| Frazier Life Sciences Management, L.P. |
$150182184 |
5032915 |
8.80% |
股份
|
| TRV GP IV, LLC |
$133502907 |
4473958 |
7.82% |
股份
|
| ARCH Venture Management, LLC |
$122983582 |
4120053 |
7.20% |
股份
|
| Deep Track Capital, LP |
$111379859 |
3732569 |
6.52% |
股份
|
| BlackRock, Inc. |
$104524775 |
3502841 |
6.12% |
股份
|
| JANUS HENDERSON GROUP PLC |
$85280271 |
2858876 |
4.99% |
股份
|
| VANGUARD GROUP INC |
$70307332 |
1697015 |
4.12% |
股份
|
| Logos Global Management LP |
$57740400 |
1935000 |
3.38% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$53062144 |
1778222 |
3.11% |
股份
|
| a16z Capital Management, L.L.C. |
$50794394 |
1702225 |
2.97% |
股份
|
| Venrock Adviser, LLC |
$47804695 |
1602034 |
2.80% |
股份
|
| Alphabet Inc. |
$41435317 |
1388583 |
2.43% |
股份
|
| BRAIDWELL LP |
$34018794 |
1140040 |
1.99% |
股份
|
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
$33057170 |
1107814 |
1.94% |
股份
|
| FMR LLC |
$31539649 |
1056959 |
1.85% |
股份
|
| General Catalyst Group Management, LLC |
$30911554 |
1035910 |
1.81% |
股份
|
| STATE STREET CORP |
$29766385 |
997533 |
1.74% |
股份
|
| Driehaus Capital Management LLC |
$28493798 |
954886 |
1.67% |
股份
|
| TRV GP V, LLC |
$28371872 |
950800 |
1.66% |
股份
|
| JPMORGAN CHASE & CO |
$27995382 |
964011 |
1.64% |
股份
|
| MARSHALL WACE, LLP |
$27290827 |
914572 |
1.60% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$25608436 |
858054 |
1.50% |
股份
|
| CITADEL ADVISORS LLC |
$25443852 |
852676 |
1.49% |
股份
|
| Casdin Capital, LLC |
$25180693 |
843857 |
1.47% |
股份
|
| ArrowMark Colorado Holdings LLC |
$22898709 |
767383 |
1.34% |
股份
|
| Woodline Partners LP |
$21968685 |
736216 |
1.29% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$12460110 |
417564 |
0.73% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$11730313 |
393107 |
0.69% |
股份
|
| Aberdeen Group plc |
$11451786 |
383773 |
0.67% |
股份
|
| Ikarian Capital, LLC |
$11309331 |
378999 |
0.66% |
股份
|
| HHLR ADVISORS, LTD. |
$10922276 |
366028 |
0.64% |
股份
|
| ADAR1 Capital Management, LLC |
$10123996 |
339276 |
0.59% |
股份
|
| Squadron Capital Management LLC |
$9996400 |
335000 |
0.59% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$9585414 |
321227 |
0.56% |
股份
|
| NORTHERN TRUST CORP |
$8795101 |
294742 |
0.52% |
股份
|
| GOLDMAN SACHS GROUP INC |
$8747417 |
293144 |
0.51% |
股份
|
| Candriam S.C.A. |
$8166266 |
273932 |
0.48% |
股份
|
| Hudson Bay Capital Management LP |
$8056800 |
270000 |
0.47% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$7775289 |
260566 |
0.46% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$7400320 |
248000 |
0.43% |
股份
|
| Mass General Brigham, Inc |
$7161421 |
239994 |
0.42% |
股份
|
| AMERIPRISE FINANCIAL INC |
$6786363 |
227425 |
0.40% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6562950 |
219938 |
0.38% |
股份
|
| RTW INVESTMENTS, LP |
$6326080 |
212000 |
0.37% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$5796288 |
199872 |
0.34% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$5757688 |
192952 |
0.34% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$5635493 |
188857 |
0.33% |
股份
|
| ExodusPoint Capital Management, LP |
$5468598 |
183264 |
0.32% |
股份
|
| SummitTX Capital, L.P. |
$5260523 |
176291 |
0.31% |
股份
|
| HighVista Strategies LLC |
$4075308 |
136572 |
0.24% |
股份
|
| MORGAN STANLEY |
$4033413 |
135168 |
0.24% |
股份
|
| Qube Research & Technologies Ltd |
$3910323 |
131043 |
0.23% |
股份
|
| Walleye Capital LLC |
$3819699 |
128006 |
0.22% |
股份
|
| Exome Asset Management LLC |
$3422409 |
114692 |
0.20% |
股份
|
| Ensign Peak Advisors, Inc |
$3033057 |
101644 |
0.18% |
股份
|
| Alyeska Investment Group, L.P. |
$2984000 |
100000 |
0.17% |
股份
|
| Bank of New York Mellon Corp |
$2912025 |
97588 |
0.17% |
股份
|
| ALGERT GLOBAL LLC |
$2785773 |
93357 |
0.16% |
股份
|
| UBS Group AG |
$2526821 |
84679 |
0.15% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2468485 |
82724 |
0.14% |
股份
|
| Trexquant Investment LP |
$2436973 |
81668 |
0.14% |
股份
|
| FRANKLIN RESOURCES INC |
$2393645 |
80216 |
0.14% |
股份
|
| Nuveen, LLC |
$2341485 |
78468 |
0.14% |
股份
|
| OSAIC HOLDINGS, INC. |
$2323044 |
77850 |
0.14% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$2305170 |
77251 |
0.13% |
股份
|
| XTX Topco Ltd |
$2247459 |
75317 |
0.13% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$2219617 |
74384 |
0.13% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1979974 |
66353 |
0.12% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$1953565 |
65468 |
0.11% |
股份
|
| DAFNA Capital Management LLC |
$1939600 |
65000 |
0.11% |
股份
|
| ALPS ADVISORS INC |
$1670145 |
55970 |
0.10% |
股份
|
| Jump Financial, LLC |
$1406329 |
47129 |
0.08% |
股份
|
| Swiss National Bank |
$1405464 |
47100 |
0.08% |
股份
|
| FIRST TRUST ADVISORS LP |
$1379413 |
46227 |
0.08% |
股份
|
| Propel Bio Management, LLC |
$1306932 |
43798 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$1279322 |
42873 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1128330 |
37800 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$1044192 |
34993 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$969800 |
32500 |
0.06% |
卖出期权
|
| WELLS FARGO & COMPANY/MN |
$956282 |
32047 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$954880 |
32000 |
0.06% |
买入期权
|
| CITIGROUP INC |
$903107 |
30265 |
0.05% |
股份
|
| Quadrature Capital Ltd |
$896602 |
30047 |
0.05% |
股份
|
| Invesco Ltd. |
$846620 |
28372 |
0.05% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$810485 |
27161 |
0.05% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$777720 |
26063 |
0.05% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$711386 |
23840 |
0.04% |
股份
|
| BARCLAYS PLC |
$708191 |
23733 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$706522 |
23677 |
0.04% |
股份
|
| TD Asset Management Inc |
$661672 |
22174 |
0.04% |
股份
|
| NOMURA HOLDINGS INC |
$626640 |
21000 |
0.04% |
买入期权
|
| NOMURA HOLDINGS INC |
$626640 |
21000 |
0.04% |
卖出期权
|
| MetLife Investment Management, LLC |
$623626 |
20899 |
0.04% |
股份
|
| TWO SIGMA ADVISERS, LP |
$613164 |
14800 |
0.04% |
股份
|
| Balyasny Asset Management L.P. |
$602470 |
20190 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$579911 |
19434 |
0.03% |
股份
|
| Verition Fund Management LLC |
$543118 |
18201 |
0.03% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$490450 |
16436 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$489436 |
16402 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$484840 |
16248 |
0.03% |
股份
|
| Legal & General Group Plc |
$470905 |
15781 |
0.03% |
股份
|
| AXQ CAPITAL, LP |
$453359 |
15193 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$432919 |
14508 |
0.03% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$428801 |
14370 |
0.03% |
股份
|
| China Universal Asset Management Co., Ltd. |
$412031 |
13808 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$405973 |
13605 |
0.02% |
股份
|
| Verdad Advisers, LP |
$376521 |
12618 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$375984 |
12600 |
0.02% |
买入期权
|
| Congress Wealth Management LLC / DE / |
$370983 |
30235 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$370016 |
12400 |
0.02% |
股份
|
| Jain Global LLC |
$365182 |
12238 |
0.02% |
股份
|
| D. E. Shaw & Co., Inc. |
$358647 |
12019 |
0.02% |
股份
|
| Entropy Technologies, LP |
$337998 |
11327 |
0.02% |
股份
|
| Engineers Gate Manager LP |
$332507 |
11143 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$329881 |
11055 |
0.02% |
股份
|
| PROFUND ADVISORS LLC |
$328986 |
11025 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$310545 |
10407 |
0.02% |
股份
|
| EntryPoint Capital, LLC |
$292850 |
9814 |
0.02% |
股份
|
| Falcon Wealth Planning |
$287359 |
9630 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$286464 |
9600 |
0.02% |
卖出期权
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$271544 |
9100 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$256445 |
8594 |
0.02% |
股份
|
| Rafferty Asset Management, LLC |
$241018 |
8077 |
0.01% |
股份
|
| Creative Planning |
$240868 |
8072 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$226545 |
7592 |
0.01% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$222756 |
7465 |
0.01% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$208134 |
6975 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$200197 |
6709 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$174504 |
5848 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$158152 |
5300 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$95548 |
3202 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$93429 |
3131 |
0.01% |
股份
|
| Quantbot Technologies LP |
$79732 |
2672 |
0.00% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$77694 |
2603682 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$73854 |
2475 |
0.00% |
股份
|
| CWM, LLC |
$63969 |
2143 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$61232 |
2052 |
0.00% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$47744 |
1600 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$40493 |
1357 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$34793 |
1166 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$32000 |
1072 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$30467 |
1021 |
0.00% |
股份
|
| State of Wyoming |
$24260 |
813 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$19545 |
655 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$14377 |
481790 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$12746 |
427 |
0.00% |
股份
|
| IFP Advisors, Inc |
$9788 |
328 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$9512 |
326 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$8325 |
279 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6624 |
222 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$6595 |
221 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$5490 |
202 |
0.00% |
股份
|
| GAMMA Investing LLC |
$5073 |
170 |
0.00% |
股份
|
| Quarry LP |
$4924 |
165 |
0.00% |
股份
|
| Arax Advisory Partners |
$4595 |
154 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$4446 |
149 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$3965 |
132870 |
0.00% |
股份
|
| Torren Management, LLC |
$3343 |
112 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$2559 |
90 |
0.00% |
股份
|
| US BANCORP \DE\ |
$2387 |
80 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$1492 |
50 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$955 |
32 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$836 |
28 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$507 |
17 |
0.00% |
股份
|
| Jackson Creek Investment Advisors LLC |
$494 |
18345 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$358 |
12 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$328 |
11 |
0.00% |
股份
|
| Essential Partners LLC |
$209 |
7 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$179 |
6 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$149 |
5 |
0.00% |
股份
|
| Allworth Financial LP |
$60 |
2 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$30 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
12 |
0.00% |
股份
|