| TCG Crossover Management, LLC |
$104441366 |
5673078 |
11.56% |
股份
|
| FMR LLC |
$90800863 |
4932149 |
10.05% |
股份
|
| FCPM III SERVICES B.V. |
$75800487 |
4117354 |
8.39% |
股份
|
| BlackRock, Inc. |
$63847850 |
3468107 |
7.07% |
股份
|
| Venrock Adviser, LLC |
$55998047 |
3041719 |
6.20% |
股份
|
| STATE STREET CORP |
$48166746 |
2616336 |
5.33% |
股份
|
| Frazier Life Sciences Management, L.P. |
$46833917 |
2543939 |
5.18% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$44222569 |
2402095 |
4.89% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$38372478 |
2084328 |
4.25% |
股份
|
| Caligan Partners LP |
$35440465 |
1925066 |
3.92% |
股份
|
| Paradigm Biocapital Advisors LP |
$32217500 |
1750000 |
3.57% |
股份
|
| GREAT POINT PARTNERS LLC |
$31297000 |
1700000 |
3.46% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$19563726 |
1062469 |
2.17% |
股份
|
| NEXTBio Capital Management LP |
$16369509 |
889164 |
1.81% |
股份
|
| Nantahala Capital Management, LLC |
$15556450 |
845000 |
1.72% |
股份
|
| ADAR1 Capital Management, LLC |
$12530325 |
680626 |
1.39% |
股份
|
| Logos Global Management LP |
$11966500 |
650000 |
1.32% |
股份
|
| Rosalind Advisors, Inc. |
$11940726 |
648600 |
1.32% |
股份
|
| NAN FUNG TRINITY (HK) LTD |
$11902986 |
646550 |
1.32% |
股份
|
| BRAIDWELL LP |
$10550845 |
573104 |
1.17% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$10285704 |
558702 |
1.14% |
股份
|
| VANGUARD GROUP INC |
$10074870 |
770250 |
1.12% |
股份
|
| UBS Group AG |
$9081248 |
493278 |
1.01% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7880713 |
428067 |
0.87% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$7666237 |
416417 |
0.85% |
股份
|
| Woodline Partners LP |
$6990700 |
379723 |
0.77% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$6266101 |
340364 |
0.69% |
股份
|
| GOLDMAN SACHS GROUP INC |
$6054902 |
328892 |
0.67% |
股份
|
| NORTHERN TRUST CORP |
$6052141 |
328742 |
0.67% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$5535961 |
300704 |
0.61% |
股份
|
| Clearline Capital LP |
$5251931 |
285276 |
0.58% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3272175 |
177739 |
0.36% |
股份
|
| CITADEL ADVISORS LLC |
$2953222 |
160414 |
0.33% |
股份
|
| Eversept Partners, LP |
$2755627 |
149681 |
0.30% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2234937 |
121398 |
0.25% |
股份
|
| Bank of New York Mellon Corp |
$1799062 |
97722 |
0.20% |
股份
|
| MARSHALL WACE, LLP |
$1760788 |
95643 |
0.19% |
股份
|
| Nuveen, LLC |
$1745544 |
94815 |
0.19% |
股份
|
| AXIOM INVESTORS LLC /DE |
$1695653 |
92105 |
0.19% |
股份
|
| XTX Topco Ltd |
$1521494 |
82645 |
0.17% |
股份
|
| Jump Financial, LLC |
$1305066 |
70889 |
0.14% |
股份
|
| Invesco Ltd. |
$1257421 |
68301 |
0.14% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1189286 |
64600 |
0.13% |
卖出期权
|
| CITIGROUP INC |
$1162224 |
63130 |
0.13% |
股份
|
| MORGAN STANLEY |
$1133338 |
61561 |
0.13% |
股份
|
| RHUMBLINE ADVISERS |
$1059081 |
57528 |
0.12% |
股份
|
| ALPS ADVISORS INC |
$1012513 |
54998 |
0.11% |
股份
|
| D. E. Shaw & Co., Inc. |
$1006493 |
54671 |
0.11% |
股份
|
| JOHNSON & JOHNSON |
$989206 |
53732 |
0.11% |
股份
|
| Rafferty Asset Management, LLC |
$898739 |
48818 |
0.10% |
股份
|
| Walleye Capital LLC |
$858127 |
46612 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$742862 |
40351 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$685036 |
37210 |
0.08% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$681391 |
37012 |
0.08% |
股份
|
| Engineers Gate Manager LP |
$680268 |
36951 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$667786 |
36273 |
0.07% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$607733 |
33011 |
0.07% |
股份
|
| Jefferies Financial Group Inc. |
$601326 |
32663 |
0.07% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$498911 |
27100 |
0.06% |
股份
|
| Sarissa Capital Management LP |
$467596 |
25399 |
0.05% |
股份
|
| PROFUND ADVISORS LLC |
$452720 |
24591 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$449977 |
24442 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$449932 |
24381 |
0.05% |
股份
|
| Squarepoint Ops LLC |
$427683 |
23231 |
0.05% |
股份
|
| SEI INVESTMENTS CO |
$423855 |
23019 |
0.05% |
股份
|
| Virtus Investment Advisers, LLC |
$419472 |
22785 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$402150 |
21621 |
0.04% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$361204 |
19620 |
0.04% |
股份
|
| Scientech Research LLC |
$346623 |
18828 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$330404 |
17947 |
0.04% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$317352 |
17238 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$302918 |
16454 |
0.03% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$281691 |
15301 |
0.03% |
股份
|
| BARCLAYS PLC |
$268142 |
14565 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$263263 |
14300 |
0.03% |
股份
|
| Shay Capital LLC |
$252125 |
13695 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$221564 |
12035 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$198699 |
10793 |
0.02% |
股份
|
| EntryPoint Capital, LLC |
$198552 |
10785 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$197134 |
10708 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$158768 |
8624 |
0.02% |
股份
|
| Legal & General Group Plc |
$147482 |
8011 |
0.02% |
股份
|
| Ameritas Investment Partners, Inc. |
$68172 |
3703 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$59942 |
3256 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$54549 |
2963 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$44607 |
2423 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$38458 |
2089 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$36360 |
1975 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$32052 |
1741 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$23000 |
1260 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$19736 |
1072 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$13890 |
728 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$10346 |
562 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6536 |
355 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$5670 |
308 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$3314 |
180 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$2706 |
147 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$770 |
41815 |
0.00% |
股份
|
| WPG Advisers, LLC |
$405 |
22 |
0.00% |
股份
|
| Allworth Financial LP |
$185 |
10 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$92 |
5 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$55 |
3 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$37 |
2 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$15 |
815 |
0.00% |
股份
|