| MPM BIOIMPACT LLC |
$177207720 |
9731341 |
13.90% |
股份
|
| Lynx1 Capital Management LP |
$163225335 |
8963500 |
12.81% |
股份
|
| BVF INC/IL |
$104719937 |
5750683 |
8.22% |
股份
|
| BlackRock, Inc. |
$95288670 |
5232766 |
7.48% |
股份
|
| STATE STREET CORP |
$66805698 |
3668627 |
5.24% |
股份
|
| Kynam Capital Management, LP |
$56708344 |
3114132 |
4.45% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$47602142 |
2614066 |
3.73% |
股份
|
| RTW INVESTMENTS, LP |
$43054759 |
2364347 |
3.38% |
股份
|
| Siren, L.L.C. |
$34478996 |
1893410 |
2.71% |
股份
|
| VANGUARD GROUP INC |
$34139516 |
3298504 |
2.68% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$28182326 |
1547309 |
2.21% |
股份
|
| Blue Owl Capital Holdings LP |
$28039102 |
1539764 |
2.20% |
股份
|
| Venrock Adviser, LLC |
$25129163 |
1379965 |
1.97% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$19714346 |
1082611 |
1.55% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$19061499 |
1046694 |
1.50% |
股份
|
| GOLDMAN SACHS GROUP INC |
$18239100 |
1001598 |
1.43% |
股份
|
| Affinity Asset Advisors, LLC |
$15947590 |
875760 |
1.25% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$13452474 |
738741 |
1.06% |
股份
|
| BOONE CAPITAL MANAGEMENT LLC |
$12827889 |
704442 |
1.01% |
股份
|
| Elmind Capital, LP |
$12564900 |
690000 |
0.99% |
股份
|
| MORGAN STANLEY |
$11454726 |
629035 |
0.90% |
股份
|
| TWIN FOCUS CAPITAL PARTNERS, LLC |
$10843855 |
595489 |
0.85% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$10586165 |
581338 |
0.83% |
股份
|
| NORTHERN TRUST CORP |
$10399367 |
571080 |
0.82% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$9293018 |
510325 |
0.73% |
股份
|
| Nuveen, LLC |
$8594154 |
471947 |
0.67% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$8450059 |
464034 |
0.66% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$7766164 |
426478 |
0.61% |
股份
|
| TCG Crossover Management, LLC |
$7407573 |
406786 |
0.58% |
股份
|
| CITADEL ADVISORS LLC |
$7238184 |
397484 |
0.57% |
股份
|
| DEUTSCHE BANK AG\ |
$6971516 |
382840 |
0.55% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6612707 |
363136 |
0.52% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$6304885 |
346232 |
0.49% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$5951228 |
326811 |
0.47% |
股份
|
| GREAT POINT PARTNERS LLC |
$5463000 |
300000 |
0.43% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$5326425 |
292500 |
0.42% |
股份
|
| JPMORGAN CHASE & CO |
$5206063 |
282631 |
0.41% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$4963700 |
272581 |
0.39% |
股份
|
| Bleichroeder LP |
$4552500 |
250000 |
0.36% |
股份
|
| UBS Group AG |
$4527498 |
248627 |
0.36% |
股份
|
| FMR LLC |
$4372486 |
240115 |
0.34% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$4333980 |
238000 |
0.34% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$4258263 |
233842 |
0.33% |
股份
|
| PFM Health Sciences, LP |
$3504369 |
192442 |
0.27% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$3458917 |
189946 |
0.27% |
股份
|
| Bank of New York Mellon Corp |
$3114469 |
171031 |
0.24% |
股份
|
| Squarepoint Ops LLC |
$3061411 |
168117 |
0.24% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$3051177 |
167555 |
0.24% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2999478 |
164716 |
0.24% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$2846533 |
156317 |
0.22% |
股份
|
| Engineers Gate Manager LP |
$2787041 |
153050 |
0.22% |
股份
|
| Trexquant Investment LP |
$2770888 |
152163 |
0.22% |
股份
|
| BARCLAYS PLC |
$2621239 |
143945 |
0.21% |
股份
|
| Invesco Ltd. |
$2614082 |
143552 |
0.21% |
股份
|
| Jump Financial, LLC |
$2525873 |
138708 |
0.20% |
股份
|
| CITIGROUP INC |
$2265488 |
124409 |
0.18% |
股份
|
| Quantinno Capital Management LP |
$2000842 |
109876 |
0.16% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1576986 |
86600 |
0.12% |
买入期权
|
| Creative Planning |
$1574400 |
86458 |
0.12% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1468600 |
80648 |
0.12% |
股份
|
| TD Asset Management Inc |
$1468236 |
80628 |
0.12% |
股份
|
| Apis Capital Advisors, LLC |
$1456800 |
80000 |
0.11% |
股份
|
| RHUMBLINE ADVISERS |
$1437306 |
78930 |
0.11% |
股份
|
| XTX Topco Ltd |
$1401533 |
76965 |
0.11% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1396907 |
76711 |
0.11% |
股份
|
| Swiss National Bank |
$1383960 |
76000 |
0.11% |
股份
|
| Point72 Asset Management, L.P. |
$1365914 |
75009 |
0.11% |
股份
|
| Mariner, LLC |
$1352532 |
74273 |
0.11% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1343523 |
129809 |
0.11% |
股份
|
| Cubist Systematic Strategies, LLC |
$1318345 |
222318 |
0.10% |
股份
|
| Knott David M Jr |
$1259804 |
69182 |
0.10% |
股份
|
| Rafferty Asset Management, LLC |
$1203535 |
66092 |
0.09% |
股份
|
| MARSHALL WACE, LLP |
$1202789 |
66051 |
0.09% |
股份
|
| CITADEL ADVISORS LLC |
$1187292 |
65200 |
0.09% |
卖出期权
|
| Longaeva Partners L.P. |
$1179735 |
64785 |
0.09% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$1127891 |
61938 |
0.09% |
股份
|
| Assenagon Asset Management S.A. |
$1123229 |
61682 |
0.09% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1069303 |
75250 |
0.08% |
股份
|
| Corient Private Wealth LP |
$999312 |
54877 |
0.08% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$965312 |
53010 |
0.08% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$961392 |
67656 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$933372 |
51256 |
0.07% |
股份
|
| CITADEL ADVISORS LLC |
$919605 |
50500 |
0.07% |
买入期权
|
| Soleus Capital Management, L.P. |
$910500 |
50000 |
0.07% |
股份
|
| FRANKLIN RESOURCES INC |
$771103 |
42345 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$733007 |
40253 |
0.06% |
股份
|
| ALGERT GLOBAL LLC |
$671057 |
36851 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$669709 |
36777 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$668307 |
36700 |
0.05% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$655560 |
36000 |
0.05% |
卖出期权
|
| Fisher Asset Management, LLC |
$655523 |
35998 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$650935 |
35746 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$648704 |
35535 |
0.05% |
股份
|
| IEQ CAPITAL, LLC |
$614041 |
33720 |
0.05% |
股份
|
| PROFUND ADVISORS LLC |
$608269 |
33403 |
0.05% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$585215 |
32137 |
0.05% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$577494 |
31713 |
0.05% |
股份
|
| Leonteq Securities AG |
$546300 |
30000 |
0.04% |
股份
|
| Verdad Advisers, LP |
$527853 |
28987 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$520514 |
28584 |
0.04% |
股份
|
| ExodusPoint Capital Management, LP |
$519659 |
28537 |
0.04% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$510991 |
28061 |
0.04% |
股份
|
| JANE STREET GROUP, LLC |
$508059 |
27900 |
0.04% |
买入期权
|
| Legal & General Group Plc |
$500356 |
27477 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$475099 |
26090 |
0.04% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$444251 |
24396 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$434909 |
23883 |
0.03% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$410053 |
22518 |
0.03% |
股份
|
| MERCER GLOBAL ADVISORS INC /ADV |
$399200 |
21922 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$386380 |
21218 |
0.03% |
股份
|
| TEMA ETFS LLC |
$382577 |
36964 |
0.03% |
股份
|
| AlphaCentric Advisors LLC |
$371957 |
20426 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$370537 |
20348 |
0.03% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$365111 |
20050 |
0.03% |
股份
|
| Birchview Capital, LP |
$364200 |
20000 |
0.03% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$364200 |
20000 |
0.03% |
买入期权
|
| Qube Research & Technologies Ltd |
$363035 |
19936 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$324885 |
17841 |
0.03% |
股份
|
| SIMPLEX TRADING, LLC |
$317655 |
17444 |
0.02% |
股份
|
| AlphaQuest LLC |
$299633 |
28950 |
0.02% |
股份
|
| TWO SIGMA SECURITIES, LLC |
$277156 |
15220 |
0.02% |
股份
|
| AXQ CAPITAL, LP |
$271966 |
14935 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$263190 |
18528 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$244852 |
13446 |
0.02% |
股份
|
| Nebula Research & Development LLC |
$239853 |
31853 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$226132 |
12418 |
0.02% |
股份
|
| Pale Fire Capital SE |
$226132 |
12418 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$222745 |
12232 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$215151 |
11815 |
0.02% |
股份
|
| GREAT LAKES ADVISORS, LLC |
$214987 |
11806 |
0.02% |
股份
|
| Inscription Capital, LLC |
$212347 |
11661 |
0.02% |
股份
|
| EntryPoint Capital, LLC |
$210435 |
11556 |
0.02% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$202475 |
11168 |
0.02% |
股份
|
| Campbell & CO Investment Adviser LLC |
$201949 |
11090 |
0.02% |
股份
|
| GROUP ONE TRADING LLC |
$195994 |
10763 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$190076 |
10438 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$178112 |
9781 |
0.01% |
股份
|
| Quarry LP |
$176127 |
9672 |
0.01% |
股份
|
| CWM, LLC |
$173305 |
12196 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$172776 |
9488 |
0.01% |
股份
|
| Corton Capital Inc. |
$160804 |
27117 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$139143 |
7641 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$132423 |
7272 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$123828 |
6800 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$106000 |
5820 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$99973 |
5490 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$69672 |
3825950 |
0.01% |
股份
|
| SIGNATUREFD, LLC |
$58399 |
3207 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$58108 |
3191 |
0.00% |
股份
|
| Quantbot Technologies LP |
$53009 |
2911 |
0.00% |
股份
|
| Allworth Financial LP |
$52682 |
2893 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$50059 |
2749 |
0.00% |
股份
|
| Arax Advisory Partners |
$47802 |
2625 |
0.00% |
股份
|
| GAMMA Investing LLC |
$35109 |
1928 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$34107 |
1873 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$26259 |
1442 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$25312 |
1390 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$22799 |
1252 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$22198 |
1219 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$21070 |
3553 |
0.00% |
股份
|
| STRS OHIO |
$18210 |
1000 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$15488 |
849 |
0.00% |
股份
|
| Bangor Savings Bank |
$15333 |
842 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$14441 |
793 |
0.00% |
股份
|
| IFP Advisors, Inc |
$13257 |
728 |
0.00% |
股份
|
| UMB Bank, n.a. |
$12474 |
685 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$12437 |
683 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$11818 |
649 |
0.00% |
股份
|
| US BANCORP \DE\ |
$9415 |
517 |
0.00% |
股份
|
| Essential Partners LLC |
$9287 |
510 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$7065 |
388 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$5736 |
315 |
0.00% |
股份
|
| Larson Financial Group LLC |
$5081 |
279 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$4607 |
253 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$4553 |
250 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$3496 |
192 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2549 |
140 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$2204 |
121 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$1439 |
79 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$1293 |
71 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1293 |
71 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$1196 |
158 |
0.00% |
股份
|
| COMERICA BANK |
$683 |
66 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$492 |
27 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$479 |
26 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$419 |
23 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$366 |
20279 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$347 |
19058 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$275 |
15 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$273 |
15 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$55 |
3 |
0.00% |
股份
|
| Capital Advisors, Ltd. LLC |
$29 |
1600 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$20 |
1104 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$18 |
1 |
0.00% |
股份
|
| Avion Wealth |
$3 |
200 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
33 |
0.00% |
股份
|