GHRS — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Lynx1 Capital Management LP | $356,517,181 | 13,263,288 | 25.76% | Shares |
| BVF INC/IL | $232,516,247 | 8,650,158 | 16.80% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $205,277,533 | 7,636,813 | 14.83% | Shares |
| FMR LLC | $160,662,969 | 5,977,045 | 11.61% | Shares |
| RTW INVESTMENTS, LP | $159,500,947 | 5,933,815 | 11.52% | Shares |
| Deep Track Capital, LP | $89,600,018 | 3,333,334 | 6.47% | Shares |
| Avoro Capital Advisors LLC | $48,384,000 | 1,800,000 | 3.50% | Shares |
| Foresite Capital Management VI LLC | $25,280,452 | 940,493 | 1.83% | Shares |
| Jefferies Financial Group Inc. | $19,146,624 | 712,300 | 1.38% | Shares |
| BlackRock, Inc. | $12,910,116 | 480,287 | 0.93% | Shares |
| UBS Group AG | $12,832,727 | 477,408 | 0.93% | Shares |
| MILLENNIUM MANAGEMENT LLC | $8,692,965 | 323,399 | 0.63% | Shares |
| BRAIDWELL LP | $5,570,611 | 207,240 | 0.40% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $5,432,529 | 202,103 | 0.39% | Shares |
| JANE STREET GROUP, LLC | $4,568,283 | 169,951 | 0.33% | Shares |
| HighVista Strategies LLC | $4,267,737 | 158,770 | 0.31% | Shares |
| Trexquant Investment LP | $4,133,257 | 153,767 | 0.30% | Shares |
| GOLDMAN SACHS GROUP INC | $3,996,330 | 148,673 | 0.29% | Shares |
| XTX Topco Ltd | $2,338,184 | 86,986 | 0.17% | Shares |
| CITADEL ADVISORS LLC | $2,310,390 | 85,952 | 0.17% | Shares |
| AdvisorShares Investments LLC | $1,915,657 | 71,267 | 0.14% | Shares |
| CenterBook Partners LP | $1,866,440 | 69,436 | 0.13% | Shares |
| MORGAN STANLEY | $1,403,620 | 52,218 | 0.10% | Shares |
| Point72 Asset Management, L.P. | $1,367,708 | 50,882 | 0.10% | Shares |
| MARSHALL WACE, LLP | $1,255,215 | 46,697 | 0.09% | Shares |
| Qube Research & Technologies Ltd | $1,181,322 | 43,948 | 0.09% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $1,088,183 | 40,483 | 0.08% | Shares |
| TUDOR INVESTMENT CORP ET AL | $921,393 | 34,278 | 0.07% | Shares |
| NORTHERN TRUST CORP | $855,967 | 31,844 | 0.06% | Shares |
| JANE STREET GROUP, LLC | $787,584 | 29,300 | 0.06% | Call option |
| D. E. Shaw & Co., Inc. | $681,274 | 25,345 | 0.05% | Shares |
| Quadrature Capital Ltd | $567,625 | 21,117 | 0.04% | Shares |
| JPMORGAN CHASE & CO | $534,985 | 18,778 | 0.04% | Shares |
| CITADEL ADVISORS LLC | $532,224 | 19,800 | 0.04% | Call option |
| Squarepoint Ops LLC | $495,398 | 18,430 | 0.04% | Shares |
| Virtus Investment Advisers, LLC | $416,425 | 15,492 | 0.03% | Shares |
| LETKO, BROSSEAU & ASSOCIATES INC | $414,624 | 15,425 | 0.03% | Shares |
| China Universal Asset Management Co., Ltd. | $360,703 | 13,419 | 0.03% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $360,192 | 13,400 | 0.03% | Call option |
| JANE STREET GROUP, LLC | $360,192 | 13,400 | 0.03% | Put option |
| HighTower Advisors, LLC | $341,376 | 12,700 | 0.02% | Shares |
| Cubist Systematic Strategies, LLC | $325,068 | 22,732 | 0.02% | Shares |
| STATE STREET CORP | $300,061 | 11,163 | 0.02% | Shares |
| Lion Point Capital, LP | $274,176 | 10,200 | 0.02% | Shares |
| Eversept Partners, LP | $233,103 | 8,672 | 0.02% | Shares |
| HSBC HOLDINGS PLC | $216,420 | 7,847 | 0.02% | Shares |
| BARCLAYS PLC | $160,661 | 5,977 | 0.01% | Shares |
| ROYAL BANK OF CANADA | $158,000 | 5,877 | 0.01% | Shares |
| OSAIC HOLDINGS, INC. | $155,232 | 5,775 | 0.01% | Shares |
| SIMPLEX TRADING, LLC | $127,384 | 4,739 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $82,468 | 3,068 | 0.01% | Shares |
| North Star Investment Management Corp. | $59,136 | 2,200 | 0.00% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $45,615 | 1,697 | 0.00% | Shares |
| CITIGROUP INC | $43,384 | 1,614 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $35,347 | 1,315 | 0.00% | Shares |
| WELLS FARGO & COMPANY/MN | $33,600 | 1,250 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $21,871 | 775 | 0.00% | Shares |
| HARBOUR INVESTMENTS, INC. | $21,504 | 800 | 0.00% | Shares |
| Tower Research Capital LLC (TRC) | $13,843 | 515 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $11,048 | 411 | 0.00% | Shares |
| HOLLENCREST CAPITAL MANAGEMENT | $6,720 | 250 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $5,510 | 205 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $2,688 | 100 | 0.00% | Shares |
| HRT FINANCIAL LP | $1,757 | 65,375 | 0.00% | Shares |
| Cornerstone Financial Management LLC | $860 | 32 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $511 | 19 | 0.00% | Shares |