| JENNISON ASSOCIATES LLC |
$62304900 |
20033730 |
14.10% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$53620894 |
17241445 |
12.13% |
股份
|
| BlackRock, Inc. |
$33447121 |
10754701 |
7.57% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$28533497 |
9174758 |
6.46% |
股份
|
| STATE STREET CORP |
$24380239 |
7839305 |
5.52% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$22476026 |
7227018 |
5.09% |
股份
|
| Cormorant Asset Management, LP |
$15550000 |
5000000 |
3.52% |
股份
|
| Woodline Partners LP |
$13062442 |
4200142 |
2.96% |
股份
|
| NORGES BANK |
$12789567 |
4112401 |
2.89% |
股份
|
| Opaleye Management Inc. |
$12016418 |
3863800 |
2.72% |
股份
|
| CITADEL ADVISORS LLC |
$10953768 |
3522112 |
2.48% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$10761875 |
3459464 |
2.44% |
股份
|
| VANGUARD GROUP INC |
$9678613 |
4419458 |
2.19% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$8771755 |
2820500 |
1.99% |
买入期权
|
| FRANKLIN RESOURCES INC |
$7507344 |
2413937 |
1.70% |
股份
|
| GOLDMAN SACHS GROUP INC |
$6878776 |
2211825 |
1.56% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$6433007 |
2068491 |
1.46% |
股份
|
| MARSHALL WACE, LLP |
$4870070 |
1565939 |
1.10% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$4774783 |
1535300 |
1.08% |
股份
|
| UBS Group AG |
$4577594 |
1471895 |
1.04% |
股份
|
| Qube Research & Technologies Ltd |
$4437472 |
1426840 |
1.00% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$4410316 |
1418108 |
1.00% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4387995 |
1410931 |
0.99% |
股份
|
| MORGAN STANLEY |
$4184586 |
1345526 |
0.95% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$4133227 |
1329012 |
0.94% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$3478020 |
1278652 |
0.79% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3385530 |
1088595 |
0.77% |
股份
|
| NORTHERN TRUST CORP |
$3132087 |
1007102 |
0.71% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$3007976 |
967195 |
0.68% |
股份
|
| Stonepine Capital Management, LLC |
$2852181 |
917100 |
0.65% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$2664141 |
856637 |
0.60% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2575531 |
828145 |
0.58% |
股份
|
| CANTOR FITZGERALD, L. P. |
$2488003 |
800001 |
0.56% |
股份
|
| HEIGHTS CAPITAL MANAGEMENT, INC |
$2349997 |
755626 |
0.53% |
股份
|
| Blue Owl Capital Holdings LP |
$2222748 |
714710 |
0.50% |
股份
|
| Ikarian Capital, LLC |
$2177000 |
700000 |
0.49% |
股份
|
| Burkehill Global Management, LP |
$2177000 |
700000 |
0.49% |
股份
|
| Nuveen, LLC |
$2010133 |
646345 |
0.45% |
股份
|
| Caption Management, LLC |
$1864445 |
599500 |
0.42% |
买入期权
|
| TWO SIGMA ADVISERS, LP |
$1616001 |
737900 |
0.37% |
股份
|
| KVP Capital Advisors, LP |
$1571890 |
505431 |
0.36% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1534207 |
493314 |
0.35% |
股份
|
| CITADEL ADVISORS LLC |
$1529187 |
491700 |
0.35% |
买入期权
|
| Jump Financial, LLC |
$1520090 |
488775 |
0.34% |
股份
|
| JANE STREET GROUP, LLC |
$1341654 |
431400 |
0.30% |
买入期权
|
| Raiffeisen Bank International AG |
$1337300 |
430000 |
0.30% |
股份
|
| TD Asset Management Inc |
$1217478 |
391472 |
0.28% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1192044 |
383294 |
0.27% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1165895 |
374886 |
0.26% |
股份
|
| Bank of New York Mellon Corp |
$947988 |
304819 |
0.21% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$890119 |
286212 |
0.20% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$831527 |
267372 |
0.19% |
股份
|
| Invesco Ltd. |
$751267 |
241565 |
0.17% |
股份
|
| WELLS FARGO & COMPANY/MN |
$612274 |
196872 |
0.14% |
股份
|
| CITIGROUP INC |
$572962 |
184232 |
0.13% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$567435 |
182455 |
0.13% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$566191 |
182055 |
0.13% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$503559 |
161916 |
0.11% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$475718 |
152964 |
0.11% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$466500 |
150000 |
0.11% |
买入期权
|
| Rafferty Asset Management, LLC |
$454393 |
146107 |
0.10% |
股份
|
| Diametric Capital, LP |
$421709 |
135598 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$409392 |
131640 |
0.09% |
股份
|
| Almitas Capital LLC |
$391549 |
125900 |
0.09% |
股份
|
| CITADEL ADVISORS LLC |
$370090 |
119000 |
0.08% |
卖出期权
|
| DEUTSCHE BANK AG\ |
$345092 |
110962 |
0.08% |
股份
|
| Virtus Investment Advisers, LLC |
$338066 |
108703 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$291623 |
108410 |
0.07% |
股份
|
| D. E. Shaw & Co., Inc. |
$281928 |
90652 |
0.06% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$281377 |
90475 |
0.06% |
股份
|
| Graham Capital Management, L.P. |
$252778 |
81279 |
0.06% |
股份
|
| LPL Financial LLC |
$245923 |
79075 |
0.06% |
股份
|
| PROFUND ADVISORS LLC |
$228302 |
73409 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$213321 |
68592 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$207589 |
66749 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$196639 |
63228 |
0.04% |
股份
|
| JANE STREET GROUP, LLC |
$190954 |
61400 |
0.04% |
卖出期权
|
| RAYMOND JAMES FINANCIAL INC |
$187499 |
60289 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$184634 |
59368 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$178427 |
57372 |
0.04% |
股份
|
| MATAURO, LLC |
$171386 |
55108 |
0.04% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$168207 |
54086 |
0.04% |
股份
|
| EntryPoint Capital, LLC |
$158383 |
50927 |
0.04% |
股份
|
| ADAR1 Capital Management, LLC |
$155500 |
50000 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$142438 |
45800 |
0.03% |
卖出期权
|
| XTX Topco Ltd |
$142133 |
45702 |
0.03% |
股份
|
| BARCLAYS PLC |
$139021 |
44701 |
0.03% |
股份
|
| KEYBANK NATIONAL ASSOCIATION/OH |
$121306 |
39005 |
0.03% |
股份
|
| Quantbot Technologies LP |
$115717 |
37208 |
0.03% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$107044 |
34419 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$103261 |
33203 |
0.02% |
股份
|
| Grey Ledge Advisors, LLC |
$93300 |
30000 |
0.02% |
股份
|
| Cubist Systematic Strategies, LLC |
$88322 |
37744 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$83970 |
27000 |
0.02% |
股份
|
| TWO SIGMA SECURITIES, LLC |
$82922 |
26663 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$80705 |
25950 |
0.02% |
股份
|
| RITHOLTZ WEALTH MANAGEMENT |
$77750 |
25000 |
0.02% |
股份
|
| Wealthfront Advisers LLC |
$75850 |
24389 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$72774 |
23400 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$71639 |
23035 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$66482 |
21377 |
0.02% |
股份
|
| E Fund Management Co., Ltd. |
$64069 |
20601 |
0.01% |
股份
|
| nVerses Capital, LLC |
$63089 |
20286 |
0.01% |
股份
|
| ProShare Advisors LLC |
$62467 |
20086 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$60984 |
19609 |
0.01% |
股份
|
| Clear Harbor Asset Management, LLC |
$60645 |
19500 |
0.01% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$58686 |
18869907 |
0.01% |
股份
|
| Callan Family Office, LLC |
$54220 |
17434 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$52823 |
16985 |
0.01% |
股份
|
| US BANCORP \DE\ |
$51293 |
16493 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$51284 |
16490 |
0.01% |
股份
|
| &PARTNERS |
$50382 |
16200 |
0.01% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$50000 |
25000 |
0.01% |
买入期权
|
| FMR LLC |
$49536 |
15928 |
0.01% |
股份
|
| CRA Financial Services, LLC |
$46650 |
15000 |
0.01% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$43643 |
14033 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$40135 |
12905 |
0.01% |
股份
|
| Kestra Advisory Services, LLC |
$36543 |
11750 |
0.01% |
股份
|
| HighTower Advisors, LLC |
$34378 |
11054 |
0.01% |
股份
|
| Legal & General Group Plc |
$34010 |
10918 |
0.01% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$33753 |
10853 |
0.01% |
股份
|
| XPONANCE LLC |
$33299 |
10707 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$31775 |
10217 |
0.01% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$31420 |
10103 |
0.01% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$31377 |
10089 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$30916 |
9941 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$26762 |
8605 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$22678 |
7292 |
0.01% |
股份
|
| Rockefeller Capital Management L.P. |
$20993 |
6750 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$20907 |
8935 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$14440 |
4643 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$14306 |
4600 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$13744 |
4418674 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$12151 |
3997 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$11000 |
3584 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$10024 |
3223 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$9041 |
2907 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4821 |
1550 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4102 |
1319 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2774 |
892 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2522 |
811 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$2079 |
668563 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1269 |
408 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$1057 |
340 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$983 |
316 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$516 |
166 |
0.00% |
股份
|
| Quarry LP |
$283 |
91 |
0.00% |
股份
|
| Virtu Financial LLC |
$216 |
69511 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$187 |
60 |
0.00% |
股份
|
| Arax Advisory Partners |
$31 |
10 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$23 |
7500 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$8 |
2440 |
0.00% |
股份
|