Performance vs S&P 500

03
Tracked Q1 2025–Q2 2026 +167.5%
S&P 500 total return (same window) +37.0%
Excess return +130.5%

Annualized: +119.8% · S&P 500: +28.7%

Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.

Priceable coverage: 93.9% · Options excluded: 11.7%

Sector breakdown

04
Healthcare 95.4%
Other/Unmapped 4.6%

Full portfolio 67 positions

05
Type Streak 8Q trend
GH Guardant Health, Inc. - Common Stock $509,098,599 7.41% 3,393,312 $200,745,278 Up ×2
IMVT Immunovant, Inc. - Common Stock $359,914,548 5.24% 9,341,151 $73,584,588 Down ×1
GPCR Structure Therapeutics Inc. - American Depositary Shares $254,399,664 3.70% 4,740,072 $48,110,990 Up ×2
PCVX Vaxcyte, Inc. - Common Stock $249,959,000 3.64% 4,300,000 $86,000
ALNY Alnylam Pharmaceuticals, Inc. - Common Stock $248,349,750 3.61% 825,000 Up ×1
MANE Veradermics, Incorporated Common Stock $245,880,000 3.58% 2,000,000 $214,305,000 Up ×1
TARS Tarsus Pharmaceuticals, Inc. - Common Stock $230,786,378 3.36% 3,666,768 $-21,753,622 Up ×5
NUVL Nuvalent, Inc. - Class A Common Stock $220,240,267 3.21% 1,783,322 $79,235,873 Up ×1
ALKS Alkermes plc - Ordinary Shares $209,580,000 3.05% 4,000,000 $82,626,179 Up ×2
OCUL Ocular Therapeutix, Inc. - Common Stock $193,319,289 2.81% 19,686,282 $26,576,480
BMRN BioMarin Pharmaceutical Inc. - Common Stock $189,254,063 2.75% 3,307,481 $124,290,563 Up ×1
NRIX Nurix Therapeutics, Inc. - Common stock $187,686,398 2.73% 7,736,455 $89,335,116 Up ×1
ORKA Oruka Therapeutics, Inc. - Common Stock $183,297,420 2.67% 1,926,000 $83,519,763 Down ×3
ALMS Alumis Inc. - Common Stock $178,648,422 2.60% 6,348,558 $29,448,154 Down ×1
IONS Ionis Pharmaceuticals, Inc. - Common Stock $174,438,000 2.54% 2,200,000 $28,012,500 Up ×2
CMPS COMPASS Pathways Plc - American Depository Shares $172,085,168 2.50% 12,161,496 $104,832,095
VERA Vera Therapeutics, Inc. - Class A Common Stock $171,640,000 2.50% 4,000,000 $6,452,925 Down ×1
AXSM Axsome Therapeutics, Inc. - Common Stock $171,339,000 2.49% 700,000 $-14,583,000 Down ×2
GMAB Genmab A/S - American Depositary Shares $155,205,500 2.26% 5,650,000 $56,920,502 Up ×1
MLTX MoonLake Immunotherapeutics - Class A Ordinary Shares $136,271,017 1.98% 6,999,025 $16,809,811 Up ×2
Unknown issuer (CUSIP: 423494103) $132,304,876 1.93% 3,602,093 Up ×1
TNGX Tango Therapeutics, Inc. - Common Stock $131,292,000 1.91% 4,200,000 $73,762,000 Up ×3
DFTX Definium Therapeutics, Inc. - Common Shares $129,360,000 1.88% 2,750,000 $72,660,000 Down ×1
GRAL GRAIL, Inc. - Common Stock $125,271,627 1.82% 1,834,944 $36,237,478 Up ×2
BCAX Bicara Therapeutics Inc. - Common Stock $121,729,000 1.77% 4,100,000 $40,925,875 Up ×3
MAZE Maze Therapeutics, Inc. - Common Stock $111,379,859 1.62% 3,732,569 $7,574,633 Up ×1
CLDX Celldex Therapeutics, Inc. - Common Stock $109,365,809 1.59% 2,939,151 $68,637,995 Up ×1
LBRX LB Pharmaceuticals Inc - Common Stock $108,815,254 1.58% 3,352,804 $26,135,107
MBX MBX Biosciences, Inc. - Common Stock $95,637,809 1.39% 1,732,569 $13,324,374 Down ×2
GHRS GH Research PLC - Ordinary Shares $89,600,018 1.30% 3,333,334
GMAB Genmab A/S - American Depositary Shares $82,410,000 1.20% 3,000,000 Call option Up ×1
COGT Cogent Biosciences, Inc. - Common Stock $77,400,000 1.13% 2,000,000 $38,910,000 Up ×2
ATAI AtaiBeckley Inc. - Common Stock $75,979,919 1.11% 14,417,442 $33,499,919 Up ×1
UTHR United Therapeutics Corporation - Common Stock $66,978,857 0.97% 123,616 Up ×1
AVTX Avalo Therapeutics, Inc. - Common Stock $66,712,800 0.97% 3,610,000
VRDN Viridian Therapeutics, Inc. - Common Stock $65,998,634 0.96% 3,592,740 $38,733,089 Up ×1
CYTK Cytokinetics, Incorporated - Common Stock $59,633,000 0.87% 700,000 $-30,948,431 Down ×3
ALT Altimmune, Inc. - Common Stock $58,520,000 0.85% 19,250,000 Up ×1
PSNL Personalis, Inc. - Common Stock $53,600,000 0.78% 4,000,000 $34,490,000 Up ×1
ACRS Aclaris Therapeutics, Inc. - Common Stock $49,435,050 0.72% 9,345,000 $14,391,300
CRMD CorMedix Inc. - Common Stock $49,251,497 0.72% 6,274,076 $6,650,521
WGS GeneDx Holdings Corp. - Class A Common Stock $48,055,000 0.70% 700,000 Up ×1
HROW Harrow, Inc. - Common Stock $41,153,430 0.60% 969,000 Up ×1
CRVS Corvus Pharmaceuticals, Inc. - Common Stock $37,229,569 0.54% 2,491,939 $778,353 Up ×1
SLDB Solid Biosciences Inc. - Common Stock $35,614,969 0.52% 3,565,062 $9,946,523
BEAM Beam Therapeutics Inc. - Common Stock $34,320,000 0.50% 1,000,000 $14,761,170 Up ×1
DYN Dyne Therapeutics, Inc. - Common Stock $33,315,000 0.48% 1,500,000 $-2,945,000 Down ×2
IMMX Immix Biopharma, Inc. - Common Stock $28,610,250 0.42% 2,775,000 Up ×1
XFOR X4 Pharmaceuticals, Inc. - Common Stock $27,453,795 0.40% 5,878,757 $1,271,515 Down ×1
STTK Shattuck Labs, Inc. - Common Stock $25,724,734 0.37% 3,706,734 Up ×1
MNKD MannKind Corporation - Common Stock $25,560,000 0.37% 6,000,000 Up ×1
IPSC Century Therapeutics, Inc. - Common Stock $23,183,480 0.34% 9,462,645 $1,741,176 Down ×1
Unknown issuer (CUSIP: 370920100) $22,501,459 0.33% 1,333,815 Up ×1
VSTM Verastem, Inc. - Common Stock $21,930,047 0.32% 5,740,850 $-8,496,458
KURA Kura Oncology, Inc. - Common Stock $21,704,858 0.32% 1,978,565 $212,862 Down ×1
ENTA Enanta Pharmaceuticals, Inc. - Common Stock $21,055,955 0.31% 1,444,167 $-3,659,275 Down ×1
NKTR Nektar Therapeutics - Common Stock $20,943,000 0.30% 300,000 Up ×1
OLMA Olema Pharmaceuticals, Inc. - Common Stock $18,765,000 0.27% 1,500,000
Unknown issuer (CUSIP: 482931102) $15,421,000 0.22% 700,000 Up ×1
Unknown issuer (CUSIP: 485925101) $14,310,000 0.21% 600,000 Up ×1
ELVN Enliven Therapeutics, Inc. - Common Stock $11,418,750 0.17% 225,000 Up ×1
PMN ProMIS Neurosciences Inc. - Common Shares $10,997,220 0.16% 835,655 $384,401
IMCR Immunocore Holdings plc - American Depositary Shares $9,881,172 0.14% 311,218 $-48,365,131 Down ×2
XNCR Xencor, Inc. - Common Stock $9,556,171 0.14% 593,551
CNTX Context Therapeutics Inc. - Common Stock $4,109,581 0.06% 7,419,355 $-15,329,129
IVA Inventiva S.A. - American Depository Shares $3,024,000 0.04% 800,000 $-3,760,614 Down ×1
ALGS Aligos Therapeutics, Inc. - Common stock $2,562,515 0.04% 444,110 $-737,222

Conviction holdings

08

Positions increased for 3+ consecutive quarters.

Share counts are as reported in 13F filings (not split-adjusted)

SecurityValue% of portfolioStreak
TARS $230,786,378 3.36% up ×5
TNGX $131,292,000 1.91% up ×3
BCAX $121,729,000 1.77% up ×3

Biggest new bets

09

New positions opened this quarter, largest first.

SecurityValueShares% of portfolio
ALNY $248,349,750 825,000 3.61%
Unknown issuer (CUSIP: 423494103) $132,304,876 3,602,093 1.93%
GHRS $89,600,018 3,333,334 1.30%
GMAB $82,410,000 3,000,000 1.20%
UTHR $66,978,857 123,616 0.97%
AVTX $66,712,800 3,610,000 0.97%
ALT $58,520,000 19,250,000 0.85%
WGS $48,055,000 700,000 0.70%
HROW $41,153,430 969,000 0.60%
IMMX $28,610,250 2,775,000 0.42%
STTK $25,724,734 3,706,734 0.37%
MNKD $25,560,000 6,000,000 0.37%
Unknown issuer (CUSIP: 370920100) $22,501,459 1,333,815 0.33%
NKTR $20,943,000 300,000 0.30%
OLMA $18,765,000 1,500,000 0.27%

Top movers (QoQ)

10
SecurityActionShares ΔValue Δ
GH Bought more +55K +$200.7M
BMRN Bought more +2.2M +$124.3M
CMPS Price move only +0 +$104.8M
NRIX Bought more +1.4M +$89.3M
ORKA Trimmed -108K +$83.5M
ALKS Bought more +410K +$82.6M
NUVL Bought more +407K +$79.2M
TNGX Bought more +1.4M +$73.8M
IMVT Trimmed -2.2M +$73.6M
DFTX Trimmed -250K +$72.7M

1 position hidden — reported move looks larger than the position itself (data completeness check)

Exited positions

11

Includes corporate events (mergers, delistings) — not all exits are sells

Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.

SecurityQuarterShares beforeValue beforePrice since exit
XBI June 30, 2026 10,000,000 $1,277,300,000 -2.4%
ITCI June 30, 2025 2,000,000 $263,840,000 No longer tracked
DVAX March 31, 2026 15,726,349 $241,871,248 No longer tracked
AKRO Dec. 31, 2025 4,000,978 $189,966,435 No longer tracked
APLS June 30, 2026 4,532,374 $182,337,406 No longer tracked
INSM Sept. 30, 2025 1,750,000 $176,120,000 -22.8%
ETNB Dec. 31, 2025 9,356,171 $137,535,714 No longer tracked
CNTA June 30, 2026 3,158,041 $125,437,389 No longer tracked
PTGX Dec. 31, 2025 1,715,691 $113,973,353 60.4%
BBIO June 30, 2026 841,445 $62,485,706 -9.7%
TERN June 30, 2026 1,073,877 $56,614,795 No longer tracked
EXAS Dec. 31, 2025 1,000,000 $54,710,000 No longer tracked
RARE Sept. 30, 2025 1,350,000 $49,086,000 -49.4%
GERN June 30, 2026 31,720,278 $47,263,214 -6.3%
ANIP June 30, 2026 600,000 $46,140,000 -12.8%
DNTH Sept. 30, 2025 2,233,148 $41,603,547 124.2%
SLNO June 30, 2026 1,078,710 $36,115,211 No longer tracked
AMGN June 30, 2025 113,035 $35,216,054 44.4%
OLMA Dec. 31, 2025 3,470,172 $33,972,984 -67.1%
MTSR Sept. 30, 2025 1,094,408 $31,135,908 No longer tracked
EWTX June 30, 2025 1,400,000 $30,800,000 215.8%
ENGN June 30, 2026 4,377,572 $29,811,265 12.1%
CDTX Dec. 31, 2025 300,000 $28,728,000 No longer tracked
QURE Dec. 31, 2025 483,092 $28,198,080 -2.0%
TECX Sept. 30, 2025 1,401,938 $27,856,508 43.7%
ABVX Sept. 30, 2025 3,480,144 $26,623,102 9.4%
APGE June 30, 2026 285,000 $23,988,450 No longer tracked
MNMD March 31, 2026 1,676,540 $22,448,871 No longer tracked
DYN June 30, 2025 2,000,000 $20,920,000 59.7%
JBIO Dec. 31, 2025 2,279,892 $19,675,468 -8.5%
GLPG June 30, 2025 741,068 $18,615,628 No longer tracked
GHRS Dec. 31, 2025 1,250,000 $17,875,000 80.6%
JANX June 30, 2026 1,187,290 $16,503,331 10.2%
XENE March 31, 2026 366,435 $16,423,617 -34.6%
SAGE June 30, 2025 2,038,845 $16,208,818 No longer tracked
UPB Sept. 30, 2025 1,442,767 $15,841,582 -73.2%
GMAB Dec. 31, 2025 481,267 $14,760,459 12.8%
MRUS Sept. 30, 2025 275,000 $14,465,000 No longer tracked
SRPT Sept. 30, 2025 709,800 $12,137,580 -9.2%
BCYC Sept. 30, 2025 1,203,244 $8,362,546 -56.3%
CBIO June 30, 2026 453,686 $8,334,212 -20.4%
IMA Dec. 31, 2025 878,516 $7,159,905 -33.3%
LRMR June 30, 2026 1,500,000 $6,750,000 -3.0%
CNTA Sept. 30, 2025 500,000 $6,570,000 No longer tracked
XNCR Dec. 31, 2025 549,439 $6,444,919 62.2%
HELP June 30, 2026 1,313,137 $6,303,058 77.0%
NVAX Sept. 30, 2025 998,542 $6,290,815 20.6%
MNPR March 31, 2026 95,408 $6,230,142 42.3%
BEAM June 30, 2025 315,765 $6,166,890 44.0%
IVVD Sept. 30, 2025 8,585,980 $6,138,976 -25.3%
RGLS June 30, 2025 3,262,564 $5,709,487 No longer tracked
BHVN March 31, 2026 500,000 $5,645,000 52.1%
PEPG Dec. 31, 2025 1,200,000 $5,544,000 -65.0%
PLRX Sept. 30, 2025 3,947,807 $4,579,456 -30.1%
AUTL Dec. 31, 2025 2,568,613 $4,186,839 -10.6%
INO Sept. 30, 2025 1,981,370 $4,032,088 -50.4%
BLLN June 30, 2026 50,000 $3,947,000 -11.7%
RAPT March 31, 2026 110,448 $3,740,874 No longer tracked
KRRO Sept. 30, 2025 277,966 $3,471,795 -79.9%
IKNA Sept. 30, 2025 2,515,513 $3,370,787 No longer tracked
SYRE Sept. 30, 2025 219,015 $3,278,655 456.0%
ACAD Dec. 31, 2025 105,085 $2,242,514 -25.3%
AVTX Dec. 31, 2025 144,600 $1,837,866 -17.5%
ALLK June 30, 2025 7,232,701 $1,646,163 No longer tracked
NGNE June 30, 2025 116,660 $1,366,089 71.6%
SEPN Sept. 30, 2025 121,716 $1,286,538 100.5%
ZURA Dec. 31, 2025 259,014 $1,121,531 -21.6%
RAPP Sept. 30, 2025 98,237 $1,116,955 8.3%
CLYM Dec. 31, 2025 509,789 $1,024,676 173.5%
OKUR Sept. 30, 2025 180,510 $431,419 -6.9%
ANL March 31, 2026 34,852 $49,490 118.1%