SEPN Septerna, Inc. - Common Stock
$44.01
价格 · 八月 19, 2026
截至...的财报数据 八月 10, 2026
52周区间
$11–$51
82% of range
分析师评级
BUY
16 analysts
目标价
$53
+21% upside
P/E (TTM)
-40.0
ROE
-12.9%
净利润率
-106.4%
SEPN 股票快照 价格、市值、P/E、EPS、ROE、负债/权益、52周范围
价格
$44.01
市值
$1.97B
P/E (TTM)
-40.0
每股收益 (TTM)
$-1.10
营收 (TTM)
$46M
股息收益率
—
ROE
-12.9%
负债/权益
—
52周区间
$11 – $51
SEPN 股价图表 包含技术指标的日 OHLCV — 平移、缩放和自定义您的视图
Configure
10年表现 收入、净利润、利润率和每股收益趋势
营收与净利润
$46M
2023-12-31
→
2025-12-31
EPS
$-1.10
2023-12-31
→
2025-12-31
自由现金流
$110M
2024-12-31
→
2025-12-31
利润率
-106.4%
估值 P/E、P/S、P/B、EV/EBITDA 比率 — 该股票是昂贵还是便宜？
指标
5年趋势
SEPN
同行中位数
P/E (TTM)
-40.0
19.1
P/S (TTM) (市销率 (TTM))
42.9
14.2
P/B (市净率)
5.2
3.6
Price / FCF (股价/自由现金流)
18.0
—
盈利能力 毛利率、营业利润率和净利率；股本回报率 (ROE)、资产回报率 (ROA)、投入资本回报率 (ROIC)
指标
5年趋势
SEPN
同行中位数
Operating Margin (营业利润率)
-148.6%
—
Net Profit Margin (净利润率)
-106.4%
-4.3%
ROA
-9.3%
-2.9%
ROE
-12.9%
-6.8%
ROIC
-17.9%
—
财务健康 债务、流动性、偿付能力 — 资产负债表强度
指标
5年趋势
SEPN
同行中位数
Current Ratio (流动比率)
4.7
4.7
Quick Ratio (速动比率)
4.6
—
成长 营收、每股收益 (EPS) 和净利润增长：同比、3年复合年增长率 (CAGR)、5年复合年增长率 (CAGR)
指标
5年趋势
SEPN
同行中位数
Revenue YoY (营收同比增长)
4174.5%
—
资本效率 资产周转率、库存周转率、应收账款周转率
指标
5年趋势
SEPN
同行中位数
SEPN 分析师共识 看涨和看跌分析师观点、12个月价格目标、上涨空间
买入
16 位分析师
- 强烈买入 5 31.2%
- 买入 10 62.5%
- 持有 1 6.2%
- 卖出 0 0.0%
- 强烈卖出 0 0.0%
12个月价格目标
9 位分析师 · 2026-08-17
中位数
$51.00
平均值
$53.11
现在
$44.01
最低
$38.00
最高
$62.00
中位数目标
$51.00
+15.9%
平均目标
$53.11
+20.7%
收益历史 每股收益实际值 vs 预估值，惊喜%，达标率，下次财报日期
平均惊喜
-0.33%
| 期间 | EPS Actual | EPS 预期 | 惊喜 |
|---|---|---|---|
| 2026年6月30日 | $-0.29 | $-0.43 | 0.14% |
| 2026年3月31日 | $-0.19 | $-0.42 | 0.23% |
| 2025年12月31日 | $-0.24 | $-0.26 | 0.02% |
| 2025年9月30日 | $-0.09 | $0.81 | -0.90% |
| 2025年6月30日 | $-0.56 | $0.88 | -1.4% |
| 2025年3月31日 | $-0.49 | $-0.46 | -0.03% |
同行比较（GICS 子行业） 关键指标与行业同行对比
| 股票代码 | 市值 | P/E | 营收同比增长 | 净利润率 | ROE | 毛利率 |
|---|---|---|---|---|---|---|
| SEPN | $1.25B | -25.3 | 4174.5% | -106.4% | -12.9% | — |
| RAPP | $1.45B | -10.6 | — | — | -29.8% | — |
| OCUL | $2.62B | -8.5 | -18.5% | -511.9% | -55.4% | — |
| NUVB | $3.03B | -14.9 | 699.0% | -325.3% | -60.3% | — |
| HRMY | $2.16B | 13.8 | 21.5% | 18.3% | 19.3% | 77.2% |
| KARD | — | — | — | — | — | — |
| TRLV | — | — | -0.45% | -10.3% | -10.4% | 60.2% |
| ANIP | $1.78B | 23.8 | 43.8% | 8.9% | 16.6% | — |
| ETON | $457M | — | 104.9% | -5.8% | -18.4% | 53.5% |
| AVLN | — | — | — | — | — | — |
完整基本面 所有年度指标 — 损益表、资产负债表、现金流量表
损益表 15
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $46M | $1M | $151.0K | |
| R&D Expense | $98M | $65M | $36M | |
| SG&A Expense | $29M | $17M | $10M | |
| Operating Expenses | $114M | $82M | $-2M | |
| Operating Income | $-68M | $-81M | $2M | |
| Interest Income | $20M | $9M | $3M | |
| Other Non-op | $-100.0K | $-90.0K | $10.0K | |
| Pretax Income | $-49M | $-72M | $-49M | |
| Income Tax | $12.0K | $-498.0K | $691.0K | |
| Net Income | $-49M | $-72M | $4M | |
| EPS (Basic) | $-1.10 | $-7.26 | $0.29 | |
| EPS (Diluted) | $-1.10 | $-7.26 | $0.29 | |
| Shares (Basic) | 44,258,338 | 9,891,126 | 1,928,586 | |
| Shares (Diluted) | 44,258,338 | 9,891,126 | 2,177,124 | |
| EBITDA | $-67M | $-79M | · |
资产负债表 23
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $121M | $238M | $88M | |
| Short-term Investments | $270M | $113M | $0 | |
| Receivables | $10M | $171.0K | $151.0K | |
| Prepaid Expense | $10M | $6M | $1M | |
| Other Current Assets | $1M | $239.0K | $92.0K | |
| Current Assets | $411M | $357M | $113M | |
| PP&E (Net) | $4M | $5M | $5M | |
| PP&E (Gross) | $9M | $8M | $6M | |
| Accum. Depreciation | $4M | $3M | $2M | |
| Other Non-current Assets | $816.0K | $267.0K | $97.0K | |
| Total Assets | $596M | $457M | $131M | |
| Accounts Payable | $10M | $3M | $3M | |
| Accrued Liabilities | $12M | $8M | $4M | |
| Current Liabilities | $87M | $13M | $7M | |
| Capital Leases | $21M | $24M | $13M | |
| Other Non-current Liabilities | $0 | $33.0K | $546.0K | |
| Total Liabilities | $214M | $37M | $20M | |
| Common Stock | $45.0K | $44.0K | $3.0K | |
| Retained Earnings | $-167M | $-118M | $-47M | |
| AOCI | $617.0K | $56.0K | $0 | |
| Stockholders' Equity | $382M | $420M | $-38M | |
| Liabilities + Equity | $596M | $457M | $131M | |
| Shares Outstanding | 44,806,272 | 44,422,505 | 3,168,134 |
现金流 11
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $2M | $1M | $800.0K | |
| Stock-based Comp | $8M | $3M | $2M | |
| Deferred Tax | $0 | $-491.0K | $491.0K | |
| Other Non-cash | $149M | $267.0K | · | |
| Operating Cash Flow | $110M | $-67M | $-39M | |
| CapEx | $518.0K | $2M | $3M | |
| Investing Cash Flow | $-229M | $-161M | $22M | |
| Financing Cash Flow | $2M | $378M | $75M | |
| Net Change in Cash | $-117M | $150M | $58M | |
| Taxes Paid | $0 | $232.0K | $75.0K | |
| Free Cash Flow | $110M | $-70M | · |
盈利能力 7
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -148.6% | -7518.4% | · | |
| Net Margin | -106.4% | -6678.9% | · | |
| Pretax Margin | -106.3% | -6725.2% | · | |
| EBITDA Margin | -145.2% | -7388.2% | · | |
| ROA | -9.3% | -24.4% | · | |
| ROE | -12.9% | -43.2% | · | |
| ROIC | -17.9% | -19.1% | · |
流动性与偿付能力 2
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 4.7 | 27.8 | · | |
| Quick Ratio | 4.6 | 27.3 | · |
效率 2
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.0 | · | |
| Receivables Turnover | 8.7 | 6.7 | · |
增长率 1
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 4174.5% | 611.9% | · |
估值 (TTM) 10
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $46M | $1M | · | |
| Net Income TTM | $-49M | $-72M | · | |
| Market Cap | $1.25B | $1.02B | · | |
| P/E | -25.3 | -3.2 | · | |
| P/S | 27.2 | 946.3 | · | |
| P/B | 3.3 | 2.4 | · | |
| P / Tangible Book | 3.3 | 2.4 | · | |
| P / Cash Flow | 11.3 | -15.1 | · | |
| P / FCF | 11.4 | -14.6 | · | |
| Earnings Yield | -4.0% | -31.7% | · |
损益表 15
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $27M | $27M | $24M | $21M | $119.0K | $219.0K | $212.0K | $176.0K | $370.0K | $317.0K | |
| R&D Expense | $35M | $30M | $32M | $24M | $22M | $19M | $19M | $18M | $15M | $13M | |
| SG&A Expense | $8M | $10M | $8M | $7M | $7M | $7M | $6M | $5M | $3M | $3M | |
| Operating Expenses | $44M | $40M | $40M | $19M | $29M | $26M | $25M | $23M | $18M | $16M | |
| Operating Income | $-17M | $-13M | $-16M | $3M | $-29M | $-26M | $-25M | $-23M | $-18M | $-15M | |
| Interest Income | $5M | $5M | $5M | $6M | $4M | $4M | $4M | $2M | $2M | $1M | |
| Other Non-op | $-23.0K | $-31.0K | $-41.0K | $-6.0K | $-25.0K | $-28.0K | $-18.0K | $-9.0K | $-15.0K | $-48.0K | |
| Pretax Income | $-12M | $-8M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| Income Tax | $973.0K | $337.0K | $12.0K | $0 | $0 | $0 | $-564.0K | $-136.0K | $109.0K | $93.0K | |
| Net Income | $-13M | $-9M | $-11M | $8M | $-25M | $-21M | $-21M | $-21M | $-17M | $-14M | |
| EPS (Basic) | $-0.29 | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| EPS (Diluted) | $-0.29 | $-0.19 | $-0.23 | $0.18 | $-0.56 | $-0.49 | $14.52 | $-8.40 | $-7.03 | $-6.35 | |
| Shares (Basic) | 45,040,075 | 44,758,800 | -88,187,325 | 44,343,085 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| Shares (Diluted) | 45,040,075 | 44,758,800 | -89,446,339 | 45,602,099 | 44,165,168 | 43,937,410 | 2,877,617 | 2,443,678 | 2,337,585 | 2,232,246 | |
| EBITDA | $-16M | $-13M | · | $3M | $-29M | $-26M | · | $-22M | · | · |
资产负债表 23
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $85M | $72M | $121M | $320M | $189M | $210M | $238M | $88M | · | · | |
| Short-term Investments | $288M | $276M | $270M | $154M | $137M | $126M | $113M | $42M | · | · | |
| Receivables | $12M | $11M | $10M | $9M | $151.0K | $250.0K | $171.0K | $210.0K | · | · | |
| Prepaid Expense | $12M | $10M | $10M | $9M | $7M | $6M | $6M | $3M | · | · | |
| Other Current Assets | $133.0K | $110.0K | $1M | $387.0K | $0 | $52.0K | $239.0K | $241.0K | · | · | |
| Current Assets | $396M | $368M | $411M | $492M | $334M | $342M | $357M | $133M | · | · | |
| PP&E (Net) | $4M | $4M | $4M | $4M | $5M | $5M | $5M | $5M | · | · | |
| PP&E (Gross) | $9M | $9M | $9M | $8M | $8M | $8M | $8M | $8M | · | · | |
| Accum. Depreciation | $5M | $5M | $4M | $4M | $4M | $3M | $3M | $3M | · | · | |
| Other Non-current Assets | $1M | $773.0K | $816.0K | $501.0K | $300.0K | $277.0K | $267.0K | $3M | · | · | |
| Total Assets | $567M | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Accounts Payable | $4M | $7M | $10M | $4M | $7M | $4M | $3M | $6M | · | · | |
| Accrued Liabilities | $13M | $9M | $12M | $8M | $7M | $4M | $8M | $6M | · | · | |
| Current Liabilities | $79M | $78M | $87M | $75M | $15M | $11M | $13M | $13M | · | · | |
| Capital Leases | $20M | $21M | $21M | $22M | $23M | $23M | $24M | $24M | · | · | |
| Other Non-current Liabilities | $521.0K | $100.0K | $0 | $0 | $2.0K | $27.0K | $33.0K | $191.0K | · | · | |
| Total Liabilities | $180M | $191M | $214M | $218M | $38M | $34M | $37M | $38M | · | · | |
| Common Stock | $46.0K | $45.0K | $45.0K | $45.0K | $45.0K | $44.0K | $44.0K | $3.0K | · | · | |
| Retained Earnings | $-189M | $-176M | $-167M | $-157M | $-165M | $-140M | $-118M | $-98M | · | · | |
| AOCI | $-1M | $-569.0K | $617.0K | $375.0K | $176.0K | $198.0K | $56.0K | $176.0K | · | · | |
| Stockholders' Equity | $387M | $378M | $382M | $389M | $378M | $400M | $420M | $-87M | · | · | |
| Liabilities + Equity | $567M | $570M | $596M | $607M | $415M | $434M | $457M | $174M | · | · | |
| Shares Outstanding | 45,667,490 | 44,916,572 | 44,806,272 | 44,638,703 | 44,567,891 | 44,448,435 | 44,422,505 | · | · | · |
现金流 11
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $400.0K | $300.0K | $300.0K | |
| Stock-based Comp | $5M | $6M | $3M | $3M | $2M | $1M | $1M | $683.0K | $628.0K | $577.0K | |
| Deferred Tax | · | · | · | · | · | · | $-153.0K | $-136.0K | $-109.0K | $-93.0K | |
| Other Non-cash | · | $-23M | · | · | · | $-4M | · | · | · | · | |
| Operating Cash Flow | $-22M | $-26M | $-15M | $169M | $-20M | $-23M | $-21M | $-17M | $-13M | $-17M | |
| CapEx | $0 | $832.0K | $65.0K | $13.0K | $58.0K | $382.0K | $612.0K | $578.0K | $149.0K | $764.0K | |
| Investing Cash Flow | $18M | $-24M | $-185M | $-38M | $-786.0K | $-5M | $-133M | $-25M | $-12M | $10M | |
| Financing Cash Flow | $17M | $333.0K | $1M | $263.0K | $339.0K | $66.0K | $304M | $-1M | · | · | |
| Net Change in Cash | $13M | $-49M | $-199M | $131M | $-21M | $-28M | $150M | $-43M | $50M | $-7M | |
| Taxes Paid | · | · | · | · | · | · | $0 | $75.0K | · | · | |
| Free Cash Flow | · | $-26M | · | · | · | $-24M | · | · | · | · |
盈利能力 7
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -62.9% | -50.1% | · | 12.2% | -24351.3% | -11831.1% | · | -12812.5% | · | · | |
| Net Margin | -48.7% | -32.6% | · | 38.0% | -20872.3% | -9806.4% | · | -11660.8% | · | · | |
| Pretax Margin | -45.1% | -31.3% | · | 38.0% | -20872.3% | -9806.4% | · | -11738.1% | · | · | |
| EBITDA Margin | -61.5% | -48.6% | · | 14.0% | -24015.1% | -11648.4% | · | -12585.2% | · | · | |
| ROA | -2.6% | -1.7% | · | 2.1% | -12.0% | -9.9% | · | -23.5% | · | · | |
| ROE | -3.4% | -2.2% | · | 5.4% | -13.2% | -10.7% | · | 47.0% | · | · | |
| ROIC | -4.7% | -3.7% | · | 0.67% | -7.7% | -6.5% | · | 25.6% | · | · |
流动性与偿付能力 2
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.0 | 4.7 | · | 6.5 | 22.1 | 32.2 | · | 10.1 | · | · | |
| Quick Ratio | 4.8 | 4.6 | · | 6.4 | 21.6 | 31.6 | · | 9.9 | · | · |
效率 2
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.1 | 0.1 | · | 0.1 | 0.0 | 0.0 | · | 0.0 | · | · | |
| Receivables Turnover | 4.3 | 4.8 | · | 4.9 | 1.6 | 1.8 | · | 1.7 | · | · |
估值 (TTM) 10
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $75M | $48M | · | $22M | $884.0K | $1M | · | $896.0K | · | · | |
| Net Income TTM | $-38M | $-47M | · | $-59M | $-83M | $-73M | · | $-62M | · | · | |
| Market Cap | $1.53B | $1.08B | · | $840M | $471M | $257M | · | · | · | · | |
| P/E | -38.9 | -22.7 | · | -2.0 | -0.6 | -0.3 | · | · | · | · | |
| P/S | 20.4 | 22.3 | · | 38.2 | 532.9 | 237.9 | · | · | · | · | |
| P/B | 4.0 | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Tangible Book | 4.0 | 2.9 | · | 2.2 | 1.2 | 0.6 | · | · | · | · | |
| P / Cash Flow | · | -42.1 | · | · | · | -11.0 | · | · | · | · | |
| P / FCF | · | -40.8 | · | · | · | -10.8 | · | · | · | · | |
| Earnings Yield | -2.6% | -4.4% | · | -49.3% | -155.9% | -384.6% | · | · | · | · |
财务报表 损益表、资产负债表、现金流量表 — 年度，近5年
损益表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| 收入 | $46M | $1M | $151.0K |
| 营业利润率 % | -148.6% | -7518.4% | — |
| 净收入 | $-49M | $-72M | $4M |
| 稀释后每股收益 (EPS) | $-1.10 | $-7.26 | $0.29 |
资产负债表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| 流动比率 | 4.7 | 27.8 | — |
| 速动比率 | 4.6 | 27.3 | — |
现金流
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| 自由现金流 | $110M | $-70M | — |
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机构持有人 (13F) 170 家申报者 · $1.5B 总计 · 截至 2026年6月30日
在其季度SEC表格13F中报告持有此股票的机构。仅限多头头寸；单个申报人可能因单独的期权腿而出现两次。 大的抵消性看跌/看涨腿通常反映做市或对冲库存，而非方向性判断。
机构活动 — Q2 2026 与上一季度对比
| 新仓位 | 已退出持仓 | 增加 | 减少 | 净股数变动 |
|---|---|---|---|---|
| 62 (+38 与上一季度对比) | 15 (-7 与上一季度对比) | 43 (+3 与上一季度对比) | 33 (+4 与上一季度对比) | +2.8M |
与Q1 2026对比。 SEC 13F表格的提交截止日期是季度末后45天，外加少量延迟提交的缓冲期——在此窗口期内的季度将被跳过，优先显示最近一个已完整报告的季度对。
| 机构 | 价值 | 股份 | % 已追踪的13F | 类型 |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234291284 | 6995858 | 15.96% | 股份 |
| TRV GP V, LLC | $208160143 | 6215591 | 14.18% | 股份 |
| Driehaus Capital Management LLC | $148463112 | 4433058 | 10.11% | 股份 |
| TRV GP VI, LLC | $141048460 | 4211659 | 9.61% | 股份 |
| SAMSARA BIOCAPITAL, LLC | $105464297 | 3149128 | 7.18% | 股份 |
| Siren, L.L.C. | $63631000 | 1900000 | 4.33% | 股份 |
| GOLDMAN SACHS GROUP INC | $57564688 | 1718862 | 3.92% | 股份 |
| Avoro Capital Advisors LLC | $44792875 | 1337500 | 3.05% | 股份 |
| VANGUARD CAPITAL MANAGEMENT LLC | $40913829 | 1221673 | 2.79% | 股份 |
| PRIMECAP MANAGEMENT CO/CA/ | $39095624 | 1167382 | 2.66% | 股份 |
| First Light Asset Management, LLC | $32259577 | 963260 | 2.20% | 股份 |
| ADAR1 Capital Management, LLC | $31505617 | 940747 | 2.15% | 股份 |
| STATE STREET CORP | $21856579 | 652630 | 1.49% | 股份 |
| JANUS HENDERSON GROUP PLC | $21333558 | 890754 | 1.45% | 股份 |
| GEODE CAPITAL MANAGEMENT, LLC | $19943040 | 595346 | 1.36% | 股份 |
| Casdin Capital, LLC | $18528945 | 553268 | 1.26% | 股份 |
| Catalio Capital Management, LP | $17955730 | 536152 | 1.22% | 股份 |
| LOOMIS SAYLES & CO L P | $17416173 | 520041 | 1.19% | 股份 |
| Caption Management, LLC | $14735600 | 440000 | 1.00% | 买入期权 |
| ALGERT GLOBAL LLC | $13311840 | 397487 | 0.91% | 股份 |
| Balyasny Asset Management L.P. | $11736303 | 350442 | 0.80% | 股份 |
| Longaeva Partners L.P. | $9985747 | 298171 | 0.68% | 股份 |
| Soleus Capital Management, L.P. | $9209750 | 275000 | 0.63% | 股份 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8774380 | 262000 | 0.60% | 买入期权 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7708862 | 230184 | 0.52% | 股份 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7458290 | 222702 | 0.51% | 股份 |
| TWO SIGMA INVESTMENTS, LP | $7397439 | 220885 | 0.50% | 股份 |
| TUDOR INVESTMENT CORP ET AL | $6698000 | 200000 | 0.46% | 买入期权 |
| Caption Management, LLC | $6698000 | 200000 | 0.46% | 卖出期权 |
| Kalehua Capital Management LLC | $6515279 | 194544 | 0.44% | 股份 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6264003 | 187041 | 0.43% | 股份 |
| Woodline Partners LP | $6213567 | 185535 | 0.42% | 股份 |
| VANGUARD FIDUCIARY TRUST CO | $5547819 | 165656 | 0.38% | 股份 |
| VANGUARD GROUP INC | $4171991 | 149641 | 0.28% | 股份 |
| TUDOR INVESTMENT CORP ET AL | $3349000 | 100000 | 0.23% | 卖出期权 |
| CITADEL ADVISORS LLC | $2739482 | 81800 | 0.19% | 买入期权 |
| UBS Group AG | $2551067 | 76174 | 0.17% | 股份 |
| LAZARD ASSET MANAGEMENT LLC | $2525983 | 75425 | 0.17% | 股份 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2499995 | 74649 | 0.17% | 股份 |
| DIMENSIONAL FUND ADVISORS LP | $2284319 | 68209 | 0.16% | 股份 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2283348 | 68180 | 0.16% | 股份 |
| HUSSMAN STRATEGIC ADVISORS, INC. | $2109870 | 63000 | 0.14% | 股份 |
| AMERICAN CENTURY COMPANIES INC | $2041986 | 60973 | 0.14% | 股份 |
| DIADEMA PARTNERS LP | $1999353 | 59700 | 0.14% | 卖出期权 |
| JANE STREET GROUP, LLC | $1915628 | 57200 | 0.13% | 买入期权 |
| XTX Topco Ltd | $1824837 | 54489 | 0.12% | 股份 |
| MILLENNIUM MANAGEMENT LLC | $1693321 | 50562 | 0.12% | 股份 |
| Elmind Capital, LP | $1655880 | 49444 | 0.11% | 股份 |
| BARCLAYS PLC | $1647541 | 49195 | 0.11% | 股份 |
| Sofinnova Investments, Inc. | $1590976 | 47506 | 0.11% | 股份 |
| D. E. Shaw & Co., Inc. | $1556716 | 46483 | 0.11% | 股份 |
| Voleon Capital Management LP | $1488128 | 44435 | 0.10% | 股份 |
| RENAISSANCE TECHNOLOGIES LLC | $1387122 | 41419 | 0.09% | 股份 |
| Caption Management, LLC | $1272821 | 38006 | 0.09% | 股份 |
| BANK OF AMERICA CORP /DE/ | $1201453 | 35875 | 0.08% | 股份 |
| Alyeska Investment Group, L.P. | $1172150 | 35000 | 0.08% | 股份 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1135311 | 33900 | 0.08% | 卖出期权 |
| Brevan Howard Capital Management LP | $986347 | 29452 | 0.07% | 股份 |
| HighVista Strategies LLC | $982496 | 29337 | 0.07% | 股份 |
| TUDOR INVESTMENT CORP ET AL | $970071 | 28966 | 0.07% | 股份 |
| RHUMBLINE ADVISERS | $925521 | 27636 | 0.06% | 股份 |
| JANE STREET GROUP, LLC | $871946 | 26036 | 0.06% | 股份 |
| Trexquant Investment LP | $858851 | 25645 | 0.06% | 股份 |
| Logos Global Management LP | $788623 | 23548 | 0.05% | 股份 |
| FMR LLC | $778308 | 23240 | 0.05% | 股份 |
| FOX RUN MANAGEMENT, L.L.C. | $738053 | 22038 | 0.05% | 股份 |
| ALLIANCEBERNSTEIN L.P. | $718497 | 29900 | 0.05% | 股份 |
| TWO SIGMA ADVISERS, LP | $716516 | 25700 | 0.05% | 股份 |
| Squarepoint Ops LLC | $710624 | 21219 | 0.05% | 股份 |
| STRS OHIO | $703290 | 21000 | 0.05% | 股份 |
| FRED ALGER MANAGEMENT, LLC | $701883 | 20958 | 0.05% | 股份 |
| Jump Financial, LLC | $676498 | 20200 | 0.05% | 股份 |
| Swiss National Bank | $663102 | 19800 | 0.05% | 股份 |
| WELLS FARGO & COMPANY/MN | $657677 | 19638 | 0.04% | 股份 |
| Aquatic Capital Management LLC | $583630 | 17427 | 0.04% | 股份 |
| BlackRock, Inc. | $582626 | 17397 | 0.04% | 股份 |
| Engineers Gate Manager LP | $581052 | 17350 | 0.04% | 股份 |
| BNP PARIBAS FINANCIAL MARKETS | $567522 | 16946 | 0.04% | 股份 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $555833 | 16597 | 0.04% | 股份 |
| CITIGROUP INC | $553623 | 16531 | 0.04% | 股份 |
| Nuveen Asset Management, LLC | $548707 | 23961 | 0.04% | 股份 |
| State of Wyoming | $548533 | 16379 | 0.04% | 股份 |
| Vanguard Global Advisers, LLC | $544112 | 16247 | 0.04% | 股份 |
| Bank of New York Mellon Corp | $516650 | 15427 | 0.04% | 股份 |
| AQR CAPITAL MANAGEMENT LLC | $510421 | 15241 | 0.03% | 股份 |
| Verdad Advisers, LP | $434365 | 12970 | 0.03% | 股份 |
| MetLife Investment Management, LLC | $431351 | 12880 | 0.03% | 股份 |
| Man Group plc | $384097 | 11469 | 0.03% | 股份 |
| FEDERATED HERMES, INC. | $368055 | 10990 | 0.03% | 股份 |
| China Universal Asset Management Co., Ltd. | $360821 | 10774 | 0.02% | 股份 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $341364 | 10193 | 0.02% | 股份 |
| Gotham Asset Management, LLC | $312194 | 9322 | 0.02% | 股份 |
| Virtus Investment Advisers, LLC | $304826 | 9102 | 0.02% | 股份 |
| CANADA PENSION PLAN INVESTMENT BOARD | $298061 | 8900 | 0.02% | 股份 |
| Invesco Ltd. | $285737 | 8532 | 0.02% | 股份 |
| NEW YORK STATE COMMON RETIREMENT FUND | $284665 | 8500 | 0.02% | 股份 |
| FIRST TRUST ADVISORS LP | $259179 | 7739 | 0.02% | 股份 |
| VANGUARD ASSET MANAGEMENT, Ltd | $248496 | 7420 | 0.02% | 股份 |
| Quantinno Capital Management LP | $245482 | 7330 | 0.02% | 股份 |
| Rangeley Capital, LLC | $241128 | 7200 | 0.02% | 股份 |
公司内部人士 15 位内幕人士 · 6 位高管 · 8 位董事
| 内部人士 | 角色 | 上次活动 | 持股数量 | 买入 12个月 | 卖出 12个月 | 净额 12个月 |
|---|---|---|---|---|---|---|
| Jeffrey Finer | Chief Executive Officer | 2026年2月6日 A | 826907 | 0 | 0 | $0 |
| Gil M Labrucherie | Chief Financial Officer | 2026年2月6日 A | 40000 | 0 | 0 | $0 |
| Samira Shaikhly | Chief People Officer | 2026年6月29日 M | 793 | 0 | 8 | $-2802156 |
| Uwe Klein | SVP, Biological Sciences | 2026年2月6日 A | 23008 | 0 | 0 | $0 |
| Jae B. Kim | Chief Medical Officer | 2026年2月6日 A | — | 0 | 0 | $0 |
| Mark Andrew Wilson | Chief Legal Officer | 2026年2月6日 A | — | 0 | 0 | $0 |
| Abraham Bassan | 董事 | 2026年6月26日 A | — | 0 | 0 | $0 |
| Jake Simson | 董事 | 2026年6月26日 A | — | 0 | 0 | $0 |
| Bernard Coulie | 董事 | 2026年6月26日 A | — | 0 | 0 | $0 |
| Alan Ezekowitz | 董事 | 2026年6月26日 A | 117420 | 0 | 0 | $0 |
| Keith Michael Gottesdiener | 董事 | 2026年6月26日 A | — | 0 | 0 | $0 |
| Jeffrey K Tong | 董事 | 2026年6月26日 A | — | 0 | 0 | $0 |
| Shalini Sharp | 董事 | 2026年6月26日 A | — | 0 | 0 | $0 |
| Elizabeth Bhatt | — | 2026年8月11日 M | 174209 | 0 | 7 | $-1449169 |
| Daniel D. Long | — | 2026年8月3日 M | 96412 | 0 | 7 | $-825272 |
来自SEC表格3/4/5申报的内部人士；净额=仅公开市场买卖
激进投资者及 5%+ 股东 1 持仓
提交了 SEC Schedule 13D 的投资者 — 持有超过 5% 的受益所有权，意图影响发行人（激进股东持股、董事会活动、并购）。每一行显示该申报人持仓的最新已知状态。
| 申报人 | 已申报 | 持股 | 状态 | 目的 | 申报 |
|---|---|---|---|---|---|
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×2 申报 | 2026年8月14日 | 11.80% | 修订 | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF持仓 由 40 只交易所交易基金持有
权重仅反映直接股权持仓（N-PORT）；杠杆基金或基于衍生品的基金可能持有未显示的额外掉期敞口。
| 基金 | 权重 | 单位 | 截至 | 来源 |
|---|---|---|---|---|
| PILL · Direxion Shares ETF Trust | 0.69% | 3760 NS | 2026年4月30日 | N-PORT |
| BBC · ETFis Series Trust I | 0.69% | 10849 NS | 2026年4月30日 | N-PORT |
| MMSC · First Trust Exchange-Traded Fund ... | 0.44% | 7698 NS | 2026年5月31日 | N-PORT |
| IHE · iShares Trust | 0.20% | 81879 SH | 2026年8月8日 | 每日 |
| FSCC · Federated Hermes ETF Trust | 0.14% | 12566 NS | 2026年5月31日 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trus... | 0.12% | 2451 SH | 2026年8月8日 | 每日 |
| IBB · iShares Trust | 0.08% | 202051 SH | 2026年8月8日 | 每日 |
| VFMO · VANGUARD WELLINGTON FUND | 0.08% | 48858 SH | 2026年8月8日 | 每日 |
| BIB · ProShares Trust | 0.07% | 1657 NS | 2026年5月31日 | N-PORT |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.06% | 51545 NS | 2026年5月31日 | N-PORT |
| JPSE · J.P. Morgan Exchange-Traded Fund ... | 0.04% | 10731 NS | 2026年4月30日 | N-PORT |
| IWO · iShares Trust | 0.04% | 135471 SH | 2026年8月8日 | 每日 |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.03% | 15806 SH | 2026年8月8日 | 每日 |
| IWM · iShares Trust | 0.03% | 566763 SH | 2026年8月8日 | 每日 |
| ISCG · iShares Trust | 0.02% | 6294 SH | 2026年8月8日 | 每日 |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.02% | 127487 SH | 2026年8月8日 | 每日 |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0.02% | 6423 SH | 2026年8月8日 | 每日 |
| IWN · iShares Trust | 0.02% | 68929 SH | 2026年8月8日 | 每日 |
| OMFS · Invesco Exchange-Traded Self-Inde... | 0.02% | 1228 SH | 2026年8月8日 | 每日 |
| ITWO · ProShares Trust | 0.02% | 1006 NS | 2026年5月31日 | N-PORT |
| RSSL · Global X Funds | 0.02% | 9265 NS | 2026年4月30日 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.01% | 108128 NS | 2026年5月31日 | N-PORT |
| ISCB · iShares Trust | 0.01% | 906 SH | 2026年8月8日 | 每日 |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.01% | 8859 SH | 2026年8月8日 | 每日 |
| VXF · VANGUARD INDEX FUNDS | 0.01% | 263629 SH | 2026年8月8日 | 每日 |
| UWM · ProShares Trust | 0.01% | 787 NS | 2026年5月31日 | N-PORT |
| URTY · ProShares Trust | 0.01% | 797 NS | 2026年5月31日 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0.00% | 17360 NS | 2026年5月31日 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0.00% | 5127 NS | 2026年4月30日 | N-PORT |
| HDG · ProShares Trust | 0.00% | 20 NS | 2026年5月31日 | N-PORT |
| DFAS · Dimensional ETF Trust | 0.00% | 16325 NS | 2026年4月30日 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.00% | 675 NS | 2026年5月31日 | N-PORT |
| IWV · iShares Trust | 0.00% | 6883 SH | 2026年8月8日 | 每日 |
| ITOT · iShares Trust | 0.00% | 29774 SH | 2026年8月8日 | 每日 |
| SCHB · SCHWAB STRATEGIC TRUST | 0.00% | 11580 NS | 2026年5月31日 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 418 NS | 2026年4月30日 | N-PORT |
| AVUS · AMERICAN CENTURY ETF TRUST | 0.00% | 672 NS | 2026年5月31日 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 927665 SH | 2026年8月8日 | 每日 |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 1866 SH | 2026年8月8日 | 每日 |
| VHT · VANGUARD WORLD FUND | 0.00% | 29744 SH | 2026年8月8日 | 每日 |