| NEA Management Company, LLC |
$150742986 |
24471264 |
10.78% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$108419826 |
17600621 |
7.75% |
股份
|
| Venrock Adviser, LLC |
$90835009 |
14745943 |
6.50% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$83585040 |
13569000 |
5.98% |
股份
|
| BlackRock, Inc. |
$76966107 |
12494498 |
5.50% |
股份
|
| TCG Crossover Management, LLC |
$76151183 |
12362205 |
5.45% |
股份
|
| VANGUARD GROUP INC |
$60551132 |
10041647 |
4.33% |
股份
|
| Frazier Life Sciences Management, L.P. |
$59880448 |
9720852 |
4.28% |
股份
|
| Polar Capital Holdings Plc |
$58777402 |
9541786 |
4.20% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$48864477 |
7932545 |
3.49% |
股份
|
| Nantahala Capital Management, LLC |
$42977150 |
6976810 |
3.07% |
股份
|
| STATE STREET CORP |
$40368624 |
6553348 |
2.89% |
股份
|
| MARSHALL WACE, LLP |
$38543053 |
6256989 |
2.76% |
股份
|
| RTW INVESTMENTS, LP |
$36666661 |
5952380 |
2.62% |
股份
|
| Woodline Partners LP |
$26149933 |
4245119 |
1.87% |
股份
|
| ORBIMED ADVISORS LLC |
$24392984 |
3959900 |
1.74% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$23857705 |
3872133 |
1.71% |
股份
|
| Spruce Street Capital LP |
$21267868 |
3452576 |
1.52% |
股份
|
| Rosalind Advisors, Inc. |
$19577225 |
3178121 |
1.40% |
股份
|
| EMERALD ADVISERS, LLC |
$19394384 |
3148439 |
1.39% |
股份
|
| Pictet Asset Management Holding SA |
$17020419 |
2763055 |
1.22% |
股份
|
| Vestal Point Capital, LP |
$16755200 |
2720000 |
1.20% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$16600042 |
2694812 |
1.19% |
股份
|
| D. E. Shaw & Co., Inc. |
$15492388 |
2514998 |
1.11% |
股份
|
| Affinity Asset Advisors, LLC |
$15474862 |
2512153 |
1.11% |
股份
|
| EMERALD MUTUAL FUND ADVISERS TRUST |
$14636154 |
2375999 |
1.05% |
股份
|
| NAN FUNG TRINITY (HK) LTD |
$11348876 |
1842350 |
0.81% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$10076762 |
1635838 |
0.72% |
股份
|
| ADAR1 Capital Management, LLC |
$8644999 |
1403409 |
0.62% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$8349627 |
1355459 |
0.60% |
股份
|
| ALGERT GLOBAL LLC |
$8188235 |
1329259 |
0.59% |
股份
|
| NORTHERN TRUST CORP |
$8025894 |
1302905 |
0.57% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$7211802 |
1170747 |
0.52% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6412597 |
1041006 |
0.46% |
股份
|
| Longaeva Partners L.P. |
$6257864 |
1015887 |
0.45% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$6219696 |
1009691 |
0.44% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$6021154 |
977460 |
0.43% |
股份
|
| DEUTSCHE BANK AG\ |
$5328129 |
864956 |
0.38% |
股份
|
| GOLDMAN SACHS GROUP INC |
$5108767 |
829345 |
0.37% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$4657970 |
756164 |
0.33% |
股份
|
| Swedbank AB |
$4409944 |
715900 |
0.32% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$4264020 |
692211 |
0.30% |
股份
|
| F/m Investments LLC |
$4055461 |
658354 |
0.29% |
股份
|
| Sio Capital Management, LLC |
$3804878 |
617675 |
0.27% |
股份
|
| AXA Investment Managers S.A. |
$3760142 |
1053261 |
0.27% |
股份
|
| KVP Capital Advisors, LP |
$3728525 |
605280 |
0.27% |
股份
|
| Integral Health Asset Management, LLC |
$3696000 |
600000 |
0.26% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3205393 |
520356 |
0.23% |
股份
|
| UBS Group AG |
$3160240 |
513026 |
0.23% |
股份
|
| Moody Aldrich Partners LLC |
$2974005 |
482793 |
0.21% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$2529351 |
410609 |
0.18% |
股份
|
| Bank of New York Mellon Corp |
$2293779 |
372367 |
0.16% |
股份
|
| MORGAN STANLEY |
$2254351 |
365966 |
0.16% |
股份
|
| Sofinnova Investments, Inc. |
$2246940 |
364763 |
0.16% |
股份
|
| Nuveen, LLC |
$2090205 |
339319 |
0.15% |
股份
|
| Seven Fleet Capital Management LP |
$1904074 |
309103 |
0.14% |
股份
|
| WEDGE CAPITAL MANAGEMENT L L P/NC |
$1681669 |
307998 |
0.12% |
股份
|
| CITADEL ADVISORS LLC |
$1608049 |
261047 |
0.11% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1533156 |
248889 |
0.11% |
股份
|
| Walleye Capital LLC |
$1532115 |
248720 |
0.11% |
股份
|
| HighVista Strategies LLC |
$1493054 |
242379 |
0.11% |
股份
|
| Eversept Partners, LP |
$1259276 |
204428 |
0.09% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$1236693 |
205090 |
0.09% |
股份
|
| Invesco Ltd. |
$1236220 |
200685 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$1146187 |
186071 |
0.08% |
股份
|
| Swiss National Bank |
$1139600 |
185000 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1106108 |
179563 |
0.08% |
股份
|
| FMR LLC |
$1076387 |
174738 |
0.08% |
股份
|
| CITIGROUP INC |
$984886 |
159884 |
0.07% |
股份
|
| Jain Global LLC |
$879605 |
142793 |
0.06% |
股份
|
| XTX Topco Ltd |
$754662 |
122510 |
0.05% |
股份
|
| GLENMEDE TRUST CO NA |
$707432 |
114843 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$693638 |
127040 |
0.05% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$621766 |
100936 |
0.04% |
股份
|
| DCF Advisers, LLC |
$616000 |
100000 |
0.04% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$585921 |
95117 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$574728 |
93300 |
0.04% |
买入期权
|
| Russell Investments Group, Ltd. |
$556309 |
90310 |
0.04% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$554400 |
90000 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$549817 |
89256 |
0.04% |
股份
|
| Rafferty Asset Management, LLC |
$547279 |
88844 |
0.04% |
股份
|
| ENVESTNET ASSET MANAGEMENT INC |
$531534 |
86288 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$518032 |
85909 |
0.04% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$516276 |
83811 |
0.04% |
股份
|
| Cresset Asset Management, LLC |
$513337 |
83334 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$494360 |
80471 |
0.04% |
股份
|
| Birchview Capital, LP |
$492800 |
80000 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$473291 |
76833 |
0.03% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$461236 |
74876 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$430492 |
69885 |
0.03% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$405427 |
65816 |
0.03% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$388560 |
63078 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$383183 |
62205 |
0.03% |
股份
|
| Verdad Advisers, LP |
$380435 |
61759 |
0.03% |
股份
|
| Creative Planning |
$378951 |
61518 |
0.03% |
股份
|
| Legal & General Group Plc |
$350819 |
56951 |
0.03% |
股份
|
| FIFTH THIRD BANCORP |
$333595 |
54155 |
0.02% |
股份
|
| Avidity Partners Management LP |
$308000 |
50000 |
0.02% |
股份
|
| Sivia Capital Partners, LLC |
$298760 |
48500 |
0.02% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$293450 |
47638 |
0.02% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$287841 |
52718 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$285824 |
46400 |
0.02% |
卖出期权
|
| PROFUND ADVISORS LLC |
$285645 |
46371 |
0.02% |
股份
|
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. |
$283360 |
46000 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$280003 |
45455 |
0.02% |
股份
|
| Jump Financial, LLC |
$273504 |
44400 |
0.02% |
股份
|
| SEI INVESTMENTS CO |
$267523 |
43429 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$256872 |
41700 |
0.02% |
卖出期权
|
| Police & Firemen's Retirement System of New Jersey |
$250324 |
40637 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$247891 |
40242 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$247018 |
45200 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$244552 |
39700 |
0.02% |
买入期权
|
| TWO SIGMA INVESTMENTS, LP |
$231906 |
37647 |
0.02% |
股份
|
| BARCLAYS PLC |
$230076 |
37350 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$217448 |
35300 |
0.02% |
买入期权
|
| Squarepoint Ops LLC |
$205054 |
33288 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$201678 |
32740 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$200902 |
32614 |
0.01% |
股份
|
| STRS OHIO |
$199584 |
32400 |
0.01% |
股份
|
| Graham Capital Management, L.P. |
$197434 |
32051 |
0.01% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$193714 |
31447 |
0.01% |
股份
|
| Skopos Labs, Inc. |
$183828 |
33668 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$183673 |
29817 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$176835 |
28707 |
0.01% |
股份
|
| Farther Finance Advisors, LLC |
$166665 |
27056 |
0.01% |
股份
|
| ProShare Advisors LLC |
$164798 |
26753 |
0.01% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$162784 |
26426 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$156741 |
25445 |
0.01% |
股份
|
| WINTON GROUP Ltd |
$151290 |
24560 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$151259 |
24555 |
0.01% |
股份
|
| Orion Porfolio Solutions, LLC |
$150698 |
24464 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$144514 |
23460 |
0.01% |
股份
|
| Trexquant Investment LP |
$133980 |
21750 |
0.01% |
股份
|
| Quantinno Capital Management LP |
$133241 |
21630 |
0.01% |
股份
|
| BANK OF MONTREAL /CAN/ |
$128584 |
20874 |
0.01% |
股份
|
| BROWN ADVISORY INC |
$128461 |
20854 |
0.01% |
股份
|
| OPPENHEIMER & CO INC |
$104720 |
17000 |
0.01% |
股份
|
| EntryPoint Capital, LLC |
$95813 |
15554 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$93632 |
15200 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$90885 |
14754 |
0.01% |
股份
|
| INCEPTIONR LLC |
$90392 |
14674 |
0.01% |
股份
|
| XPONANCE LLC |
$90145 |
14634 |
0.01% |
股份
|
| US BANCORP \DE\ |
$86825 |
14095 |
0.01% |
股份
|
| Sanctuary Advisors, LLC |
$86579 |
14055 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$85991 |
24087 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$85532 |
13885 |
0.01% |
股份
|
| Magnetar Financial LLC |
$84392 |
13700 |
0.01% |
股份
|
| MML INVESTORS SERVICES, LLC |
$81552 |
13239 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$80696 |
13100 |
0.01% |
卖出期权
|
| E Fund Management Co., Ltd. |
$77166 |
12527 |
0.01% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$75947 |
12329 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$73101 |
11867 |
0.01% |
股份
|
| PRINCIPAL FINANCIAL GROUP INC |
$72060 |
11698 |
0.01% |
股份
|
| Sequoia Financial Advisors, LLC |
$69473 |
11278 |
0.00% |
股份
|
| TWO SIGMA ADVISERS, LP |
$64774 |
10742 |
0.00% |
股份
|
| Granite Investment Partners, LLC |
$64606 |
10488 |
0.00% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$63565 |
10319 |
0.00% |
股份
|
| TEACHER RETIREMENT SYSTEM OF TEXAS |
$62592 |
10161 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$60322 |
16897 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$56456 |
9165 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$52633 |
14743 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$40231 |
6531 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$35000 |
5651 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$26525 |
4306 |
0.00% |
股份
|
| 1620 INVESTMENT ADVISORS, INC. |
$18480 |
3000 |
0.00% |
股份
|
| COMERICA BANK |
$12693 |
2105 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$10842 |
1760 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$10091 |
1638 |
0.00% |
股份
|
| Larson Financial Group LLC |
$4873 |
791 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$4318 |
701 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3308 |
537 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$3049 |
495 |
0.00% |
股份
|
| CWM, LLC |
$3025 |
554 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2723 |
442 |
0.00% |
股份
|
| GAMMA Investing LLC |
$2519 |
409 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$2203 |
617 |
0.00% |
股份
|
| Allworth Financial LP |
$1701 |
276 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$1386 |
225 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$1312 |
213 |
0.00% |
股份
|
| Quarry LP |
$1109 |
180 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$861 |
146 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$775 |
125676 |
0.00% |
股份
|
| Arax Advisory Partners |
$721 |
117 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$616 |
100 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$401 |
65 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$382 |
61977 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$289 |
47 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$179 |
29 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$136 |
25 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$74 |
11940 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$37 |
6 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$19 |
3 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$9 |
1484 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
74 |
0.00% |
股份
|