RA CAPITAL MANAGEMENT, L.P.

CIK 1346824 · View on SEC EDGAR ↗

Portfolio value
$11.5B
#438 of 9,443 by 13F value · top 4.6%
Positions
84
As of
June 30, 2026

Portfolio value QoQ: +21.8% 13F does not disclose cash

Top 10 holdings weight
60.59%
Top 25 holdings weight
82.33%
Positions above 1%
25
Effective number of positions
12.7

Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)

Turnover Q2 2026: 33.11% Est. buys $4,664,404,899 · sells $3,459,175,401

Median holding: 3.0 quarters Tracked Q4 2024–Q2 2026 · 48.6% still held

New positions
17
Increased
10
Decreased
10
Closed
17
On this page

Performance vs S&P 500

Tracked Q4 2024–Q2 2026
+49.5%
S&P 500 total return (same window)
+28.1%
Excess return
+21.4%

Annualized: +30.8% · S&P 500: +18.0%

Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.

Priceable coverage: 97.0% · Options excluded: 0.0%

Sector breakdown

Healthcare
63.7%
N/A
0.1%
Other/Unmapped
36.2%

Full portfolio 84 positions

Type Streak 8Q trend
Unknown issuer (CUSIP: K08588103) $2,742,280,613 23.90% 10,281,496 Up ×1
Unknown issuer (CUSIP: 698955101) $791,906,364 6.90% 28,933,371 Up ×1
RYTM Rhythm Pharmaceuticals, Inc. - Common Stock $740,218,912 6.45% 6,666,837 $160,404,098
PCVX Vaxcyte, Inc. - Common Stock $667,018,440 5.81% 11,474,599 $229,492
SION Sionna Therapeutics, Inc. - Common Stock $435,722,930 3.80% 9,905,045 $38,629,676
TYRA Tyra Biosciences, Inc. - Common Stock $389,624,083 3.40% 12,198,625 $-77,583,255
EWTX Edgewise Therapeutics, Inc. - Common Stock $340,996,620 2.97% 8,392,730 $12,500,854 Down ×1
NAMS NewAmsterdam Pharma Company N.V. - Ordinary Shares $323,655,973 2.82% 9,550,191 $17,954,359
Unknown issuer (CUSIP: 423494103) $286,810,870 2.50% 7,808,627 Up ×1
SEPN Septerna, Inc. - Common Stock $234,291,284 2.04% 6,995,858 $66,180,816
BCAX Bicara Therapeutics Inc. - Common Stock $215,430,432 1.88% 7,255,993 $71,108,731
MLYS Mineralys Therapeutics, Inc. - Common Stock $207,550,395 1.81% 7,692,750 $-846,203
GHRS GH Research PLC - Ordinary Shares $205,277,533 1.79% 7,636,813 $97,343,173 Down ×1
IRON Disc Medicine, Inc. - Common Stock $179,209,164 1.56% 2,450,221 $22,542,033
SGP SpyGlass Pharma, Inc. - Common Stock $178,550,064 1.56% 8,021,117 $-29,277,077
ARTV Artiva Biotherapeutics, Inc. - Common Stock $174,169,727 1.52% 17,955,642 $110,714,462 Up ×1
JANX Janux Therapeutics, Inc. - Common Stock $171,873,684 1.50% 11,189,693 $16,336,951
TSHA Taysha Gene Therapies, Inc. - Common Stock $160,413,963 1.40% 23,555,648 $55,120,216
BCRX BioCryst Pharmaceuticals, Inc. - Common Stock $158,271,860 1.38% 15,827,186 $7,597,049
WVE Wave Life Sciences Ltd. - Ordinary Shares $156,727,684 1.37% 26,975,505 $-38,844,727
NUVL Nuvalent, Inc. - Class A Common Stock $153,937,316 1.34% 1,246,456 $-105,685,839 Down ×1
ABVX Abivax SA - American Depositary Shares $150,924,546 1.32% 1,132,557 Up ×1
ORKA Oruka Therapeutics, Inc. - Common Stock $147,950,996 1.29% 1,554,597 Up ×1
SLDB Solid Biosciences Inc. - Common Stock $120,240,899 1.05% 12,036,126 $52,993,057 Up ×2
CLYM Climb Bio, Inc. - Common Stock $115,026,714 1.00% 8,821,067 $54,602,405
ZLAB Zai Lab Limited - American Depositary Shares $109,127,127 0.95% 5,743,533 $1,773,529 Up ×1
SPRY ARS Pharmaceuticals, Inc. - Common Stock $86,996,426 0.76% 10,860,977 $-217,219
XNCR Xencor, Inc. - Common Stock $84,915,811 0.74% 5,274,274 $25,855,133 Up ×1
JBIO Jade Biosciences, Inc. - Common Stock $81,571,464 0.71% 3,671,083 $29,992,748
NTLA Intellia Therapeutics, Inc. - Common Stock $76,595,588 0.67% 4,526,926 Up ×1
LBRX LB Pharmaceuticals Inc - Common Stock $71,680,243 0.62% 2,208,604 $17,216,068
DFTX Definium Therapeutics, Inc. - Common Shares $70,560,000 0.61% 1,500,000 Up ×1
ACRS Aclaris Therapeutics, Inc. - Common Stock $67,304,808 0.59% 12,723,026 $41,789,538 Up ×1
FDMT 4D Molecular Therapeutics, Inc. - Common Stock $67,162,061 0.59% 5,049,779 $20,148,619
SANA Sana Biotechnology, Inc. - Common Stock $65,437,500 0.57% 18,750,000 Up ×1
GLTO Galecto, Inc. - Common Stock $62,416,249 0.54% 2,399,702 $274,120 Up ×1
MNPR Monopar Therapeutics Inc. - Common Stock $61,776,696 0.54% 667,207 $25,220,424
ABOS Acumen Pharmaceuticals, Inc. - Common Stock $56,050,426 0.49% 20,992,669 $6,507,727
GERN Geron Corporation - Common Stock $54,796,481 0.48% 42,809,751 $-40,222,854 Down ×1
RZLT Rezolute, Inc. - Common Stock (NV) $49,114,203 0.43% 9,445,039 $21,115,203 Up ×1
EVMN Evommune, Inc. Common Stock $46,443,739 0.40% 3,494,638 $-33,897,989
VOR Vor Biopharma Inc. - Common Stock $44,222,569 0.39% 2,402,095 $-52,202,595 Down ×1
IPSC Century Therapeutics, Inc. - Common Stock $43,498,354 0.38% 17,754,430 $3,373,342
AKTS Aktis Oncology, Inc. - Common stock $42,363,273 0.37% 1,314,405 $15,473,100 Down ×1
BIOA BioAge Labs, Inc. - Common Stock $40,972,092 0.36% 1,671,648 $12,102,258 Up ×1
CCCC C4 Therapeutics, Inc. - Common Stock $37,360,000 0.33% 8,000,000 $16,320,000
MIRM Mirum Pharmaceuticals, Inc. - common stock $37,293,117 0.32% 318,554 $7,865,098
CAPR Capricor Therapeutics, Inc. - Common Stock $36,308,884 0.32% 1,507,844 $-9,529,574
PEPG PepGen Inc. - Common Stock $36,116,181 0.31% 20,064,545 $601,936
PRLD Prelude Therapeutics Incorporated - Common Stock $34,516,451 0.30% 6,475,882 Up ×1
NKTX Nkarta, Inc. - Common Stock $30,578,515 0.27% 10,805,129 $7,779,693
QTTB Q32 Bio Inc. - Common Stock $29,715,502 0.26% 2,332,457 Up ×1
AVR Anteris Technologies Global Corp. - Common Stock $29,550,000 0.26% 3,000,000 $12,900,000
EDIT Editas Medicine, Inc. - Common Stock $28,800,360 0.25% 8,889,000 Up ×1
OVID Ovid Therapeutics Inc. - Common Stock $28,247,604 0.25% 10,500,968 $4,462,524 Down ×1
ASMB Assembly Biosciences, Inc. - Common Stock $28,040,867 0.24% 1,020,410 $-275,511
ALXO ALX Oncology Holdings Inc. - Common Stock $26,934,527 0.23% 13,011,849 $845,770
BNTC Benitec Biopharma Inc. - Common Stock $24,753,000 0.22% 1,850,000 $5,050,500
LENZ LENZ Therapeutics, Inc. - Common Stock $23,735,715 0.21% 4,178,823 $-14,500,515
LXEO Lexeo Therapeutics, Inc. - Common Stock $23,275,000 0.20% 5,000,000 $-5,425,000
ACRV Acrivon Therapeutics, Inc. - Common Stock $21,768,325 0.19% 12,229,396 $10,175,019 Up ×1
ALT Altimmune, Inc. - Common Stock $19,760,000 0.17% 6,500,000 Up ×1
KPTI Karyopharm Therapeutics Inc. - Common Stock $18,732,549 0.16% 1,917,354 $8,052,887
DRUG Bright Minds Biosciences Inc. - common stock $18,603,000 0.16% 265,000 $-734,050
AVTX Avalo Therapeutics, Inc. - Common Stock $18,480,000 0.16% 1,000,000 $8,581,888 Up ×1
OKUR OnKure Therapeutics, Inc. - Class A Common Stock $18,232,398 0.16% 3,998,333 $1,679,299
SNSE Sensei Biotherapeutics, Inc. - Common Stock $18,050,500 0.16% 722,020 Up ×1
AURA Aura Biosciences, Inc. - Common Stock $17,750,000 0.15% 2,500,000 Up ×1
SABS SAB Biotherapeutics, Inc. - Common Stock $17,165,850 0.15% 4,401,500 $308,105
Unknown issuer (CUSIP: 81221K108) $15,204,000 0.13% 700,000 Up ×1
PALI Palisade Bio, Inc. - Common Stock $14,889,402 0.13% 7,124,116 $2,422,199
HLXC Helix Acquisition Corp. III - Class A Ordinary Shares $13,300,000 0.12% 1,250,000 $600,000
WAY Waystar Holding Corp. - Common Stock $10,868,582 0.09% 529,400 $-1,895,252
EQ Equillium, Inc. - Common Stock $9,908,275 0.09% 3,096,336 $3,715,603
MGNX MacroGenics, Inc. - Common Stock $8,612,493 0.08% 1,864,176 $3,225,024
PCSC Perceptive Capital Solutions Corp - Class A Ordinary Shares $8,160,000 0.07% 750,000 $-67,500
ACET Adicet Bio, Inc. - Common Stock $8,057,871 0.07% 932,624 $4,202 Down ×1
NAMSW NewAmsterdam Pharma Company N.V. - Warrant $7,123,326 0.06% 333,333 $443,333
CRVS Corvus Pharmaceuticals, Inc. - Common Stock $6,723,000 0.06% 450,000 $139,500
RANI Rani Therapeutics Holdings, Inc. - Class A Common Stock $6,463,400 0.06% 8,500,000 $217,600
Unknown issuer (CUSIP: G50765109) $5,680,000 0.05% 500,000 Up ×1
Unknown issuer (CUSIP: G0375M101) $3,810,000 0.03% 375,000 Up ×1
HOWL Werewolf Therapeutics, Inc. - Common Stock $859,349 0.01% 2,387,744 $-4,703,507 Down ×1
PTN Palatin Technologies, Inc. - Common Stock $670,318 0.01% 62,124 $-549,082 Down ×1

Biggest new bets

New positions opened this quarter, largest first.

Security Value Shares % of portfolio
Unknown issuer (CUSIP: K08588103) $2,742,280,613 10,281,496 23.90%
Unknown issuer (CUSIP: 698955101) $791,906,364 28,933,371 6.90%
Unknown issuer (CUSIP: 423494103) $286,810,870 7,808,627 2.50%
ABVX $150,924,546 1,132,557 1.32%
ORKA $147,950,996 1,554,597 1.29%
NTLA $76,595,588 4,526,926 0.67%
DFTX $70,560,000 1,500,000 0.61%
SANA $65,437,500 18,750,000 0.57%
PRLD $34,516,451 6,475,882 0.30%
QTTB $29,715,502 2,332,457 0.26%
EDIT $28,800,360 8,889,000 0.25%
ALT $19,760,000 6,500,000 0.17%
SNSE $18,050,500 722,020 0.16%
AURA $17,750,000 2,500,000 0.15%
Unknown issuer (CUSIP: 81221K108) $15,204,000 700,000 0.13%

Top movers (QoQ)

Security Action Shares Δ Value Δ
RYTM Price move only +0 +$160.4M
ARTV Bought more +8.1M +$110.7M
NUVL Trimmed -1.3M -$105.7M
GHRS Trimmed -40K +$97.3M
TYRA Price move only +0 -$77.6M
BCAX Price move only +0 +$71.1M
SEPN Price move only +0 +$66.2M
TSHA Price move only +0 +$55.1M
CLYM Price move only +0 +$54.6M
SLDB Bought more +2.7M +$53.0M

Exited positions

Includes corporate events (mergers, delistings) — not all exits are sells

Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.

SecurityQuarter Shares before Value before Price since exit
ASND June 30, 2026 10,281,496 $2,351,686,580 -2.8%
CDTX March 31, 2026 3,365,523 $743,410,375 No longer tracked
RNA March 31, 2026 8,641,031 $623,277,566 1.9%
ETNB Dec. 31, 2025 19,889,683 $292,378,340 No longer tracked
LEGN March 31, 2025 7,506,934 $244,275,632 -33.9%
DNTH June 30, 2026 2,611,733 $219,176,633 13.9%
PRAX June 30, 2026 373,787 $120,430,434 13.2%
XBI March 31, 2025 1,228,240 $110,615,294 No longer tracked
DYN Sept. 30, 2025 9,714,392 $92,481,012 105.7%
SRPT June 30, 2026 3,902,596 $84,920,489 6.6%
AXSM March 31, 2025 1,000,000 $84,610,000 85.5%
ACLX March 31, 2026 1,267,156 $82,618,571 No longer tracked
VRNA March 31, 2025 1,766,830 $82,051,585 No longer tracked
SYRE June 30, 2026 1,621,620 $81,794,513 19.3%
BLTE March 31, 2026 432,484 $69,180,141 6.3%
VORXXXX Sept. 30, 2025 39,646,039 $64,226,583 No longer tracked
PRAX March 31, 2025 761,955 $58,640,057 900.8%
APGE June 30, 2025 1,569,491 $58,636,184 210.2%
RXRX March 31, 2025 7,725,096 $52,221,649 -36.7%
RXST Sept. 30, 2025 3,702,967 $48,138,571 -31.4%
ZLAB June 30, 2025 1,295,040 $46,802,746 -25.1%
FULC June 30, 2026 6,053,960 $46,433,873 5.7%
DAWN June 30, 2025 5,755,577 $45,641,726 No longer tracked
SRRK Dec. 31, 2025 1,166,788 $43,451,185 25.8%
GPCR Dec. 31, 2025 1,517,418 $42,487,704 -23.4%
IVVD March 31, 2026 17,119,096 $42,284,167 -24.3%
TRML Sept. 30, 2025 2,538,925 $40,597,411 No longer tracked
EVH March 31, 2025 3,577,197 $40,243,466 -51.7%
OLMA June 30, 2026 2,600,000 $38,766,000 -12.5%
URGN June 30, 2025 3,206,271 $35,461,357 258.4%
MTSR Dec. 31, 2025 675,525 $35,350,223 No longer tracked
DSGN June 30, 2026 2,972,973 $31,632,433 7.9%
CMRX March 31, 2025 8,800,000 $30,624,000 No longer tracked
TVTX Dec. 31, 2025 1,150,000 $27,485,000 69.7%
ATXS June 30, 2025 5,105,213 $27,261,837 No longer tracked
KURA June 30, 2025 4,004,610 $26,430,426 111.0%
AVTE June 30, 2025 9,192,092 $23,072,151 No longer tracked
TVTX June 30, 2026 746,841 $22,188,646 14.1%
GRAL June 30, 2026 428,266 $22,132,787 9.5%
IDYA June 30, 2025 1,347,252 $22,067,988 81.4%
ITOS June 30, 2025 3,649,057 $21,784,870 No longer tracked
RLMD June 30, 2026 2,947,369 $20,513,688 -31.4%
LRMR Dec. 31, 2025 6,045,351 $19,526,484 8.0%
GKOS June 30, 2025 190,256 $18,724,996 84.5%
STRO June 30, 2026 715,307 $17,818,297 -36.3%
CCCC March 31, 2025 4,878,000 $17,560,800 150.7%
EYPT June 30, 2025 3,181,818 $17,245,454 -39.6%
ELVN Sept. 30, 2025 848,986 $17,030,659 183.0%
CTNM June 30, 2026 1,296,012 $16,925,917 -3.1%
PLRX March 31, 2025 1,281,000 $16,870,770 -13.3%
TNGX Dec. 31, 2025 2,000,000 $16,800,000 175.6%
INSP June 30, 2026 325,663 $16,797,698 38.3%
PRME Dec. 31, 2025 3,000,000 $16,620,000 -2.0%
CBLL June 30, 2025 824,582 $15,840,220 32.9%
NRIX June 30, 2025 1,333,333 $15,839,996 136.8%
HNGE Sept. 30, 2025 300,000 $15,525,000 80.6%
RCUS Dec. 31, 2025 1,136,364 $15,454,550 22.4%
INSM June 30, 2025 200,000 $15,258,000 27.6%
MDLN March 31, 2026 335,000 $14,070,000 -23.7%
HNGE June 30, 2026 364,613 $14,059,477 6.8%
WGS June 30, 2026 209,887 $13,478,943 18.0%
ALEC June 30, 2025 9,695,228 $11,925,130 73.6%
QURE Dec. 31, 2025 200,000 $11,674,000 100.2%
SERA June 30, 2025 3,032,808 $11,160,733 -28.2%
THRD March 31, 2025 960,620 $9,884,780 No longer tracked
BCYC June 30, 2025 1,093,477 $9,283,620 -41.7%
ELDN Dec. 31, 2025 3,566,338 $9,236,815 133.8%
CTMX Dec. 31, 2025 2,661,331 $8,489,646 -17.8%
ARVN March 31, 2025 421,348 $8,077,241 34.9%
IMTX June 30, 2025 1,750,000 $7,892,500 63.2%
SRZN Dec. 31, 2025 602,626 $7,764,836 5.6%
DRUG June 30, 2025 206,427 $7,445,822 215.8%
OMDA Sept. 30, 2025 400,000 $7,320,000 11.3%
BBNX Sept. 30, 2025 500,000 $7,280,000 1.1%
ACRS June 30, 2025 4,666,667 $7,140,001 350.7%
XNCR June 30, 2025 575,000 $6,118,000 240.8%
ENTA March 31, 2025 1,038,000 $5,968,500 144.4%
HUMA June 30, 2025 3,312,356 $5,647,567 -66.8%
TXG Sept. 30, 2025 475,343 $5,504,472 433.4%
MPLT June 30, 2026 248,294 $5,047,817 -66.8%
EVH Dec. 31, 2025 579,052 $4,898,780 14.4%
GKOS Dec. 31, 2025 54,180 $4,418,379 68.7%
MBX Sept. 30, 2025 377,841 $4,311,166 281.0%
ZURA June 30, 2025 3,217,503 $4,150,579 444.8%
BIOA June 30, 2025 1,052,494 $3,957,377 150.8%
BOLD June 30, 2025 2,180,631 $3,292,753 186.1%
TARA Sept. 30, 2025 1,039,295 $3,149,064 -10.1%
EXAS Dec. 31, 2025 54,939 $3,005,713 No longer tracked
STRO June 30, 2025 4,434,637 $2,885,175 2878.9%
IFRX Dec. 31, 2025 1,973,233 $2,644,132 109.9%
PGNY March 31, 2026 96,628 $2,481,407 56.0%
QGENXXXX March 31, 2026 43,976 $2,081,683 No longer tracked
ACHC Sept. 30, 2025 89,262 $2,025,355 11.9%
KIDS March 31, 2026 109,959 $1,952,872 65.3%
HCAT March 31, 2026 793,749 $1,897,060 33.9%
LXEO June 30, 2025 546,554 $1,896,542 29.6%
ALLK March 31, 2025 1,129,931 $1,367,217 No longer tracked
RGLS March 31, 2025 336,843 $532,212 No longer tracked
SCLXXXXX June 30, 2025 1,036,218 $257,500 No longer tracked