| FMR LLC |
$357981753 |
4894473 |
11.37% |
股份
|
| BlackRock, Inc. |
$180502133 |
2467899 |
5.73% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$179209164 |
2450221 |
5.69% |
股份
|
| VANGUARD GROUP INC |
$140371470 |
1767680 |
4.46% |
股份
|
| JPMORGAN CHASE & CO |
$139868053 |
1875795 |
4.44% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$127362413 |
1741351 |
4.05% |
股份
|
| STATE STREET CORP |
$120595865 |
1648836 |
3.83% |
股份
|
| Vestal Point Capital, LP |
$113367000 |
1550000 |
3.60% |
股份
|
| Atlas Venture Life Science Advisors, LLC |
$110724818 |
1513875 |
3.52% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$100130635 |
1369027 |
3.18% |
股份
|
| Frazier Life Sciences Management, L.P. |
$99093875 |
1354852 |
3.15% |
股份
|
| TCG Crossover Management, LLC |
$98143787 |
1341862 |
3.12% |
股份
|
| BVF INC/IL |
$84375182 |
1153612 |
2.68% |
股份
|
| Woodline Partners LP |
$70088672 |
958281 |
2.23% |
股份
|
| Siren, L.L.C. |
$64977649 |
888401 |
2.06% |
股份
|
| Logos Global Management LP |
$63997500 |
875000 |
2.03% |
股份
|
| Opaleye Management Inc. |
$62534700 |
855000 |
1.99% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$57772342 |
789724 |
1.84% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$48052980 |
657000 |
1.53% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$41622451 |
569018 |
1.32% |
股份
|
| Bellevue Group AG |
$40958400 |
560000 |
1.30% |
股份
|
| Saturn V Capital Management LP |
$38378752 |
524730 |
1.22% |
股份
|
| ARMISTICE CAPITAL, LLC |
$33644400 |
460000 |
1.07% |
股份
|
| JENNISON ASSOCIATES LLC |
$32146492 |
439520 |
1.02% |
股份
|
| Aberdeen Group plc |
$32048046 |
438174 |
1.02% |
股份
|
| Palo Alto Investors LP |
$30473488 |
416646 |
0.97% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$28938480 |
395651 |
0.92% |
股份
|
| Pictet Asset Management Holding SA |
$28186328 |
385375 |
0.90% |
股份
|
| Assenagon Asset Management S.A. |
$28097316 |
384158 |
0.89% |
股份
|
| LOOMIS SAYLES & CO L P |
$27929533 |
381864 |
0.89% |
股份
|
| Foresite Capital Management V, LLC |
$27359407 |
374069 |
0.87% |
股份
|
| ORBIMED ADVISORS LLC |
$26150110 |
357535 |
0.83% |
股份
|
| BAKER BROS. ADVISORS LP |
$25573913 |
349657 |
0.81% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$20620872 |
281937 |
0.66% |
股份
|
| Octagon Capital Advisors LP |
$19747800 |
270000 |
0.63% |
股份
|
| NORTHERN TRUST CORP |
$19381368 |
264990 |
0.62% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$18824919 |
257382 |
0.60% |
股份
|
| Checkpoint Capital L.P. |
$17562743 |
240125 |
0.56% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$16470982 |
225198 |
0.52% |
股份
|
| CITADEL ADVISORS LLC |
$15308787 |
209308 |
0.49% |
股份
|
| Bank of New York Mellon Corp |
$14973763 |
204727 |
0.48% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$13508592 |
184695 |
0.43% |
股份
|
| Catalio Capital Management, LP |
$11657346 |
159384 |
0.37% |
股份
|
| Caption Management, LLC |
$10971000 |
150000 |
0.35% |
买入期权
|
| Sofinnova Investments, Inc. |
$10695920 |
146239 |
0.34% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$10329855 |
141234 |
0.33% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$10001895 |
136750 |
0.32% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$9882018 |
135111 |
0.31% |
股份
|
| Alyeska Investment Group, L.P. |
$9142500 |
125000 |
0.29% |
股份
|
| Ensign Peak Advisors, Inc |
$8931199 |
122111 |
0.28% |
股份
|
| UBS Group AG |
$8116419 |
110971 |
0.26% |
股份
|
| Trexquant Investment LP |
$7877105 |
107699 |
0.25% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$7809085 |
106769 |
0.25% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7770979 |
106248 |
0.25% |
股份
|
| GOLDMAN SACHS GROUP INC |
$7122593 |
97383 |
0.23% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$7090307 |
110890 |
0.23% |
股份
|
| MORGAN STANLEY |
$6699315 |
91595 |
0.21% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$6055992 |
82800 |
0.19% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$5703384 |
77980 |
0.18% |
股份
|
| Squarepoint Ops LLC |
$5549278 |
75872 |
0.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5383104 |
73600 |
0.17% |
买入期权
|
| DNB Asset Management AS |
$5348509 |
73127 |
0.17% |
股份
|
| Casdin Capital, LLC |
$4754100 |
65000 |
0.15% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$4647169 |
63538 |
0.15% |
股份
|
| Nuveen, LLC |
$4414511 |
60357 |
0.14% |
股份
|
| PEAK6 LLC |
$4388400 |
60000 |
0.14% |
买入期权
|
| KVP Capital Advisors, LP |
$4260405 |
58250 |
0.14% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$4227199 |
57796 |
0.13% |
股份
|
| XTX Topco Ltd |
$4147769 |
56710 |
0.13% |
股份
|
| NEXTBio Capital Management LP |
$3851187 |
52655 |
0.12% |
股份
|
| ALGERT GLOBAL LLC |
$3792309 |
51850 |
0.12% |
股份
|
| ExodusPoint Capital Management, LP |
$3775706 |
51623 |
0.12% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$3725000 |
50000 |
0.12% |
股份
|
| Burkehill Global Management, LP |
$3657000 |
50000 |
0.12% |
股份
|
| Brevan Howard Capital Management LP |
$3656707 |
49996 |
0.12% |
股份
|
| Swiss National Bank |
$3642372 |
49800 |
0.12% |
股份
|
| AMERIPRISE FINANCIAL INC |
$3355224 |
45874 |
0.11% |
股份
|
| Atle Fund Management AB |
$3194901 |
43682 |
0.10% |
股份
|
| Quadrature Capital Ltd |
$3102526 |
42419 |
0.10% |
股份
|
| Invesco Ltd. |
$3076049 |
42057 |
0.10% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2878790 |
39360 |
0.09% |
股份
|
| ALPS ADVISORS INC |
$2820644 |
38565 |
0.09% |
股份
|
| CITIGROUP INC |
$2802506 |
38317 |
0.09% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$2798483 |
38262 |
0.09% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$2679411 |
36634 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$2621620 |
35844 |
0.08% |
股份
|
| LAZARD ASSET MANAGEMENT LLC |
$2562387 |
35034 |
0.08% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$2559900 |
35000 |
0.08% |
股份
|
| MARSHALL WACE, LLP |
$2515577 |
34394 |
0.08% |
股份
|
| Jump Financial, LLC |
$2380634 |
32549 |
0.08% |
股份
|
| BANK OF MONTREAL /CAN/ |
$2363007 |
32308 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$2241229 |
30643 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$2216800 |
34670 |
0.07% |
股份
|
| RTW INVESTMENTS, LP |
$2194200 |
30000 |
0.07% |
股份
|
| Squadron Capital Management LLC |
$2194200 |
30000 |
0.07% |
买入期权
|
| VICTORY CAPITAL MANAGEMENT INC |
$2129618 |
29117 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2115464 |
28924 |
0.07% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$2096412 |
28663 |
0.07% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2031171 |
27771 |
0.06% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1966588 |
26888 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$1943037 |
26566 |
0.06% |
股份
|
| Campbell & CO Investment Adviser LLC |
$1870044 |
25568 |
0.06% |
股份
|
| PNC Financial Services Group, Inc. |
$1633435 |
22333 |
0.05% |
股份
|
| TD Asset Management Inc |
$1579824 |
21600 |
0.05% |
股份
|
| Engineers Gate Manager LP |
$1430033 |
19552 |
0.05% |
股份
|
| BARCLAYS PLC |
$1368450 |
18710 |
0.04% |
股份
|
| Legal & General Group Plc |
$1350019 |
18458 |
0.04% |
股份
|
| DLD Asset Management, LP |
$1330238 |
18200 |
0.04% |
卖出期权
|
| CITADEL ADVISORS LLC |
$1258008 |
17200 |
0.04% |
卖出期权
|
| MetLife Investment Management, LLC |
$1213246 |
16588 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1182775 |
16114 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1178359 |
16111 |
0.04% |
股份
|
| JANE STREET GROUP, LLC |
$1171045 |
16011 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$1155612 |
15800 |
0.04% |
买入期权
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1128477 |
15429 |
0.04% |
股份
|
| Man Group plc |
$1091615 |
14925 |
0.03% |
股份
|
| HighVista Strategies LLC |
$1039978 |
14219 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$988048 |
13509 |
0.03% |
股份
|
| Ikarian Capital, LLC |
$972762 |
13300 |
0.03% |
买入期权
|
| Ikarian Capital, LLC |
$972762 |
13300 |
0.03% |
卖出期权
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$948699 |
12971 |
0.03% |
股份
|
| Qube Research & Technologies Ltd |
$933120 |
12758 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$925008 |
12647 |
0.03% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$878339 |
12009 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$848205 |
11597 |
0.03% |
股份
|
| JANUS HENDERSON GROUP PLC |
$739462 |
11555 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$736959 |
10076 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$721745 |
9868 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$665574 |
9100 |
0.02% |
买入期权
|
| Entropy Technologies, LP |
$614961 |
8408 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$610353 |
8345 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$602600 |
8239 |
0.02% |
股份
|
| Lion Point Capital, LP |
$592434 |
8100 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$591190 |
8083 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$586583 |
8020 |
0.02% |
股份
|
| PSP Research LLC |
$585120 |
8000 |
0.02% |
股份
|
| Cubist Systematic Strategies, LLC |
$575848 |
8714 |
0.02% |
股份
|
| Quantinno Capital Management LP |
$533703 |
7297 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$526608 |
7200 |
0.02% |
卖出期权
|
| ARIZONA STATE RETIREMENT SYSTEM |
$500570 |
6844 |
0.02% |
股份
|
| EntryPoint Capital, LLC |
$465975 |
6371 |
0.01% |
股份
|
| SummitTX Capital, L.P. |
$461440 |
6309 |
0.01% |
股份
|
| Creative Planning |
$457418 |
6254 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$442790 |
6054 |
0.01% |
股份
|
| AXQ CAPITAL, LP |
$441400 |
6035 |
0.01% |
股份
|
| D. E. Shaw & Co., Inc. |
$440815 |
6027 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$435841 |
5959 |
0.01% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$424797 |
5808 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$412510 |
5640 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$397150 |
5430 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$380328 |
5200 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$365700 |
5000 |
0.01% |
卖出期权
|
| ProShare Advisors LLC |
$362701 |
4959 |
0.01% |
股份
|
| Virtus Investment Advisers, LLC |
$351950 |
4812 |
0.01% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$345184 |
4616 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$338638 |
4630 |
0.01% |
股份
|
| Eleva Capital SAS |
$327053 |
5115 |
0.01% |
股份
|
| Fiduciary Trust Co |
$296290 |
4051 |
0.01% |
股份
|
| AlphaCentric Advisors LLC |
$294754 |
4030 |
0.01% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$292560 |
4000 |
0.01% |
买入期权
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$292560 |
4000 |
0.01% |
卖出期权
|
| E Fund Management Co., Ltd. |
$273982 |
3746 |
0.01% |
股份
|
| Bryce Point Capital, LLC |
$258505 |
3912 |
0.01% |
股份
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$245385 |
3355 |
0.01% |
股份
|
| Jain Global LLC |
$228928 |
3130 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$225417 |
3082 |
0.01% |
股份
|
| DLD Asset Management, LP |
$219420 |
3000 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$213130 |
2914 |
0.01% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$211741 |
2895 |
0.01% |
股份
|
| STRS OHIO |
$197478 |
2700 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$187824 |
2568 |
0.01% |
股份
|
| Quantbot Technologies LP |
$152863 |
2090 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$137168 |
1875399 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$124923 |
1708 |
0.00% |
股份
|
| US BANCORP \DE\ |
$89889 |
1229 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$73000 |
989 |
0.00% |
股份
|
| Foresite Capital Management VI LLC |
$70946 |
970 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$68678 |
939 |
0.00% |
股份
|
| CWM, LLC |
$66178 |
1035 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$59170 |
809 |
0.00% |
股份
|
| Allworth Financial LP |
$46298 |
633 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$41397 |
566 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$38618 |
528 |
0.00% |
股份
|
| Bayforest Capital Ltd |
$32986 |
451 |
0.00% |
股份
|
| AlphaQuest LLC |
$29064 |
366 |
0.00% |
股份
|
| State of Wyoming |
$25306 |
346 |
0.00% |
股份
|
| GAMMA Investing LLC |
$21357 |
292 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$19675 |
269 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$19602 |
268 |
0.00% |
股份
|
| TORONTO DOMINION BANK |
$14482 |
198 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$11776 |
161 |
0.00% |
股份
|
| Larson Financial Group LLC |
$8996 |
123 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7241 |
99 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$6854 |
92 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$6642 |
90822 |
0.00% |
股份
|
| Arax Advisory Partners |
$6290 |
86 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$5705 |
78 |
0.00% |
股份
|
| iA Global Asset Management Inc. |
$4829 |
66023 |
0.00% |
股份
|
| Optiver Holding B.V. |
$4754 |
65 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$3439 |
47 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$3273 |
50 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$2879 |
58 |
0.00% |
股份
|
| FIRST HORIZON CORP |
$2633 |
36 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2340 |
32 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$1902 |
26 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$1844 |
25 |
0.00% |
股份
|
| COMERICA BANK |
$1544 |
19 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1462 |
20 |
0.00% |
股份
|
| Quarry LP |
$1317 |
18 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$1287 |
17599 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$1244 |
17 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1243 |
17 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$1194 |
16324 |
0.00% |
股份
|
| Geneos Wealth Management Inc. |
$951 |
13 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$878 |
12 |
0.00% |
股份
|
| ASSETMARK, INC |
$878 |
12 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$805 |
11 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$658 |
9 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$563 |
7704 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$439 |
6 |
0.00% |
股份
|
| Essential Partners LLC |
$366 |
5 |
0.00% |
股份
|
| Virtu Financial LLC |
$343 |
4694 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$293 |
4 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$148 |
2 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$146 |
2 |
0.00% |
股份
|
| Downshift Financial, LLC |
$146 |
2 |
0.00% |
股份
|
| KBC Group NV |
$74 |
1011 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$73 |
1 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$73 |
1 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$73 |
1 |
0.00% |
股份
|
| IFP Advisors, Inc |
$73 |
1 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$53 |
730 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$32 |
444 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
7 |
0.00% |
股份
|
| GW&K Investment Management, LLC |
$1 |
16 |
0.00% |
股份
|