| Soleus Capital Management, L.P. |
$27303106 |
13063687 |
7.52% |
股份
|
| B Group, Inc. |
$23855856 |
11414285 |
6.57% |
股份
|
| AMERIPRISE FINANCIAL INC |
$23160197 |
11081434 |
6.38% |
股份
|
| BlackRock, Inc. |
$21812829 |
10436760 |
6.01% |
股份
|
| Octagon Capital Advisors LP |
$21477503 |
10276317 |
5.92% |
股份
|
| JANUS HENDERSON GROUP PLC |
$18759988 |
10689452 |
5.17% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$17608386 |
8425065 |
4.85% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$14889402 |
7124116 |
4.10% |
股份
|
| FRANKLIN RESOURCES INC |
$12091045 |
5785189 |
3.33% |
股份
|
| Point72 Asset Management, L.P. |
$10979612 |
5253403 |
3.02% |
股份
|
| Boxer Capital Management, LLC |
$10031739 |
4799875 |
2.76% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$9405000 |
4500000 |
2.59% |
股份
|
| Eversept Partners, LP |
$8742021 |
4182785 |
2.41% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$7861359 |
3760485 |
2.17% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$7741226 |
3703936 |
2.13% |
股份
|
| GOLDMAN SACHS GROUP INC |
$7478062 |
3578020 |
2.06% |
股份
|
| FEDERATED HERMES, INC. |
$6555509 |
3136607 |
1.81% |
股份
|
| Squadron Capital Management LLC |
$6270000 |
3000000 |
1.73% |
股份
|
| Propel Bio Management, LLC |
$5397191 |
2582388 |
1.49% |
股份
|
| Vestal Point Capital, LP |
$5225000 |
2500000 |
1.44% |
股份
|
| STATE STREET CORP |
$5174104 |
2475648 |
1.43% |
股份
|
| MORGAN STANLEY |
$5170803 |
2474069 |
1.42% |
股份
|
| VANGUARD GROUP INC |
$4971711 |
2115622 |
1.37% |
股份
|
| ORBIMED ADVISORS LLC |
$4875970 |
2333000 |
1.34% |
股份
|
| GREAT POINT PARTNERS LLC |
$4775272 |
2284819 |
1.32% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$4717352 |
2257106 |
1.30% |
股份
|
| HighVista Strategies LLC |
$4244638 |
2030927 |
1.17% |
股份
|
| Siren, L.L.C. |
$4180000 |
2000000 |
1.15% |
股份
|
| Artia Global Partners LP |
$4164047 |
1992367 |
1.15% |
股份
|
| Aberdeen Group plc |
$3992328 |
1910205 |
1.10% |
股份
|
| Balyasny Asset Management L.P. |
$3920200 |
1875694 |
1.08% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$3617510 |
1730866 |
1.00% |
股份
|
| ADAR1 Capital Management, LLC |
$3608724 |
1726662 |
0.99% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$3600688 |
1722817 |
0.99% |
股份
|
| Ally Bridge Group (NY) LLC |
$2568610 |
1229000 |
0.71% |
股份
|
| NORTHERN TRUST CORP |
$2503026 |
1197620 |
0.69% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2350832 |
1124800 |
0.65% |
股份
|
| CITADEL ADVISORS LLC |
$2125216 |
1016850 |
0.59% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2077659 |
994095 |
0.57% |
股份
|
| Nuveen, LLC |
$2026165 |
969457 |
0.56% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1952384 |
934155 |
0.54% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1851556 |
885912 |
0.51% |
股份
|
| Ikarian Capital, LLC |
$1567500 |
750000 |
0.43% |
股份
|
| UBS Group AG |
$1540972 |
737307 |
0.42% |
股份
|
| BIT Capital GmbH |
$1199660 |
574000 |
0.33% |
股份
|
| Simplify Asset Management Inc. |
$941635 |
450543 |
0.26% |
股份
|
| Creek Drive Management Group LLC |
$919600 |
440000 |
0.25% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$913616 |
437137 |
0.25% |
股份
|
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
$912758 |
436726 |
0.25% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$909114 |
434983 |
0.25% |
股份
|
| MARSHALL WACE, LLP |
$833471 |
398790 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$728300 |
348469 |
0.20% |
股份
|
| ACT CAPITAL MANAGEMENT, LLC |
$642675 |
307500 |
0.18% |
股份
|
| Seven Fleet Capital Management LP |
$568906 |
272204 |
0.16% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$363370 |
173861 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$336007 |
160773 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$300960 |
144000 |
0.08% |
股份
|
| LPL Financial LLC |
$297102 |
142154 |
0.08% |
股份
|
| XTX Topco Ltd |
$272250 |
130263 |
0.07% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$264598 |
126602 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$262435 |
125567 |
0.07% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$260604 |
124691 |
0.07% |
股份
|
| Pale Fire Capital SE |
$232847 |
111410 |
0.06% |
股份
|
| Verdad Advisers, LP |
$208289 |
99660 |
0.06% |
股份
|
| SECTORAL ASSET MANAGEMENT INC |
$183920 |
88000 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$183659 |
87875 |
0.05% |
股份
|
| Squarepoint Ops LLC |
$179694 |
85978 |
0.05% |
股份
|
| EntryPoint Capital, LLC |
$164061 |
78498 |
0.05% |
股份
|
| Invesco Ltd. |
$161762 |
77398 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$144314 |
64715 |
0.04% |
股份
|
| CITIGROUP INC |
$143241 |
68536 |
0.04% |
股份
|
| China Universal Asset Management Co., Ltd. |
$141890 |
67890 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$141439 |
67674 |
0.04% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$122025 |
58385 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$109290 |
52292 |
0.03% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$108764 |
52040 |
0.03% |
股份
|
| Quinn Opportunity Partners LLC |
$104500 |
50000 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$90978 |
43530 |
0.03% |
股份
|
| Persistent Asset Partners Ltd |
$86659 |
41464 |
0.02% |
股份
|
| PCG Wealth Advisors, LLC |
$85899 |
41100 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$83876 |
40132 |
0.02% |
股份
|
| BARCLAYS PLC |
$75769 |
36253 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$69179 |
33100 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$67354 |
32227 |
0.02% |
股份
|
| Total Clarity Wealth Management, Inc. |
$66452 |
31795 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$65110 |
31153 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$64591 |
30905 |
0.02% |
股份
|
| STRS OHIO |
$60401 |
28900 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$58819 |
28143 |
0.02% |
股份
|
| TWO SIGMA SECURITIES, LLC |
$57371 |
27450 |
0.02% |
股份
|
| ExodusPoint Capital Management, LP |
$51332 |
24561 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$47130 |
22550 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$46534 |
22265 |
0.01% |
股份
|
| NFSG Corp |
$42323 |
20250 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$41292 |
19757 |
0.01% |
股份
|
| ProShare Advisors LLC |
$40389 |
19325 |
0.01% |
股份
|
| Voleon Capital Management LP |
$39390 |
18847 |
0.01% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$33247 |
29228 |
0.01% |
股份
|
| CHOREO, LLC |
$32903 |
15743 |
0.01% |
股份
|
| Cetera Investment Advisers |
$32408 |
15506 |
0.01% |
股份
|
| Legal & General Group Plc |
$29935 |
14323 |
0.01% |
股份
|
| XPONANCE LLC |
$29398 |
14066 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$27996 |
13395 |
0.01% |
股份
|
| Kestra Advisory Services, LLC |
$26133 |
12504 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$25249 |
12081 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$24599 |
11770 |
0.01% |
股份
|
| NorthCrest Asset Manangement, LLC |
$24040 |
12203 |
0.01% |
股份
|
| CIBC Bancorp USA Inc. |
$21209 |
10148 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$10000 |
4568 |
0.00% |
股份
|
| Quantbot Technologies LP |
$9909 |
4741 |
0.00% |
股份
|
| State of Wyoming |
$7614 |
3643 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5304 |
2538 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$5225 |
2500 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4249 |
2033 |
0.00% |
股份
|
| FMR LLC |
$1152 |
551 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$1045 |
500 |
0.00% |
股份
|
| Quarry LP |
$1041 |
498 |
0.00% |
股份
|
| Virtu Financial LLC |
$349 |
167156 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$254 |
121152 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$137 |
66 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$54 |
25896 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$33 |
16 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$17 |
8500 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$2 |
1 |
0.00% |
股份
|
| Avion Wealth |
$1 |
500 |
0.00% |
股份
|