| RTW INVESTMENTS, LP |
$167215336 |
4543895 |
11.19% |
股份
|
| BlackRock, Inc. |
$117813765 |
3201461 |
7.88% |
股份
|
| MORGAN STANLEY |
$94810189 |
2576363 |
6.34% |
股份
|
| Kynam Capital Management, LP |
$89578818 |
2434207 |
5.99% |
股份
|
| Jefferies Financial Group Inc. |
$80947194 |
2199652 |
5.42% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$62034564 |
1685719 |
4.15% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$61581856 |
1673420 |
4.12% |
股份
|
| Point72 Asset Management, L.P. |
$56140203 |
1525549 |
3.76% |
股份
|
| FRONTIER CAPITAL MANAGEMENT CO LLC |
$55514521 |
1508547 |
3.71% |
股份
|
| Opaleye Management Inc. |
$52991853 |
1439996 |
3.55% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$47912827 |
1301979 |
3.21% |
股份
|
| MENORA MIVTACHIM HOLDINGS LTD. |
$42413141 |
1152531 |
2.84% |
股份
|
| D. E. Shaw & Co., Inc. |
$42166139 |
1145819 |
2.82% |
股份
|
| STATE STREET CORP |
$36913013 |
1003071 |
2.47% |
股份
|
| MPM BIOIMPACT LLC |
$34349672 |
933415 |
2.30% |
股份
|
| Soleus Capital Management, L.P. |
$30537008 |
829810 |
2.04% |
股份
|
| GOLDMAN SACHS GROUP INC |
$30169892 |
819834 |
2.02% |
股份
|
| Migdal Insurance & Financial Holdings Ltd. |
$28369451 |
770909 |
1.90% |
股份
|
| ORBIMED ADVISORS LLC |
$24883682 |
676187 |
1.67% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$22461394 |
610364 |
1.50% |
股份
|
| Woodline Partners LP |
$18426717 |
500726 |
1.23% |
股份
|
| Boxer Capital Management, LLC |
$18400000 |
500000 |
1.23% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$17505834 |
475702 |
1.17% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$16801334 |
456558 |
1.12% |
股份
|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
$14244323 |
387074 |
0.95% |
股份
|
| NORTHERN TRUST CORP |
$11208175 |
304570 |
0.75% |
股份
|
| RICE HALL JAMES & ASSOCIATES, LLC |
$11063920 |
300650 |
0.74% |
股份
|
| VANGUARD GROUP INC |
$10298969 |
439751 |
0.69% |
股份
|
| ADAR1 Capital Management, LLC |
$9288136 |
252395 |
0.62% |
股份
|
| J. Goldman & Co LP |
$7830120 |
212775 |
0.52% |
股份
|
| Privium Fund Management B.V. |
$7728000 |
210000 |
0.52% |
股份
|
| FMR LLC |
$7253198 |
197098 |
0.49% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$7040318 |
191313 |
0.47% |
股份
|
| Parkman Healthcare Partners LLC |
$6405555 |
174064 |
0.43% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$5531040 |
150300 |
0.37% |
买入期权
|
| AQR CAPITAL MANAGEMENT LLC |
$5491591 |
149228 |
0.37% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$5481838 |
148963 |
0.37% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4724016 |
128370 |
0.32% |
股份
|
| UBS Group AG |
$4469764 |
121461 |
0.30% |
股份
|
| Elmind Capital, LP |
$4416000 |
120000 |
0.30% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$4245322 |
115362 |
0.28% |
股份
|
| Bank of New York Mellon Corp |
$4159416 |
113028 |
0.28% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$4089989 |
111141 |
0.27% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4084800 |
111000 |
0.27% |
卖出期权
|
| Aisling Capital Management LP |
$3974400 |
108000 |
0.27% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$3926266 |
106692 |
0.26% |
股份
|
| ARK Investment Management LLC |
$3735494 |
101508 |
0.25% |
股份
|
| Russell Investments Group, Ltd. |
$3495260 |
94979 |
0.23% |
股份
|
| Nuveen, LLC |
$3389354 |
92102 |
0.23% |
股份
|
| OAK RIDGE INVESTMENTS LLC |
$3260149 |
88591 |
0.22% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2952612 |
80234 |
0.20% |
股份
|
| Informed Momentum Co LLC |
$2917173 |
79271 |
0.20% |
股份
|
| Swiss National Bank |
$2863040 |
77800 |
0.19% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$2724083 |
74024 |
0.18% |
股份
|
| TRUIST FINANCIAL CORP |
$2660125 |
72286 |
0.18% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$2622368 |
71260 |
0.18% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2587040 |
70300 |
0.17% |
股份
|
| Ally Bridge Group (NY) LLC |
$2545934 |
69183 |
0.17% |
股份
|
| RHUMBLINE ADVISERS |
$2021123 |
54922 |
0.14% |
股份
|
| DEUTSCHE BANK AG\ |
$1897040 |
51550 |
0.13% |
股份
|
| CITADEL ADVISORS LLC |
$1865760 |
50700 |
0.12% |
买入期权
|
| Atom Investors LP |
$1717235 |
46664 |
0.11% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1654123 |
44949 |
0.11% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$1604443 |
43599 |
0.11% |
股份
|
| JPMORGAN CHASE & CO |
$1426352 |
39544 |
0.10% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1369218 |
37207 |
0.09% |
股份
|
| Coastal Bridge Advisors, LLC |
$1361600 |
37000 |
0.09% |
股份
|
| Legal & General Group Plc |
$1318543 |
35830 |
0.09% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1289987 |
35054 |
0.09% |
股份
|
| J. Goldman & Co LP |
$1251200 |
34000 |
0.08% |
买入期权
|
| Focus Partners Wealth |
$1216645 |
33061 |
0.08% |
股份
|
| Schonfeld Strategic Advisors LLC |
$1194491 |
32459 |
0.08% |
股份
|
| ALGERT GLOBAL LLC |
$1190480 |
32350 |
0.08% |
股份
|
| AMERIPRISE FINANCIAL INC |
$1165383 |
31668 |
0.08% |
股份
|
| POLEN CAPITAL MANAGEMENT LLC |
$1089832 |
29615 |
0.07% |
股份
|
| Cetera Investment Advisers |
$1065434 |
28952 |
0.07% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$956947 |
26004 |
0.06% |
股份
|
| Invesco Ltd. |
$954113 |
25927 |
0.06% |
股份
|
| HighVista Strategies LLC |
$918822 |
24968 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$915032 |
24865 |
0.06% |
股份
|
| Palo Alto Investors LP |
$901600 |
24500 |
0.06% |
股份
|
| JANE STREET GROUP, LLC |
$897920 |
24400 |
0.06% |
买入期权
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$852594 |
47419 |
0.06% |
股份
|
| CITIGROUP INC |
$841653 |
22871 |
0.06% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$785906 |
43710 |
0.05% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$761613 |
20696 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$718925 |
19536 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$717600 |
19500 |
0.05% |
卖出期权
|
| Susquehanna Portfolio Strategies, LLC |
$714067 |
19404 |
0.05% |
股份
|
| XTX Topco Ltd |
$713405 |
19386 |
0.05% |
股份
|
| FRANKLIN RESOURCES INC |
$708878 |
19263 |
0.05% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$677046 |
18398 |
0.05% |
股份
|
| Quantinno Capital Management LP |
$671674 |
18252 |
0.04% |
股份
|
| CAPITAL FUND MANAGEMENT S.A. |
$647128 |
17585 |
0.04% |
股份
|
| GLENMEDE TRUST CO NA |
$633180 |
17206 |
0.04% |
股份
|
| Toroso Investments, LLC |
$631684 |
26972 |
0.04% |
股份
|
| CITADEL ADVISORS LLC |
$610880 |
16600 |
0.04% |
卖出期权
|
| Birchview Capital, LP |
$606722 |
16487 |
0.04% |
股份
|
| Engineers Gate Manager LP |
$602710 |
16378 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$579122 |
15737 |
0.04% |
股份
|
| PARTNERS CAPITAL INVESTMENT GROUP, LLP |
$566131 |
15384 |
0.04% |
股份
|
| LPL Financial LLC |
$532018 |
14457 |
0.04% |
股份
|
| Verdad Advisers, LP |
$531392 |
14440 |
0.04% |
股份
|
| MML INVESTORS SERVICES, LLC |
$527160 |
14325 |
0.04% |
股份
|
| MAI Capital Management |
$521198 |
14163 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$477848 |
12985 |
0.03% |
股份
|
| DNB Asset Management AS |
$474941 |
12906 |
0.03% |
股份
|
| State of New Jersey Common Pension Fund D |
$463422 |
12593 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$462429 |
12566 |
0.03% |
股份
|
| Creative Planning |
$444360 |
12075 |
0.03% |
股份
|
| Integrated Wealth Concepts LLC |
$432069 |
11741 |
0.03% |
股份
|
| Arax Advisory Partners |
$431996 |
11739 |
0.03% |
股份
|
| Squarepoint Ops LLC |
$430523 |
11699 |
0.03% |
股份
|
| WOLVERINE TRADING, LLC |
$415338 |
21700 |
0.03% |
买入期权
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$412050 |
11197 |
0.03% |
股份
|
| ROYAL BANK OF CANADA |
$407000 |
11060 |
0.03% |
股份
|
| Vanguard Investments Australia, Ltd. |
$398176 |
10820 |
0.03% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$395453 |
10746 |
0.03% |
股份
|
| KLP KAPITALFORVALTNING AS |
$375360 |
10200 |
0.03% |
股份
|
| BARCLAYS PLC |
$374439 |
10175 |
0.03% |
股份
|
| Allianz Asset Management GmbH |
$371680 |
10100 |
0.02% |
股份
|
| Cresset Asset Management, LLC |
$366749 |
9966 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$355488 |
9660 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$349784 |
9505 |
0.02% |
股份
|
| Orion Porfolio Solutions, LLC |
$345810 |
9397 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$343132 |
19100 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$311770 |
8472 |
0.02% |
股份
|
| Main Street Financial Solutions, LLC |
$301377 |
8190 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$298816 |
8120 |
0.02% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$294676 |
7642 |
0.02% |
股份
|
| Baader Bank Aktiengesellschaft |
$294400 |
8000 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$292818 |
7957 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$285347 |
7754 |
0.02% |
股份
|
| DEBUSSY CAPITAL MANAGEMENT LP |
$281585 |
15661 |
0.02% |
股份
|
| Mariner, LLC |
$280527 |
7623 |
0.02% |
股份
|
| HAP Trading, LLC |
$271342 |
19806 |
0.02% |
股份
|
| Kathmere Capital Management, LLC |
$270848 |
7360 |
0.02% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$265402 |
7212 |
0.02% |
股份
|
| ProShare Advisors LLC |
$264187 |
7179 |
0.02% |
股份
|
| DIADEMA PARTNERS LP |
$262642 |
7137 |
0.02% |
股份
|
| Pictet Asset Management Holding SA |
$257600 |
7000 |
0.02% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$256680 |
6975 |
0.02% |
股份
|
| Jain Global LLC |
$253994 |
6902 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$249578 |
6782 |
0.02% |
股份
|
| Brookstone Capital Management |
$220800 |
6000 |
0.01% |
股份
|
| RITHOLTZ WEALTH MANAGEMENT |
$201002 |
5462 |
0.01% |
股份
|
| Nebula Research & Development LLC |
$162249 |
11843 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$142306 |
3867 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$112093 |
3046 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$83535 |
2270 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$82837 |
2251 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$80187 |
2179 |
0.01% |
股份
|
| Quantbot Technologies LP |
$78494 |
2133 |
0.01% |
股份
|
| SG Americas Securities, LLC |
$75547 |
2052906 |
0.01% |
股份
|
| CWM, LLC |
$70014 |
3894 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$65872 |
1790 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$40664 |
1105 |
0.00% |
股份
|
| Activest Wealth Management |
$36837 |
1001 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$36542 |
993 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$35254 |
958 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$34540 |
1000 |
0.00% |
股份
|
| Rossby Financial, LCC |
$28336 |
770 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$25318 |
688 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$21896 |
595 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$21492 |
584 |
0.00% |
股份
|
| State of Wyoming |
$19504 |
530 |
0.00% |
股份
|
| Larson Financial Group LLC |
$17848 |
485 |
0.00% |
股份
|
| GAMMA Investing LLC |
$16229 |
441 |
0.00% |
股份
|
| Napier Financial, LLC |
$14720 |
400 |
0.00% |
股份
|
| NFSG Corp |
$12880 |
350 |
0.00% |
股份
|
| CIBC Private Wealth Group LLC |
$10155 |
509 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$9090 |
247 |
0.00% |
股份
|
| Allworth Financial LP |
$8869 |
241 |
0.00% |
股份
|
| Costello Asset Management, INC |
$7360 |
200 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$4122 |
112 |
0.00% |
股份
|
| NewEdge Advisors, LLC |
$3680 |
100 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$3091 |
84 |
0.00% |
股份
|
| US BANCORP \DE\ |
$2981 |
81 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2650 |
72 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$2597 |
72 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2502 |
68 |
0.00% |
股份
|
| Essential Partners LLC |
$1766 |
48 |
0.00% |
股份
|
| Annandale Capital, LLC |
$1672 |
45425 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1660 |
45 |
0.00% |
股份
|
| Altshuler Shaham Ltd |
$1435 |
39 |
0.00% |
股份
|
| Quarry LP |
$1325 |
36 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1289 |
35003 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1141 |
31 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$883 |
24 |
0.00% |
股份
|
| DecisionPoint Financial, LLC |
$835 |
22 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$589 |
16 |
0.00% |
股份
|
| True Wealth Design, LLC |
$589 |
16 |
0.00% |
股份
|
| Jackson Creek Investment Advisors LLC |
$540 |
14134 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$405 |
11 |
0.00% |
股份
|
| SHIKIAR ASSET MANAGEMENT INC |
$322 |
8750 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$297 |
8113 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$221 |
6 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$147 |
4 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$110 |
3 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$74 |
2 |
0.00% |
股份
|
| KBC Group NV |
$49 |
1340 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$37 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
14 |
0.00% |
股份
|