| TANG CAPITAL MANAGEMENT LLC |
$7001038 |
6141261 |
12.30% |
股份
|
| ADAR1 Capital Management, LLC |
$6281085 |
5509724 |
11.04% |
股份
|
| VANGUARD GROUP INC |
$3438255 |
2818241 |
6.04% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$2782000 |
2440351 |
4.89% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$2579628 |
2262832 |
4.53% |
股份
|
| CITADEL ADVISORS LLC |
$2442138 |
2142226 |
4.29% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2336856 |
2049874 |
4.11% |
股份
|
| Monaco Asset Management SAM |
$2210172 |
1938747 |
3.88% |
股份
|
| Lynx1 Capital Management LP |
$2049800 |
1798070 |
3.60% |
股份
|
| BML Capital Management, LLC |
$1762596 |
1546137 |
3.10% |
股份
|
| Prosight Management, LP |
$1562066 |
1370233 |
2.74% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1519632 |
1245600 |
2.67% |
股份
|
| Peapod Lane Capital LLC |
$1492275 |
1309013 |
2.62% |
股份
|
| Woodline Partners LP |
$1478049 |
1296534 |
2.60% |
股份
|
| BlackRock, Inc. |
$1312384 |
1151214 |
2.31% |
股份
|
| Ikarian Capital, LLC |
$1140000 |
1000000 |
2.00% |
股份
|
| Eversept Partners, LP |
$1016224 |
891425 |
1.79% |
股份
|
| MARSHALL WACE, LLP |
$952041 |
835124 |
1.67% |
股份
|
| Redmile Group, LLC |
$880224 |
772126 |
1.55% |
股份
|
| JPMORGAN CHASE & CO |
$783894 |
681647 |
1.38% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$733157 |
643120 |
1.29% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$659954 |
578577 |
1.16% |
股份
|
| UBS Group AG |
$651806 |
571760 |
1.15% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$637770 |
559447 |
1.12% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$631138 |
553630 |
1.11% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$611132 |
536081 |
1.07% |
股份
|
| DAFNA Capital Management LLC |
$555180 |
487000 |
0.98% |
股份
|
| XTX Topco Ltd |
$502562 |
440844 |
0.88% |
股份
|
| Laurion Capital Management LP |
$470587 |
412796 |
0.83% |
股份
|
| TORNO CAPITAL, LLC |
$400647 |
351445 |
0.70% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$389596 |
341751 |
0.68% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$345420 |
303000 |
0.61% |
股份
|
| MORGAN STANLEY |
$340833 |
298976 |
0.60% |
股份
|
| SEI INVESTMENTS CO |
$338909 |
297291 |
0.60% |
股份
|
| Verdad Advisers, LP |
$320731 |
281343 |
0.56% |
股份
|
| ArrowMark Colorado Holdings LLC |
$320555 |
281189 |
0.56% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$313500 |
275000 |
0.55% |
股份
|
| STATE STREET CORP |
$288897 |
253418 |
0.51% |
股份
|
| Stonepine Capital Management, LLC |
$262813 |
230538 |
0.46% |
股份
|
| Rangeley Capital, LLC |
$256500 |
225000 |
0.45% |
股份
|
| GOLDMAN SACHS GROUP INC |
$237787 |
208585 |
0.42% |
股份
|
| Congress Wealth Management LLC / DE / |
$231907 |
199920 |
0.41% |
股份
|
| Marquette Asset Management, LLC |
$198930 |
174500 |
0.35% |
股份
|
| HighMark Wealth Management LLC |
$189495 |
166224 |
0.33% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$175232 |
153712 |
0.31% |
股份
|
| JANE STREET GROUP, LLC |
$148144 |
129951 |
0.26% |
股份
|
| NORTHERN TRUST CORP |
$142568 |
125060 |
0.25% |
股份
|
| ALGERT GLOBAL LLC |
$140678 |
123402 |
0.25% |
股份
|
| OSAIC HOLDINGS, INC. |
$131013 |
114924 |
0.23% |
股份
|
| Invesco Ltd. |
$119333 |
104678 |
0.21% |
股份
|
| Bond & Devick Financial Network, Inc. |
$114182 |
100160 |
0.20% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$113779 |
99773 |
0.20% |
股份
|
| KOTLER KEVIN |
$113460 |
93000 |
0.20% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$93366 |
81900 |
0.16% |
卖出期权
|
| Cubist Systematic Strategies, LLC |
$80463 |
54367 |
0.14% |
股份
|
| JANE STREET GROUP, LLC |
$70566 |
61900 |
0.12% |
买入期权
|
| AMERIPRISE FINANCIAL INC |
$62847 |
55129 |
0.11% |
股份
|
| Squarepoint Ops LLC |
$46528 |
40814 |
0.08% |
股份
|
| Headlands Technologies LLC |
$38404 |
33688 |
0.07% |
股份
|
| Quadrature Capital Ltd |
$37939 |
33280 |
0.07% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$33891 |
29729 |
0.06% |
股份
|
| FEDERATED HERMES, INC. |
$33123 |
29055 |
0.06% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$32490 |
28500 |
0.06% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$32419 |
21905 |
0.06% |
股份
|
| Spark Investment Management LLC |
$25764 |
22600 |
0.05% |
股份
|
| Blackstone Inc. |
$25315 |
22206 |
0.04% |
股份
|
| Point72 Asset Management, L.P. |
$22883 |
20073 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$22238 |
19507 |
0.04% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$20594 |
18065 |
0.04% |
股份
|
| Bank of New York Mellon Corp |
$18277 |
16032 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$17647 |
15480 |
0.03% |
股份
|
| NewEdge Advisors, LLC |
$17100 |
15000 |
0.03% |
股份
|
| AlphaQuest LLC |
$14294 |
11716 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$13794 |
12100 |
0.02% |
卖出期权
|
| Fiduciary Trust Co |
$13247 |
11620 |
0.02% |
股份
|
| Qube Research & Technologies Ltd |
$11438 |
10033 |
0.02% |
股份
|
| SIMPLEX TRADING, LLC |
$5614 |
4925 |
0.01% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$2747 |
2416508 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$2000 |
995 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$752 |
660 |
0.00% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$749 |
657 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$672 |
590 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$606 |
532079 |
0.00% |
股份
|
| BARCLAYS PLC |
$486 |
426 |
0.00% |
股份
|
| FMR LLC |
$478 |
419 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$342 |
300 |
0.00% |
股份
|
| CWM, LLC |
$267 |
212 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$185 |
162206 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$166 |
112 |
0.00% |
股份
|
| Truvestments Capital LLC |
$57 |
50 |
0.00% |
股份
|
| WELLS FARGO & COMPANY/MN |
$57 |
50 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$41 |
36 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$9 |
8 |
0.00% |
股份
|
| COMERICA BANK |
$7 |
6 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$6 |
5 |
0.00% |
股份
|
| IFG Advisory, LLC |
$5 |
4 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$5 |
4 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$5 |
4 |
0.00% |
股份
|
| Capital Advisors, Ltd. LLC |
$0 |
31 |
0.00% |
股份
|