| FMR LLC |
$419179123 |
7810306 |
11.69% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$396054169 |
7379433 |
11.05% |
股份
|
| Avoro Capital Advisors LLC |
$351836637 |
6555555 |
9.81% |
股份
|
| JANUS HENDERSON GROUP PLC |
$258260143 |
5354981 |
7.20% |
股份
|
| Deep Track Capital, LP |
$254399664 |
4740072 |
7.10% |
股份
|
| BVF INC/IL |
$180697390 |
3366823 |
5.04% |
股份
|
| MORGAN STANLEY |
$150632372 |
2806640 |
4.20% |
股份
|
| ORBIMED ADVISORS LLC |
$118578498 |
2209400 |
3.31% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$94070254 |
1752753 |
2.62% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$90282956 |
1682179 |
2.52% |
股份
|
| RTW INVESTMENTS, LP |
$86274901 |
1607507 |
2.41% |
股份
|
| Driehaus Capital Management LLC |
$83361264 |
1553219 |
2.33% |
股份
|
| BAKER BROS. ADVISORS LP |
$76883831 |
1432529 |
2.14% |
股份
|
| Casdin Capital, LLC |
$63062250 |
1175000 |
1.76% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$58285620 |
1086000 |
1.63% |
股份
|
| CAPITOLIS LIQUID GLOBAL MARKETS LLC |
$55875837 |
1041100 |
1.56% |
股份
|
| Siren, L.L.C. |
$46852139 |
872967 |
1.31% |
股份
|
| Pacific Heights Asset Management LLC |
$42936000 |
800000 |
1.20% |
股份
|
| Rock Springs Capital Management LP |
$34365813 |
640317 |
0.96% |
股份
|
| Aberdeen Group plc |
$34344238 |
639915 |
0.96% |
股份
|
| FRANKLIN RESOURCES INC |
$31066308 |
578839 |
0.87% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$30238858 |
563422 |
0.84% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$29484326 |
611708 |
0.82% |
股份
|
| BlackRock, Inc. |
$27433368 |
511149 |
0.77% |
股份
|
| Logos Global Management LP |
$26835000 |
500000 |
0.75% |
股份
|
| Parkman Healthcare Partners LLC |
$26065426 |
485661 |
0.73% |
股份
|
| Davern Capital Partners, LP |
$23939987 |
446059 |
0.67% |
股份
|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
$22476996 |
418800 |
0.63% |
股份
|
| UBS Group AG |
$20340179 |
378986 |
0.57% |
股份
|
| DEUTSCHE BANK AG\ |
$17811302 |
331867 |
0.50% |
股份
|
| NEXTBio Capital Management LP |
$16771660 |
312496 |
0.47% |
股份
|
| Catalio Capital Management, LP |
$14842438 |
276550 |
0.41% |
股份
|
| MARSHALL WACE, LLP |
$14361663 |
267592 |
0.40% |
股份
|
| HSG Holding Ltd |
$14279548 |
266062 |
0.40% |
股份
|
| SEB Asset Management AB |
$13151433 |
245043 |
0.37% |
股份
|
| GOLDMAN SACHS GROUP INC |
$13030539 |
242790 |
0.36% |
股份
|
| AMERIPRISE FINANCIAL INC |
$12371685 |
230514 |
0.35% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$11581986 |
215800 |
0.32% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$10957053 |
204156 |
0.31% |
股份
|
| Eversept Partners, LP |
$10535528 |
196302 |
0.29% |
股份
|
| Schonfeld Strategic Advisors LLC |
$10234062 |
190685 |
0.29% |
股份
|
| Woodline Partners LP |
$8254875 |
153808 |
0.23% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$8218000 |
153119 |
0.23% |
股份
|
| ArrowMark Colorado Holdings LLC |
$8081575 |
150579 |
0.23% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$7994039 |
148948 |
0.22% |
股份
|
| CenterBook Partners LP |
$7944770 |
148030 |
0.22% |
股份
|
| Rhenman & Partners Asset Management AB |
$7787517 |
145100 |
0.22% |
股份
|
| GOLDMAN SACHS GROUP INC |
$7782150 |
145000 |
0.22% |
买入期权
|
| B Group, Inc. |
$7513800 |
140000 |
0.21% |
股份
|
| HighVista Strategies LLC |
$7019177 |
130784 |
0.20% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$6745728 |
125689 |
0.19% |
股份
|
| Squarepoint Ops LLC |
$6739610 |
125575 |
0.19% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$6566202 |
122344 |
0.18% |
股份
|
| D. E. Shaw & Co., Inc. |
$6188151 |
115300 |
0.17% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$6027141 |
112300 |
0.17% |
股份
|
| Soleus Capital Management, L.P. |
$5742690 |
107000 |
0.16% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5302596 |
98800 |
0.15% |
买入期权
|
| Avidity Partners Management LP |
$5259660 |
98000 |
0.15% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$5215811 |
97183 |
0.15% |
股份
|
| Qube Research & Technologies Ltd |
$5012939 |
93403 |
0.14% |
股份
|
| PEREGRINE CAPITAL MANAGEMENT LLC |
$4949930 |
92229 |
0.14% |
股份
|
| PFM Health Sciences, LP |
$4913489 |
91550 |
0.14% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$4849782 |
90363 |
0.14% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$4807115 |
89568 |
0.13% |
股份
|
| ExodusPoint Capital Management, LP |
$4200536 |
78266 |
0.12% |
股份
|
| Boxer Capital Management, LLC |
$4025250 |
75000 |
0.11% |
股份
|
| Cormorant Asset Management, LP |
$4025250 |
75000 |
0.11% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$4025250 |
75000 |
0.11% |
股份
|
| CITADEL ADVISORS LLC |
$4014516 |
74800 |
0.11% |
买入期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3869607 |
72100 |
0.11% |
卖出期权
|
| ALPS ADVISORS INC |
$3855277 |
71833 |
0.11% |
股份
|
| TD Asset Management Inc |
$3701191 |
68962 |
0.10% |
股份
|
| Point72 Europe (London) LLP |
$3267516 |
116697 |
0.09% |
股份
|
| Brevan Howard Capital Management LP |
$3258144 |
60336 |
0.09% |
股份
|
| Burkehill Global Management, LP |
$3220200 |
60000 |
0.09% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$3185689 |
59357 |
0.09% |
股份
|
| JANE STREET GROUP, LLC |
$3026988 |
56400 |
0.08% |
买入期权
|
| CITADEL ADVISORS LLC |
$2908914 |
54200 |
0.08% |
卖出期权
|
| TUDOR INVESTMENT CORP ET AL |
$2879718 |
53656 |
0.08% |
股份
|
| ANTIPODES PARTNERS Ltd |
$2751232 |
51262 |
0.08% |
股份
|
| SCOGGIN MANAGEMENT LP |
$2683500 |
50000 |
0.07% |
买入期权
|
| Buckland Partners Management Co LLC |
$2683500 |
50000 |
0.07% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$2683500 |
50000 |
0.07% |
股份
|
| DAFNA Capital Management LLC |
$2495655 |
46500 |
0.07% |
股份
|
| Mariner, LLC |
$2484116 |
46285 |
0.07% |
股份
|
| OSAIC HOLDINGS, INC. |
$2403594 |
44786 |
0.07% |
股份
|
| STATE STREET CORP |
$2395238 |
44629 |
0.07% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$2383485 |
44410 |
0.07% |
股份
|
| BANQUE PICTET & CIE SA |
$2325628 |
43332 |
0.06% |
股份
|
| Jump Financial, LLC |
$2289455 |
42658 |
0.06% |
股份
|
| BANK OF MONTREAL /CAN/ |
$2284733 |
42570 |
0.06% |
股份
|
| Cinctive Capital Management LP |
$2193869 |
40877 |
0.06% |
股份
|
| Jefferies Financial Group Inc. |
$2180344 |
40625 |
0.06% |
股份
|
| Jones Hill Capital LP |
$2177231 |
40567 |
0.06% |
股份
|
| STEMPOINT CAPITAL LP |
$2049013 |
38178 |
0.06% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2045256 |
38108 |
0.06% |
股份
|
| CAPITAL FUND MANAGEMENT S.A. |
$2000871 |
37281 |
0.06% |
股份
|
| PSquared Asset Management AG |
$1996524 |
37200 |
0.06% |
股份
|
| FLAX POND CAPITAL, LLC |
$1932120 |
36000 |
0.05% |
股份
|
| TrueMark Investments, LLC |
$1803312 |
33600 |
0.05% |
股份
|
| NOMURA ASSET MANAGEMENT CO LTD |
$1759839 |
32790 |
0.05% |
股份
|
| DCF Advisers, LLC |
$1722807 |
32100 |
0.05% |
股份
|
| EXCHANGE TRADED CONCEPTS, LLC |
$1651587 |
30773 |
0.05% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$1534962 |
28600 |
0.04% |
股份
|
| Verition Fund Management LLC |
$1530615 |
28519 |
0.04% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1479843 |
27573 |
0.04% |
股份
|
| Seven Fleet Capital Management LP |
$1441572 |
26800 |
0.04% |
股份
|
| MML INVESTORS SERVICES, LLC |
$1374006 |
25601 |
0.04% |
股份
|
| Birchview Capital, LP |
$1288080 |
24000 |
0.04% |
股份
|
| NOMURA HOLDINGS INC |
$1227594 |
22873 |
0.03% |
股份
|
| BARCLAYS PLC |
$1085798 |
20231 |
0.03% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$954306 |
17781 |
0.03% |
股份
|
| ADAR1 Capital Management, LLC |
$939225 |
17500 |
0.03% |
股份
|
| STIFEL FINANCIAL CORP |
$806771 |
15032 |
0.02% |
股份
|
| LPL Financial LLC |
$769252 |
14333 |
0.02% |
股份
|
| WEXFORD CAPITAL LP |
$735762 |
13709 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$734422 |
13684 |
0.02% |
股份
|
| BRANDYWINE MANAGERS, LLC |
$716870 |
13357 |
0.02% |
股份
|
| Gladstone Institutional Advisory LLC |
$712469 |
13275 |
0.02% |
股份
|
| Fulcrum Asset Management LLP |
$684996 |
13252 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$665991 |
12409 |
0.02% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$621241 |
11575 |
0.02% |
股份
|
| Verdad Advisers, LP |
$608349 |
11335 |
0.02% |
股份
|
| DNB Asset Management AS |
$578509 |
10779 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$578348 |
10776 |
0.02% |
股份
|
| WELLS FARGO & COMPANY/MN |
$558033 |
10398 |
0.02% |
股份
|
| HighTower Advisors, LLC |
$538253 |
10029 |
0.02% |
股份
|
| Quinn Opportunity Partners LLC |
$536700 |
10000 |
0.01% |
股份
|
| SmartHarvest Portfolios, LLC |
$532836 |
9928 |
0.01% |
股份
|
| CITIGROUP INC |
$519526 |
9680 |
0.01% |
股份
|
| Gilbert & Cook, Inc. |
$491993 |
9167 |
0.01% |
股份
|
| IMC-Chicago, LLC |
$462528 |
8618 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$456736 |
16312 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$450828 |
8400 |
0.01% |
卖出期权
|
| SIMPLEX TRADING, LLC |
$422436 |
7871 |
0.01% |
股份
|
| Clearstead Advisors, LLC |
$420021 |
7826 |
0.01% |
股份
|
| Quadcap Wealth Management, LLC |
$409769 |
7635 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$409073 |
7622 |
0.01% |
股份
|
| Allianz Asset Management GmbH |
$407892 |
7600 |
0.01% |
股份
|
| MISSION WEALTH MANAGEMENT, LP |
$406980 |
7583 |
0.01% |
股份
|
| Vestmark Advisory Solutions, Inc. |
$404350 |
7534 |
0.01% |
股份
|
| Parallel Advisors, LLC |
$394582 |
7352 |
0.01% |
股份
|
| Cetera Investment Advisers |
$356261 |
6638 |
0.01% |
股份
|
| EntryPoint Capital, LLC |
$329319 |
6136 |
0.01% |
股份
|
| Good Life Advisors, LLC |
$311100 |
15000 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$274093 |
5107 |
0.01% |
股份
|
| NORTHERN TRUST CORP |
$272644 |
5080 |
0.01% |
股份
|
| Concurrent Investment Advisors, LLC |
$268350 |
5000 |
0.01% |
股份
|
| Bellevue Group AG |
$255577 |
4762 |
0.01% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$249297 |
4645 |
0.01% |
股份
|
| Independent Advisor Alliance |
$243823 |
4543 |
0.01% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$232123 |
4325 |
0.01% |
股份
|
| PEAK6 LLC |
$222999 |
4155 |
0.01% |
股份
|
| Walleye Trading LLC |
$220745 |
4113 |
0.01% |
股份
|
| Prospera Financial Services Inc |
$220042 |
4100 |
0.01% |
股份
|
| E. Ohman J:or Asset Management AB |
$217768 |
4518 |
0.01% |
股份
|
| GABELLI FUNDS LLC |
$217364 |
4050 |
0.01% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$214680 |
4000 |
0.01% |
买入期权
|
| Invesco Ltd. |
$212050 |
3951 |
0.01% |
股份
|
| JPMORGAN CHASE & CO |
$205933 |
3984 |
0.01% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$187845 |
3500 |
0.01% |
股份
|
| State of Wyoming |
$166431 |
3101 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$149310 |
2782 |
0.00% |
股份
|
| ASSETMARK, INC |
$146304 |
2726 |
0.00% |
股份
|
| NATIXIS |
$135095 |
2482 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$134926 |
2514 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$109755 |
2045 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$88878 |
1656 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$88609 |
1651 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$80490 |
1500 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$75138 |
1400 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$48142 |
897 |
0.00% |
股份
|
| IFP Advisors, Inc |
$46049 |
858 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$45380 |
845532 |
0.00% |
股份
|
| GAMMA Investing LLC |
$44868 |
836 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$30000 |
550 |
0.00% |
股份
|
| WOLFF WIESE MAGANA LLC |
$21468 |
400 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$20663 |
385 |
0.00% |
股份
|
| North Star Investment Management Corp. |
$17711 |
330 |
0.00% |
股份
|
| Quarry LP |
$13149 |
245 |
0.00% |
股份
|
| Godfrey Financial Associates, Inc. |
$13149 |
245 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$8699 |
175 |
0.00% |
股份
|
| Dynamic Wealth Strategies, LLC |
$8051 |
150 |
0.00% |
股份
|
| CWM, LLC |
$6025 |
125 |
0.00% |
股份
|
| Key Financial Inc |
$5367 |
100 |
0.00% |
股份
|
| SHP Wealth Management |
$5367 |
100 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$5367 |
100 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$4240 |
79 |
0.00% |
股份
|
| Rakuten Securities, Inc. |
$3220 |
60 |
0.00% |
股份
|
| Arax Advisory Partners |
$1825 |
34 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$1538 |
28665 |
0.00% |
股份
|
| Transamerica Financial Advisors, LLC |
$1180 |
22 |
0.00% |
股份
|
| Ares Financial Consulting, LLC |
$1073 |
20 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$928 |
17297 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$879 |
17 |
0.00% |
股份
|
| Janney Capital Management LLC |
$592 |
8513 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$537 |
10 |
0.00% |
股份
|
| Cullen/Frost Bankers, Inc. |
$429 |
8 |
0.00% |
股份
|
| Larson Financial Group LLC |
$322 |
6 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$288 |
5364 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$130 |
2427 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$28 |
1 |
0.00% |
股份
|
| Capital Analysts, LLC |
$1 |
18 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$1 |
22 |
0.00% |
股份
|