| FMR LLC |
$305029074 |
16604740 |
11.87% |
股份
|
| VANGUARD GROUP INC |
$174649921 |
5612144 |
6.79% |
股份
|
| BlackRock, Inc. |
$157090835 |
8551488 |
6.11% |
股份
|
| Bellevue Group AG |
$123665169 |
6731909 |
4.81% |
股份
|
| Paradigm Biocapital Advisors LP |
$123515986 |
6723788 |
4.81% |
股份
|
| Kynam Capital Management, LP |
$118557720 |
6453877 |
4.61% |
股份
|
| STATE STREET CORP |
$112515809 |
6124976 |
4.38% |
股份
|
| Fairmount Funds Management LLC |
$93520347 |
5090928 |
3.64% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$84076918 |
4576860 |
3.27% |
股份
|
| Deep Track Capital, LP |
$65998634 |
3592740 |
2.57% |
股份
|
| Venrock Adviser, LLC |
$59847935 |
3257917 |
2.33% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$57468009 |
3128362 |
2.24% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$50569432 |
2752827 |
1.97% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$45968039 |
2501869 |
1.79% |
股份
|
| Avoro Capital Advisors LLC |
$45925000 |
2500000 |
1.79% |
股份
|
| BAKER BROS. ADVISORS LP |
$43776169 |
2383025 |
1.70% |
股份
|
| Point72 Asset Management, L.P. |
$43044731 |
2343208 |
1.67% |
股份
|
| Caligan Partners LP |
$40303431 |
2193981 |
1.57% |
股份
|
| NOVO HOLDINGS A/S |
$39219950 |
2135000 |
1.53% |
股份
|
| TANG CAPITAL MANAGEMENT LLC |
$32930540 |
1792626 |
1.28% |
股份
|
| Fisher Asset Management, LLC |
$32163113 |
1750850 |
1.25% |
股份
|
| Candriam S.C.A. |
$31340230 |
1707698 |
1.22% |
股份
|
| GOLDMAN SACHS GROUP INC |
$31069254 |
1691304 |
1.21% |
股份
|
| First Turn Management, LLC |
$30677900 |
1670000 |
1.19% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$29607274 |
1611521 |
1.15% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$27220459 |
1391639 |
1.06% |
股份
|
| UBS Group AG |
$26247845 |
1428843 |
1.02% |
股份
|
| Parkman Healthcare Partners LLC |
$25306071 |
1377576 |
0.98% |
股份
|
| Balyasny Asset Management L.P. |
$23511010 |
1279859 |
0.91% |
股份
|
| D. E. Shaw & Co., Inc. |
$21717418 |
1182222 |
0.84% |
股份
|
| RICE HALL JAMES & ASSOCIATES, LLC |
$21601393 |
1175906 |
0.84% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$20435027 |
1112413 |
0.79% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$18592975 |
1012138 |
0.72% |
股份
|
| Elmind Capital, LP |
$18093182 |
984931 |
0.70% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$17375111 |
888298 |
0.68% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$17347618 |
944345 |
0.67% |
股份
|
| NORTHERN TRUST CORP |
$15862330 |
863491 |
0.62% |
股份
|
| Eversept Partners, LP |
$15268079 |
831142 |
0.59% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$14972046 |
815027 |
0.58% |
股份
|
| Schonfeld Strategic Advisors LLC |
$14576741 |
793508 |
0.57% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$14119182 |
768600 |
0.55% |
股份
|
| MORGAN STANLEY |
$13388384 |
728817 |
0.52% |
股份
|
| Woodline Partners LP |
$12876066 |
700929 |
0.50% |
股份
|
| JPMORGAN CHASE & CO |
$12106209 |
639929 |
0.47% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$12079892 |
657588 |
0.47% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$10690973 |
581980 |
0.42% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$9939235 |
541058 |
0.39% |
股份
|
| EMERALD ADVISERS, LLC |
$9870715 |
537328 |
0.38% |
股份
|
| DEUTSCHE BANK AG\ |
$8870414 |
482875 |
0.35% |
股份
|
| ALGERT GLOBAL LLC |
$8858694 |
482237 |
0.34% |
股份
|
| Ikarian Capital, LLC |
$7807251 |
425000 |
0.30% |
股份
|
| Yiheng Capital Management, L.P. |
$7356524 |
400464 |
0.29% |
股份
|
| Jump Financial, LLC |
$7315871 |
398251 |
0.28% |
股份
|
| EMERALD MUTUAL FUND ADVISERS TRUST |
$7266180 |
395546 |
0.28% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$5963967 |
324658 |
0.23% |
股份
|
| XTX Topco Ltd |
$5054781 |
275165 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$4924265 |
268060 |
0.19% |
股份
|
| Blue Owl Capital Holdings LP |
$4776200 |
260000 |
0.19% |
股份
|
| Affinity Asset Advisors, LLC |
$4592500 |
250000 |
0.18% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$4588146 |
249763 |
0.18% |
股份
|
| TD Asset Management Inc |
$4328082 |
235606 |
0.17% |
股份
|
| Nuveen, LLC |
$3659856 |
199230 |
0.14% |
股份
|
| CAPITAL FUND MANAGEMENT S.A. |
$3634467 |
197848 |
0.14% |
股份
|
| FIRST TRUST ADVISORS LP |
$3329268 |
181234 |
0.13% |
股份
|
| Knott David M Jr |
$3324970 |
181000 |
0.13% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$3312993 |
180348 |
0.13% |
股份
|
| Squarepoint Ops LLC |
$3250663 |
176955 |
0.13% |
股份
|
| Privium Fund Management B.V. |
$3187489 |
173516 |
0.12% |
股份
|
| HighVista Strategies LLC |
$2937087 |
159885 |
0.11% |
股份
|
| Swiss National Bank |
$2849187 |
155100 |
0.11% |
股份
|
| CITIGROUP INC |
$2579424 |
140415 |
0.10% |
股份
|
| CITADEL ADVISORS LLC |
$2555267 |
139100 |
0.10% |
买入期权
|
| F/m Investments LLC |
$2475560 |
134761 |
0.10% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$2469939 |
134455 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2393317 |
130284 |
0.09% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$2338520 |
127301 |
0.09% |
股份
|
| KVP Capital Advisors, LP |
$2296250 |
125000 |
0.09% |
股份
|
| Lighthouse Investment Partners, LLC |
$2204400 |
120000 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$2162997 |
117747 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$2122893 |
115563 |
0.08% |
股份
|
| Russell Investments Group, Ltd. |
$2117986 |
115296 |
0.08% |
股份
|
| ALPS ADVISORS INC |
$2049578 |
111572 |
0.08% |
股份
|
| Rafferty Asset Management, LLC |
$1997719 |
108749 |
0.08% |
股份
|
| J. Safra Sarasin Holding AG |
$1981002 |
107839 |
0.08% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$1862975 |
101414 |
0.07% |
股份
|
| Invesco Ltd. |
$1853441 |
100895 |
0.07% |
股份
|
| NOMURA HOLDINGS INC |
$1840674 |
100200 |
0.07% |
买入期权
|
| DIADEMA PARTNERS LP |
$1837000 |
100000 |
0.07% |
股份
|
| Voleon Capital Management LP |
$1792875 |
97598 |
0.07% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1777408 |
96756 |
0.07% |
股份
|
| Merck & Co., Inc. |
$1716015 |
93414 |
0.07% |
股份
|
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. |
$1692765 |
92148 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1679055 |
91402 |
0.07% |
股份
|
| Caption Management, LLC |
$1580555 |
86040 |
0.06% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$1499525 |
81629 |
0.06% |
股份
|
| BARCLAYS PLC |
$1495851 |
81429 |
0.06% |
股份
|
| Aquatic Capital Management LLC |
$1466753 |
79845 |
0.06% |
股份
|
| Knights of Columbus Asset Advisors LLC |
$1296059 |
70553 |
0.05% |
股份
|
| J. Goldman & Co LP |
$1239975 |
67500 |
0.05% |
买入期权
|
| Burkehill Global Management, LP |
$1194050 |
65000 |
0.05% |
股份
|
| Legal & General Group Plc |
$1190155 |
64788 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$1142320 |
62184 |
0.04% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$1117740 |
60846 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$1008789 |
54915 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$1006180 |
54773 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$998223 |
54051 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$968264 |
52709 |
0.04% |
股份
|
| Greenland Capital Management LP |
$918500 |
50000 |
0.04% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$918500 |
50000 |
0.04% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$912401 |
49668 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$911152 |
49600 |
0.04% |
卖出期权
|
| Advisory Services Network, LLC |
$879188 |
47860 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$856042 |
46600 |
0.03% |
买入期权
|
| Headlands Technologies LLC |
$855013 |
46544 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$840611 |
45760 |
0.03% |
股份
|
| Quadrature Capital Ltd |
$828083 |
45078 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$758736 |
41303 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$748578 |
40750 |
0.03% |
股份
|
| Verdad Advisers, LP |
$711323 |
38722 |
0.03% |
股份
|
| DCF Advisers, LLC |
$698060 |
38000 |
0.03% |
股份
|
| DNB Asset Management AS |
$657187 |
35775 |
0.03% |
股份
|
| TWINBEECH CAPITAL LP |
$646624 |
35200 |
0.03% |
股份
|
| AlphaQuest LLC |
$617639 |
19847 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$582678 |
31719 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$573144 |
31200 |
0.02% |
卖出期权
|
| JANE STREET GROUP, LLC |
$551100 |
30000 |
0.02% |
买入期权
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$540000 |
29370 |
0.02% |
股份
|
| AMERIPRISE FINANCIAL INC |
$537928 |
29283 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$536666 |
27472 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$521947 |
28413 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$489395 |
26641 |
0.02% |
股份
|
| Persistent Asset Partners Ltd |
$468251 |
25490 |
0.02% |
股份
|
| Greenland Capital Management LP |
$459250 |
25000 |
0.02% |
买入期权
|
| State of New Jersey Common Pension Fund D |
$459177 |
24996 |
0.02% |
股份
|
| SBI Okasan Asset Management Co.Ltd. |
$417138 |
22200 |
0.02% |
股份
|
| Quantinno Capital Management LP |
$403203 |
21949 |
0.02% |
股份
|
| 71 West Capital Partners |
$393118 |
21400 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$391832 |
21330 |
0.02% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$387056 |
21070 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$367620 |
20012 |
0.01% |
股份
|
| Bayforest Capital Ltd |
$363267 |
19775 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$358233 |
19501 |
0.01% |
股份
|
| Creative Planning |
$332644 |
18108 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$321475 |
17500 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$297043 |
16170 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$281686 |
15334 |
0.01% |
股份
|
| Graham Capital Management, L.P. |
$281502 |
15324 |
0.01% |
股份
|
| ALLSTATE CORP |
$274723 |
14955 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$271325 |
14770 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$266980 |
14535 |
0.01% |
股份
|
| FEDERATED HERMES, INC. |
$261552 |
14238 |
0.01% |
股份
|
| Point72 Asset Management, L.P. |
$238810 |
13000 |
0.01% |
买入期权
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$221910 |
12080 |
0.01% |
股份
|
| ProShare Advisors LLC |
$217226 |
11825 |
0.01% |
股份
|
| Glenmede Investment Management, LP |
$214505 |
9940 |
0.01% |
股份
|
| Corton Capital Inc. |
$212865 |
9864 |
0.01% |
股份
|
| NATIONS FINANCIAL GROUP INC, /IA/ /ADV |
$207067 |
11272 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$206203 |
11225 |
0.01% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$203907 |
11100 |
0.01% |
股份
|
| Man Group plc |
$197294 |
10740 |
0.01% |
股份
|
| Ensign Peak Advisors, Inc |
$185537 |
10100 |
0.01% |
股份
|
| OpenArc Corporate Advisory, LLC |
$184398 |
10038 |
0.01% |
股份
|
| Greenland Capital Management LP |
$183700 |
10000 |
0.01% |
卖出期权
|
| Velan Capital Investment Management LP |
$183700 |
10000 |
0.01% |
股份
|
| LMR Partners LLP |
$183700 |
10000 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$159360 |
8675 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$150597 |
8198 |
0.01% |
股份
|
| Larson Financial Group LLC |
$142955 |
7782 |
0.01% |
股份
|
| Eleva Capital SAS |
$139385 |
7126 |
0.01% |
股份
|
| Ghisallo Capital Management LLC |
$128590 |
7000 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$105599 |
5748410 |
0.00% |
股份
|
| LAZARD ASSET MANAGEMENT LLC |
$98941 |
5386 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$92384 |
5029 |
0.00% |
股份
|
| STRS OHIO |
$82665 |
4500 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$61317 |
3338 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$60713 |
3305 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$53000 |
2909 |
0.00% |
股份
|
| State of Wyoming |
$42747 |
2327 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$31192 |
1698 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$30531 |
1662 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$30035 |
1635 |
0.00% |
股份
|
| Kemnay Advisory Services Inc. |
$17543 |
955 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$17488 |
952 |
0.00% |
股份
|
| Allworth Financial LP |
$11482 |
625 |
0.00% |
股份
|
| CWM, LLC |
$10523 |
538 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$10416 |
567 |
0.00% |
股份
|
| Optiver Holding B.V. |
$9957 |
542 |
0.00% |
股份
|
| COMERICA BANK |
$9542 |
307 |
0.00% |
股份
|
| GAMMA Investing LLC |
$8487 |
462 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$6233 |
338 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$5750 |
313 |
0.00% |
股份
|
| IFG Advisory, LLC |
$4997 |
272 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$4959 |
270 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$4886 |
266 |
0.00% |
股份
|
| Arax Advisory Partners |
$4372 |
238 |
0.00% |
股份
|
| Quarry LP |
$4225 |
230 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$4097 |
223 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$4078 |
222 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$3814 |
208 |
0.00% |
股份
|
| US BANCORP \DE\ |
$3490 |
190 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$3047 |
148 |
0.00% |
股份
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$2772 |
150 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$2518 |
134 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$2131 |
116 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$2021 |
110 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$2004 |
109073 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$1470 |
80 |
0.00% |
股份
|
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ |
$1359 |
74 |
0.00% |
股份
|
| Elequin Capital, LP |
$1304 |
71 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1286 |
70 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1194 |
65 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$903 |
49177 |
0.00% |
股份
|
| LRI Investments, LLC |
$845 |
46 |
0.00% |
股份
|
| Owl Creek Wealth Partners LLC |
$827 |
45 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$707 |
38465 |
0.00% |
股份
|
| Essential Partners LLC |
$569 |
31 |
0.00% |
股份
|
| Torren Management, LLC |
$411 |
21 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$367 |
20 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$349 |
19 |
0.00% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO |
$252 |
13692 |
0.00% |
股份
|
| IFP Advisors, Inc |
$184 |
10 |
0.00% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$147 |
8 |
0.00% |
股份
|
| KBC Group NV |
$76 |
4120 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$33 |
1816 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$7 |
355 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
29 |
0.00% |
股份
|