| RA CAPITAL MANAGEMENT, L.P. |
$234291284 |
6995858 |
14.22% |
股份
|
| TRV GP V, LLC |
$208160143 |
6215591 |
12.64% |
股份
|
| Driehaus Capital Management LLC |
$148463112 |
4433058 |
9.01% |
股份
|
| TRV GP VI, LLC |
$141048460 |
4211659 |
8.56% |
股份
|
| SAMSARA BIOCAPITAL, LLC |
$105464297 |
3149128 |
6.40% |
股份
|
| GOLDMAN SACHS GROUP INC |
$102572033 |
3062766 |
6.23% |
股份
|
| BlackRock, Inc. |
$64705629 |
1932088 |
3.93% |
股份
|
| Siren, L.L.C. |
$63631000 |
1900000 |
3.86% |
股份
|
| Avoro Capital Advisors LLC |
$44792875 |
1337500 |
2.72% |
股份
|
| VANGUARD GROUP INC |
$42048476 |
1508195 |
2.55% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$40913829 |
1221673 |
2.48% |
股份
|
| PRIMECAP MANAGEMENT CO/CA/ |
$39095624 |
1167382 |
2.37% |
股份
|
| First Light Asset Management, LLC |
$32259577 |
963260 |
1.96% |
股份
|
| ADAR1 Capital Management, LLC |
$31505617 |
940747 |
1.91% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$22750071 |
679163 |
1.38% |
股份
|
| STATE STREET CORP |
$21856579 |
652630 |
1.33% |
股份
|
| JANUS HENDERSON GROUP PLC |
$21333558 |
890754 |
1.30% |
股份
|
| LOOMIS SAYLES & CO L P |
$20922944 |
624752 |
1.27% |
股份
|
| Casdin Capital, LLC |
$18528945 |
553268 |
1.12% |
股份
|
| Catalio Capital Management, LP |
$17955730 |
536152 |
1.09% |
股份
|
| Caption Management, LLC |
$14735600 |
440000 |
0.89% |
买入期权
|
| ALGERT GLOBAL LLC |
$13311840 |
397487 |
0.81% |
股份
|
| Balyasny Asset Management L.P. |
$11736303 |
350442 |
0.71% |
股份
|
| Longaeva Partners L.P. |
$9985747 |
298171 |
0.61% |
股份
|
| Soleus Capital Management, L.P. |
$9209750 |
275000 |
0.56% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$8774380 |
262000 |
0.53% |
买入期权
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7708862 |
230184 |
0.47% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$7458290 |
222702 |
0.45% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$7397439 |
220885 |
0.45% |
股份
|
| NORTHERN TRUST CORP |
$6735877 |
201131 |
0.41% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$6698000 |
200000 |
0.41% |
买入期权
|
| Caption Management, LLC |
$6698000 |
200000 |
0.41% |
卖出期权
|
| Kalehua Capital Management LLC |
$6515279 |
194544 |
0.40% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$6264003 |
187041 |
0.38% |
股份
|
| Woodline Partners LP |
$6213567 |
185535 |
0.38% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$5547819 |
165656 |
0.34% |
股份
|
| MORGAN STANLEY |
$4500286 |
134377 |
0.27% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$3349000 |
100000 |
0.20% |
卖出期权
|
| UBS Group AG |
$3009880 |
89874 |
0.18% |
股份
|
| JPMORGAN CHASE & CO |
$2964211 |
85301 |
0.18% |
股份
|
| FEDERATED HERMES, INC. |
$2905358 |
86753 |
0.18% |
股份
|
| CITADEL ADVISORS LLC |
$2739482 |
81800 |
0.17% |
买入期权
|
| LAZARD ASSET MANAGEMENT LLC |
$2525983 |
75425 |
0.15% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$2522961 |
75309 |
0.15% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$2499995 |
74649 |
0.15% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$2283348 |
68180 |
0.14% |
股份
|
| HUSSMAN STRATEGIC ADVISORS, INC. |
$2109870 |
63000 |
0.13% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$2041986 |
60973 |
0.12% |
股份
|
| DIADEMA PARTNERS LP |
$1999353 |
59700 |
0.12% |
卖出期权
|
| JANE STREET GROUP, LLC |
$1915628 |
57200 |
0.12% |
买入期权
|
| Bank of New York Mellon Corp |
$1881334 |
56176 |
0.11% |
股份
|
| XTX Topco Ltd |
$1824837 |
54489 |
0.11% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1693321 |
50562 |
0.10% |
股份
|
| BARCLAYS PLC |
$1668506 |
49821 |
0.10% |
股份
|
| Elmind Capital, LP |
$1655880 |
49444 |
0.10% |
股份
|
| Nuveen, LLC |
$1615189 |
48229 |
0.10% |
股份
|
| Sofinnova Investments, Inc. |
$1590976 |
47506 |
0.10% |
股份
|
| D. E. Shaw & Co., Inc. |
$1556716 |
46483 |
0.09% |
股份
|
| JANE STREET GROUP, LLC |
$1525537 |
45552 |
0.09% |
股份
|
| Voleon Capital Management LP |
$1488128 |
44435 |
0.09% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1387122 |
41419 |
0.08% |
股份
|
| Russell Investments Group, Ltd. |
$1346606 |
40209 |
0.08% |
股份
|
| Caption Management, LLC |
$1272821 |
38006 |
0.08% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1201453 |
35875 |
0.07% |
股份
|
| Alyeska Investment Group, L.P. |
$1172150 |
35000 |
0.07% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1135311 |
33900 |
0.07% |
卖出期权
|
| Brevan Howard Capital Management LP |
$986347 |
29452 |
0.06% |
股份
|
| HighVista Strategies LLC |
$982496 |
29337 |
0.06% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$970071 |
28966 |
0.06% |
股份
|
| RHUMBLINE ADVISERS |
$925521 |
27636 |
0.06% |
股份
|
| Trexquant Investment LP |
$858851 |
25645 |
0.05% |
股份
|
| Invesco Ltd. |
$806908 |
24094 |
0.05% |
股份
|
| Logos Global Management LP |
$788623 |
23548 |
0.05% |
股份
|
| FMR LLC |
$778308 |
23240 |
0.05% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$738053 |
22038 |
0.04% |
股份
|
| DEUTSCHE BANK AG\ |
$732527 |
21873 |
0.04% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$718497 |
29900 |
0.04% |
股份
|
| TWO SIGMA ADVISERS, LP |
$716516 |
25700 |
0.04% |
股份
|
| Squarepoint Ops LLC |
$710624 |
21219 |
0.04% |
股份
|
| STRS OHIO |
$703290 |
21000 |
0.04% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$701883 |
20958 |
0.04% |
股份
|
| Jump Financial, LLC |
$676498 |
20200 |
0.04% |
股份
|
| Swiss National Bank |
$663102 |
19800 |
0.04% |
股份
|
| WELLS FARGO & COMPANY/MN |
$659218 |
19684 |
0.04% |
股份
|
| FRANKLIN RESOURCES INC |
$623148 |
18607 |
0.04% |
股份
|
| CITIGROUP INC |
$596390 |
17808 |
0.04% |
股份
|
| Aquatic Capital Management LLC |
$583630 |
17427 |
0.04% |
股份
|
| Engineers Gate Manager LP |
$581052 |
17350 |
0.04% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$567522 |
16946 |
0.03% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$555833 |
16597 |
0.03% |
股份
|
| State of Wyoming |
$548533 |
16379 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$544112 |
16247 |
0.03% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$515646 |
15397 |
0.03% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$445417 |
13300 |
0.03% |
股份
|
| Verdad Advisers, LP |
$434365 |
12970 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$431351 |
12880 |
0.03% |
股份
|
| OSAIC HOLDINGS, INC. |
$421772 |
12594 |
0.03% |
股份
|
| Man Group plc |
$384097 |
11469 |
0.02% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$363902 |
10866 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$360821 |
10774 |
0.02% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$341364 |
10193 |
0.02% |
股份
|
| Legal & General Group Plc |
$336976 |
10062 |
0.02% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$334297 |
9982 |
0.02% |
股份
|
| Gotham Asset Management, LLC |
$312194 |
9322 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$304826 |
9102 |
0.02% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$298061 |
8900 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$284665 |
8500 |
0.02% |
股份
|
| FIRST TRUST ADVISORS LP |
$259179 |
7739 |
0.02% |
股份
|
| Creative Planning |
$255729 |
7636 |
0.02% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$248496 |
7420 |
0.02% |
股份
|
| Quantinno Capital Management LP |
$245482 |
7330 |
0.01% |
股份
|
| CIBC Bancorp USA Inc. |
$241865 |
7222 |
0.01% |
股份
|
| Rangeley Capital, LLC |
$241128 |
7200 |
0.01% |
股份
|
| OCCUDO QUANTITATIVE STRATEGIES LP |
$240827 |
7191 |
0.01% |
股份
|
| WINTON GROUP Ltd |
$240525 |
7182 |
0.01% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$218589 |
6527 |
0.01% |
股份
|
| CITADEL ADVISORS LLC |
$212662 |
6350 |
0.01% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$211121 |
6304 |
0.01% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$208006 |
6211 |
0.01% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$204122 |
6095 |
0.01% |
股份
|
| Chung Wu Investment Group, LLC |
$160752 |
4800 |
0.01% |
股份
|
| Congress Wealth Management LLC / DE / |
$133065 |
12589 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$130444 |
3895 |
0.01% |
股份
|
| Lindbrook Capital, LLC |
$121590 |
21000 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$83725 |
2500 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$70000 |
2098 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$67516 |
2016 |
0.00% |
股份
|
| Ameritas Investment Partners, Inc. |
$65105 |
1944 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$44374 |
1325 |
0.00% |
股份
|
| GAMMA Investing LLC |
$37475 |
1119 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$35466 |
1059 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$32519 |
971 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$32351 |
966 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$31816 |
950 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$25720 |
768 |
0.00% |
股份
|
| CWM, LLC |
$21483 |
894 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$18207 |
152 |
0.00% |
卖出期权
|
| Quantbot Technologies LP |
$17247 |
515 |
0.00% |
股份
|
| Amova Asset Management Americas, Inc. |
$16934 |
507 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$12123 |
362 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$10784 |
322 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$10213 |
261 |
0.00% |
股份
|
| Arax Advisory Partners |
$7904 |
236 |
0.00% |
股份
|
| US BANCORP \DE\ |
$7368 |
220 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6698 |
200 |
0.00% |
股份
|
| Larson Financial Group LLC |
$6564 |
196 |
0.00% |
股份
|
| N.E.W. Advisory Services LLC |
$6028 |
180 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$3725 |
155 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$3483 |
104 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$3416 |
102 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2579 |
77 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2142 |
64 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$1842 |
55 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$1741 |
52 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$1507 |
45 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1407 |
42022 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1183 |
35323 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1005 |
30 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$701 |
20996 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$670 |
20 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$603 |
18 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$234 |
7 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$201 |
6 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$100 |
3 |
0.00% |
股份
|
| Covestor Ltd |
$72 |
2123 |
0.00% |
股份
|
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
$65 |
1946 |
0.00% |
股份
|
| Allworth Financial LP |
$34 |
1 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$33 |
1 |
0.00% |
股份
|