| RA CAPITAL MANAGEMENT, L.P. |
$67162061 |
5049779 |
9.10% |
股份
|
| BlackRock, Inc. |
$60462583 |
4546059 |
8.19% |
股份
|
| GOLDMAN SACHS GROUP INC |
$56640284 |
4258668 |
7.67% |
股份
|
| JANUS HENDERSON GROUP PLC |
$48868164 |
5247151 |
6.62% |
股份
|
| NOVO HOLDINGS A/S |
$43214067 |
3249178 |
5.85% |
股份
|
| STATE STREET CORP |
$38717750 |
2911109 |
5.24% |
股份
|
| BVF INC/IL |
$38294544 |
2879289 |
5.19% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$29914400 |
2249203 |
4.05% |
股份
|
| Trails Edge Capital Partners, LP |
$29631296 |
2227917 |
4.01% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$27917432 |
2099055 |
3.78% |
股份
|
| ARMISTICE CAPITAL, LLC |
$26600000 |
2000000 |
3.60% |
股份
|
| VANGUARD GROUP INC |
$23201453 |
3093527 |
3.14% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$15012796 |
1128466 |
2.03% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$14904964 |
1120674 |
2.02% |
股份
|
| Evergreen Quality Fund GP, Ltd. |
$12654604 |
951474 |
1.71% |
股份
|
| Parkman Healthcare Partners LLC |
$12610847 |
948184 |
1.71% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$9717799 |
730857 |
1.32% |
股份
|
| DEUTSCHE BANK AG\ |
$9455529 |
710942 |
1.28% |
股份
|
| CITADEL ADVISORS LLC |
$9145040 |
687597 |
1.24% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$8173821 |
614573 |
1.11% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7712710 |
579903 |
1.04% |
股份
|
| DIADEMA PARTNERS LP |
$7595723 |
571107 |
1.03% |
股份
|
| NORTHERN TRUST CORP |
$7486956 |
562929 |
1.01% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$6753753 |
507801 |
0.91% |
股份
|
| Nuveen, LLC |
$6690844 |
503071 |
0.91% |
股份
|
| MORGAN STANLEY |
$6690165 |
503020 |
0.91% |
股份
|
| RTW INVESTMENTS, LP |
$6327302 |
475737 |
0.86% |
股份
|
| Catalio Capital Management, LP |
$6267678 |
471254 |
0.85% |
股份
|
| Schonfeld Strategic Advisors LLC |
$5419350 |
407470 |
0.73% |
股份
|
| JPMORGAN CHASE & CO |
$5179524 |
402137 |
0.70% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4512358 |
339275 |
0.61% |
股份
|
| Opaleye Management Inc. |
$4448012 |
334437 |
0.60% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3673965 |
276238 |
0.50% |
股份
|
| Burkehill Global Management, LP |
$3657500 |
275000 |
0.50% |
股份
|
| UBS Group AG |
$3413751 |
256673 |
0.46% |
股份
|
| Propel Bio Management, LLC |
$3360298 |
252654 |
0.46% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$3223242 |
242349 |
0.44% |
股份
|
| FEDERATED HERMES, INC. |
$2958132 |
222416 |
0.40% |
股份
|
| ArrowMark Colorado Holdings LLC |
$2698091 |
202864 |
0.37% |
股份
|
| CITADEL ADVISORS LLC |
$2679950 |
201500 |
0.36% |
买入期权
|
| Woodline Partners LP |
$2660013 |
200001 |
0.36% |
股份
|
| Brevan Howard Capital Management LP |
$2352105 |
176850 |
0.32% |
股份
|
| TWO SIGMA ADVISERS, LP |
$2064750 |
275300 |
0.28% |
股份
|
| Bank of New York Mellon Corp |
$2026079 |
152337 |
0.27% |
股份
|
| Invesco Ltd. |
$2000081 |
150382 |
0.27% |
股份
|
| Perigon Wealth Management, LLC |
$1944261 |
146185 |
0.26% |
股份
|
| Persistent Asset Partners Ltd |
$1936281 |
145585 |
0.26% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1864660 |
140200 |
0.25% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1708571 |
128464 |
0.23% |
股份
|
| FMR LLC |
$1706596 |
128316 |
0.23% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1627920 |
122400 |
0.22% |
买入期权
|
| AMERICAN CENTURY COMPANIES INC |
$1516200 |
114000 |
0.21% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1422236 |
106935 |
0.19% |
股份
|
| Greenland Capital Management LP |
$1330000 |
100000 |
0.18% |
买入期权
|
| Privium Fund Management B.V. |
$1198463 |
90110 |
0.16% |
股份
|
| Assenagon Asset Management S.A. |
$1108329 |
83333 |
0.15% |
股份
|
| Greenland Capital Management LP |
$961018 |
72257 |
0.13% |
股份
|
| Caption Management, LLC |
$931000 |
70000 |
0.13% |
买入期权
|
| TWO SIGMA INVESTMENTS, LP |
$924097 |
69481 |
0.13% |
股份
|
| CITIGROUP INC |
$920520 |
69212 |
0.12% |
股份
|
| Man Group plc |
$909042 |
68349 |
0.12% |
股份
|
| Engineers Gate Manager LP |
$907140 |
68206 |
0.12% |
股份
|
| XTX Topco Ltd |
$892723 |
67122 |
0.12% |
股份
|
| Fisher Asset Management, LLC |
$874488 |
65751 |
0.12% |
股份
|
| RHUMBLINE ADVISERS |
$793180 |
59638 |
0.11% |
股份
|
| Quantinno Capital Management LP |
$772491 |
58082 |
0.10% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$748152 |
56252 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$705645 |
53056 |
0.10% |
股份
|
| TD Asset Management Inc |
$684711 |
51482 |
0.09% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$668737 |
50281 |
0.09% |
股份
|
| Birchview Capital, LP |
$645117 |
48505 |
0.09% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$624861 |
46982 |
0.08% |
股份
|
| Rafferty Asset Management, LLC |
$594696 |
44714 |
0.08% |
股份
|
| D. E. Shaw & Co., Inc. |
$589908 |
44354 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$555036 |
41732 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$518939 |
55740 |
0.07% |
股份
|
| Virtus Investment Advisers, LLC |
$492832 |
37055 |
0.07% |
股份
|
| Allspring Global Investments Holdings, LLC |
$472068 |
37200 |
0.06% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$380030 |
28574 |
0.05% |
股份
|
| Creative Planning |
$376669 |
28321 |
0.05% |
股份
|
| OMERS ADMINISTRATION Corp |
$369740 |
27800 |
0.05% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$354365 |
26644 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$349465 |
26444 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$346558 |
26057 |
0.05% |
股份
|
| Squarepoint Ops LLC |
$340161 |
25576 |
0.05% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$332500 |
25000 |
0.05% |
股份
|
| TRUIST FINANCIAL CORP |
$332500 |
25000 |
0.05% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$328510 |
24700 |
0.04% |
股份
|
| Kera Capital Partners, Inc. |
$320104 |
24068 |
0.04% |
股份
|
| BARCLAYS PLC |
$316873 |
23825 |
0.04% |
股份
|
| Rockefeller Capital Management L.P. |
$315596 |
23729 |
0.04% |
股份
|
| Jain Global LLC |
$313042 |
23537 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$312004 |
23459 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$301897 |
22699 |
0.04% |
股份
|
| MARSHALL WACE, LLP |
$283849 |
21342 |
0.04% |
股份
|
| Rangeley Capital, LLC |
$278835 |
20965 |
0.04% |
股份
|
| Headlands Technologies LLC |
$255865 |
19238 |
0.03% |
股份
|
| Landing Point Financial Group, LLC |
$246050 |
18500 |
0.03% |
股份
|
| Parallel Advisors, LLC |
$237897 |
17887 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$221633 |
16664 |
0.03% |
股份
|
| Ballentine Partners, LLC |
$217575 |
16359 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$207480 |
15600 |
0.03% |
买入期权
|
| Vanguard Global Advisers, LLC |
$200617 |
15084 |
0.03% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$198157 |
14899 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$185721 |
13964 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$183952 |
13831 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$166822 |
12543 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$166104 |
12489 |
0.02% |
股份
|
| LPL Financial LLC |
$165465 |
12441 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$161741 |
12161 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$160930 |
12100 |
0.02% |
卖出期权
|
| Graham Capital Management, L.P. |
$159640 |
12003 |
0.02% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$148229 |
11145 |
0.02% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$146832 |
11040 |
0.02% |
股份
|
| Inscription Capital, LLC |
$143414 |
10783 |
0.02% |
股份
|
| AlphaQuest LLC |
$117983 |
15731 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$110656 |
8320 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$109007 |
8196 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$81263 |
6110 |
0.01% |
股份
|
| Abich Financial Wealth Management LLC |
$80070 |
9214 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$73163 |
5501 |
0.01% |
股份
|
| STRS OHIO |
$66500 |
5000 |
0.01% |
股份
|
| Legal & General Group Plc |
$59158 |
4448 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$55315 |
4159 |
0.01% |
股份
|
| CWM, LLC |
$44744 |
4806 |
0.01% |
股份
|
| Arax Advisory Partners |
$42920 |
3227 |
0.01% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$33409 |
2511887 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$31095 |
2338 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$26000 |
1911 |
0.00% |
股份
|
| Optiver Holding B.V. |
$23701 |
1782 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$19710 |
1482 |
0.00% |
股份
|
| GAMMA Investing LLC |
$17742 |
1334 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$14391 |
1082 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$12289 |
924 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$10418 |
728 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$8246 |
620 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$7581 |
570 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$6650 |
500 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$6433 |
691 |
0.00% |
股份
|
| SUMMIT SECURITIES GROUP LLC |
$5746 |
432 |
0.00% |
股份
|
| NewEdge Advisors, LLC |
$2820 |
212 |
0.00% |
股份
|
| Pacific Center for Financial Services |
$2754 |
207 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$2172 |
163545 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1782 |
134 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1663 |
125 |
0.00% |
股份
|
| Marshall & Sterling Wealth Advisors Inc. |
$1330 |
100 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$1330 |
100 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1037 |
78 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$884 |
66440 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$785 |
59 |
0.00% |
股份
|
| US BANCORP \DE\ |
$771 |
58 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$730 |
54869 |
0.00% |
股份
|
| True Wealth Design, LLC |
$719 |
54 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$532 |
40 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$466 |
35 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$466 |
35 |
0.00% |
股份
|
| Quarry LP |
$359 |
27 |
0.00% |
股份
|
| Peloton Wealth Strategists |
$333 |
25000 |
0.00% |
股份
|
| COMERICA BANK |
$263 |
35 |
0.00% |
股份
|
| DekaBank Deutsche Girozentrale |
$256 |
30000 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$40 |
3 |
0.00% |
股份
|
| Essential Partners LLC |
$40 |
3 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$13 |
1 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$13 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$10 |
747 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
34 |
0.00% |
股份
|