
8.08% |
股份
|
| Sands Capital Alternatives, LLC |
$58105034 |
3708043 |
7.02% |
股份
|
| BlackRock, Inc. |
$52340479 |
3340171 |
6.32% |
股份
|
| Point72 Asset Management, L.P. |
$35330883 |
2254683 |
4.27% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$27929362 |
1782346 |
3.37% |
股份
|
| Vestal Point Capital, LP |
$25072000 |
1600000 |
3.03% |
股份
|
| RTW INVESTMENTS, LP |
$23505000 |
1500000 |
2.84% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$20747080 |
1324000 |
2.51% |
股份
|
| Omega Fund Management, LLC |
$20624588 |
1316183 |
2.49% |
股份
|
| Eversept Partners, LP |
$19578740 |
1249441 |
2.37% |
股份
|
| Divisadero Street Capital Management, LP |
$17453277 |
1113802 |
2.11% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$16824964 |
1073452 |
2.03% |
股份
|
| STATE STREET CORP |
$15202909 |
970192 |
1.84% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$14984343 |
956244 |
1.81% |
股份
|
| Balyasny Asset Management L.P. |
$13408537 |
855682 |
1.62% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$13052232 |
832944 |
1.58% |
股份
|
| JPMORGAN CHASE & CO |
$11957052 |
703356 |
1.44% |
股份
|
| Bruce & Co., Inc. |
$10431519 |
665700 |
1.26% |
股份
|
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
$9323650 |
595000 |
1.13% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$8566005 |
546650 |
1.03% |
股份
|
| GOLDMAN SACHS GROUP INC |
$8416435 |
537105 |
1.02% |
股份
|
| Trexquant Investment LP |
$7747796 |
494435 |
0.94% |
股份
|
| Tri Locum Partners LP |
$7730700 |
493344 |
0.93% |
股份
|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
$6413731 |
409300 |
0.77% |
股份
|
| UBS Group AG |
$6058382 |
386623 |
0.73% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$5498180 |
350873 |
0.66% |
股份
|
| NORTHERN TRUST CORP |
$5201751 |
331956 |
0.63% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$4833693 |
308468 |
0.58% |
股份
|
| Granahan Investment Management, LLC |
$4695233 |
299632 |
0.57% |
股份
|
| PURA VIDA INVESTMENTS, LLC |
$4405840 |
281164 |
0.53% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$4277659 |
272984 |
0.52% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$4198228 |
267915 |
0.51% |
股份
|
| TWO SIGMA ADVISERS, LP |
$4180484 |
137200 |
0.51% |
股份
|
| Mariner, LLC |
$3452986 |
220359 |
0.42% |
股份
|
| Jain Global LLC |
$2704391 |
172584 |
0.33% |
股份
|
| Squarepoint Ops LLC |
$2524406 |
161098 |
0.30% |
股份
|
| Kent Lake PR LLC |
$2483750 |
125000 |
0.30% |
股份
|
| Bank of New York Mellon Corp |
$1925797 |
122897 |
0.23% |
股份
|
| LAZARD ASSET MANAGEMENT LLC |
$1497331 |
95554 |
0.18% |
股份
|
| Nuveen, LLC |
$1431784 |
91371 |
0.17% |
股份
|
| CITIGROUP INC |
$1160442 |
74055 |
0.14% |
股份
|
| Bellevue Group AG |
$1130622 |
72152 |
0.14% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1096258 |
69959 |
0.13% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$999887 |
63809 |
0.12% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$987821 |
63039 |
0.12% |
股份
|
| JANE STREET GROUP, LLC |
$902592 |
57600 |
0.11% |
买入期权
|
| Archon Capital Management LLC |
$844190 |
53873 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$803141 |
51254 |
0.10% |
股份
|
| Values First Advisors, Inc. |
$797600 |
50900 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$755639 |
48222 |
0.09% |
股份
|
| Creative Planning |
$726351 |
46353 |
0.09% |
股份
|
| Aquatic Capital Management LLC |
$646450 |
41254 |
0.08% |
股份
|
| CITADEL ADVISORS LLC |
$633068 |
40400 |
0.08% |
买入期权
|
| ALLIANCEBERNSTEIN L.P. |
$567132 |
56600 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$557491 |
35577 |
0.07% |
股份
|
| Brevan Howard Capital Management LP |
$527358 |
33654 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$432492 |
27600 |
0.05% |
买入期权
|
| EntryPoint Capital, LLC |
$428919 |
27372 |
0.05% |
股份
|
| Man Group plc |
$419486 |
26770 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$409739 |
26148 |
0.05% |
股份
|
| Quantinno Capital Management LP |
$377083 |
24064 |
0.05% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$369800 |
23599 |
0.04% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$357950 |
22843 |
0.04% |
股份
|
| Invesco Ltd. |
$329400 |
21021 |
0.04% |
股份
|
| Evanson Asset Management, LLC |
$313345 |
31272 |
0.04% |
股份
|
| Caprock Group, LLC |
$287482 |
18346 |
0.03% |
股份
|
| LPL Financial LLC |
$270746 |
17278 |
0.03% |
股份
|
| OSAIC HOLDINGS, INC. |
$264696 |
16893 |
0.03% |
股份
|
| Quantbot Technologies LP |
$263554 |
16819 |
0.03% |
股份
|
| KOTLER KEVIN |
$250342 |
8216 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$243794 |
15558 |
0.03% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$240691 |
15360 |
0.03% |
股份
|
| INTREPID FAMILY OFFICE LLC |
$235050 |
15000 |
0.03% |
股份
|
| BARCLAYS PLC |
$234046 |
14936 |
0.03% |
股份
|
| IEQ CAPITAL, LLC |
$228735 |
14597 |
0.03% |
股份
|
| BANK OF MONTREAL /CAN/ |
$223737 |
14278 |
0.03% |
股份
|
| Gladstone Institutional Advisory LLC |
$222531 |
14201 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$209790 |
13388 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$191174 |
12200 |
0.02% |
股份
|
| BROWN ADVISORY INC |
$187194 |
11946 |
0.02% |
股份
|
| Engineers Gate Manager LP |
$185031 |
11808 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$184153 |
11752 |
0.02% |
股份
|
| Focus Partners Wealth |
$179077 |
11428 |
0.02% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$177071 |
11300 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$172072 |
10981 |
0.02% |
股份
|
| XTX Topco Ltd |
$170725 |
10895 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$161761 |
10323 |
0.02% |
股份
|
| IAMS WEALTH MANAGEMENT, LLC |
$156700 |
10000 |
0.02% |
股份
|
| ROYAL BANK OF CANADA |
$110000 |
6993 |
0.01% |
股份
|
| Arax Advisory Partners |
$98126 |
6262 |
0.01% |
股份
|
| Legal & General Group Plc |
$61975 |
3955 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$57932 |
3697 |
0.01% |
股份
|
| CWM, LLC |
$55250 |
5514 |
0.01% |
股份
|
| FMR LLC |
$55033 |
3512 |
0.01% |
股份
|
| EverSource Wealth Advisors, LLC |
$52589 |
3356 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$49031 |
3129 |
0.01% |
股份
|
| Steward Partners Investment Advisory, LLC |
$47057 |
3003 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$22032 |
1406 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$20450 |
1305 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$17728 |
1054 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$17159 |
1095 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$12865 |
821 |
0.00% |
股份
|
| Allworth Financial LP |
$11111 |
709 |
0.00% |
股份
|
| ADIRONDACK TRUST CO |
$9449 |
603 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$8693 |
458 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$8556 |
546 |
0.00% |
股份
|
| Larson Financial Group LLC |
$8430 |
538 |
0.00% |
股份
|
| GAMMA Investing LLC |
$7616 |
486 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$7334 |
468 |
0.00% |
股份
|
| US BANCORP \DE\ |
$7052 |
450 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4853 |
309 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$3886 |
248 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$2930 |
187 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2930 |
187 |
0.00% |
股份
|
| COMERICA BANK |
$2903 |
95 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$2805 |
179 |
0.00% |
股份
|
| Quarry LP |
$1927 |
123 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1662 |
106 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1661 |
106 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$1661 |
106 |
0.00% |
股份
|
| Essential Partners LLC |
$1536 |
98 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$1129 |
72 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$882 |
88 |
0.00% |
股份
|
| WPG Advisers, LLC |
$862 |
55 |
0.00% |
股份
|
| Torren Management, LLC |
$822 |
82 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$815 |
52 |
0.00% |
股份
|
| Blue Trust, Inc. |
$736 |
47 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$681 |
43450 |
0.00% |
股份
|
| Bogart Wealth, LLC |
$642 |
41 |
0.00% |
股份
|
| True Wealth Design, LLC |
$471 |
30 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$447 |
29 |
0.00% |
股份
|
| IFP Advisors, Inc |
$345 |
22 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$204 |
13 |
0.00% |
股份
|
| Concord Wealth Partners |
$172 |
11 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$157 |
10 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$140 |
14 |
0.00% |
股份
|
| Freestone Grove Partners LP |
$63 |
4 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$20 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
26 |
0.00% |
股份
|
| Avion Wealth |
$0 |
53 |
0.00% |
股份
|