| MONTANOVA CAPITAL, LLC |
$173512745 |
1135406 |
7.97% |
股份
|
| JENNISON ASSOCIATES LLC |
$146801795 |
960619 |
6.75% |
股份
|
| BlackRock, Inc. |
$140343317 |
918357 |
6.45% |
股份
|
| Frazier Life Sciences Management, L.P. |
$134848368 |
882400 |
6.20% |
股份
|
| First Light Asset Management, LLC |
$117961911 |
771901 |
5.42% |
股份
|
| BVF INC/IL |
$102815615 |
672789 |
4.72% |
股份
|
| STATE STREET CORP |
$99817745 |
653172 |
4.59% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$78517999 |
513794 |
3.61% |
股份
|
| FRONTIER CAPITAL MANAGEMENT CO LLC |
$73175272 |
478833 |
3.36% |
股份
|
| FEDERATED HERMES, INC. |
$66173352 |
433015 |
3.04% |
股份
|
| VANGUARD GROUP INC |
$58679676 |
560616 |
2.70% |
股份
|
| Woodline Partners LP |
$48522948 |
317517 |
2.23% |
股份
|
| ORBIMED ADVISORS LLC |
$44678455 |
292360 |
2.05% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$42213033 |
276164 |
1.94% |
股份
|
| Siren, L.L.C. |
$39348858 |
257485 |
1.81% |
股份
|
| PRIMECAP MANAGEMENT CO/CA/ |
$39149734 |
256182 |
1.80% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$35375385 |
231484 |
1.63% |
股份
|
| EMERALD ADVISERS, LLC |
$35070051 |
229486 |
1.61% |
股份
|
| FMR LLC |
$32831927 |
214841 |
1.51% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$31557391 |
253168 |
1.45% |
股份
|
| MPM BIOIMPACT LLC |
$31179406 |
204027 |
1.43% |
股份
|
| GOLDMAN SACHS GROUP INC |
$30795370 |
201514 |
1.42% |
股份
|
| MORGAN STANLEY |
$27725827 |
181428 |
1.27% |
股份
|
| First Turn Management, LLC |
$23908689 |
156450 |
1.10% |
股份
|
| Bellevue Group AG |
$23687100 |
155000 |
1.09% |
股份
|
| Caption Management, LLC |
$21394800 |
140000 |
0.98% |
卖出期权
|
| EMERALD MUTUAL FUND ADVISERS TRUST |
$19843219 |
129847 |
0.91% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$19707973 |
128962 |
0.91% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$18430092 |
120600 |
0.85% |
买入期权
|
| Aberdeen Group plc |
$18374771 |
120238 |
0.84% |
股份
|
| NORTHERN TRUST CORP |
$14853034 |
97193 |
0.68% |
股份
|
| NEXTBio Capital Management LP |
$13739893 |
89909 |
0.63% |
股份
|
| Clio Asset Management LLC |
$13194937 |
86343 |
0.61% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$12700411 |
83107 |
0.58% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$11706012 |
76600 |
0.54% |
卖出期权
|
| VANGUARD FIDUCIARY TRUST CO |
$11307916 |
73995 |
0.52% |
股份
|
| UBS Group AG |
$11083424 |
72526 |
0.51% |
股份
|
| Avidity Partners Management LP |
$10697400 |
70000 |
0.49% |
股份
|
| AWM Investment Company, Inc. |
$10608153 |
69416 |
0.49% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$9169200 |
60000 |
0.42% |
股份
|
| Clearbridge Investments, LLC |
$9068458 |
59341 |
0.42% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$8713159 |
69901 |
0.40% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$8336942 |
54554 |
0.38% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$8140721 |
53270 |
0.37% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7979038 |
52212 |
0.37% |
股份
|
| Ensign Peak Advisors, Inc |
$7894681 |
51660 |
0.36% |
股份
|
| HSBC HOLDINGS PLC |
$7641156 |
50001 |
0.35% |
股份
|
| Nicholas Investment Partners, LP |
$7597905 |
49718 |
0.35% |
股份
|
| Balyasny Asset Management L.P. |
$6805992 |
44536 |
0.31% |
股份
|
| Lisanti Capital Growth, LLC |
$6567440 |
42975 |
0.30% |
股份
|
| WCM INVESTMENT MANAGEMENT, LLC |
$6215278 |
40140 |
0.29% |
股份
|
| ROYCE & ASSOCIATES LP |
$6190585 |
40509 |
0.28% |
股份
|
| ORBIMED ADVISORS LLC |
$6112800 |
40000 |
0.28% |
买入期权
|
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
$6092169 |
39865 |
0.28% |
股份
|
| Jump Financial, LLC |
$6023095 |
39413 |
0.28% |
股份
|
| Apis Capital Advisors, LLC |
$5959980 |
39000 |
0.27% |
股份
|
| Blue Owl Capital Holdings LP |
$5541100 |
36259 |
0.25% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$5439475 |
35594 |
0.25% |
股份
|
| FIFTH THIRD BANCORP |
$5438100 |
35585 |
0.25% |
股份
|
| Invesco Ltd. |
$5142699 |
33652 |
0.24% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4979334 |
32583 |
0.23% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$4802216 |
31424 |
0.22% |
股份
|
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
$4786017 |
31318 |
0.22% |
股份
|
| Bank of New York Mellon Corp |
$4674306 |
30587 |
0.21% |
股份
|
| CITADEL ADVISORS LLC |
$4645728 |
30400 |
0.21% |
买入期权
|
| Caption Management, LLC |
$4584600 |
30000 |
0.21% |
买入期权
|
| JANE STREET GROUP, LLC |
$4095576 |
26800 |
0.19% |
买入期权
|
| Nuveen, LLC |
$3855801 |
25231 |
0.18% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$3820500 |
25000 |
0.18% |
股份
|
| NOMURA HOLDINGS INC |
$3662026 |
23963 |
0.17% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$3616180 |
23663 |
0.17% |
股份
|
| Legato Capital Management LLC |
$3589741 |
23490 |
0.16% |
股份
|
| TD Asset Management Inc |
$3476044 |
22746 |
0.16% |
股份
|
| ACT CAPITAL MANAGEMENT, LLC |
$3438450 |
22500 |
0.16% |
股份
|
| Russell Investments Group, Ltd. |
$3414891 |
22345 |
0.16% |
股份
|
| Swiss National Bank |
$2964708 |
19400 |
0.14% |
股份
|
| Informed Momentum Co LLC |
$2880504 |
18849 |
0.13% |
股份
|
| F/m Investments LLC |
$2666098 |
17446 |
0.12% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2658610 |
17397 |
0.12% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2375587 |
15545 |
0.11% |
股份
|
| CITIGROUP INC |
$2367640 |
15493 |
0.11% |
股份
|
| ALPS ADVISORS INC |
$2193884 |
14356 |
0.10% |
股份
|
| Capricorn Fund Managers Ltd |
$2152928 |
14088 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$2067339 |
13528 |
0.09% |
股份
|
| Trexquant Investment LP |
$2062306 |
13495 |
0.09% |
股份
|
| CITADEL ADVISORS LLC |
$2032506 |
13300 |
0.09% |
卖出期权
|
| WELLS FARGO & COMPANY/MN |
$1987844 |
13008 |
0.09% |
股份
|
| SEI INVESTMENTS CO |
$1957202 |
12807 |
0.09% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1878769 |
12294 |
0.09% |
股份
|
| OAK RIDGE INVESTMENTS LLC |
$1839647 |
12038 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$1809083 |
11838 |
0.08% |
股份
|
| Cresset Asset Management, LLC |
$1777144 |
11629 |
0.08% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$1762167 |
11531 |
0.08% |
股份
|
| Rafferty Asset Management, LLC |
$1736188 |
11361 |
0.08% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1705777 |
11162 |
0.08% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1593913 |
10430 |
0.07% |
股份
|
| Mariner, LLC |
$1583364 |
10361 |
0.07% |
股份
|
| Knights of Columbus Asset Advisors LLC |
$1532937 |
10031 |
0.07% |
股份
|
| XTX Topco Ltd |
$1354138 |
8861 |
0.06% |
股份
|
| JPMORGAN CHASE & CO |
$1303753 |
8420 |
0.06% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$1284605 |
8406 |
0.06% |
股份
|
| Legal & General Group Plc |
$1221642 |
7994 |
0.06% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$1208195 |
7906 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$978812 |
6405 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$977895 |
6399 |
0.04% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$976825 |
6392 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$976436 |
6372 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$948859 |
6209 |
0.04% |
股份
|
| ASPIRIANT, LLC |
$894303 |
5852 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$879173 |
5753 |
0.04% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$873519 |
5716 |
0.04% |
股份
|
| Penn Capital Management Company, LLC |
$841427 |
5506 |
0.04% |
股份
|
| ExodusPoint Capital Management, LP |
$839593 |
5494 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$790996 |
5176 |
0.04% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$787176 |
5151 |
0.04% |
股份
|
| FRANKLIN RESOURCES INC |
$739343 |
4838 |
0.03% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$722991 |
4731 |
0.03% |
股份
|
| LPL Financial LLC |
$706792 |
4625 |
0.03% |
股份
|
| BROWN ADVISORY INC |
$664614 |
4349 |
0.03% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$658195 |
4307 |
0.03% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$641538 |
4198 |
0.03% |
股份
|
| Creative Planning |
$630688 |
4127 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$537926 |
3520 |
0.02% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$534870 |
3500 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$495137 |
3240 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$494526 |
3236 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$459530 |
3007 |
0.02% |
股份
|
| CERTUITY, LLC |
$458460 |
3000 |
0.02% |
股份
|
| KEYBANK NATIONAL ASSOCIATION/OH |
$455862 |
2983 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$449946 |
3600 |
0.02% |
股份
|
| MARSHALL WACE, LLP |
$435842 |
2852 |
0.02% |
股份
|
| BARCLAYS PLC |
$426827 |
2793 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$422547 |
2765 |
0.02% |
股份
|
| KLP KAPITALFORVALTNING AS |
$397332 |
2600 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$395193 |
2586 |
0.02% |
股份
|
| Calamos Advisors LLC |
$392900 |
2571 |
0.02% |
股份
|
| DELTEC ASSET MANAGEMENT LLC |
$366768 |
2400 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$353932 |
2316 |
0.02% |
股份
|
| DNB Asset Management AS |
$342928 |
2244 |
0.02% |
股份
|
| Alyeska Investment Group, L.P. |
$339719 |
2223 |
0.02% |
股份
|
| SIMPLEX TRADING, LLC |
$338954 |
2218 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$335746 |
2197 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$333148 |
2180 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$320922 |
2100 |
0.01% |
卖出期权
|
| ENVESTNET ASSET MANAGEMENT INC |
$308238 |
2017 |
0.01% |
股份
|
| AlphaQuest LLC |
$288261 |
2754 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$268199 |
1755 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$244818 |
1602 |
0.01% |
股份
|
| TWO SIGMA ADVISERS, LP |
$240741 |
2300 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$231828 |
1517 |
0.01% |
股份
|
| ProShare Advisors LLC |
$219143 |
1434 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$207377 |
1357 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$203403 |
1331 |
0.01% |
股份
|
| Fulcrum Asset Management LLP |
$174350 |
1126 |
0.01% |
股份
|
| Chung Wu Investment Group, LLC |
$168102 |
1100 |
0.01% |
股份
|
| Spire Wealth Management |
$152820 |
1000 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$152209 |
996 |
0.01% |
股份
|
| State of Wyoming |
$134329 |
879 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$105000 |
685 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$97632 |
638868 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$83286 |
545 |
0.00% |
股份
|
| Quantbot Technologies LP |
$70603 |
462 |
0.00% |
股份
|
| Archer Investment Corp |
$68616 |
449 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$57155 |
374 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$49181 |
322 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$34996 |
229 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$33495 |
226 |
0.00% |
股份
|
| Bayforest Capital Ltd |
$31787 |
208 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$25674 |
168 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$16046 |
105 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$13906 |
91 |
0.00% |
股份
|
| Larson Financial Group LLC |
$11156 |
73 |
0.00% |
股份
|
| EASTERN BANK |
$7947 |
52 |
0.00% |
股份
|
| PRIVATE TRUST CO NA |
$7641 |
50 |
0.00% |
股份
|
| COMERICA BANK |
$5966 |
57 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5960 |
39 |
0.00% |
股份
|
| GAMMA Investing LLC |
$5654 |
37 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$4737 |
31 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$4737 |
31 |
0.00% |
股份
|
| CWM, LLC |
$4363 |
35 |
0.00% |
股份
|
| Rossby Financial, LCC |
$3668 |
24 |
0.00% |
股份
|
| Quarry LP |
$3515 |
23 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$3209 |
21 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$3056 |
20 |
0.00% |
股份
|
| Arax Advisory Partners |
$2903 |
19 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$2751 |
18 |
0.00% |
股份
|
| US BANCORP \DE\ |
$2598 |
17 |
0.00% |
股份
|
| Allworth Financial LP |
$2140 |
14 |
0.00% |
股份
|
| Truvestments Capital LLC |
$2139 |
14 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1987 |
13 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$1681 |
11 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1528 |
10 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$1223 |
8 |
0.00% |
股份
|
| WPG Advisers, LLC |
$1223 |
8 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$1070 |
7 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$917 |
6 |
0.00% |
股份
|
| PEAPACK GLADSTONE FINANCIAL CORP |
$898 |
5875 |
0.00% |
股份
|
| Mitsubishi UFJ Asset Management (UK) Ltd. |
$841 |
5500 |
0.00% |
股份
|
| FINANCIAL CONSULATE, INC |
$765 |
5 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$764 |
5 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$728 |
12 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$473 |
3098 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$458 |
3 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$155 |
1 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$153 |
1 |
0.00% |
股份
|
| Essential Partners LLC |
$153 |
1 |
0.00% |
股份
|
| NFSG Corp |
$115 |
1 |
0.00% |
股份
|
| KBC Group NV |
$34 |
224 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$29 |
190 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
4 |
0.00% |
股份
|