| RA CAPITAL MANAGEMENT, L.P. |
$18732549 |
1917354 |
8.69% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$14863316 |
1521322 |
6.89% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$14831964 |
1518113 |
6.88% |
股份
|
| GOLDMAN SACHS GROUP INC |
$13918908 |
1424658 |
6.46% |
股份
|
| BlackRock, Inc. |
$13861666 |
1418799 |
6.43% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$9369225 |
958979 |
4.35% |
股份
|
| Catalio Capital Management, LP |
$9192153 |
940855 |
4.26% |
股份
|
| Avidity Partners Management LP |
$9032238 |
924487 |
4.19% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$6792729 |
695264 |
3.15% |
股份
|
| Kalehua Capital Management LLC |
$6698742 |
685644 |
3.11% |
股份
|
| NEA Management Company, LLC |
$5635141 |
576780 |
2.61% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$5191417 |
531231 |
2.41% |
股份
|
| Ghisallo Capital Management LLC |
$4885000 |
500000 |
2.27% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4736496 |
484800 |
2.20% |
买入期权
|
| Soleus Capital Management, L.P. |
$4298800 |
440000 |
1.99% |
股份
|
| VANGUARD GROUP INC |
$4118796 |
559619 |
1.91% |
股份
|
| UBS Group AG |
$3454135 |
353545 |
1.60% |
股份
|
| STATE STREET CORP |
$3184932 |
325991 |
1.48% |
股份
|
| Affinity Asset Advisors, LLC |
$3053125 |
312500 |
1.42% |
股份
|
| Brevan Howard Capital Management LP |
$3026912 |
309817 |
1.40% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$2986455 |
305676 |
1.39% |
股份
|
| Boxer Capital Management, LLC |
$2955777 |
302536 |
1.37% |
股份
|
| Davidson Kempner Capital Management LP |
$2931000 |
300000 |
1.36% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$2906184 |
297460 |
1.35% |
股份
|
| Caption Management, LLC |
$2791289 |
285700 |
1.29% |
买入期权
|
| Eversept Partners, LP |
$2698220 |
276174 |
1.25% |
股份
|
| Tetragon Partners GP Ltd |
$2445431 |
250300 |
1.13% |
买入期权
|
| JPMORGAN CHASE & CO |
$2093737 |
207609 |
0.97% |
股份
|
| MORGAN STANLEY |
$1978485 |
202506 |
0.92% |
股份
|
| Trexquant Investment LP |
$1840355 |
188368 |
0.85% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1837131 |
188038 |
0.85% |
股份
|
| BARCLAYS PLC |
$1620882 |
165904 |
0.75% |
股份
|
| NORTHERN TRUST CORP |
$1563258 |
160006 |
0.73% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1420568 |
145401 |
0.66% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1317172 |
134818 |
0.61% |
股份
|
| MARSHALL WACE, LLP |
$1254967 |
128451 |
0.58% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1057251 |
108214 |
0.49% |
股份
|
| DLD Asset Management, LP |
$989625 |
101500 |
0.46% |
卖出期权
|
| SILVERBACK ASSET MANAGEMENT LLC |
$977000 |
100000 |
0.45% |
买入期权
|
| Jump Financial, LLC |
$918380 |
94000 |
0.43% |
股份
|
| Caption Management, LLC |
$903725 |
92500 |
0.42% |
卖出期权
|
| Invesco Ltd. |
$882270 |
90304 |
0.41% |
股份
|
| DLD Asset Management, LP |
$780975 |
80100 |
0.36% |
买入期权
|
| Connor, Clark & Lunn Investment Management Ltd. |
$746399 |
76397 |
0.35% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$702199 |
71873 |
0.33% |
股份
|
| J. Goldman & Co LP |
$660452 |
67600 |
0.31% |
卖出期权
|
| TWO SIGMA ADVISERS, LP |
$660405 |
89729 |
0.31% |
股份
|
| J. Goldman & Co LP |
$659475 |
67500 |
0.31% |
股份
|
| Squarepoint Ops LLC |
$623336 |
63801 |
0.29% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$605183 |
61943 |
0.28% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$594993 |
60900 |
0.28% |
卖出期权
|
| ROYAL BANK OF CANADA |
$590000 |
60430 |
0.27% |
股份
|
| Bank of New York Mellon Corp |
$559446 |
57262 |
0.26% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$532905 |
54545 |
0.25% |
股份
|
| XTX Topco Ltd |
$520467 |
53272 |
0.24% |
股份
|
| CITADEL ADVISORS LLC |
$509994 |
52200 |
0.24% |
买入期权
|
| CITADEL ADVISORS LLC |
$508714 |
52069 |
0.24% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$487758 |
49924 |
0.23% |
股份
|
| CITIGROUP INC |
$370449 |
37917 |
0.17% |
股份
|
| Nuveen, LLC |
$369971 |
37868 |
0.17% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$351720 |
36000 |
0.16% |
卖出期权
|
| Engineers Gate Manager LP |
$331848 |
33966 |
0.15% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$326000 |
33333 |
0.15% |
股份
|
| JANE STREET GROUP, LLC |
$324100 |
33173 |
0.15% |
股份
|
| TORONTO DOMINION BANK |
$302186 |
30930 |
0.14% |
股份
|
| SILVERBACK ASSET MANAGEMENT LLC |
$293100 |
30000 |
0.14% |
股份
|
| Baird Financial Group, Inc. |
$291058 |
29791 |
0.14% |
股份
|
| JANE STREET GROUP, LLC |
$286261 |
29300 |
0.13% |
买入期权
|
| ExodusPoint Capital Management, LP |
$259706 |
26582 |
0.12% |
股份
|
| China Universal Asset Management Co., Ltd. |
$244250 |
25000 |
0.11% |
股份
|
| SIMPLEX TRADING, LLC |
$235320 |
24086 |
0.11% |
股份
|
| JANE STREET GROUP, LLC |
$232526 |
23800 |
0.11% |
卖出期权
|
| RHUMBLINE ADVISERS |
$229266 |
23467 |
0.11% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$227299 |
23265 |
0.11% |
股份
|
| Velan Capital Investment Management LP |
$195400 |
20000 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$189782 |
19425 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$165142 |
16903 |
0.08% |
股份
|
| SEI INVESTMENTS CO |
$147361 |
15083 |
0.07% |
股份
|
| HSBC HOLDINGS PLC |
$137363 |
13750 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$133849 |
13700 |
0.06% |
卖出期权
|
| Headlands Technologies LLC |
$118344 |
12113 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$117406 |
12017 |
0.05% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$101364 |
10375 |
0.05% |
股份
|
| Quadrature Capital Ltd |
$100592 |
10296 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$89601 |
9171 |
0.04% |
股份
|
| FMR LLC |
$87305 |
8936 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$80182 |
8207 |
0.04% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$57389 |
5874 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$54712 |
5600 |
0.03% |
股份
|
| TD Waterhouse Canada Inc. |
$54502 |
5707 |
0.03% |
股份
|
| Legal & General Group Plc |
$18905 |
1935 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$17664 |
1808 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$15553 |
1592 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$12300 |
1259 |
0.01% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$7683 |
786309 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$3927 |
402 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3439 |
352 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$2916 |
298997 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$2784 |
285 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2677 |
274 |
0.00% |
股份
|
| Quent Capital, LLC |
$1622 |
166 |
0.00% |
股份
|
| MB, LEVIS & ASSOCIATES, LLC |
$977 |
100 |
0.00% |
股份
|
| C WorldWide Group Holding A/S |
$977 |
100000 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$655 |
67 |
0.00% |
股份
|
| Activest Wealth Management |
$645 |
66 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$266 |
27225 |
0.00% |
股份
|
| Allworth Financial LP |
$255 |
26 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$137 |
14 |
0.00% |
股份
|
| Virtu Financial LLC |
$105 |
10728 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$20 |
3 |
0.00% |
股份
|
| West Branch Capital LLC |
$17 |
3 |
0.00% |
股份
|
| PlanVest Financial, Inc |
$10 |
1 |
0.00% |
股份
|