| MORGAN STANLEY |
$123937898 |
1308051 |
8.63% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$122963044 |
1297763 |
8.56% |
股份
|
| Sanofi |
$109713489 |
1157926 |
7.64% |
股份
|
| VIKING GLOBAL INVESTORS LP |
$106492273 |
1123929 |
7.41% |
股份
|
| HighTower Advisors, LLC |
$82484676 |
870551 |
5.74% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$79698110 |
841141 |
5.55% |
股份
|
| BlackRock, Inc. |
$78260825 |
825972 |
5.45% |
股份
|
| Schonfeld Strategic Advisors LLC |
$66096272 |
697586 |
4.60% |
股份
|
| STATE STREET CORP |
$60683396 |
640458 |
4.22% |
股份
|
| VANGUARD GROUP INC |
$49223636 |
623084 |
3.43% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$46662196 |
492477 |
3.25% |
股份
|
| Woodline Partners LP |
$37984517 |
400892 |
2.64% |
股份
|
| Capital Research Global Investors |
$34398988 |
363050 |
2.39% |
股份
|
| GOLDMAN SACHS GROUP INC |
$32042176 |
338176 |
2.23% |
股份
|
| PFM Health Sciences, LP |
$29219479 |
308385 |
2.03% |
股份
|
| Sofinnova Investments, Inc. |
$28719009 |
303103 |
2.00% |
股份
|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
$25743575 |
271700 |
1.79% |
股份
|
| Parkman Healthcare Partners LLC |
$24346013 |
256950 |
1.69% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$24278247 |
256175 |
1.69% |
股份
|
| First Turn Management, LLC |
$15613189 |
164783 |
1.09% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$13947200 |
147200 |
0.97% |
股份
|
| CDC Financial, Inc. |
$13277318 |
140130 |
0.92% |
股份
|
| FIRST TRUST ADVISORS LP |
$12168174 |
128424 |
0.85% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$11612276 |
122557 |
0.81% |
股份
|
| CAPITOLIS LIQUID GLOBAL MARKETS LLC |
$11294200 |
119200 |
0.79% |
股份
|
| NORTHERN TRUST CORP |
$9565676 |
100957 |
0.67% |
股份
|
| NORGES BANK |
$8555925 |
90300 |
0.60% |
股份
|
| CITIGROUP INC |
$7174565 |
75721 |
0.50% |
股份
|
| Jefferies Financial Group Inc. |
$6956166 |
73416 |
0.48% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$6840950 |
72200 |
0.48% |
买入期权
|
| VANGUARD FIDUCIARY TRUST CO |
$6624920 |
69920 |
0.46% |
股份
|
| GOLDMAN SACHS GROUP INC |
$6300875 |
66500 |
0.44% |
买入期权
|
| RENAISSANCE TECHNOLOGIES LLC |
$5893545 |
62201 |
0.41% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$5831389 |
61545 |
0.41% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$5669935 |
59841 |
0.39% |
股份
|
| Voleon Capital Management LP |
$5529421 |
58358 |
0.38% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$4620484 |
48765 |
0.32% |
股份
|
| Western Standard LLC |
$4453250 |
47000 |
0.31% |
股份
|
| NOMURA HOLDINGS INC |
$3837375 |
40500 |
0.27% |
买入期权
|
| Caption Management, LLC |
$3827900 |
40400 |
0.27% |
买入期权
|
| CITADEL ADVISORS LLC |
$3534175 |
37300 |
0.25% |
买入期权
|
| VICTORY CAPITAL MANAGEMENT INC |
$3452974 |
36443 |
0.24% |
股份
|
| ArrowMark Colorado Holdings LLC |
$3332926 |
35176 |
0.23% |
股份
|
| UBS Group AG |
$3318050 |
35019 |
0.23% |
股份
|
| HUSSMAN STRATEGIC ADVISORS, INC. |
$2984625 |
31500 |
0.21% |
股份
|
| Empyrean Capital Partners, LP |
$2842500 |
30000 |
0.20% |
股份
|
| CDC Financial, Inc. |
$2842500 |
30000 |
0.20% |
买入期权
|
| Atom Investors LP |
$2804032 |
29594 |
0.20% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2717241 |
28678 |
0.19% |
股份
|
| Corient Private Wealth LP |
$2714873 |
28653 |
0.19% |
股份
|
| Bank of New York Mellon Corp |
$2482451 |
26200 |
0.17% |
股份
|
| Point72 Asset Management, L.P. |
$2464542 |
26011 |
0.17% |
股份
|
| Russell Investments Group, Ltd. |
$2388604 |
25209 |
0.17% |
股份
|
| NOMURA HOLDINGS INC |
$2359275 |
24900 |
0.16% |
卖出期权
|
| Informed Momentum Co LLC |
$2186546 |
23077 |
0.15% |
股份
|
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management |
$2139834 |
22584 |
0.15% |
股份
|
| D. E. Shaw & Co., Inc. |
$2115010 |
22322 |
0.15% |
股份
|
| Nicholas Investment Partners, LP |
$2031724 |
21443 |
0.14% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2029640 |
21421 |
0.14% |
股份
|
| Opaleye Management Inc. |
$1922572 |
20291 |
0.13% |
股份
|
| JANE STREET GROUP, LLC |
$1819200 |
19200 |
0.13% |
买入期权
|
| Nuveen, LLC |
$1767846 |
18658 |
0.12% |
股份
|
| XTX Topco Ltd |
$1739894 |
18363 |
0.12% |
股份
|
| Verition Fund Management LLC |
$1704837 |
17993 |
0.12% |
股份
|
| D. E. Shaw & Co., Inc. |
$1667600 |
17600 |
0.12% |
买入期权
|
| Quantinno Capital Management LP |
$1648271 |
17396 |
0.11% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1636522 |
17272 |
0.11% |
股份
|
| Invesco Ltd. |
$1597295 |
16858 |
0.11% |
股份
|
| Ratan Capital Management LP |
$1573987 |
16612 |
0.11% |
股份
|
| SummitTX Capital, L.P. |
$1445032 |
15251 |
0.10% |
股份
|
| Laird Norton Wetherby Wealth Management, LLC |
$1369295 |
40656 |
0.10% |
股份
|
| Swiss National Bank |
$1317025 |
13900 |
0.09% |
股份
|
| FRANKLIN RESOURCES INC |
$1264249 |
13343 |
0.09% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1222275 |
12900 |
0.09% |
卖出期权
|
| RHUMBLINE ADVISERS |
$1142299 |
12056 |
0.08% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1065654 |
11247 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$1056273 |
11148 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$907611 |
9579 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$906094 |
9563 |
0.06% |
股份
|
| Ethic Inc. |
$885439 |
9345 |
0.06% |
股份
|
| MARSHALL WACE, LLP |
$833801 |
8800 |
0.06% |
股份
|
| Meridian Wealth Advisors, LLC |
$805375 |
8500 |
0.06% |
股份
|
| NOMURA HOLDINGS INC |
$758000 |
8000 |
0.05% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$734028 |
7747 |
0.05% |
股份
|
| Brevan Howard Capital Management LP |
$724743 |
7649 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$701340 |
7402 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$648770 |
9650 |
0.05% |
股份
|
| Squarepoint Ops LLC |
$619949 |
6543 |
0.04% |
股份
|
| Creative Planning |
$617180 |
6514 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$599389 |
6326 |
0.04% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$582334 |
6146 |
0.04% |
股份
|
| Cannon Global Investment Management, LLC |
$559025 |
5900 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$538678 |
5675 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$534201 |
5638 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$532495 |
5620 |
0.04% |
股份
|
| ExodusPoint Capital Management, LP |
$531737 |
5612 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$511650 |
5400 |
0.04% |
卖出期权
|
| Qube Research & Technologies Ltd |
$509566 |
5378 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$502331 |
5260 |
0.03% |
股份
|
| Legal & General Group Plc |
$486825 |
5138 |
0.03% |
股份
|
| D. E. Shaw & Co., Inc. |
$483225 |
5100 |
0.03% |
卖出期权
|
| Persium Advisors, LLC |
$461906 |
4875 |
0.03% |
股份
|
| Dynamic Advisor Solutions LLC |
$457074 |
4824 |
0.03% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$454705 |
4799 |
0.03% |
股份
|
| Balyasny Asset Management L.P. |
$447978 |
4728 |
0.03% |
股份
|
| Mariner, LLC |
$432908 |
4569 |
0.03% |
股份
|
| SIG BROKERAGE, LP |
$426375 |
4500 |
0.03% |
买入期权
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$405151 |
4276 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$398519 |
4206 |
0.03% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$379000 |
4000 |
0.03% |
股份
|
| MACQUARIE GROUP LTD |
$379000 |
4000 |
0.03% |
股份
|
| LANARK FINANCIAL, INC. |
$369525 |
3900 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$336268 |
3549 |
0.02% |
股份
|
| Marble Bar Asset Management LLP |
$335131 |
3537 |
0.02% |
股份
|
| NewEdge Wealth, LLC |
$332288 |
3507 |
0.02% |
股份
|
| Presidio Capital Management, LLC |
$321582 |
3394 |
0.02% |
股份
|
| Jain Global LLC |
$312486 |
3298 |
0.02% |
股份
|
| FORA Capital, LLC |
$300639 |
3177 |
0.02% |
股份
|
| GROUP ONE TRADING LLC |
$296473 |
3129 |
0.02% |
股份
|
| NINE MASTS CAPITAL Ltd |
$284250 |
3000 |
0.02% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$279134 |
2946 |
0.02% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$267010 |
2818 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$252035 |
2660 |
0.02% |
股份
|
| HARVEST MANAGEMENT LLC |
$246350 |
2600 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$228684 |
3400 |
0.02% |
股份
|
| BARCLAYS PLC |
$222380 |
2347 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$221241 |
2335 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$212524 |
2243 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$207314 |
2188 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$205797 |
2172 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$198028 |
2090 |
0.01% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$193764 |
2045 |
0.01% |
股份
|
| AlphaQuest LLC |
$173168 |
2192 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$151600 |
1600 |
0.01% |
股份
|
| SIMPLEX TRADING, LLC |
$151410 |
1598 |
0.01% |
股份
|
| State of Wyoming |
$116258 |
1227 |
0.01% |
股份
|
| FMR LLC |
$107488 |
1134 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$81769 |
863 |
0.01% |
股份
|
| Fulcrum Asset Management LLP |
$78119 |
818 |
0.01% |
股份
|
| Quantbot Technologies LP |
$68315 |
721 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$62156 |
656 |
0.00% |
股份
|
| Optiver Holding B.V. |
$54576 |
576 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$41690 |
440 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$36000 |
386 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$34773 |
367 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$29562 |
312 |
0.00% |
股份
|
| Dynamic Advisor Solutions LLC |
$28425 |
300 |
0.00% |
买入期权
|
| GAMMA Investing LLC |
$17150 |
181 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$16813 |
168 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$11939 |
126 |
0.00% |
股份
|
| CWM, LLC |
$10690 |
159 |
0.00% |
股份
|
| Torren Management, LLC |
$7395 |
110 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$7390 |
78 |
0.00% |
股份
|
| Arax Advisory Partners |
$6917 |
73 |
0.00% |
股份
|
| US BANCORP \DE\ |
$5875 |
62 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5780 |
61 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$4504 |
67 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$3885 |
41 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2558 |
27 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$2085 |
22 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$1990 |
21 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1611 |
17 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$1421 |
15 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1232 |
13 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$1181 |
12466 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$927 |
9787 |
0.00% |
股份
|
| Allworth Financial LP |
$758 |
8 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$741 |
7812 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$538 |
8 |
0.00% |
股份
|
| EASTERN BANK |
$474 |
5 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$284 |
3 |
0.00% |
股份
|
| Essential Partners LLC |
$190 |
2 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$190 |
2 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$95 |
1 |
0.00% |
股份
|
| Larson Financial Group LLC |
$95 |
1 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$23 |
250 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$18 |
186 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
3 |
0.00% |
股份
|